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Liang Zhong

Publications and source records attributed to Liang Zhong.

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Randomization Tests in Randomized Saturation Designs

Randomized saturation designs are widely used to study spillover effects in clustered populations. In these designs, clusters are first assigned to treatment saturation levels, and units are then randomized within clusters according to the assigned saturation. This paper develops randomization tests for such experiments under several null hypotheses that arise naturally in spillover analysis. For a fixed pair of saturation levels, we first study two individual-level hypotheses: a partially sharp null of no spillover effect for every untreated unit and a bounded null that restricts individual spillover effects by a prespecified constant. Both hypotheses can be tested using a common conditional randomization framework, with finite-sample validity obtained by combining the same focal-unit relabeling distribution with null-specific statistics. We then study weak average-spillover nulls and show that, although these nulls do not yield finite-sample exact conditional tests, studentized relabeling statistics deliver asymptotically valid randomization-based inference. Finally, for multiple ordered saturation levels, we develop a finite-sample valid unconditional pairwise-imputation test for global monotonicity of spillover effects. Simulations and an application to the Zomba Cash Transfer experiment illustrate the finite-sample behavior and practical implementation of the methods.

stat.ME

Uncertainty-Based Ensemble Learning in CMR Semantic Segmentation

Existing methods derive clinical functional metrics from ventricular semantic segmentation in cardiac cine sequences. While performing well on overall segmentation, they struggle with the end slices. To address this, we extract global uncertainty from segmentation variance and use it in our ensemble learning method, Streaming, for classifier weighting, balancing overall and end-slice performance. We introduce the End Coefficient (EC) to quantify end-slice accuracy. Experiments on ACDC and M\&Ms datasets show that our framework achieves near state-of-the-art Dice Similarity Coefficient (DSC) and outperforms all models on end-slice performance, improving patient-specific segmentation accuracy. We open-sourced our code on https://github.com/LEw1sin/Uncertainty-Ensemble.

cs.CV

Hybrid Quantum-Classical Branch-and-Price for Intra-Day Electric Vehicle Charging Scheduling via Partition Coloring

The rapid deployment of electric vehicles (EVs) in public parking facilities and fleet operations raises challenging intra-day charging scheduling problems under tight charger capacity and limited dwell times. We model this problem as a variant of the Partition Coloring Problem (PCP), where each vehicle defines a partition, its candidate charging intervals are vertices, and temporal and resource conflicts are represented as edges in a conflict graph. On this basis, we design a branch-and-price algorithm in which the restricted master problem selects feasible combinations of intervals, and the pricing subproblem is a maximum independent set problem. The latter is reformulated as a quadratic unconstrained binary optimization (QUBO) model and solved by quantum-annealing-inspired algorithms (QAIA) implemented in the MindQuantum framework, specifically the ballistic simulated branching (BSB) and simulated coherent Ising machine (SimCIM) methods, while the master problem is solved by Gurobi. Computational experiments on a family of synthetic EV charging instances show that the QAIA-enhanced algorithms match the pure Gurobi-based branch-and-price baseline on small and medium instances, and clearly outperform it on large and hard instances. In several cases where the baseline reaches the time limit with non-zero optimality gaps, the QAIA-based variants close the gap and prove optimality within the same time budget. These results indicate that integrating QAIA into classical decomposition schemes are a promising direction for large-scale EV charging scheduling and related PCP applications.

cs.CE

Challenges in Deep Learning-Based Small Organ Segmentation: A Benchmarking Perspective for Medical Research with Limited Datasets

