arXiv subjects

Laura Ferrante

Publications and source records attributed to Laura Ferrante.

3 recordsLinked to original sources

arXiv2026

Agonist-Antagonist Neural Coordination without Mechanical Coupling after Targeted Muscle Reinnervation

Following limb amputation and targeted muscle reinnervation (TMR), nerves that originally innervated agonist and antagonist muscles are rerouted into one or more residual target muscles. This rerouting profoundly alters the natural mechanical coupling and afferent signalling that normally link muscle groups in intact limbs. Despite this disruption, in this study we demonstrate, using high-density intramuscular microelectrode arrays implanted in reinnervated muscles of three TMR participants, that motor units (MUs) associated with agonist and antagonist tasks remain functionally coupled. Specifically, over 40% of motor units active during agonist tasks were also recruited during the corresponding antagonist tasks, even though no visual feedback on antagonist neural activity was provided. These motor units exhibited significantly different firing rates depending on their functional role. These results provide the first motor-unit-level evidence that the central nervous system preserves coordinated agonist-antagonist control after TMR and inform restorative surgical strategies and prosthetic systems capable of regulating both limb kinematics and dynamics based on agonist-antagonist commands interplay.

q-bio.NC↗

arXiv2024

Separation of Neural Drives to Muscles from Transferred Polyfunctional Nerves using Implanted Micro-electrode Arrays

Following limb amputation, neural signals for limb functions persist in the residual peripheral nerves. Targeted muscle reinnervation (TMR) allows to redirected these signals into spare muscles to recover the neural information through electromyography (EMG). However, a significant challenge arises in separating distinct neural commands redirected from the transferred nerves to the muscles. Disentangling overlapping signals from EMG recordings remains complex, as they can contain mixed neural information that complicates limb function interpretation. To address this challenge, Regenerative Peripheral Nerve Interfaces (RPNIs) surgically partition the nerve into individual fascicles that reinnervate specific muscle grafts, isolating distinct neural sources for more precise control and interpretation of EMG signals. We introduce a novel biointerface that combines TMR surgery of polyvalent nerves with a high-density micro-electrode array implanted at a single site within a reinnervated muscle. Instead of surgically identifying distinct nerve fascicles, our approach separates all neural signals that are re-directed into a single muscle, using the high spatio-temporal selectivity of the micro-electrode array and mathematical source separation methods. We recorded EMG signals from four reinnervated muscles while volunteers performed phantom limb tasks. The decomposition of these signals into motor unit activity revealed distinct clusters of motor neurons associated with diverse functional tasks. Notably, our method enabled the extraction of multiple neural commands within a single reinnervated muscle, eliminating the need for surgical nerve division. This approach not only has the potential of enhancing prosthesis control but also uncovers mechanisms of motor neuron synergies following TMR, providing valuable insights into how the central nervous system encodes movement after reinnervation.

q-bio.NC↗

arXiv2022

Toward a Framework for Adaptive Impedance Control of an Upper-limb Prosthesis

Adapting upper-limb impedance (i.e., stiffness, damping, inertia) is essential for humans interacting with dynamic environments for executing grasping or manipulation tasks. On the other hand, control methods designed for state-of-the-art upper-limb prostheses infer motor intent from surface electromyography (sEMG) signals in terms of joint kinematics, but they fail to infer and use the underlying impedance properties of the limb. We present a framework that allows a human user to simultaneously control the kinematics, stiffness, and damping of a simulated robot through wrist's flexion-extension. The framework includes muscle-tendon units and a forward dynamics block to estimate the motor intent from sEMG signals, and a variable impedance controller that implements the estimated intent on the robot, allowing the user to adapt the robot's kinematics and dynamics online. We evaluate our framework with 8 able-bodied subjects and an amputee during reaching tasks performed in free space, and in the presence of unexpected external perturbations that require adaptation of the wrist impedance to ensure stable interaction with the environment. We experimentally demonstrate that our approach outperforms a data-driven baseline in terms of its ability to adapt to external perturbations, overall controllability, and feedback from participants.

cs.RO↗