Searcharxiv⌕ Search

arXiv subjects

Liisa Petäinen

Publications and source records attributed to Liisa Petäinen.

2 recordsLinked to original sources

Continued Pretraining of FinBERT on Finnish Histopathological Reports: Train-Time Signals and Proxy Downstream Correlations

In Natural Language Processing (NLP) classification tasks where a lack of labeled data is an issue, continued pretraining (CPT) of transformer models on unlabeled data is an established approach. In this paper, we have two aims. (1) We describe our observations from continued pretraining of the Finnish BERT transformer model (FinBERT) on a Finnish histopathological dataset (below, \emph{the Histopathology data}). (2) Since the Histopathology data has no classification labels, we gather public Finnish datasets as proxy data to analyze whether the signals observed in (1) are associated with downstream classification gains. We observe that CPT train-time loss curves differ strongly by domain, and that, in an exploratory analysis, certain CPT-derived features correlate with proxy classification improvement. In particular, this report contributes to the limited literature on NLP for Finnish healthcare data.

cs.CL↗

Domain-specific transfer learning in the automated scoring of tumor-stroma ratio from histopathological images of colorectal cancer

Tumor-stroma ratio (TSR) is a prognostic factor for many types of solid tumors. In this study, we propose a method for automated estimation of TSR from histopathological images of colorectal cancer. The method is based on convolutional neural networks which were trained to classify colorectal cancer tissue in hematoxylin-eosin stained samples into three classes: stroma, tumor and other. The models were trained using a data set that consists of 1343 whole slide images. Three different training setups were applied with a transfer learning approach using domain-specific data i.e. an external colorectal cancer histopathological data set. The three most accurate models were chosen as a classifier, TSR values were predicted and the results were compared to a visual TSR estimation made by a pathologist. The results suggest that classification accuracy does not improve when domain-specific data are used in the pre-training of the convolutional neural network models in the task at hand. Classification accuracy for stroma, tumor and other reached 96.1$\%$ on an independent test set. Among the three classes the best model gained the highest accuracy (99.3$\%$) for class tumor. When TSR was predicted with the best model, the correlation between the predicted values and values estimated by an experienced pathologist was 0.57. Further research is needed to study associations between computationally predicted TSR values and other clinicopathological factors of colorectal cancer and the overall survival of the patients.

cs.CV↗