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Li Liang

Publications and source records attributed to Li Liang.

At least 19 recordsLinked to original sources

Transfer of abelian model structures to equivariant categories and homotopy squares

Let $G$ be a finite group acting on a Grothendieck category $\mathcal{A}$ with enough projectives, such that $|G|$ is invertible in $\mathcal{A}$. We prove a general lifting theorem for abelian model structures from $\mathcal{A}$ to its equivariant category $\mathcal{A}^G$, and establish a triangle equivalence up to retracts between the corresponding homotopy categories. We also construct a commutative square whose horizontal functors are triangle equivalences and whose vertical comparison functors are triangle equivalences up to retracts. This square relates derived functors on the lifted equivariant model categories to the equivariantizations of the derived functors on the original homotopy categories. In the module category setting, we illustrate the above results using the PGF Hovey triples, and apply them to homotopy squares induced by a Frobenius bimodule and by a stable equivalence of adjoint type.

math.RT

Flat models for Q-shaped derived categories via PGF objects

We develop a unified approach, based on projectively coresolved Gorenstein flat (PGF) objects, for constructing flat model structures on diagram categories. Specifically, we show that PGF objects in such categories are fully determined by their objectwise components, which in turn enables us to establish hereditary abelian model structures whose trivial cofibrant objects are precisely the flat objects. As an application, we reobtain flat model structures on $Q$-shaped derived categories, thereby providing a common framework that subsumes classical constructions for chain complexes. Moreover, we obtain an explicit description of the cofibrant objects in these models.

math.RT

Democratizing and accelerating AI-driven pathology research through agentic intelligence

Computational pathology has advanced rapidly with the emergence of foundation models, yet widespread adoption remains limited by substantial technical complexity and programming requirements. Here we present PathLab, an autonomous agentic framework that translates natural-language research objectives into executable and validated computational pathology workflows through the structured composition of domain-specific skills and tools. By organizing workflow generation around reusable methodological modules, including data preprocessing, model development, evaluation and interpretation, PathLab enables studies to be specified at the level of scientific intent rather than implementation details. We evaluated PathLab across 12 public datasets spanning four representative task families: region-of-interest classification, whole-slide image classification, segmentation and survival prediction. Across all task categories, PathLab achieved non-inferior performance relative to expert implementations, while consistently enforcing semantic validity of user prompts and proactively rejecting incompatible workflow specifications prior to execution. In controlled user studies, PathLab substantially reduced the time required to generate executable analytical pipelines and enabled domain experts without programming experience to independently design, execute and evaluate computational pathology studies. Together, these results establish PathLab as a reliable interface between biomedical intent and computational execution, enabling computational pathology studies to be designed at the level of scientific questions rather than programming expertise. By lowering technical barriers to advanced AI methodologies, PathLab provides a foundation for the broader democratization of computational pathology.

cs.AI

Coupling Chirality, Polar Order, and Altermagnetic Spin Splitting in a Hybrid Manganese Chloride

Hybrid manganese halides enable the coexistence of molecular chirality, polar order, and magnetic exchange within a single lattice. Here, we combine first-principles calculations with spin-space-group analysis to investigate the synthesized enantiomeric pair [(R)/(S)-MPA]2[MnCl4(H2O)] (MPA = beta-methylphenethylammonium). We predict that its compensated magnetic state hosts altermagnetic spin splitting in the nonrelativistic limit, and that the coupled chiral, polar, and magnetic degrees of freedom define a symmetry-related manifold. From this manifold, we derive simple sign rules for the electronic and magneto-optical response: reversing both chirality and polarity, or reversing the magnetic domain alone, inverts the spin splitting throughout the Brillouin zone, whereas reversing chirality alone or polarity alone changes the spin-splitting sign only in symmetry-selected regions. With spin-orbit coupling, reversing chirality or magnetic order flips the Kerr rotation angle, while changing the polar variant leaves it unchanged. These results reveal a chemically accessible route to translate molecular handedness into symmetry-controlled spin splitting and magneto-optical readout in hybrid manganese halides. Critically, we show that the sign and momentum pattern of the splitting are governed by the interplay of the chiral, polar, and magnetic degrees of freedom. This interplay opens the possibility to control the spin splitting through a judicious design of the organic cations, by modulating their chirality and polarity.

