arXiv subjects

Lei Xing

Publications and source records attributed to Lei Xing.

108 records · Page 6Linked to original sources

arXiv2019

Modified U-Net (mU-Net) with Incorporation of Object-Dependent High Level Features for Improved Liver and Liver-Tumor Segmentation in CT Images

Segmentation of livers and liver tumors is one of the most important steps in radiation therapy of hepatocellular carcinoma. The segmentation task is often done manually, making it tedious, labor intensive, and subject to intra-/inter- operator variations. While various algorithms for delineating organ-at-risks (OARs) and tumor targets have been proposed, automatic segmentation of livers and liver tumors remains intractable due to their low tissue contrast with respect to the surrounding organs and their deformable shape in CT images. The U-Net has gained increasing popularity recently for image analysis tasks and has shown promising results. Conventional U-Net architectures, however, suffer from three major drawbacks. To cope with these problems, we added a residual path with deconvolution and activation operations to the skip connection of the U-Net to avoid duplication of low resolution information of features. In the case of small object inputs, features in the skip connection are not incorporated with features in the residual path. Furthermore, the proposed architecture has additional convolution layers in the skip connection in order to extract high level global features of small object inputs as well as high level features of high resolution edge information of large object inputs. Efficacy of the modified U-Net (mU-Net) was demonstrated using the public dataset of Liver tumor segmentation (LiTS) challenge 2017. The proposed mU-Net outperformed existing state-of-art networks.

eess.IV↗

arXiv2019

On Sample Complexity of Projection-Free Primal-Dual Methods for Learning Mixture Policies in Markov Decision Processes

We study the problem of learning policy of an infinite-horizon, discounted cost, Markov decision process (MDP) with a large number of states. We compute the actions of a policy that is nearly as good as a policy chosen by a suitable oracle from a given mixture policy class characterized by the convex hull of a set of known base policies. To learn the coefficients of the mixture model, we recast the problem as an approximate linear programming (ALP) formulation for MDPs, where the feature vectors correspond to the occupation measures of the base policies defined on the state-action space. We then propose a projection-free stochastic primal-dual method with the Bregman divergence to solve the characterized ALP. Furthermore, we analyze the probably approximately correct (PAC) sample complexity of the proposed stochastic algorithm, namely the number of queries required to achieve near optimal objective value. We also propose a modification of our proposed algorithm with the polytope constraint sampling for the smoothed ALP, where the restriction to lower bounding approximations are relaxed. In addition, we apply the proposed algorithms to a queuing problem, and compare their performance with a penalty function algorithm. The numerical results illustrates that the primal-dual achieves better efficiency and low variance across different trials compared to the penalty function method.

cs.LG↗

arXiv2019

Water-based Reconfigurable Frequency Selective Rasorber with Thermally Tunable Absorption Band

In this paper, a novel water-based reconfigurable frequency selective rasorber (FSR) at microwave band is proposed, which has a thermally tunable absorption band above the transmission band. The water-based FSR consists of a bandpass type frequency selective surface (FSS) and a 3D printing container. The water substrate is filled into the sealed space constructed by the above two structures. The numerical simulation results show that the FSR can achieve absorption with high absorptivity from 8.3 to 15.2 GHz, and obtain a transmission band of 5.2 to 7.0 GHz. The minimum insertion loss of the transmission band reaches 0.72 dB at 6.14 GHz. In addition, the FSR has the reconfigurable characteristics of absorbing or reflecting electromagnetic waves by filling with water or not. The proposed water-based FSR shows its good transmission/absorption performance under different polarizations and oblique incident angles. Due to the Debye model of water, the absorption band can be adjusted by water temperature, while the passband remains stable. At last, prototype of the FSR based on water has been fabricated, and the experimental results are presented to demonstrate the validity of the proposed structure.

physics.app-ph↗

arXiv2019

Automatic target positioning and tracking for image-guided radiotherapy without implanted fiducials

Current image-guided prostate radiotherapy often relies on the use of implanted fiducials or transducers for target localization. Fiducial or transducer insertion requires an invasive procedure that adds cost and risks for bleeding, infection, and discomfort to some patients. We are developing a novel markerless prostate localization strategy using a pre-trained deep learning model to interpret routine projection kV X-ray images without the need for daily cone-beam computed tomography (CBCT). A deep learning model was first trained by using several thousand annotated projection X-ray images. The trained model is capable of identifying the location of the prostate target for a given input X-ray projection image. To assess the accuracy of the approach, three patients with prostate cancer received volumetric modulated arc therapy (VMAT) were retrospectively studied. The results obtained by using the deep learning model and the actual position of the prostate were compared quantitatively. The deviations between the target positions obtained by the deep learning model and the corresponding annotations ranged from 1.66 mm to 2.77 mm for anterior-posterior (AP) direction, and from 1.15 mm to 2.88 mm for lateral direction. Target position provided by deep learning model for the kV images acquired using OBI is found to be consistent that derived from the fiducials. This study demonstrates, for the first time, that highly accurate markerless prostate localization based on deep learning is achievable. The strategy provides a clinically valuable solution to daily patient positioning and real-time target tracking for image-guided radiotherapy (IGRT) and interventions.

