arXiv subjects

Laura Forastiere

Publications and source records attributed to Laura Forastiere.

At least 19 recordsLinked to original sources

arXiv2026

Higher-order Spillover Effects Under Partial Interference

Interference, under which a unit's outcome is affected by the treatment of other units through network connections, is often present when units interact on a network. When the network of interactions is measured, researchers are often interested in the spillover effect from first-order neighbors. When this is the case, the prevailing approach often involves the neighborhood interference assumption, which is oftentimes overly restrictive. In this paper, we instead rely on a generalized interference assumption, which allows one's potential outcomes to be influenced by the treatment of units from a wider area of the network, referred to as the "interference set". For instance, this can be a community detected through a community detection algorithm, or the set of units that can be reached through a finite network path. Under this assumption, we define new causal estimands to quantify spillover effects from first-order neighbors and, in general, from units at a specific network distance h. We employ two hypothetical Bernoulli distributions with different probabilities for the h-order neighborhood and for the rest of the units in the interference set. We first derive the bias of an approach that relies on a wrong interference set or incorrect exposure mapping function. We then develop new Horvitz-Thompson and Hajek estimators and corresponding weighted regression estimators under the generalized interference assumption. We conduct a series of simulations to assess the bias of OLS estimators -- which rely on restrictive interference assumptions and an exposure mapping function -- , and the performance of our estimators in different interference scenarios and random graphs. We then apply our estimators to a two-stage randomized trial implemented in Honduras to assess a maternal and child health intervention.

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arXiv2025

Design-Based Weighted Regression Estimators for Average and Conditional Spillover Effects

When individuals engage in social or physical interactions, a unit's outcome may depend on the treatments received by others. In such interference environments, we provide a unified framework characterizing a broad class of spillover estimands as weighted averages of unit-to-unit spillover effects, with estimand-specific weights. We then develop design-based weighted least squares (WLS) estimators for both average and conditional spillover effects. We introduce three nonparametric estimators under the dyadic, sender, and receiver perspectives, which distribute the estimand weights differently across the outcome vector, design matrix, and weight matrix. For the average-type estimands, we show that all three estimators are equivalent to the Hajek estimator. For conditional spillover effects, we establish conditions under which the estimands are consistent for the target conditional spillover effects. We further derive concentration inequalities, a central limit theorem, and conservative variance estimators in an asymptotic regime where both the number of clusters and cluster sizes grow.

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arXiv2025

Educational Intervention Re-Wires Social Interactions in Isolated Village Networks

Social networks shape behavior, disseminate information, and undergird collective action within communities. Consequently, they can be very valuable in the design of effective interventions to improve community well-being. But any exogenous intervention in networked groups, including ones that just involve the provision of information, can also possibly modify the underlying network structure itself, and some interventions are indeed designed to do so. While social networks obey certain fundamental principles (captured by network-level statistics, such as the degree distribution or transitivity level), they can nevertheless undergo change across time, as people form and break ties with each other within an overall population. Here, using a randomized controlled trial in 110 remote Honduran villages involving 8,331 people, we evaluated the effects of a 22-month public health intervention on pre-existing social network structures. We leverage a two-stage randomized design, where a varying fraction of households received the intervention in each village. In low-dosage villages (5%, 10%, 20%, and 30%) compared to untreated villages (0%), over a two-year period, individuals who received the intervention tended to sever both inbound and outbound ties with untreated individuals whom they previously trusted for health advice. Conversely, in high-dosage villages (50%, 75%, and 100%), treated individuals increased both their inbound and outbound ties. Furthermore, although the intervention was health-focused, it also reshaped broader friendship and financial ties. In aggregate, the imposition of a novel health information regime in rural villages (as a kind of social institution) led to a significant rewiring in individuals particular connections, but it still had a limited effect on the overall global structure of the village-wide social networks.