cond-mat.mtrl-sci

A Multimodal Agentic Pathology Co-pilot via Evidence Grounded Reasoning

Pathology is the cornerstone of modern medicine, where accurate decision-making relies heavily on evidence-based practices. While artificial intelligence (AI) has the potential to transform clinical workflows, the intersection of AI and evidence-based medicine remains under-explored, with primitive attempts restricted to text-only general medicine. In this work, we present PathPocket, a multimodal AI agentic co-pilot designed specifically for evidence grounded pathology. We construct the most comprehensive pathology evidence corpus to date, encompassing approximately 110,472 public and authorized documents structured across a rigorous hierarchy of evidence from clinical guideline to expert opinion. From this meticulously graded foundation, we build a large-scale multimodal pathology hypergraph containing over 4.55 million entities and 7.10 million relations. Serving as a robust knowledge engine, this hypergraph provides traceable evidence for a collaborative multi-agent reasoning framework integrating input understanding, evidence retrieval, filtering, and diagnosis generation. This enables PathPocket to seamlessly resolve a wide spectrum of clinical tasks, ranging from text-only queries to complex multimodal diagnostics involving region-of-interest (ROI) and gigapixel whole-slide images (WSIs). We rigorously evaluate the system on a multidimensional benchmark of over 200,000 real-world cases, where it significantly outperforms existing state-of-the-arts. Crucially, extensive user studies demonstrate that PathPocket substantially improves the diagnostic accuracy and confidence of pathologists. By directly grounding pathology interpretations in verifiable literature, PathPocket offers a practical and scalable solution for the future of evidence grounded computational pathology.

cs.AI

A Pathology Foundation Model for Gastric Cancer with Real-World Validation

Gastric cancer remains a major cause of cancer mortality, yet its histological and molecular heterogeneity complicates diagnosis and risk stratification. General-purpose pathology foundation models (PFMs) often plateau on fine-grained endpoints central to gastric cancer care, and few have undergone rigorous prospective validation or clinical reader studies. We present GRACE, a Gastric-specific foundation model for Real-world Assessment and Clinical dEcision support. GRACE was developed from multicenter gastric pathology datasets totaling 48,364 primarily HE-stained whole-slide images from 37,493 patients. When evaluated on 28 clinically relevant tasks, GRACE consistently outperformed representative pancancer PFMs, achieving a macro-AUC of 0.9188, with strong performance for precancerous lesion diagnosis (macro-AUC 0.9322), tumor histopathological assessment (macro-AUC 0.9119), molecular profiling (macro-AUC 0.8682), and prognostic prediction. Beyond benchmarking, GRACE's translational value was substantiated through a rigorous evidence chain. Under safety-gated criteria requiring 100% NPV for rule-out and 100% PPV for rule-in, GRACE streamlined review for up to 69.6% of malignancy-diagnosis cases and triaged 46.8% of MMR-IHC follow-up requests. This translational feasibility was further strengthened by a randomized crossover reader study of pathologist-AI collaboration. With GRACE assistance, diagnostic accuracy improved from 82.0% to 89.9%, yielding nearly twofold higher adjusted odds of a correct diagnosis (OR 1.987) alongside concurrent gains in sensitivity and specificity. AI assistance also reduced diagnostic time by 14.9%, elevated diagnostic confidence by 9.0%, and markedly improved inter-rater agreement. When calibrated to maintain non-inferior performance to senior pathologists, the AI-assisted workflow could triage 60.7% of atrophy and 82.7% of intestinal metaplasia cases.

