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Lang Qin

Publications and source records attributed to Lang Qin.

At least 19 recordsLinked to original sources

Fast and Accurate: An Adaptive VLA Inference Framework through Environment-aware Model Selection

Embodied intelligence demands both long-horizon reasoning and real-time closed-loop responsiveness. Recent dual-system Vision-Language-Action (VLA) architectures combine fast reactive control with slow deliberative reasoning to balance inference speed and task success rate. However, existing dual-process VLAs tightly couple the fast module to intermediate representations of the slow module, necessitating end-to-end joint training and limiting modularity, extensibility and flexible system switching. In this paper, we propose Environment-aware Model Selection (EMS), an adaptive VLA inference framework that switches between two fully decoupled systems of different scales through environment-aware model selection. The large-scale deliberative system provides globally consistent trajectory planning to ensure task success, while a lightweight reactive system enables high-frequency closed-loop control. A reinforcement-learning-based switching policy dynamically selects which system to invoke based on real-time feedback, enabling sparse use of the slow system and thereby balancing pretrained knowledge utilisation with runtime efficiency. Our design offers three key advantages over prior hierarchical VLA frameworks: (1) a fully decoupled and modular dual-system architecture that supports plug-and-play model replacement; (2) an adaptive, environment-aware switching strategy; (3) high-frequency inference for responsive closed-loop control. We extensively evaluate EMS in both simulation and real-world environments. On the LIBERO benchmark, EMS achieves success rates comparable to the large-scale baseline while increasing the effective action frequency to 93.4 Hz. The framework further demonstrates strong extensibility in real-world dual-arm manipulation tasks, where it accelerates task completion while maintaining robust performance.

cs.RO

APCyc: Property-Informed Design of Cyclic Peptides via Automated Cyclization

Cyclic peptides represent a promising class of therapeutic compounds in modern drug discovery, often offering improved stability and binding affinity. However, the de novo design of cyclic peptides remains challenging because methods must identify pocket-adaptive cyclization patterns and linkage sites while simultaneously controlling drug-relevant properties. This challenge is particularly pronounced for recent generative models trained predominantly on linear peptide data, which may fail to capture cyclization-specific constraints. To address the limitation, we introduce APCyc, a target-aware de novo cyclic peptide generation framework that explicitly models cyclization and jointly optimizes multiple essential physicochemical properties. By using an expanded residue vocabulary and explicitly encoding cyclization-site and linkage-type information, APCyc learns cyclization-aware representations and leverages Bayesian posterior guidance to steer sampling toward cyclic peptides satisfying multiple property objectives. Experimental results demonstrate that our model learns target-dependent cyclization preferences, and enables effective and controllable multi-property optimization for cyclic peptide design. The source code of this paper is available at https://github.com/HKUSTGZ-ML4Health-Lab/APCyc.

cs.AI

Can Broad Biomedical Knowledge be Contextualized into Scenario-Grounded Propositions?

Biomedical discovery often requires connecting broad biomedical knowledge with specific experimental or clinical data. Background knowledge suggests relevant mechanisms but is usually too general to map directly onto dataset variables, while data-driven patterns can be dataset-specific and hard to interpret mechanistically. We study this missing link as knowledge contextualization: transforming broad biomedical knowledge into evidence-supported, scenario-grounded propositions that domain experts can inspect, replay, and validate. We propose SCENE, a bi-level multi-agent framework that treats knowledge contextualization as iterative search. The upper level converts broad knowledge into search directions and grounds them in the dataset schema. The lower level executes these directions through multi-objective optimization to identify concrete propositions that balance evidential strength and data support. Feedback between the two levels progressively refines the search. We evaluate SCENE in two settings: discovering patient subgroups with heterogeneous treatment benefits in clinical trial scenarios, and identifying context-specific biological responses in LINCS L1000 studies. In clinical trials, SCENE discovers specific, well-supported subgroups and outperforms existing baselines. In L1000 studies, SCENE identifies perturbational contexts with strong target-response matching and high positive rates. These results show that SCENE bridges broad knowledge and scenario-specific evidence, producing traceable, inspectable hypotheses for follow-up validation.

cs.AI

Spatiotemporal decoupled physics-informed Stone-Weierstrass neural operator for long-time prediction of time-dependent parametric PDEs

