arXiv subjects

Ling Yang

Publications and source records attributed to Ling Yang.

At least 19 recordsLinked to original sources

arXiv2026

ECG2Gene: Deep Learning-Based Germline Tumor Susceptibility Gene Risk Assessment Using Electrocardiograms

Electrocardiograms (ECGs) may contain physiological information related to hereditary cancer susceptibility, but its relationship with future cancer risk remains unclear. Here, we present ECG2Gene, a two-stage deep-learning framework that derives digital phenotypes related to germline tumor susceptibility from routine 12-lead ECGs and predicts future cancer risk. In Stage 1, carrier status for pathogenic or likely pathogenic variants in ATM, BRIP1, CHEK2, PALB2, BRCA1, and BRCA2 supervises a multitask model that generates six continuous ECG-derived gene scores. In Stage 2, XGBoost integrates these scores with clinical variables to predict subsequent breast and ovarian cancer in women and prostate cancer in men. We also introduce ECG-Wide Association Analysis (EWAS) to characterize associations between ECG-derived gene scores and ECG waveforms. Across the clinical feature combinations evaluated in UK Biobank, the best-performing sex-specific models achieve AUROCs of 0.683, 0.633, and 0.660 for breast, ovarian, and prostate cancer, respectively. In external evaluations, models combining ECG-derived gene scores with age achieve prostate cancer AUROCs of 0.709 and 0.579 among men in the overall China Kadoorie Biobank and MIMIC-IV-ECG cohorts, respectively. ECG2Gene links genetically supervised ECG phenotyping and waveform association analysis to future cancer outcomes, demonstrating the potential of routine ECGs combined with clinical information for non-invasive, opportunistic cancer risk assessment.

cs.LG↗

arXiv2026

DiscoveryRSI: Recursively Learning to Discover Valuable Hypotheses

Scientific discovery requires developing worthwhile hypotheses into practical investigations, yet learning from this evolving research process remains challenging. We introduce an operational definition of valuable and testable research hypotheses: evidence-grounded claims about consequential uncertainties, coupled with feasible investigations, explicit decision criteria, and alternative explanations. Our DiscoveryRSI framework develops hypothesis trees through multi-agent evolutionary search, compiles selected investigations into executable Harbor tasks, and recursively learns through three mechanisms: hypothesis credit optimization attributes scientific assessments to documented research contributions; harness replay identifies productive strategies and recurring failures to refine research workflows; and rediscovery applies accepted improvements to new investigations, generating further experience for subsequent learning. We also introduce DFM-Bench, which provides comprehensive assessment of hypothesis quality and cumulative research progress at the levels of hypotheses, revisions, development paths and research runs. Across four life-science domains, automated evaluation shows that hypothesis quality rises from 4.86 for the base model to 5.39 after two rounds of self-improvement, with the large gains in falsifiability and data resolvability. We further validate hypothesis quality through expert review, comparing our DiscoveryRSI-27B with other research agents. Preliminary human assessments show that DiscoveryRSI-27B scores higher than GPT-6 Luna on hypothesis importance and whether claims are plausible and evidence-bounded. DiscoveryRSI-27B achieved a 6.3% rate of hypothesis correspondence with research published after the model cutoff, largely outperform GPT-6 with 2.5% and Claude Opus 5 with 2.3%, while delivering greater human-rated improvement along research paths.

cs.CL↗

arXiv2026

JevAgentHarness: Benchmarking, Deploying and Training Decision Models That Share Control with LLMs