physics.med-ph↗

arXiv2018

A Convex Optimization Approach to Radiation Treatment Planning with Dose Constraints

We present a method for handling dose constraints as part of a convex programming framework for inverse treatment planning. Our method uniformly handles mean dose, maximum dose, minimum dose, and dose-volume (i.e., percentile) constraints as part of a convex formulation. Since dose-volume constraints are non-convex, we replace them with a convex restriction. This restriction is, by definition, conservative; to mitigate its impact on the clinical objectives, we develop a two-pass planning algorithm that allows each dose-volume constraint to be met exactly on a second pass by the solver if its corresponding restriction is feasible on the first pass. In another variant, we add slack variables to each dose constraint to prevent the problem from becoming infeasible when the user specifies an incompatible set of constraints or when the constraints are made infeasible by our restriction. Finally, we introduce ConRad, a Python-embedded open-source software package for convex radiation treatment planning. ConRad implements the methods described above and allows users to construct and plan cases through a simple interface.

physics.med-ph↗

arXiv2018

Single Layer PCB Broadband Circular Polarisation Millimetre Wave Massive MIMO Array

A single layer broadband millimetre wave (mm-wave) array with circular polarisation is proposed for the fifth generation (5G) mm-wave communication applications. The antenna element is designed to integrate the matching circuit into a single layer. Hence no additional matching and feeding networks are required which makes the antenna element very easy to synthesise a massive array. The array has a 10 dB return loss bandwidth between 26 GHz and 32 GHz. The polar angle axial ratio is less than 3 within the beamwidth of -60 degree to 60 degree. The proposed antenna structure is simple, low cost and robust, which we envisage suitable for the massive multiple-input and multiple-output (MIMO) applications.

eess.SP↗

arXiv2018

A unified image reconstruction framework for quantitative dual- and triple-energy CT imaging of material compositions

Many clinical applications depend critically on the accurate differentiation and classification of different types of materials in patient anatomy. This work introduces a unified framework for accurate nonlinear material decomposition and applies it, for the first time, in the concept of triple-energy CT (TECT) for enhanced material differentiation and classification as well as dual-energy CT. The triple-energy data acquisition is implemented at the scales of micro-CT and clinical CT imaging with commercial "TwinBeam" dual-source DECT configuration and a fast kV switching DECT configuration. Material decomposition and quantitative comparison with a photon counting detector and with the presence of a bow-tie filter are also performed. The proposed method provides quantitative material- and energy-selective images examining realistic configurations for both dual- and triple-energy CT measurements. Compared to the polychromatic kV CT images, virtual monochromatic images show superior image quality. For the mouse phantom, quantitative measurements show that the differences between gadodiamide and iodine concentrations obtained using TECT and idealized photon counting CT (PCCT) are smaller than 8 mg/mL and 1 mg/mL, respectively. TECT outperforms DECT for multi-contrast CT imaging and is robust with respect to spectrum estimation. For the thorax phantom, the differences between the concentrations of the contrast map and the corresponding true reference values are smaller than 7 mg/mL for all of the realistic configurations. A unified framework for both dual- and triple-energy CT imaging has been established for the accurate extraction of material compositions; considering currently available commercial DECT configurations. The novel technique is promising to provide an urgently needed solution for several CT-based diagnosis and therapy applications.

physics.med-ph↗

arXiv2017

Robustness of Maximum Correntropy Estimation Against Large Outliers

The maximum correntropy criterion (MCC) has recently been successfully applied in robust regression, classification and adaptive filtering, where the correntropy is maximized instead of minimizing the well-known mean square error (MSE) to improve the robustness with respect to outliers (or impulsive noises). Considerable efforts have been devoted to develop various robust adaptive algorithms under MCC, but so far little insight has been gained as to how the optimal solution will be affected by outliers. In this work, we study this problem in the context of parameter estimation for a simple linear errors-in-variables (EIV) model where all variables are scalar. Under certain conditions, we derive an upper bound on the absolute value of the estimation error and show that the optimal solution under MCC can be very close to the true value of the unknown parameter even with outliers (whose values can be arbitrarily large) in both input and output variables. Illustrative examples are presented to verify and clarify the theory.