Driven by rapid advances in artificial intelligence and modern GPU computing capabilities, deep learning methods based on the optimization paradigm have provided new pathways to solve spatiotemporal physical problems, whose mathematical core lies in solving partial differential equations (PDEs). As an emerging class of function-space learning methods, neural operators (NOs) have exhibited great potential in efficient PDE solving. However, existing mainstream neural operator frameworks suffer from critical bottlenecks when modeling time-dependent PDEs over long time horizons, including accuracy degradation, insufficient stability, high training costs, and excessive memory consumption, which severely limit their practical deployment. To address these challenges in long-time prediction with neural operators, we propose a novel spatiotemporally decoupled physics-informed neural operator architecture, termed the physics-informed Stone-Weierstrass neural operator (PI-SWNO). The design is theoretically grounded in the decoupling paradigm combining time-invariant spatial basis functions with time-varying evolution coefficients, as well as the Stone-Weierstrass approximation theorem. By encoding spatial and temporal information via two separate subnetworks, the framework structurally mitigates the accumulation of errors over extended time intervals. Furthermore, we introduce a time-marching batch-wise sampling strategy to resolve the memory bottleneck of full-range modeling over extended time spans, ensuring continuity and convergence of full-time-domain solutions.

physics.comp-ph

Multi-site Radar Systems for High-Precision Indoor Positioning and Tracking

This paper introduces a high-precision indoor positioning and tracking method that utilizes multi-site single-input single-output (SISO) radar systems. We propose a novel velocity synthesis-assisted (VSA) localization algorithm that iteratively refines target position estimates within range bins by fusing radial velocity measurements from multiple radars. This approach ensures enhanced accuracy in both velocity and position estimation. Moreover, the inherent geometric constraints introduced by velocity synthesis enable the proposed algorithm to remain robust under low signal-to-noise ratio (SNR), severe multipath propagation, and large synchronization latency. Notably, our method eliminates the use of multiple-input-multiple-output (MIMO) configurations and stringent phase synchronization requirements, substantially reducing hardware complexity while maintaining high positioning accuracy. We define standardized reference trajectories to facilitate a comprehensive and reproducible performance evaluation. Extensive simulations and experimental validations demonstrate that our multi-site radar systems achieve centimeter-level tracking accuracy for human subjects, outperforming existing methods in complex trajectory tracking.

eess.SP

Unified Error Analysis of Multi-site Radar via Equivalent Angular Resolution

High-precision indoor sensing using monostatic multiple-input multiple-output (MIMO) radar typically relies on increasing the physical aperture size of antennas, leading to high hardware complexity and cost. To overcome this bottleneck, this paper establishes a unified framework for multi-site radar sensing based on equivalent angular resolution, together with a design methodology that uses this metric to optimize distributed Single-Input Single-Output (SISO) configurations. By mapping spatial diversity into the angular domain, the proposed metric enables a direct and physically interpretable comparison with monostatic MIMO beamwidth. The associated methodology provides a principled way to select node placement and geometry to synthesize an effective virtual aperture that suppresses angular glint and multipath. Experiments with commercial 60-GHz radars in cluttered indoor environments validate the superiority of the multi-site SISO configuration over monostatic MIMO, demonstrating a reduction in maximum localization error from 0.58 m to 0.20 m and mean error from 0.35 m to 0.12 m.

eess.SP

Respiration Monitoring of Multiple People using Multi-site FMCW SISO Radar Systems

Continuous contactless respiration monitoring of co-sleeping subjects faces a dilemma: conventional single-site multiple-input multiple-output (MIMO) radars struggle with limited angular resolution for closely spaced individuals, while distributed radar networks typically require complex hardware synchronization. To address these limitations, this paper proposes non-coherent multi-site single-input-single-output (SISO) radar systems that completely eliminate the need for physical synchronization cables or common reference clocks. The fundamental challenge of ghost target ambiguity in such non-coherent multilateration is resolved through a novel physiological-feature-assisted suppression technique. By exploiting the inherent statistical independence of individual respiratory rhythms, true target locations are robustly distinguished from ghosts via cross-correlation analysis. Experimental validation demonstrates that the proposed system can accurately resolve two subjects spaced less than 20 cm apart, surpassing the resolution limits of traditional compact MIMO arrays, while achieving a respiration rate estimation accuracy of 0.7 bpm root mean square error (RMSE) compared to contact-based ground truth.

