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Levent Degertekin

Publications and source records attributed to Levent Degertekin.

2 recordsLinked to original sources

A Reconfigurable Pipelined-SAR ADC with Embedded Compression for Temporal Compressed-Sensing Ultrasound Imaging

Compact ultrasound imaging systems are increasingly constrained by receiver-side sampling, conversion, memory, and data-transfer requirements. This work presents a compressed-sensing pipelined successive-approximation-register analog-to-digital converter (CS-SAR ADC) for acquisition-side temporal compression of pre-beamformed medical ultrasound radio-frequency (RF) data. Pseudo-random polarity modulation and charge-domain accumulation are embedded in the SAR sampling network so that multiple consecutive RF samples are encoded into one measurement before quantization, supporting temporal compression ratios of $N_{cT}=1$, 2, and 4. The compressed outputs are recovered off chip using a probe-specific pulse-dictionary RF model and then processed with conventional ultrasound beamforming. A 65-nm CMOS prototype was measured with a 1.2-V supply and 50-MHz master clock. In the non-compressed mode, it operates at 10 MS/s, consumes 964.49~$\mu$W, and achieves 44.12-dB SNDR and 56.40-dB SFDR for a 7.7-kHz input. The ADC output rates decrease to 5 MS/s and 2.5 MS/s for $N_{cT}=2$ and 4. Across all evaluated RF traces, median NCC values were 0.981 and 0.932, with median NRMSE values of 0.36 and 0.56, respectively. Wire-phantom localization error remained below 0.04 mm with no appreciable FWHM degradation. In the speckle-rich cyst phantom, SSIM remained 0.94 and 0.87, while CNR decreased from 3.534 in the reference to 2.047 and 1.379. These results demonstrate a hardware-realistic tradeoff in which temporal compression substantially reduces ADC conversion count and output data rate while preserving point-target geometry, whereas low-contrast cyst conspicuity is more compression-sensitive.

physics.med-ph

A CMUT-Based Transcranial Focused Ultrasound Platform for Blood-Brain Barrier Opening in Small Animal Models

Drug delivery to the brain is limited by the blood-brain barrier (BBB). We developed a capacitive micromachined ultrasonic transducer (CMUT)-based transcranial focused ultrasound system capable of both delivering therapy via BBB opening and monitoring microbubble activity across a broad frequency range. The performance of the geometrically focused half-ring array consisting of five transmitters and one receiving element was first assessed through simulations and in-vitro acoustic measurements with microbubbles. Use of phase-inversion (PI) during transmission effectively suppressed CMUT-generated harmonics and enhanced broadband detection of microbubble emissions. In rats, the same system achieved spatially localized BBB opening, confirmed by T1-weighted magnetic resonance imaging. BBB permeability mapping using dynamic contrast-enhanced magnetic resonance imaging (Ktrans) scaled with pressure. Time-resolved acoustic spectra captured microbubble arrival and decay kinetics, and 7-20dB enhancement in the effective dynamic range is observed with PI processing of acoustic emission signals. Together, these findings establish an integrated CMUT platform for combined therapeutic and sensing applications for BBB opening in small animal models, providing a foundation for future real-time, frequency-agile, closed-loop control of ultrasound-mediated drug delivery to the brain.

physics.med-ph