cs.CV

Edge-aware Decoding for Neural Asymmetric Routing

Neural asymmetric routing models increasingly encode directionality through matrix representations and asymmetry-aware attention. The final routing action, however, is not a node in isolation but a directed transition chosen under the current partial route. This creates a representation--decision mismatch: pairwise cost information may be encoded upstream while the final candidate logit is still largely parameterized as context--node compatibility. We propose a decoder-design principle for neural asymmetric routing: the final score should explicitly expose transition-level quantities suggested by the problem's cost-to-go structure. We instantiate this principle with an edge-aware decoder that adds candidate-specific terms for the current directed edge, return-to-start closure, and static lightweight lookahead, while keeping the representation backbone fixed. On a controlled SVD/Sinkhorn asymmetric backbone, the decoder improves over the RADAR reference when trained on ATSP-100 and evaluated zero-shot on ATSP-100/200/500/1000, reducing the ATSP-1000 gap from $4.13\%$ to $2.73\%$. On ACVRP, the same score-level modification shows the same qualitative trend under a richer routing state. ATSP ablations and directed-transition diagnostics sharpen the mechanism: the strongest evidence concerns sensitivity to the current directed edge, while closure and static lookahead act as heuristic continuation cues. The results support a mechanism study: a key decoder-side signal in neural asymmetric routing is decision-time exposure of transition-level edge information.

cs.LG

Spatial Transcriptomics-Guided Alignment Enhances Molecular Profiling in Pathology Foundation Model

Comprehensive molecular profiling is essential for modern precision oncology but remains hindered by prohibitive costs, specimen exhaustion, and protracted turnaround times. While pathology foundation models (PFMs) have demonstrated potential for inferring molecular phenotypes from routine hematoxylin and eosin (H&E) whole-slide images (WSIs), current architectures primarily rely on vision-centric self-supervised learning or vision-language alignment, lacking the spatially resolved molecular supervision required to connect subtle morphological features with underlying genomic alterations. Spatial transcriptomics (ST) emerges as a transformative technology that enables transcriptomic quantification within intact tissue sections, thereby preserving the precise spatial link between histology and molecular profiles. In this study, we present a Spatial Transcriptomics-guided Alignment framework for Molecular Profiling (STAMP), which endows PFMs with intrinsic molecular awareness. To support this paradigm, we curated HumanST-1k, a human ST dataset spanning diverse anatomical organs and sequencing platforms. This atlas yields 1.8 million pairs of H&E patches and corresponding transcriptomic profiles, providing a corpus that links histological structures with their molecular states. To mitigate the technical noise inherent to raw transcriptomics, STAMP applies a pathway-informed alignment strategy that aggregates transcriptomic data into biologically functional pathways, which are subsequently integrated into PFMs via parameter-efficient fine-tuning. This alignment enriches the representation space of PFMs and unlocks their capacity to resolve sub-visual molecular signatures. The clinical utility of these augmented representations was validated through a multi-tier evaluation framework.

cs.LG

A Clinically Validated Foundation Model for Comprehensive Lung Pathology Interpretation

Pathological assessment guides lung cancer diagnosis, treatment selection, and prognostic evaluation, yet current CPath approaches rely on task-specific models for isolated objectives. Although pan-cancer foundation models offer versatility, they lack subspecialty-level depth and have not been evaluated across clinical workflows or prospectively validated in real-world settings. We introduce PulmoFoundation, a multi-center, prospectively validated, randomized controlled trial (RCT)-evaluated foundation model for comprehensive lung pathology assessment across pre-operative, intra-operative, and post-operative care. Built upon Virchow2 via subspecialty-specific pretraining using ~40,000 diagnostic H&E-stained whole-slide images (WSIs), PulmoFoundation was systematically evaluated on ~26,000 WSIs across 32 clinically relevant tasks. In addition to accurately predicting molecular markers and patient survival, our model achieves clinical-grade performance in core diagnostic tasks across biopsy, frozen section, and surgical resection slides. In a registered prospective study of 1,357 patients across 11 diagnostic tasks, our model achieved an average AUC of 92.3%. Using pre-specified triage thresholds, PulmoFoundation could reduce additional second-review burden for 68.8% of biopsies and 83.0% of frozen sections, and defer 44.5% of IHC stain orders, with PPVs of 1.000, 0.991, and 0.966. Beyond prospective validation, we conducted a crossover RCT with eight pathologists, in which AI assistance improved diagnostic accuracy across 5,264 case-reader pairs (91.7% w/ AI vs. 83.2% w/o AI). AI assistance also reduced median diagnostic time by 18.3%, increased diagnostic confidence by 9.0%, and improved inter-rater agreement from moderate (kappa = 0.55) to substantial (kappa = 0.76). Together, these evaluations support PulmoFoundation as a clinically validated decision-support system for lung pathology.