eess.SP

Stable Reasoning, Unstable Responses: Mitigating LLM Deception via Stability Asymmetry

As Large Language Models (LLMs) expand in capability and application scope, their trustworthiness becomes critical. A vital risk is intrinsic deception, wherein models strategically mislead users to achieve their own objectives. Existing alignment approaches based on chain-of-thought (CoT) monitoring supervise explicit reasoning traces. However, under optimization pressure, models are incentivized to conceal deceptive reasoning, rendering semantic supervision fundamentally unreliable. Grounded in cognitive psychology, we hypothesize that a deceptive LLM maintains a stable internal belief in its CoT while its external response remains fragile under perturbation. We term this phenomenon stability asymmetry and quantify it by measuring the contrast between internal CoT stability and external response stability under perturbation. Building on this structural signature, we propose the Stability Asymmetry Regularization (SAR), a novel alignment objective that penalizes this distributional asymmetry during reinforcement learning. Unlike CoT monitoring, SAR targets the statistical structure of model outputs, rendering it robust to semantic concealment. Extensive experiments confirm that stability asymmetry reliably identifies deceptive behavior, and that SAR effectively suppresses intrinsic deception without degrading general model capability.

cs.LG

AllMem: A Memory-centric Recipe for Efficient Long-context Modeling

Large Language Models (LLMs) encounter significant performance bottlenecks in long-sequence tasks due to the computational complexity and memory overhead inherent in the self-attention mechanism. To address these challenges, we introduce \textsc{AllMem}, a novel and efficient hybrid architecture that integrates Sliding Window Attention (SWA) with non-linear Test-Time Training (TTT) memory networks. \textsc{AllMem} enables models to effectively scale to ultra-long contexts while mitigating catastrophic forgetting. This approach not only overcomes the representation constraints typical of linear memory models but also significantly reduces the computational and memory footprint during long-sequence inference. Furthermore, we implement a Memory-Efficient Fine-Tuning strategy to replace standard attention layers in pre-trained models with memory-augmented sliding window layers. This framework facilitates the efficient transformation of any off-the-shelf pre-trained LLM into an \textsc{AllMem}-based architecture. Empirical evaluations confirm that our 4k window model achieves near-lossless performance on 37k LongBench with a marginal 0.83 drop compared to full attention. Furthermore, on InfiniteBench at a 128k context, our 8k window variant outperforms full attention, which validates the effectiveness of our parameterized memory in mitigating noise and maintaining robust long-range modeling without the prohibitive costs of global attention.

cs.AI

Region-aware Spatiotemporal Modeling with Collaborative Domain Generalization for Cross-Subject EEG Emotion Recognition

Cross-subject EEG-based emotion recognition (EER) remains challenging due to strong inter-subject variability, which induces substantial distribution shifts in EEG signals, as well as the high complexity of emotion-related neural representations in both spatial organization and temporal evolution. Existing approaches typically improve spatial modeling, temporal modeling, or generalization strategies in isolation, which limits their ability to align representations across subjects while capturing multi-scale dynamics and suppressing subject-specific bias within a unified framework. To address these gaps, we propose a Region-aware Spatiotemporal Modeling framework with Collaborative Domain Generalization (RSM-CoDG) for cross-subject EEG emotion recognition. RSM-CoDG incorporates neuroscience priors derived from functional brain region partitioning to construct region-level spatial representations, thereby improving cross-subject comparability. It also employs multi-scale temporal modeling to characterize the dynamic evolution of emotion-evoked neural activity. In addition, the framework employs a collaborative domain generalization strategy, incorporating multidimensional constraints to reduce subject-specific bias in a fully unseen target subject setting, which enhances the generalization to unknown individuals. Extensive experimental results on SEED series datasets demonstrate that RSM-CoDG consistently outperforms existing competing methods, providing an effective approach for improving robustness. The source code is available at https://github.com/RyanLi-X/RSM-CoDG.