Accurate segmentation of carotid artery structures in histopathological images is vital for cardiovascular disease research. This study systematically evaluates ten deep learning segmentation models including classical architectures, modern CNNs, a Vision Transformer, and foundation models, on a limited dataset of nine cardiovascular histology images. We conducted ablation studies on data augmentation, input resolution, and random seed stability to quantify sources of variance. Evaluation on an independent generalization dataset ($N=153$) under distribution shift reveals that foundation models maintain performance while classical architectures fail, and that rankings change substantially between in-distribution and out-of-distribution settings. Training on the second dataset at varying sample sizes reveals dataset-specific ranking hierarchies confirming that model rankings are not generalizable across datasets. Despite rigorous Bayesian hyperparameter optimization, model performance remains highly sensitive to data splits. The bootstrap analysis reveals substantially overlapping confidence intervals among top models, with differences driven more by statistical noise than algorithmic superiority. This instability exposes limitations of standard benchmarking in low-data clinical settings and challenges assumptions that performance rankings reflect clinical utility. We advocate for uncertainty-aware evaluation in low-data clinical research scenarios from two perspectives. First, the scenario is not niche and is rather widely spread; and second, it enables pursuing or discontinuing research tracks with limited datasets from incipient stages of observations.

cs.CV

Randomization Tests in Switchback Experiments

Switchback experiments--alternating treatment and control over time--are widely used when unit-level randomization is infeasible, outcomes are aggregated, or user interference is unavoidable. In practice, experimentation must support fast product cycles, so teams often run studies for limited durations and make decisions with modest samples. At the same time, outcomes in these time-indexed settings exhibit serial dependence, seasonality, and occasional heavy-tailed shocks, and temporal interference (carryover or anticipation) can render standard asymptotics and naive randomization tests unreliable. In this paper, we develop a randomization-test framework that delivers finite-sample valid, distribution-free p-values for several null hypotheses of interest using only the known assignment mechanism, without parametric assumptions on the outcome process. For causal effects of interests, we impose two primitive conditions--non-anticipation and a finite carryover horizon m--and construct conditional randomization tests (CRTs) based on an ex ante pooling of design blocks into "sections," which yields a tractable conditional assignment law and ensures imputability of focal outcomes. We provide diagnostics for learning the carryover window and assessing non-anticipation, and we introduce studentized CRTs for a session-wise weak null that accommodates within-session seasonality with asymptotic validity. Power approximations under distributed-lag effects with AR(1) noise guide design and analysis choices, and simulations demonstrate favorable size and power relative to common alternatives. Our framework extends naturally to other time-indexed designs.

stat.ME

Development and validation of an AI foundation model for endoscopic diagnosis of esophagogastric junction adenocarcinoma: a cohort and deep learning study

The early detection of esophagogastric junction adenocarcinoma (EGJA) is crucial for improving patient prognosis, yet its current diagnosis is highly operator-dependent. This paper aims to make the first attempt to develop an artificial intelligence (AI) foundation model-based method for both screening and staging diagnosis of EGJA using endoscopic images. In this cohort and learning study, we conducted a multicentre study across seven Chinese hospitals between December 28, 2016 and December 30, 2024. It comprises 12,302 images from 1,546 patients; 8,249 of them were employed for model training, while the remaining were divided into the held-out (112 patients, 914 images), external (230 patients, 1,539 images), and prospective (198 patients, 1,600 images) test sets for evaluation. The proposed model employs DINOv2 (a vision foundation model) and ResNet50 (a convolutional neural network) to extract features of global appearance and local details of endoscopic images for EGJA staging diagnosis. Our model demonstrates satisfactory performance for EGJA staging diagnosis across three test sets, achieving an accuracy of 0.9256, 0.8895, and 0.8956, respectively. In contrast, among representative AI models, the best one (ResNet50) achieves an accuracy of 0.9125, 0.8382, and 0.8519 on the three test sets, respectively; the expert endoscopists achieve an accuracy of 0.8147 on the held-out test set. Moreover, with the assistance of our model, the overall accuracy for the trainee, competent, and expert endoscopists improves from 0.7035, 0.7350, and 0.8147 to 0.8497, 0.8521, and 0.8696, respectively. To our knowledge, our model is the first application of foundation models for EGJA staging diagnosis and demonstrates great potential in both diagnostic accuracy and efficiency.