Large language model (LLM) agents now fix software, operate computers and serve customers, but their harnesses, the programs that run them, call a large LLM at every step, which makes long tasks slow and costly. Most of these calls end in a multiple-choice decision, such as which tool to call next. Decision models such as Jev answer these questions directly, at a fraction of an LLM call's time and price. We ask how a harness can delegate these decisions to a decision model with little loss of success. To evaluate decision models in agentic tasks, we build AgentDecisionBench, which tests them from isolated questions up to control of a running agent, on public benchmarks and our DecisionGym environment. The decision model most accurate on isolated questions solved only 69.5% of agent tasks, and without a fitted confidence threshold, delegating tool choices lowered success by 19.0 points. Building on these findings, we then design JevAgentHarness, which fits this threshold for each choice on the agent's own trajectories and lets the LLM decide below it. Because existing decision models never see the states an agent reaches after its own mistakes, we train AgentDecision-4B, an open 4B model, on such states with Jev's answers as labels. On tasks unlike its training data, the agent solved 91.5% of them with AgentDecision-4B and 82.0% with Jev. On tasks like their training data, 4B models trained this way made agents 81.1-89.0% cheaper and up to 2.5 times faster, without losing 3 or more points of task success. The models, data, and harness will be released at https://github.com/JevAgentHarness/JevAgentHarness.

cs.AI↗

arXiv2026

OmniVerifier-C1: Decomposed Graded Verifier for Rule-Governed Generative World Modeling

Generative visual verifiers play a crucial role in advancing multimodal intelligence. To enhance the robustness of visual verifiers in complex multimodal scenarios involving compositional requirements, we move beyond conventional binary verifiers that produce only True/False discrete judgments and introduce a verifier that automatically decomposes complex prompts or environmental rules into fine-grained components and assigns pointwise scores to provide a continuous and more informative critique signal. Our experiments further demonstrate that these structured and interpretable outputs improve the verifier's generalization to out-of-domain multimodal critic tasks. To train this verifier, we introduce a Decoupled RL training strategy that jointly optimizes sub-question-level binary judgment and global alignment scoring, using precise local feedback to develop fine-grained verification capabilities that provide a foundation for reliable continuous scoring at the global level. Under a general reinforcement learning framework, we first empirically demonstrate that the proposed pointwise graded verifier significantly outperforms binary verifiers in traditional text-to-image scenarios. We then extend our investigation to rule-governed generative world modeling where generative models are leveraged for world simulation and world reasoning under explicit rules. From a theoretical standpoint, we further show that a pairwise verification paradigm yields more accurate critiques than the pointwise formulation when ground-truth images are available, with empirical results on diverse structured world-modeling tasks such as Maze and Sudoku further validating the effectiveness of our approach. Overall, our findings suggest a key insight: the transition from generative models to structured world-modeling agents critically hinges on the availability of accurate pairwise graded visual verifiers.

cs.CL↗

arXiv2026

RSI-Anything: Unlocking Recursive Self-Improvement with World Models

Recursive self-improvement (RSI) aims to transform interaction experience into persistent improvements, yet external feedback is costly and world-model predictions may become unreliable as policies evolve. We introduce RSI-Anything, a domain-general framework built on JEPA-Anything that uses predictive world models to guide action and learning-data selection. Observed feedback drives policy or workflow improvement and conditional world-model adaptation, while component and compatibility checks govern the retention of updated policy-model pairs. Across diverse computational and scientific domains, RSI-Anything demonstrates substantial gains. In code repair, with the coder fixed, success increases from 26.3% with a static verifier to 29.2% through predictive selection and 31.2% after world-model adaptation, at comparable test usage. Graphical user interface (GUI) evaluations showed higher task completion, while average actions decrease by 39.4%. Across five successive policy versions, laboratory-planning scores more than double from 21.80% to 46.01%. In reaction optimization, RSI-Anything achieves 96.15% mean best observed yield versus 82.16% for Bayesian optimization under the same 40-experiment budget. An end-to-end immune-science application further connects workflow evolution and predictive modeling with therapeutic hypothesis generation. These results demonstrate how predictive world models and retained system updates enable recursive improvement across diverse environments.

cs.CL↗

arXiv2026

An optimal pinching theorem on compact minimal submanifolds in the Euclidean spheres via eigenvalues of fundamental matrices II