stat.ML↗

arXiv2017

Quantized Minimum Error Entropy Criterion

Comparing with traditional learning criteria, such as mean square error (MSE), the minimum error entropy (MEE) criterion is superior in nonlinear and non-Gaussian signal processing and machine learning. The argument of the logarithm in Renyis entropy estimator, called information potential (IP), is a popular MEE cost in information theoretic learning (ITL). The computational complexity of IP is however quadratic in terms of sample number due to double summation. This creates computational bottlenecks especially for large-scale datasets. To address this problem, in this work we propose an efficient quantization approach to reduce the computational burden of IP, which decreases the complexity from O(N*N) to O (MN) with M << N. The new learning criterion is called the quantized MEE (QMEE). Some basic properties of QMEE are presented. Illustrative examples are provided to verify the excellent performance of QMEE.

stat.ML↗

arXiv2017

Segmentation-Free X-ray Energy Spectrum Estimation for Computed Tomography Using Dual-Energy Material Decomposition

X-ray energy spectrum plays an essential role in computed tomography (CT) imaging and related tasks. Due to the high photon flux of clinical CT scanners, most of spectrum estimation methods are indirect and usually suffered from various limitations. In this study, we aim to provide a segmentation-free indirect transmission measurement-based energy spectrum estimation method using dual-energy material decomposition. The general principle of the method is to minimize the quadratic error between the polychromatic forward projection and the raw projection to calibrate a set of unknown weights which are used to express the unknown spectrum together with a set of model spectra. The polychromatic forward projection is performed using material-specific images which are obtained using dual-energy material decomposition. The algorithm has been evaluated using numerical simulations, experimental phantom data as well as realistic patient data. The results show the estimated spectrum matches the reference spectrum quite well and the method is robust. Extensive studies suggest the method provides accurate estimate of the CT spectrum without dedicated physical phantom and prolonged work flow. This paper may be attractive for CT dose calculations, artifacts reduction, polychromatic image reconstruction and other spectrum-involved CT applications.

physics.med-ph↗

arXiv2017

Deep Generative Adversarial Networks for Compressed Sensing Automates MRI

Magnetic resonance image (MRI) reconstruction is a severely ill-posed linear inverse task demanding time and resource intensive computations that can substantially trade off {\it accuracy} for {\it speed} in real-time imaging. In addition, state-of-the-art compressed sensing (CS) analytics are not cognizant of the image {\it diagnostic quality}. To cope with these challenges we put forth a novel CS framework that permeates benefits from generative adversarial networks (GAN) to train a (low-dimensional) manifold of diagnostic-quality MR images from historical patients. Leveraging a mixture of least-squares (LS) GANs and pixel-wise $\ell_1$ cost, a deep residual network with skip connections is trained as the generator that learns to remove the {\it aliasing} artifacts by projecting onto the manifold. LSGAN learns the texture details, while $\ell_1$ controls the high-frequency noise. A multilayer convolutional neural network is then jointly trained based on diagnostic quality images to discriminate the projection quality. The test phase performs feed-forward propagation over the generator network that demands a very low computational overhead. Extensive evaluations are performed on a large contrast-enhanced MR dataset of pediatric patients. In particular, images rated based on expert radiologists corroborate that GANCS retrieves high contrast images with detailed texture relative to conventional CS, and pixel-wise schemes. In addition, it offers reconstruction under a few milliseconds, two orders of magnitude faster than state-of-the-art CS-MRI schemes.

cs.CV↗

arXiv2016

Robust Learning with Kernel Mean p-Power Error Loss

Correntropy is a second order statistical measure in kernel space, which has been successfully applied in robust learning and signal processing. In this paper, we define a nonsecond order statistical measure in kernel space, called the kernel mean-p power error (KMPE), including the correntropic loss (CLoss) as a special case. Some basic properties of KMPE are presented. In particular, we apply the KMPE to extreme learning machine (ELM) and principal component analysis (PCA), and develop two robust learning algorithms, namely ELM-KMPE and PCA-KMPE. Experimental results on synthetic and benchmark data show that the developed algorithms can achieve consistently better performance when compared with some existing methods.

stat.ML↗

arXiv2016

Kernel Risk-Sensitive Loss: Definition, Properties and Application to Robust Adaptive Filtering

Nonlinear similarity measures defined in kernel space, such as correntropy, can extract higher-order statistics of data and offer potentially significant performance improvement over their linear counterparts especially in non-Gaussian signal processing and machine learning. In this work, we propose a new similarity measure in kernel space, called the kernel risk-sensitive loss (KRSL), and provide some important properties. We apply the KRSL to adaptive filtering and investigate the robustness, and then develop the MKRSL algorithm and analyze the mean square convergence performance. Compared with correntropy, the KRSL can offer a more efficient performance surface, thereby enabling a gradient based method to achieve faster convergence speed and higher accuracy while still maintaining the robustness to outliers. Theoretical analysis results and superior performance of the new algorithm are confirmed by simulation.