cs.CV

Unconditional Randomization Tests for Interference

Researchers are often interested in the existence and extent of interference between units when conducting causal inference or designing policy. However, testing for interference presents significant econometric challenges, particularly due to complex clustering patterns and dependencies that can invalidate standard methods. This paper introduces the pairwise imputation-based randomization test (PIRT), a general and robust framework for assessing the existence and extent of interference in experimental settings. PIRT employs unconditional randomization testing and pairwise comparisons, enabling straightforward implementation and ensuring finite-sample validity under minimal assumptions about network structure. The method's practical value is demonstrated through an application to a large-scale policing experiment in Bogota, Colombia (Blattman et al., 2021), which evaluates the effects of hotspot policing on crime at the street segment level. The analysis reveals that increased police patrolling in hotspots significantly displaces violent crime, but not property crime. Simulations calibrated to this context further underscore the power and robustness of PIRT.

econ.EM

Convexity Not Required: Estimation of Smooth Moment Condition Models

Generalized and Simulated Method of Moments are often used to estimate structural Economic models. Yet, it is commonly reported that optimization is challenging because the corresponding objective function is non-convex. For smooth problems, this paper shows that convexity is not required: under conditions involving the Jacobian of the moments, certain algorithms are globally convergent. These include a gradient-descent and a Gauss-Newton algorithm with appropriate choice of tuning parameters. The results are robust to 1) non-convexity, 2) one-to-one moderately non-linear reparameterizations, and 3) moderate misspecification. The conditions preclude non-global optima. Numerical and empirical examples illustrate the condition, non-convexity, and convergence properties of different optimizers.

econ.EM

RICAU-Net: Residual-block Inspired Coordinate Attention U-Net for Segmentation of Small and Sparse Calcium Lesions in Cardiac CT

The Agatston score, which is the sum of the calcification in the four main coronary arteries, has been widely used in the diagnosis of coronary artery disease (CAD). However, many studies have emphasized the importance of the vessel-specific Agatston score, as calcification in a specific vessel is significantly correlated with the occurrence of coronary heart disease (CHD). In this paper, we propose the Residual-block Inspired Coordinate Attention U-Net (RICAU-Net), which incorporates coordinate attention in two distinct manners and a customized combo loss function for lesion-specific coronary artery calcium (CAC) segmentation. This approach aims to tackle the high class-imbalance issue associated with small and sparse CAC lesions. Experimental results and the ablation study demonstrate that the proposed method outperforms the five other U-Net based methods used in medical applications, by achieving the highest per-lesion Dice scores across all four lesions.

eess.IV

Iterative distributed minimum total-MSE approach for secure communications in MIMO interference channels

In this paper, we consider the problem of joint transmit precoding (TPC) matrix and receive filter matrix design subject to both secrecy and per-transmitter power constraints in the MIMO interference channel, where $K$ legitimate transmitter-receiver pairs communicate in the presence of an external eavesdropper. Explicitly, we jointly design the TPC and receive filter matrices based on the minimum total mean-squared error (MT-MSE) criterion under a given and feasible information-theoretic degrees of freedom. More specifically, we formulate this problem by minimizing the total MSEs of the signals communicated between the legitimate transmitter-receiver pairs, whilst ensuring that the MSE of the signals decoded by the eavesdropper remains higher than a certain threshold. We demonstrate that the joint design of the TPC and receive filter matrices subject to both secrecy and transmit power constraints can be accomplished by an efficient iterative distributed algorithm. The convergence of the proposed iterative algorithm is characterized as well. Furthermore, the performance of the proposed algorithm, including both its secrecy rate and MSE, is characterized with the aid of numerical results. We demonstrate that the proposed algorithm outperforms the traditional interference alignment (IA) algorithm in terms of both the achievable secrecy rate and the MSE. As a benefit, secure communications can be guaranteed by the proposed algorithm for the MIMO interference channel even in the presence of a "sophisticated/strong" eavesdropper, whose number of antennas is much higher than that of each legitimate transmitter and receiver.

cs.IT