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arXiv2025

Inward and Outward Spillover Effects of One Unit's Treatment on Network Neighbors under Partial Interference

In settings where interference is present, direct effects are commonly defined as the average effect of a unit's treatment on their own outcome while fixing the treatment status or probability among interfering units. Spillover effects measure the average effect of a change in the latter while the individual's treatment status is kept fixed. Here, we define the average causal effect of a unit's treatment status on the outcome of their network neighbors, while fixing the treatment probability in the remaining interference set. We propose two different weighting schemes defining two causal effects: i) the outward spillover effect, which represents the average effect of a unit's treatment on their neighbors' potential outcomes, and ii) the inward spillover effect, which represents the impact of each neighbor's treatment on an individual's own potential outcome. We provide a necessary and sufficient condition for when outward and inward spillover effects differ--even in undirected networks--and show that they are equivalent under specific conditions. We provide numerous examples illustrating the conditions for equivalence or discrepancy of the two spillover effects. We then compare their Horvitz-Thompson estimators, examining their relative variance under various graph structures and structural assumptions on potential outcomes.

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arXiv2025

Effective treatment allocation strategies under partial interference

Interference occurs when the potential outcomes of a unit depend on the treatment of others. Interference can be highly heterogeneous, where treating certain individuals might have a larger effect on the population's overall outcome. A better understanding of how covariates explain this heterogeneity may lead to more effective interventions. In the presence of clusters of units, we assume that interference occurs within clusters but not across them. We define novel causal estimands under hypothetical, stochastic treatment allocation strategies that fix the marginal treatment probability in a cluster and vary how the treatment probability depends on covariates, such as a unit's network position and characteristics. We illustrate how these causal estimands can shed light on the heterogeneity of interference and on the network and covariate profile of influential individuals. For experimental settings, we develop standardized weighting estimators for our novel estimands and derive their asymptotic distribution. We design an inferential procedure for testing the null hypothesis of interference homogeneity with respect to covariates. We validate the performance of the estimator and inferential procedure through simulations.We then apply the novel estimators to a clustered experiment in China to identify the important characteristics that drive heterogeneity in the effect of providing information sessions on insurance uptake.

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arXiv2025

Identifying Key Influencers using an Egocentric Network-based Randomized Design

Behavioral health interventions, such as trainings or incentives, are implemented in settings where individuals are interconnected, and the intervention assigned to some individuals may also affect others within their network. Evaluating such interventions requires assessing both the effect of the intervention on those who receive it and the spillover effect on those connected to the treated individuals. With behavioral interventions, spillover effects can be heterogeneous in that certain individuals, due to their social connectedness and individual characteristics, are more likely to respond to the intervention and influence their peers' behaviors. Targeting these individuals can enhance the effectiveness of interventions in the population. In this paper, we focus on an Egocentric Network-based Randomized Trial (ENRT) design, wherein a set of index participants is recruited from the population and randomly assigned to the treatment group, while concurrently collecting outcome data on their nominated network members, who remina untreated. In such design, spillover effects on network members may vary depending on the characteristics of the index participant. Here, we develop a testing method, the Multiple Comparison with Best (MCB), to identify subgroups of index participants whose treatment exhibits the largest spillover effect on their network members. Power and sample size calculations are then provided to design ENRTs that can detect key influencers. The proposed methods are demonstrated in a study on network-based peer HIV prevention education program, providing insights into strategies for selecting peer educators in peer education interventions.

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arXiv2024

Regression Discontinuity Designs Under Interference

We extend the continuity-based framework to Regression Discontinuity Designs (RDDs) to identify and estimate causal effects under interference when units are connected through a network. Assignment to an "effective treatment," combining the individual treatment and a summary of neighbors' treatments, is determined by the unit's score and those of interfering units, yielding a multiscore RDD with complex, multidimensional boundaries. We characterize these boundaries and derive assumptions to identify boundary causal effects. We develop a distance-based nonparametric estimator and establish its asymptotic properties under restrictions on the network degree distribution. We show that while direct effects converge at the standard rate, the rate for indirect effects depends on the number of scores fixed at the cutoff. Finally, we propose a variance estimator accounting for network correlation and apply our method to PROGRESA data to estimate the direct and indirect effects of cash transfers on school attendance.

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arXiv2024

Forecasting Causal Effects of Future Interventions: Confounding and Transportability Issues

Recent developments in causal inference allow us to transport a causal effect of a time-fixed treatment from a randomized trial to a target population across space but within the same time frame. In contrast to transportability across space, transporting causal effects across time or forecasting causal effects of future interventions is more challenging due to time-varying confounders and time-varying effect modifiers. In this article, we seek to formally clarify the causal estimands for forecasting causal effects over time and the structural assumptions required to identify these estimands. Specifically, we develop a set of novel nonparametric identification formulas--g-computation formulas--for these causal estimands, and lay out the conditions required to accurately forecast causal effects from a past observed sample to a future population in a future time window. Our overarching objective is to leverage the modern causal inference theory to provide a theoretical framework for investigating whether the effects seen in a past sample would carry over to a new future population. Throughout the article, a working example addressing the effect of public policies or social events on COVID-related deaths is considered to contextualize the developments of analytical results.