eess.IV

Valley-contrasting Spin Textures in Janus Metal Phosphochalcogenides

Momentum-resolved spin textures and potential valley-contrasting physical properties in the momentum space are two intriguing characteristics of noncentrosymmetric materials, and they have broad applications in spintronics and valleytronics. The realization of diverse spin textures within a single material, along with their further coupling to the valley degree of freedom, is highly desirable. Via first-principles calculations, we investigate electronic properties of Janus MP$_2$S$_3$Se$_3$ monolayers, which exhibits distinct spin textures at different valleys. While Ising-type spin textures are located at $K_\pm$ valleys, the symmetry breaking from the Janus structure brings about a coexistence of Weyl-type and Rashba-type spin textures at $\Gamma$ valley. In addition to valley-contrasting spin textures, valley dependence also occurs in Berry-curvature-driven anomalous Hall currents and optical selectivity. Besides, energy differences between $\Gamma$ and $K_\pm$, as well as band gaps, are highly tunable by applied strain. These findings present an intriguing coupling between diverse spin textures and multiple valleys, and pave the way for designing advanced electronic devices that leverage spin and valley degrees of freedom.

cond-mat.mtrl-sci

A Breast Vision Pathology Foundation Model for Real-world Clinical Utility

Pathology foundation models have shown strong retrospective performance, but whether such systems can support clinically relevant use remains unclear. This challenge is particularly important in breast cancer, where pathological assessment serves as the gold standard for diagnosis and guides treatment planning, surgical decision-making and risk stratification across pre-, intra- and post-operative stages. Here we present \textbf{BRAVE}, a breast-adaptive pathology foundation model developed and evaluated using a total resource of 101,638 breast whole-slide images from 32 sources across Asia, Europe and North America. We assessed BRAVE across 34 tasks in 82 cohorts spanning pre-operative biopsy, intra-operative frozen section and post-operative resection, using an evidence chain comprising retrospective benchmarking, clinically challenging scenarios, workflow-oriented clinical impact simulations, prospective observational validation with the thresholds locked in the retrospective cohorts and crossover pathologist-AI interaction studies. Across these settings, BRAVE supported practical roles in the clinical workflow, including safe exclusion of low-risk cases from routine review, AI-assisted second-review rescue of initially missed positives and prioritization of cases for further assessment. In prospective validation across three centres, BRAVE excluded 76.9% of negative biopsy cases (NPV 0.953) and 70.1% of negative frozen-section cases (NPV 0.973), and triaged 78.8% of post-operative subtyping cases as high-confidence clear-cut cases (NPV 1.000). In reader studies, AI assistance improved balanced accuracy from 88.5% to 95.1% (OR 3.14, P<0.001), with better efficiency, confidence and inter-rater agreement. BRAVE-derived scores also independently predicted disease-free survival (adjusted HR 4.79, P<0.001) and overall survival (adjusted HR 8.14, P<0.001).

cs.CV

A Deployment-Friendly Foundational Framework for Efficient Computational Pathology

Pathology foundation models (PFMs) generalize well across computational pathology tasks but remain costly for gigapixel whole-slide image analysis. Here, we present LitePath, a deployment-friendly framework that addresses model over-parameterization and patch-level redundancy. LitePath combines LiteFM, a compact model distilled from Virchow2, H-Optimus-1 and UNI2 using 190 million patches, with the Adaptive Patch Selector for task-specific patch selection. Compared with Virchow2, LitePath uses 28x fewer parameters and 403.5x fewer FLOPs. On an NVIDIA Jetson Orin Nano Super, it processes 208 slides per hour, 104.5x faster than Virchow2, and consumes 0.36 kWh per 3,000 slides, 171x less energy than Virchow2 on an RTX 3090 GPU. We evaluated LitePath on 45 multicenter cohorts across four organs and 33 tasks, comprising 37 classification and 8 survival cohorts, including 33 internal, 10 external and 2 prospective cohorts, with 17,837 slides from 9,977 patients disjoint from the pretraining data. Among 22 PFMs, LitePath achieved the best average rank (6.56 vs. 6.58 for Virchow2), retained 99.71% of Virchow2's Macro-AUC across classification cohorts, and improved mean C-index by 2.14 percentage points across survival cohorts (71.91% vs. 69.77%). We further introduce the Deployability Score (D-Score), a weighted geometric mean of normalized task performance and FLOPs. LitePath achieved the highest D-Score (0.8455), outperforming H0-mini (0.7723) and Virchow2 (0.7297). In a randomized paired crossover study of four pathologists and 120 cases, LitePath increased diagnostic accuracy by 4.1-15.8 percentage points and reduced diagnostic time by 10.9-14.2%. These results demonstrate rapid, cost-effective and energy-efficient pathology image analysis on accessible hardware while maintaining competitive performance.