cs.CV

RareAgent: Self-Evolving Reasoning for Drug Repurposing in Rare Diseases

Computational drug repurposing for rare diseases is especially challenging when no prior associations exist between drugs and target diseases. Therefore, knowledge graph completion and message-passing GNNs have little reliable signal to learn and propagate, resulting in poor performance. We present RareAgent, a self-evolving multi-agent system that reframes this task from passive pattern recognition to active evidence-seeking reasoning. RareAgent organizes task-specific adversarial debates in which agents dynamically construct evidence graphs from diverse perspectives to support, refute, or entail hypotheses. The reasoning strategies are analyzed post hoc in a self-evolutionary loop, producing textual feedback that refines agent policies, while successful reasoning paths are distilled into transferable heuristics to accelerate future investigations. Comprehensive evaluations reveal that RareAgent improves the indication AUPRC by 18.1% over reasoning baselines and provides a transparent reasoning chain consistent with clinical evidence.

cs.AI

Rising bubbles draw surface patterns: a numerical study

Small bubbles rising in a chain can self-organize into regular patterns upon reaching a liquid's free surface. This phenomenon is investigated through direct numerical simulations. By varying the bubble release period, distinct branching patterns characterized by different numbers of arms are observed. These macroscopic regular configurations arise from localized non-contact repulsion and pair collisions between bubbles as they arrive at the free-surface emergence site. A theoretical model is proposed to quantitatively relate the number of branches to the bubble release period. The model also predicts probabilities of observing specific arm counts in reality. This study provides insights into broader nonlinear pattern formation and self-organization phenomena.

physics.flu-dyn

OH$^-$-Enhanced Alkaline Hydrogen Evolution Reaction at the Au(111) Electrode

The hydrogen evolution reaction (HER) in alkaline media suffers from sluggish kinetics but the origin of the pH-dependent activity remains debated. This study investigates the role of hydroxide ions (OH) in enhancing the alkaline HER at Au(111) by systematically varying the pH and the NaOH concentration both with and without fixing the total Na concentration.Contrary to conventional cation-centric models of alkaline HER, we demonstrate a notable anion effect by showing that the HER activity increases monotonically with pH and OH concentration, even at extremely high NaOH concentrations(up to 9 M).Tafel slopes decrease from 181 mV/dec at pH=10 to 124 mV/dec at pH=13 and to 111 mV/dec for the case with 9 M NaOH, indicating accelerated kinetics.Infrared spectroscopy reveals that interfacial OH strengthens the hydrogen-bond network, which is expected to lower the activation energy for the Volmer step,the rate-determining step of HER on Au(111). Hence,OH enhances alkaline HER kinetics by strengthening the hydrogen bond network and its connectivity at the electrochemical interface;this allows us to propose a unified mechanism for the electrolyte effects on alkaline HER where structure-making ions (Li,K,and OH) improve the reaction kinetics by optimizing the interfacial hydrogen bond network.

physics.chem-ph

A Machine Learning Framework for Climate-Resilient Insurance and Real Estate Decisions

Extreme weather events increasingly threaten the insurance and real estate industries, creating conflicts between profitability and homeowner burdens. To address this, we propose the SSC-Insurance Model, which integrates SMOTE, SVM, and C-D-C algorithms to evaluate weather impacts on policies and investments. Our model achieves 88.3% accuracy in Zhejiang and 79.6% in Ireland, identifying a critical threshold (43% weather increase) for insurance viability. Additionally, we develop the TOA-Preservation Model using TOPSIS-ORM and AHP to prioritize building protection, with cultural value scoring highest (weight: 0.3383). Case studies on Nanxun Ancient Town show a 65.32% insurability probability and a protection score of 0.512. This work provides actionable tools for insurers, developers, and policymakers to manage climate risks sustainably.

cs.CE

AI shares emotion with humans across languages and cultures

Effective and safe human-machine collaboration requires the regulated and meaningful exchange of emotions between humans and artificial intelligence (AI). Current AI systems based on large language models (LLMs) can provide feedback that makes people feel heard. Yet it remains unclear whether LLMs represent emotion in language as humans do, or whether and how the emotional tone of their output can be controlled. We assess human-AI emotional alignment across linguistic-cultural groups and model-families, using interpretable LLM features translated from concept-sets for over twenty nuanced emotion categories (including six basic emotions). Our analyses reveal that LLM-derived emotion spaces are structurally congruent with human perception, underpinned by the fundamental affective dimensions of valence and arousal. Furthermore, these emotion-related features also accurately predict large-scale behavioural data on word ratings along these two core dimensions, reflecting both universal and language-specific patterns. Finally, by leveraging steering vectors derived solely from human-centric emotion concepts, we show that model expressions can be stably and naturally modulated across distinct emotion categories, which provides causal evidence that human emotion concepts can be used to systematically induce LLMs to produce corresponding affective states when conveying content. These findings suggest AI not only shares emotional representations with humans but its affective outputs can be precisely guided using psychologically grounded emotion concepts.