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arXiv2024

Estimating the age-conditioned average treatment effects curves: An application for assessing load-management strategies in the NBA

In the realm of competitive sports, understanding the performance dynamics of athletes, represented by the age curve (showing progression, peak, and decline), is vital. Our research introduces a novel framework for quantifying age-specific treatment effects, enhancing the granularity of performance trajectory analysis. Firstly, we propose a methodology for estimating the age curve using game-level data, diverging from traditional season-level data approaches, and tackling its inherent complexities with a meta-learner framework that leverages advanced machine learning models. This approach uncovers intricate non-linear patterns missed by existing methods. Secondly, our framework enables the identification of causal effects, allowing for a detailed examination of age curves under various conditions. By defining the Age-Conditioned Treatment Effect (ACTE), we facilitate the exploration of causal relationships regarding treatment impacts at specific ages. Finally, applying this methodology to study the effects of rest days on performance metrics, particularly across different ages, offers valuable insights into load management strategies' effectiveness. Our findings underscore the importance of tailored rest periods, highlighting their positive impact on athlete performance and suggesting a reevaluation of current management practices for optimizing athlete performance.

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arXiv2023

Estimation and inference for causal spillover effects in egocentric-network randomized trials in the presence of network membership misclassification

To leverage peer influence and increase population behavioral changes, behavioral interventions often rely on peer-based strategies. A common study design that assesses such strategies is the egocentric-network randomized trial (ENRT), in which those receiving the intervention are encouraged to disseminate information to their peers. The Average Spillover Effect (ASpE) measures the impact of the intervention on participants who do not receive it, but whose outcomes may be affected by others who do. The assessment of the ASpE relies on assumptions about, and correct measurement of, interference sets within which individuals may influence one another's outcomes. It can be challenging to properly specify interference sets, such as networks in ENRTs, and when mismeasured, intervention effects estimated by existing methods will be biased. In HIV prevention studies where social networks play an important role in disease transmission, correcting ASpE estimates for bias due to network misclassification is critical for accurately evaluating the full impact of interventions. We combined measurement error and causal inference methods to bias-correct the ASpE estimate for network misclassification in ENRTs, when surrogate networks are recorded in place of true ones, and validation data that relate the misclassified to the true networks are available. We investigated finite sample properties of our methods in an extensive simulation study, and illustrated our methods in the HIV Prevention Trials Network (HPTN) 037 study.

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arXiv2023

Doubly Robust Estimator for Off-Policy Evaluation with Large Action Spaces

We study Off-Policy Evaluation (OPE) in contextual bandit settings with large action spaces. The benchmark estimators suffer from severe bias and variance tradeoffs. Parametric approaches suffer from bias due to difficulty specifying the correct model, whereas ones with importance weight suffer from variance. To overcome these limitations, Marginalized Inverse Propensity Scoring (MIPS) was proposed to mitigate the estimator's variance via embeddings of an action. Nevertheless, MIPS is unbiased under the no direct effect, which assumes that the action embedding completely mediates the effect of an action on a reward. To overcome the dependency on these unrealistic assumptions, we propose a Marginalized Doubly Robust (MDR) estimator. Theoretical analysis shows that the proposed estimator is unbiased under weaker assumptions than MIPS while reducing the variance against MIPS. The empirical experiment verifies the supremacy of MDR against existing estimators with large action spaces.

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arXiv2023

Design of egocentric network-based studies to estimate causal effects under interference

Many public health interventions are conducted in settings where individuals are connected to one another and the intervention assigned to randomly selected individuals may spill over to other individuals they are connected to. In these spillover settings, the effects of such interventions can be quantified in several ways. The average individual effect measures the intervention effect among those directly treated, while the spillover effect measures the effect among those connected to those directly treated. In addition, the overall effect measures the average intervention effect across the study population, over those directly treated along with those to whom the intervention spills over but who are not directly treated. Here, we develop methods for study design with the aim of estimating individual, spillover, and overall effects. In particular, we consider an egocentric network-based randomized design in which a set of index participants is recruited from the population and randomly assigned to treatment, while data are also collected from their untreated network members. We use the potential outcomes framework to define two clustered regression modeling approaches and clarify the underlying assumptions required to identify and estimate causal effects. We then develop sample size formulas for detecting individual, spillover, and overall effects. We investigate the roles of the intra-class correlation coefficient and the probability of treatment allocation on the required number of egocentric networks with a fixed number of network members for each egocentric network and vice-versa.

