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Laura Vinckenbosch

Publications and source records attributed to Laura Vinckenbosch.

5 recordsLinked to original sources

Stochastic Control Problems Motivated by Sailboat Trajectory Optimization

We develop a mathematical model for sailboat navigation that captures the essential features of the problem and can provide insights that might not be available otherwise. In our model, the motion of the sailboat, which would travel at speed $v>0$ in a constant wind, is the solution of a system of two stochastic differential equations driven by a Brownian motion on a circle with speed $σ> 0$. We formulate two stochastic control/optimal switching problems, in which the objective is to reach a circular upwind target of radius $η\geq 0$ as quickly as possible. In the first problem, there is a tacking cost $c > 0$, so this is an impulse control problems, while in the second problem, we assume that $c=0$ and singular controls are needed. We establish the viability of both models (assuming that $η> 0$ in the second model), that is, their value functions are finite, and we obtain bounds on these value functions related to the parameters of the problem. In the second problem, since the state equation for the optimally controlled motion has discontinuous coefficients and is driven by a degenerate diffusion, standard results on existence and uniqueness of strong solutions do not apply: we provide a proof via the Yamada-Watanabe argument.

math.OC

The feasibility of equilibria in large ecosystems: a primary but neglected concept in the complexity-stability debate

The consensus that complexity begets stability in ecosystems was challenged in the seventies, a result recently extended to ecologically-inspired networks. The approaches assume the existence of a feasible equilibrium, i.e. with positive abundances. However, this key assumption has not been tested. We provide analytical results complemented by simulations which show that equilibrium feasibility vanishes in species rich systems. This result leaves us in the uncomfortable situation in which the existence of a feasible equilibrium assumed in local stability criteria is far from granted. We extend our analyses by changing interaction structure and intensity, and find that feasibility and stability is warranted irrespective of species richness with weak interactions. Interestingly, we find that the dynamical behaviour of ecologically inspired architectures is very different and richer than that of unstructured systems. Our results suggest that a general understanding of ecosystem dynamics requires focusing on the interplay between interaction strength and network architecture.

q-bio.PE

Ultrasensitivity and sharp threshold theorems for multisite systems

We study the ultrasensitivity of multisite binding processes where ligand molecules can bind to several binding sites, considering more particularly recent models involving complex chemical reactions in phosphorylation systems such as allosteric phosphorylation processes, or substrate-catalyst chain reactions and nucleosome mediated cooperativity. New statistics based formulas for the Hill coefficient and the effective Hill coefficient are provided and necessary conditions for a system to be ultrasensitive are exhibited. We then assume that the binding process is described by a density dependent birth and death process. We provide precise large deviation results for the steady state distribution of the process, and show that switch-like ultrasensitive responses are strongly related to the multi-stability of the associated dynamical system. Ultrasensitivity occurs if and only if the entropy of the dynamical system has more than one global minimum for some critical ligand concentration. In this case, the Hill coefficient is proportional to the number of binding sites, and the systems is highly ultrasensitive. We also discuss the interpretation of an extension $I_q$ of the effective Hill coefficient $I_{0.9}$ for which we recommend the computation of a broad range of values of $q$ instead of just the standard one corresponding to the 10% to 90% variation in the dose-response. It is shown that this single choice can sometimes mislead the conclusion by not detecting ultrasensitivity. This new approach allows a better understanding of multisite ultrasensitive systems and provides new tools for the design of such systems.

q-bio.SC

Monte Carlo methods for light propagation in biological tissues

Light propagation in turbid media is driven by the equation of radiative transfer. We give a formal probabilistic representation of its solution in the framework of biological tissues and we implement algorithms based on Monte Carlo methods in order to estimate the quantity of light that is received by an homogeneous tissue when emitted by an optic fiber. A variance reduction method is studied and implemented, as well as a Markov chain Monte Carlo method based on the Metropolis-Hastings algorithm. The resulting estimating methods are then compared to the so-called Wang-Prahl (or Wang) method. Finally, the formal representation allows to derive a non-linear optimization algorithm close to Levenberg-Marquardt that is used for the estimation of the scattering and absorption coefficients of the tissue from measurements.

stat.CO

Optimal expulsion and optimal confinement of a Brownian particle with a switching cost

We solve two stochastic control problems in which a player tries to minimize or maximize the exit time from an interval of a Brownian particle, by controlling its drift. The player can change from one drift to another but is subject to a switching cost. In each problem, the value function is written as the solution of a free boundary problem involving second order ordinary differential equations, in which the unknown boundaries are found by applying the principle of smooth fit. For both problems, we compute the value function, we exhibit the optimal strategy and we prove its generic uniqueness.

math.PR