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Le Song

Publications and source records attributed to Le Song.

147 records · Page 9Linked to original sources

Infinite Hierarchical MMSB Model for Nested Communities/Groups in Social Networks

Actors in realistic social networks play not one but a number of diverse roles depending on whom they interact with, and a large number of such role-specific interactions collectively determine social communities and their organizations. Methods for analyzing social networks should capture these multi-faceted role-specific interactions, and, more interestingly, discover the latent organization or hierarchy of social communities. We propose a hierarchical Mixed Membership Stochastic Blockmodel to model the generation of hierarchies in social communities, selective membership of actors to subsets of these communities, and the resultant networks due to within- and cross-community interactions. Furthermore, to automatically discover these latent structures from social networks, we develop a Gibbs sampling algorithm for our model. We conduct extensive validation of our model using synthetic networks, and demonstrate the utility of our model in real-world datasets such as predator-prey networks and citation networks.

stat.ML↗

Time-Varying Networks: Recovering Temporally Rewiring Genetic Networks During the Life Cycle of Drosophila melanogaster

Due to the dynamic nature of biological systems, biological networks underlying temporal process such as the development of {\it Drosophila melanogaster} can exhibit significant topological changes to facilitate dynamic regulatory functions. Thus it is essential to develop methodologies that capture the temporal evolution of networks, which make it possible to study the driving forces underlying dynamic rewiring of gene regulation circuity, and to predict future network structures. Using a new machine learning method called Tesla, which builds on a novel temporal logistic regression technique, we report the first successful genome-wide reverse-engineering of the latent sequence of temporally rewiring gene networks over more than 4000 genes during the life cycle of \textit{Drosophila melanogaster}, given longitudinal gene expression measurements and even when a single snapshot of such measurement resulted from each (time-specific) network is available. Our methods offer the first glimpse of time-specific snapshots and temporal evolution patterns of gene networks in a living organism during its full developmental course. The recovered networks with this unprecedented resolution chart the onset and duration of many gene interactions which are missed by typical static network analysis, and are suggestive of a wide array of other temporal behaviors of the gene network over time not noticed before.

q-bio.MN↗

Supervised Feature Selection via Dependence Estimation

We introduce a framework for filtering features that employs the Hilbert-Schmidt Independence Criterion (HSIC) as a measure of dependence between the features and the labels. The key idea is that good features should maximise such dependence. Feature selection for various supervised learning problems (including classification and regression) is unified under this framework, and the solutions can be approximated using a backward-elimination algorithm. We demonstrate the usefulness of our method on both artificial and real world datasets.

cs.LG↗