arXiv subjects

Lauritz Hahn

Publications and source records attributed to Lauritz Hahn.

4 recordsLinked to original sources

arXiv2024

Single cells can resolve graded stimuli

Cells use signalling pathways as windows into the environment to gather information, transduce it into their interior, and use it to drive behaviours. MAPK (ERK) is a highly conserved signalling pathway in eukaryotes, directing multiple fundamental cellular behaviours such as proliferation, migration, and differentiation, making it of few central hubs in the signalling circuitry of cells. Despite this versatility of behaviors, population-level measurements have reported low information content (\textless 1 bit) relayed through the ERK pathway, rendering the population barely able to distinguish the presence or absence of stimuli. Here, we contrast the information transmitted by a single cell and a population of cells. Using a combination of optogenetic experiments, data analysis based on information theory framework, and numerical simulations we quantify the amount of information transduced from the receptor to ERK, from responses to singular, brief and sparse input pulses. We show that single cells are indeed able to resolve between graded stimuli, yielding over 2 bit of information, however showing a large population heterogeneity.

q-bio.CB↗

arXiv2024

Active screws: Emergent active chiral nematics of spinning self-propelled rods

Several types of active agents self-propel by spinning around their propulsion axis, thus behaving as active screws. Examples include cytoskeletal filaments in gliding assays, magnetically driven colloidal helices, and microorganisms such as the bacterium $\it{Myxococcus}$ $\it{xanthus}$. Here, we develop a model for spinning self-propelled rods on a substrate, and we coarse grain it to derive the corresponding hydrodynamic equations. If the rods propel purely along their axis, they form an active nematic at high density and activity. However, spinning rods can also roll sideways as they move. We find that this transverse motion turns the system into a chiral active nematic. Thus, we identify a mechanism whereby individual chirality can give rise to collective local chiral flows. Finally, we analyze experiments on $\it{M.}$ $\it{xanthus}$ colonies to show that they exhibit chiral flows around topological defects, with a chiral activity about an order of magnitude weaker than the achiral one. Our work reveals the collective behavior of active screws, which is relevant to colonies of social bacteria and groups of unicellular parasites.

cond-mat.soft↗

arXiv2023

Dynamical information synergy in biochemical signaling networks

Biological cells encode information about their environment through biochemical signaling networks that control their internal state and response. This information is often encoded in the dynamical patterns of the signaling molecules, rather than just their instantaneous concentrations. Here, we analytically calculate the information contained in these dynamics for a number of paradigmatic cases in the linear regime, for both static and time-dependent input signals. When considering oscillatory output dynamics, we report the emergence of synergy between successive measurements, meaning that the joint information in two measurements exceeds the sum of the individual information. We extend our analysis numerically beyond the scope of linear input encoding to reveal synergetic effects in the cases of frequency or damping modulation, both of which are relevant to classical biochemical signaling systems.

q-bio.MN↗

arXiv2021

Dynamical signatures of thermal spin-charge deconfinement in the doped Ising model

The mechanism underlying charge transport in strongly correlated quantum systems, such as doped antiferromagnetic Mott insulators, remains poorly understood. Here we study the expansion dynamics of an initially localized hole inside a two-dimensional (2D) Ising antiferromagnet at variable temperature. Using a combination of classical Monte Carlo and a truncated basis method, we reveal two dynamically distinct regimes: A spin-charge confined region below a critical temperature $T^*$, characterized by slow spreading, and a spin-charge deconfined region above $T^*$, characterized by an unbounded diffusive expansion. The deconfinement temperature $T^*\approx 0.65 J_z$ we find is around the N\'eel temperature $T_{\rm N} = 0.567 J_z$ of the Ising background in 2D, but we expect $T^* < T_{\rm N}$ in higher dimensions. In both regimes we find that the mobile hole does not thermalize with the Ising spin background on the considered time scales, indicating weak effective coupling of spin- and charge degrees of freedom. Our results can be qualitatively understood by an effective parton model, and can be tested experimentally in state-of-the-art quantum gas microscopes.

cond-mat.quant-gas↗