cs.CV

Representations of generalized linear Reedy categories and abelian model structures

In this paper we consider representations of generalized $k$-linear Reedy categories $\underline{\mathscr{C}}$, a common generalization of $k$-linear Reedy categories introduced by Georgiois-\v{S}t'ov\'{\i}\v{c}ek and $k$-linearizations of generalized Reedy categories introduced by Berger-Moerdijk, and construct abelian model structures on $\underline{\mathscr{C}} \text{-}\mathrm{Mod}$. In the first part, we show that $\underline{\mathscr{C}}$ can be viewed as an infinite categorical analogue of standardly stratified algebras. Explicitly, we give a parameterization of irreducible representations of $\underline{\mathscr{C}} \text{-}\mathrm{Mod}$, provide several sufficient criteria such that $\underline{\mathscr{C}} \text{-}\mathrm{Mod}$ is equivalent to the Cartesian product of module categories over the ``local" endomorphism algebras of $\underline{\mathscr{C}}$, and describe applications of these results to representation theory of some interesting combinatorial categories including categories of spans and the category of finite dimensional vector spaces over a finite field and linear maps. In the second part, using the technique of Grothendieck bifibrations, we glue a family of complete cotorsion pairs in the module categories of these ``local" endomorphism algebras to a complete cotorsion pair in $\underline{\mathscr{C}} \text{-}\mathrm{Mod}$, and deduce that under certain mild conditions a family of abelian model structures on these ``local" module categories can be glued to an abelian model structure on $\underline{\mathscr{C}} \text{-}\mathrm{Mod}$. As applications, we obtain a few abelian model structures on generalized $k$-linear direct or inverse categories.

math.RT

HippMetric: A skeletal-representation-based framework for cross-sectional and longitudinal hippocampal substructural morphometry

Accurate characterization of hippocampal substructure is crucial for detecting subtle structural changes and identifying early neurodegenerative biomarkers. However, high inter-subject variability and complex folding pattern of human hippocampus hinder consistent cross-subject and longitudinal analysis. Most existing approaches rely on subject-specific modelling and lack a stable intrinsic coordinate system to accommodate anatomical variability, which limits their ability to establish reliable inter- and intra-individual correspondence. To address this, we propose HippMetric, a skeletal representation (s-rep)-based framework for hippocampal substructural morphometry and point-wise correspondence across individuals and scans. HippMetric builds on the Axis-Referenced Morphometric Model (ARMM) and employs a deformable skeletal coordinate system aligned with hippocampal anatomy and function, providing a biologically grounded reference for correspondence. Our framework comprises two core modules: a skeletal-based coordinate system that respects the hippocampus' conserved longitudinal lamellar architecture, in which functional units (lamellae) are stacked perpendicular to the long-axis, enabling anatomically consistent localization across subjects and time; and individualized s-reps generated through surface reconstruction, deformation, and geometrically constrained spoke refinement, enforcing boundary adherence, orthogonality and non-intersection to produce mathematically valid skeletal geometry. Extensive experiments on two international cohorts demonstrate that HippMetric achieves higher accuracy, reliability, and correspondence stability compared to existing shape models.

cs.CV

MambaMIL+: Modeling Long-Term Contextual Patterns for Gigapixel Whole Slide Image