stat.ML↗

arXiv2016

A Model-Based Scatter Artifacts Correction for Cone Beam CT

The purpose of this work is to provide a fast and accurate scatter artifacts correction algorithm for cone beam CT (CBCT) imaging. The method starts with an estimation of coarse scatter profiles for a set of CBCT data in either image domain or projection domain. A denoising algorithm designed specifically for Poisson signals is then applied to derive the final scatter distribution. Qualitative and quantitative evaluations using thorax and abdomen phantoms with Monte Carlo (MC) simulations, experimental Catphan phantom data, and in vivo human data acquired for a clinical image guided radiation therapy were performed. Results show that the proposed algorithm can significantly reduce scatter artifacts and recover the correct HU in either projection domain or image domain. For the MC thorax phantom study, four components segmentation yield the best results, while the results of three components segmentation are still acceptable. For the Catphan phantom data, the mean value over all pixels in the residual image is reduced from -21.8 HU to -0.2 HU and 0.7 HU for projection domain and image domain, respectively. The contrast of the in vivo human images are greatly improved after correction. The software-based technique has a number of advantages, such as high computational efficiency and accuracy, and the capability of performing scatter correction without modifying the clinical workflow or modifying the imaging hardware. When implemented practically, this should improve the accuracy of CBCT image quantitation and significantly impact CBCT-based interventional procedures and adaptive radiation therapy.

physics.med-ph↗

arXiv2016

Using Edge-Preserving Algorithm with Non-local Mean for Significantly Improved Image-Domain Material Decomposition in Dual Energy CT

Increased noise is a general concern for dual-energy material decomposition. Here, we develop an image-domain material decomposition algorithm for dual-energy CT (DECT) by incorporating an edge-preserving filter into the Local HighlY constrained backPRojection Reconstruction (HYPR-LR) framework. With effective use of the non-local mean, the proposed algorithm, which is referred to as HYPR-NLM, reduces the noise in dual energy decomposition while preserving the accuracy of quantitative measurement and spatial resolution of the material-specific dual energy images. We demonstrate the noise reduction and resolution preservation of the algorithm with iodine concentrate numerical phantom by comparing the HYPR-NLM algorithm to the direct matrix inversion, HYPR-LR and iterative image-domain material decomposition (Iter-DECT). We also show the superior performance of the HYPR-NLM over the existing methods by using two sets of cardiac perfusing imaging data. The reference drawn from the comparison study includes: (1) HYPR-NLM significantly reduces the DECT material decomposition noise while preserving quantitative measurements and high-frequency edge information, and (2) HYPR-NLM is robust with respect to parameter selection.

physics.med-ph↗

arXiv2015

Generalized Correntropy for Robust Adaptive Filtering

As a robust nonlinear similarity measure in kernel space, correntropy has received increasing attention in domains of machine learning and signal processing. In particular, the maximum correntropy criterion (MCC) has recently been successfully applied in robust regression and filtering. The default kernel function in correntropy is the Gaussian kernel, which is, of course, not always the best choice. In this work, we propose a generalized correntropy that adopts the generalized Gaussian density (GGD) function as the kernel (not necessarily a Mercer kernel), and present some important properties. We further propose the generalized maximum correntropy criterion (GMCC), and apply it to adaptive filtering. An adaptive algorithm, called the GMCC algorithm, is derived, and the mean square convergence performance is studied. We show that the proposed algorithm is very stable and can achieve zero probability of divergence (POD). Simulation results confirm the theoretical expectations and demonstrate the desirable performance of the new algorithm.

stat.ML↗

arXiv2008

The classical hydrodynamics of the Calogero-Sutherland model

We explore the classical version of the mapping, due to Abanov and Wiegmann, of Calogero-Sutherland hydrodynamics onto the Benjamin-Ono equation ``on the double.'' We illustrate the mapping by constructing the soliton solutions to the hydrodynamic equations, and show how certain subtleties arise from the need to include corrections to the naive replacement of singular sums by principal-part integrals.

cond-mat.str-el↗

arXiv1994

Nuclear Spin-Lattice Relaxation Induced by Thermally Fluctuating Flux Lines in Type-II Superconductors

Thermal motion of the flux lines (FL) gives rise to fluctuating magnetic fields. These dynamic fields couple to the nuclei in the sample and relax the nuclear spins. Based on a model of harmonic fluctuations, we provide a theoretical description of the nuclear spin-lattice relaxation (NSLR) process due to the fluctuating FLs in clean type-II superconductors. At low fields, the calculated longitudinal relaxation rate $T_1^{-1}$ is enormously enhanced at temperatures just below $T_c$. At intermediate fields, the resulting $T_1^{-1}$ exhibits a peak structure as a function of temperature, which is eventually suppressed as the field is increased. The vibrational modes which have components propagating along the FLs play an essential role in the $T_1^{-1}$ process.

cond-mat↗