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arXiv2023

Evaluating Spillover Effects in Network-Based Studies In the Presence of Missing Outcomes

Estimating causal effects in the presence of spillover among individuals embedded within a social network is often challenging with missing information. The spillover effect is the effect of an intervention if a participant is not exposed to the intervention themselves but is connected to intervention recipients in the network. In network-based studies, outcomes may be missing due to the administrative end of a study or participants being lost to follow-up due to study dropout, also known as censoring. We propose an inverse probability censoring weighted (IPCW) estimator, which is an extension of an IPW estimator for network-based observational studies to settings where the outcome is subject to possible censoring. We demonstrated that the proposed estimator was consistent and asymptotically normal. We also derived a closed-form estimator of the asymptotic variance estimator. We used the IPCW estimator to quantify the spillover effects in a network-based study of a nonrandomized intervention with censoring of the outcome. A simulation study was conducted to evaluate the finite-sample performance of the IPCW estimators. The simulation study demonstrated that the estimator performed well in finite samples when the sample size and number of connected subnetworks (components) were fairly large. We then employed the method to evaluate the spillover effects of community alerts on self-reported HIV risk behavior among people who inject drugs and their contacts in the Transmission Reduction Intervention Project (TRIP), 2013 to 2015, Athens, Greece. Community alerts were protective not only for the person who received the alert from the study but also among others in the network likely through information shared between participants. In this study, we found that the risk of HIV behavior was reduced by increasing the proportion of a participant's immediate contacts exposed to community alerts.

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arXiv2023

Using Overlap Weights to Address Extreme Propensity Scores in Estimating Restricted Mean Counterfactual Survival Times

While the inverse probability of treatment weighting (IPTW) is a commonly used approach for treatment comparisons in observational data, the resulting estimates may be subject to bias and excessively large variance when there is lack of overlap in the propensity score distributions. By smoothly down-weighting the units with extreme propensity scores, overlap weighting (OW) can help mitigate the bias and variance issues associated with IPTW. Although theoretical and simulation results have supported the use of OW with continuous and binary outcomes, its performance with right-censored survival outcomes remains to be further investigated, especially when the target estimand is defined based on the restricted mean survival time (RMST)-a clinically meaningful summary measure free of the proportional hazards assumption. In this article, we combine propensity score weighting and inverse probability of censoring weighting to estimate the restricted mean counterfactual survival times, and propose computationally-efficient variance estimators. We conduct simulations to compare the performance of IPTW, trimming, and OW in terms of bias, variance, and 95% confidence interval coverage, under various degrees of covariate overlap. Regardless of overlap, we demonstrate the advantage of OW over IPTW and trimming methods in bias, variance, and coverage when the estimand is defined based on RMST.

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arXiv2022

Selecting Subpopulations for Causal Inference in Regression Discontinuity Designs

The Brazil Bolsa Familia (BF) program is a conditional cash transfer program aimed to reduce short-term poverty by direct cash transfers and to fight long-term poverty by increasing human capital among poor Brazilian people. Eligibility for Bolsa Familia benefits depends on a cutoff rule, which classifies the BF study as a regression discontinuity (RD) design. Extracting causal information from RD studies is challenging. Following Li et al (2015) and Branson and Mealli (2019), we formally describe the BF RD design as a local randomized experiment within the potential outcome approach. Under this framework, causal effects can be identified and estimated on a subpopulation where a local overlap assumption, a local SUTVA and a local ignorability assumption hold. We first discuss the potential advantages of this framework over local regression methods based on continuity assumptions, which concern the definition of the causal estimands, the design and the analysis of the study, and the interpretation and generalizability of the results. A critical issue of this local randomization approach is how to choose subpopulations for which we can draw valid causal inference. We propose a Bayesian model-based finite mixture approach to clustering to classify observations into subpopulations where the RD assumptions hold and do not hold. This approach has important advantages: a) it allows to account for the uncertainty in the subpopulation membership, which is typically neglected; b) it does not impose any constraint on the shape of the subpopulation; c) it is scalable to high-dimensional settings; e) it allows to target alternative causal estimands than the average treatment effect (ATE); and f) it is robust to a certain degree of manipulation/selection of the running variable. We apply our proposed approach to assess causal effects of the Bolsa Familia program on leprosy incidence in 2009.