cs.CL

3D Deep-learning-based Segmentation of Human Skin Sweat Glands and Their 3D Morphological Response to Temperature Variations

Skin, the primary regulator of heat exchange, relies on sweat glands for thermoregulation. Alterations in sweat gland morphology play a crucial role in various pathological conditions and clinical diagnoses. Current methods for observing sweat gland morphology are limited by their two-dimensional, in vitro, and destructive nature, underscoring the urgent need for real-time, non-invasive, quantifiable technologies. We proposed a novel three-dimensional (3D) transformer-based multi-object segmentation framework, integrating a sliding window approach, joint spatial-channel attention mechanism, and architectural heterogeneity between shallow and deep layers. Our proposed network enables precise 3D sweat gland segmentation from skin volume data captured by optical coherence tomography (OCT). For the first time, subtle variations of sweat gland 3D morphology in response to temperature changes, have been visualized and quantified. Our approach establishes a benchmark for normal sweat gland morphology and provides a real-time, non-invasive tool for quantifying 3D structural parameters. This enables the study of individual variability and pathological changes in sweat gland structure, advancing dermatological research and clinical applications, including thermoregulation and bromhidrosis treatment.

eess.IV

Mutual Validation of Datasets for Analyzing Tilt Angles in Solar Active Regions

The tilt angle of solar active regions (AR) is crucial for the Babcock-Leighton type dynamo models in the buildup of polar field. However, divergent results regarding properties of tilt angles were reported due to their wide scatter, caused by intrinsic solar mechanisms and measurement errors. Here, we mutually validate the magnetogram-based AR tilt angle dataset from Wang, Jiang, & Luo with the Debrecen Photoheliographic Data by identifying common data points where both datasets provide comparable tilt angles for the same AR/sunspot. The mutually validated datasets effectively reduce measurement errors, enabling a more accurate analysis of the intrinsic properties of tilt angles. Our mutually validated datasets reveal that the difference between white-light-based and magnetogram-based tilt angles has no significant difference. Also, the datasets show that an upward revision of average tilt angle ($\bar\alpha$) and a downward revision of the tilt scatter ($\sigma_\alpha$) compared to previous results are necessary, with typical values of about 7$^\circ$ and 16$^\circ$, respectively. The $\sigma_\alpha$ values demonstrate a strong correlation with AR flux and sunspot area, with the dependency functions re-evaluated using mutually validated datasets. Furthermore, both $\bar\alpha$ and the tilt coefficient for the weak cycle 24 are larger than those for cycle 23. This supports the tilt quenching mechanism, which posits an anti-correlation between the cycle-averaged tilt angle and cycle amplitude. Additionally, tilt angle from the mutually validated dataset has a weak non-monotonic relationship with magnetic flux and does not depend on the maximum magnetic field strength of ARs.

astro-ph.SR

Listening to Patients: A Framework of Detecting and Mitigating Patient Misreport for Medical Dialogue Generation

Medical Dialogue Systems aim to provide automated healthcare support through patient-agent conversations. Previous efforts typically regard patients as ideal users -- one who accurately and consistently reports their health conditions. However, in reality, patients often misreport their symptoms, leading to discrepancies between their reports and actual health conditions. Overlooking patient misreport will affect the quality of healthcare consultations provided by MDS. To address this issue, we argue that MDS should ''listen to patients'' and tackle two key challenges: how to detect and mitigate patient misreport effectively. In this work, we propose PaMis, a framework of detecting and mitigating Patient Misreport for medical dialogue generation. PaMis first constructs dialogue entity graphs, then detects patient misreport based on graph entropy, and mitigates patient misreport by formulating clarifying questions. Experiments indicate that PaMis effectively enhances medical response generation, enabling models like GPT-4 to detect and mitigate patient misreports, and provide high-quality healthcare assistance.

cs.CL