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Lawrence H. Le

Publications and source records attributed to Lawrence H. Le.

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Accelerated 3D-3D rigid registration of echocardiographic images obtained from apical window using particle filter

The perfect alignment of 3D echocardiographic images captured from various angles has improved image quality and broadened the field of view. This study proposes an accelerated sequential Monte Carlo (SMC) algorithm for 3D-3D rigid registration of transthoracic echocardiographic images with significant and limited overlap taken from apical window that is robust to the noise and intensity variation in ultrasound images. The algorithm estimates the translational and rotational components of the rigid transform through an iterative process and requires an initial approximation of the rotation and translation limits. We perform registration in two ways: the image-based registration computes the transform to align the end-diastolic frame of the apical nonstandard image to the apical standard image and applies the same transform to all frames of the cardiac cycle, whereas the mask-based registration approach uses the binary masks of the left ventricle in the same way. The SMC and exhaustive search (EX) algorithms were evaluated for 4D temporal sequences recorded from 7 volunteers who participated in a study conducted at the Mazankowski Alberta Heart Institute. The evaluations demonstrate that the mask-based approach of the accelerated SMC yielded a Dice score value of 0.819 +/- 0.045 for the left ventricle and gained 16.7x speedup compared to the CPU version of the SMC algorithm.

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Neural Implicit Surface Reconstruction of Freehand 3D Ultrasound Volume with Geometric Constraints

Three-dimensional (3D) freehand ultrasound (US) is a widely used imaging modality that allows non-invasive imaging of medical anatomy without radiation exposure. Surface reconstruction of US volume is vital to acquire the accurate anatomical structures needed for modeling, registration, and visualization. However, traditional methods cannot produce a high-quality surface due to image noise. Despite improvements in smoothness, continuity, and resolution from deep learning approaches, research on surface reconstruction in freehand 3D US is still limited. This study introduces FUNSR, a self-supervised neural implicit surface reconstruction method to learn signed distance functions (SDFs) from US volumes. In particular, FUNSR iteratively learns the SDFs by moving the 3D queries sampled around volumetric point clouds to approximate the surface, guided by two novel geometric constraints: sign consistency constraint and onsurface constraint with adversarial learning. Our approach has been thoroughly evaluated across four datasets to demonstrate its adaptability to various anatomical structures, including a hip phantom dataset, two vascular datasets and one publicly available prostate dataset. We also show that smooth and continuous representations greatly enhance the visual appearance of US data. Furthermore, we highlight the potential of our method to improve segmentation performance, and its robustness to noise distribution and motion perturbation.

eess.IV