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arXiv2021

Causal Effects with Hidden Treatment Diffusion on Observed or Partially Observed Networks

In randomized experiments, interactions between units might generate a treatment diffusion process. This is common when the treatment of interest is an actual object or product that can be shared among peers (e.g., flyers, booklets, videos). For instance, if the intervention of interest is an information campaign realized through the distribution of a video to targeted individuals, some of these treated individuals might share the video they received with their friends. Such a phenomenon is usually unobserved, causing a misallocation of individuals in the two treatment arms: some of the initially untreated units might have actually received the treatment by diffusion. Treatment misclassification can, in turn, introduce a bias in the estimation of the causal effect. Inspired by a recent field experiment on the effect of different types of school incentives aimed at encouraging students to attend cultural events, we present a novel approach to deal with a hidden diffusion process on observed or partially observed networks.Specifically, we develop a simulation-based sensitivity analysis that assesses the robustness of the estimates against the possible presence of a treatment diffusion. We simulate several diffusion scenarios within a plausible range of sensitivity parameters and we compare the treatment effect which is estimated in each scenario with the one that is obtained while ignoring the diffusion process. Results suggest that even a treatment diffusion parameter of small size may lead to a significant bias in the estimation of the treatment effect.

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arXiv2021

Estimating Causal Effects of HIV Prevention Interventions with Interference in Network-based Studies among People Who Inject Drugs

Evaluating causal effects in the presence of interference is challenging in network-based studies of hard-to-reach populations. Like many such populations, people who inject drugs (PWID) are embedded in social networks and often exert influence on others in their network. In our setting, the study design is observational with a non-randomized network-based HIV prevention intervention. Information is available on each participant and their connections that confer possible HIV risk through injection and sexual behaviors. We considered two inverse probability weighted (IPW) estimators to quantify the population-level effects of non-randomized interventions on subsequent health outcomes. We demonstrated that these two IPW estimators are consistent, asymptotically normal, and derived a closed-form estimator for the asymptotic variance, while allowing for overlapping interference sets (groups of individuals in which the interference is assumed possible). A simulation study was conducted to evaluate the finite-sample performance of the estimators. We analyzed data from the Transmission Reduction Intervention Project, which ascertained a network of PWID and their contacts in Athens, Greece, from 2013 to 2015. We evaluated the effects of community alerts on HIV risk behavior in this observed network, where the links between participants were defined by using substances or having unprotected sex together. In the study, community alerts were distributed to inform people of recent HIV infections among individuals in close proximity in the observed network. The estimates of the risk differences for spillover using either IPW estimator demonstrated a protective effect. The results suggest that HIV risk behavior can be mitigated by exposure to a community alert when an increased risk of HIV is detected in the network.

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arXiv2020

Bipartite Interference and Air Pollution Transport: Estimating Health Effects of Power Plant Interventions

Evaluating air quality interventions is confronted with the challenge of interference since interventions at a particular pollution source likely impact air quality and health at distant locations and air quality and health at any given location are likely impacted by interventions at many sources. The structure of interference in this context is dictated by complex atmospheric processes governing how pollution emitted from a particular source is transformed and transported across space, and can be cast with a bipartite structure reflecting the two distinct types of units: 1) interventional units on which treatments are applied or withheld to change pollution emissions; and 2) outcome units on which outcomes of primary interest are measured. We propose new estimands for bipartite causal inference with interference that construe two components of treatment: a "key-associated" (or "individual") treatment and an "upwind" (or "neighborhood") treatment. Estimation is carried out using a semi-parametric adjustment approach based on joint propensity scores. A reduced-complexity atmospheric model is deployed to characterize the structure of the interference network by modeling the movement of air parcels through time and space. The new methods are deployed to evaluate the effectiveness of installing flue-gas desulfurization scrubbers on 472 coal-burning power plants (the interventional units) in reducing Medicare hospitalizations among 21,577,552 Medicare beneficiaries residing across 25,553 ZIP codes in the United States (the outcome units).

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