Is the kinetic resonance in human glucokinase genuine?
In the recent paper by Mu et al (J. Phys. Chem. Lett. 2021, 12, 2900) the maximal cooperativity of human glucokinase is explained by the "kinetic resonance" effect derived from a minimal three-state model. However, a closer inspection of the latter shows that this effect seems to be rather a particular quantitative coincidence than a general phenomenon that reflects a physical mechanism of conformational regulation.
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