Whole-slide images (WSIs) are an important data modality in computational pathology, yet their gigapixel resolution and lack of fine-grained annotations challenge conventional deep learning models. Multiple instance learning (MIL) offers a solution by treating each WSI as a bag of patch-level instances, but effectively modeling ultra-long sequences with rich spatial context remains difficult. Recently, Mamba has emerged as a promising alternative for long sequence learning, scaling linearly to thousands of tokens. However, despite its efficiency, it still suffers from limited spatial context modeling and memory decay, constraining its effectiveness to WSI analysis. To address these limitations, we propose MambaMIL+, a new MIL framework that explicitly integrates spatial context while maintaining long-range dependency modeling without memory forgetting. Specifically, MambaMIL+ introduces 1) overlapping scanning, which restructures the patch sequence to embed spatial continuity and instance correlations; 2) a selective stripe position encoder (S2PE) that encodes positional information while mitigating the biases of fixed scanning orders; and 3) a contextual token selection (CTS) mechanism, which leverages supervisory knowledge to dynamically enlarge the contextual memory for stable long-range modeling. Extensive experiments on 20 benchmarks across diagnostic classification, molecular prediction, and survival analysis demonstrate that MambaMIL+ consistently achieves state-of-the-art performance under three feature extractors (ResNet-50, PLIP, and CONCH), highlighting its effectiveness and robustness for large-scale computational pathology

cs.CV

A dispersion-driven 3D color near-eye meta-display

Chromatic dispersion, an inherent wavelength-dependent phenomenon in optical systems, has traditionally been regarded as a detrimental effect to be minimized in imaging and display. Here, we present a paradigm shift by deliberately engineering and harnessing metalens dispersion as a functional mechanism for three-dimensional (3D) near-eye displays. Specifically, we exploit lateral dispersion to transform transverse offset between green and red objects into image-space angular separations that make their images intersected virtually, thereby creating color-merged 3D virtual-image perception. This meta-display architecture preserves compactness of conventional planar display while exhibiting less data requirements and lower hardware complexity than other near-eye 3D displays. Experimentally, we demonstrate a multi-color near-eye 3D system achieving an 11{\deg} field of view, 22 pixels-per-degree angular resolution, 0.9 m depth of field, and 19 distinct image planes. This work establishes a new pathway for metasurfaces toward visual displays and highlights great potential for future virtual/augmented reality.

physics.optics

Manipulation of photonic topological edge and corner states via trivial claddings

Crystalline symmetry offers a powerful tool to realize photonic topological phases, in which additional trivial claddings are typically required to confine topological boundary states. However, the utility of the trivial cladding in manipulating topological waves is often overlooked. Here, we demonstrate two topologically distinct kagome photonic crystals (KPCs) based on different crystalline symmetries: \mathbit{C}_\mathbf{6}- symmetric KPCs exhibit a quantum spin Hall phase, while \mathbit{C}_\mathbf{3}-symmetric KPCs serve as trivial cladding. By tuning the geometric parameter of the trivial cladding, we observe that a pair of topological interface states featured with pseudospin-momentum locking undergoes a phase transition, accompanied by the appearance and disappearance of corner states in a finite hexagonal supercell. Such a geometry-induced band inversion is characterized by a sign change in the Dirac mass of the topological interface states and holds potential for applications such as rainbow trapping. Furthermore, we experimentally demonstrate the corner states, which is a hallmark of higher-order topology, also depend critically on the trivial cladding. Our work highlights the crucial role of trivial claddings on the formation of topological boundary states, and offers a novel approach for their manipulation.

physics.optics

Value of Multi-pursuer Single-evader Pursuit-evasion Game with Terminal Cost of Evader's Position: Relaxation of Convexity Condition

In this study, we consider a multi-pursuer single-evader quantitative pursuit-evasion game with payoff function that includes only the terminal cost. The terminal cost is a function related only to the terminal position of the evader. This problem has been extensively studied in target defense games. Here, we prove that a candidate for the value function generated by geometric method is the viscosity solution of the corresponding Hamilton-Jacobi-Isaacs partial differential equation (HJI PDE) Dirichlet problem. Therefore, the value function of the game at each point can be computed by a mathematical program. In our work, the convexity of the terminal cost or the target is not required. The terminal cost only needs to be locally Lipschitz continuous. The cases in which the terminal costs or the targets are not convex are covered. Therefore, our result is more universal than those of previous studies, and the complexity of the proof is improved. We also discuss the optimal strategies in this game and present an intuitive explanation of this value function.

math.OC