Let $M^n\subset S^{n+m}$ be a compact minimal submanifold of the unit sphere, and let $λ_1\geq\cdots\geqλ_m\geq0$ be the eigenvalues of its fundamental matrix. We prove that $\sum\limits_{α=1}^{\min\{n,m\}}λ_α+λ_2\leq n$ forces $M$ to be a totally geodesic subsphere, a generalized Clifford torus, or a Veronese manifold. We first show that equality everywhere in the pinching condition forces the second fundamental form to be parallel. Next, by computing the eigenvalues of the fundamental matrices of irreducible symmetric $R$-spaces, we obtain a complete classification of the equality cases among minimal submanifolds with parallel second fundamental form.

math.DG↗

arXiv2026

An optimal pinching theorem on compact minimal submanifolds in the Euclidean spheres via eigenvalues of fundamental matrices

Based on an inequality on the upper bound of the sum of squared norms of Lie bracket of symmetric matrices, we establish a rigidity theorem for compact minimal submanifolds in the Euclidean spheres via eigenvalues of fundamental matrices, which are the critical values of the squared norms of the second fundamental form on all normal directions. This conclusion is optimal for all dimensions without the restriction of the codimension, giving a new characterization for generalized Clifford tori and Veronese manifolds.

math.DG↗

arXiv2026

JEPA-Anything: Learning Predictive Models across Different Worlds

World modeling enables intelligence to anticipate consequences, guide interventions, and learn from interaction. Yet predictive models remain domain-specific: can a common learning principle support world modeling across radically different systems? We introduce JEPA-Anything, a domain-agnostic framework based on orthogonal predictive factorization (OPF). Extending joint-embedding predictive architectures, OPF decomposes latent targets into complementary factors, learns them through dedicated pathways, and recombines them within a shared predictive design. We evaluate JEPA-Anything across seven domains: vision, biology, clinical trajectories, control, molecular dynamics, physical fields, and weather. Experiments span representation learning, intervention prediction, out-of-distribution generalization, and long-horizon dynamics, including 10 matched dynamics tasks, forecasting of over 1,000 clinical events, and 100-step molecular rollouts across four systems. Against matched JEPA baselines, JEPA-Anything improves reported metrics on all 10 dynamics tasks and reduces single-intervention prediction error on Interventional Pong by 34.8%. It achieves the lowest one-step and 100-step molecular errors among compared methods in all four systems. Beyond prediction, a factor-nominated biological intervention receives experimental support in cell co-cultures, patient-derived organoids, tumor fragments, and mice; latent orbital modes recover the Keplerian scaling exponent with a fitted slope of -1.4991. These results support a common factorized predictive principle across heterogeneous worlds, connecting world modeling with intervention and experimentally grounded scientific discovery. Code: https://github.com/Gen-Verse/JEPA-Anything

cs.CL↗

arXiv2026

ScienceIDE: Turning World's Scientific Codebase into Agent Learnable Environments

Scientific code repositories encode decades of human knowledge in executable models, methods, and tools. Yet fragmented toolchains, implicit domain conventions, and specialized correctness criteria make this knowledge difficult to convert into reliable learning experience-a challenge we call the scientific experience bottleneck. We introduce ScienceIDE, infrastructure for turning the world's scientific code into programmable environments for scientific agents. Guided by expert-defined scientific cases and acceptance criteria, agents transform repositories into executable environments that support task generation, execution, and scientific verification. These environments provide a shared foundation for supervised fine-tuning, reinforcement learning, and evaluation. Using verified interaction trajectories, we train PhAI-IDE-72B, PhAI-IDE-9B, and PhAI-IDE-4B. The model family shows gains in held-out scientific-code repair and across selected general-purpose benchmarks in code, reasoning, and knowledge, providing evidence of positive transfer from scientific experience to broader capabilities. ScienceIDE lays the foundation for an integrated workspace for agent learning and scientific practice, making humanity's scientific software a shared substrate for developing scientific intelligence. Code: https://github.com/aitofound/ScienceIDE

cs.CL↗

arXiv2026

ScienceBuddy: Recursive-in-Recursive Self-Improvement for Interactive Scientific Agents

We introduce and release ScienceBuddy, an interactive scientific research workspace that brings continually improving scientific agents into researchers' everyday workflows. ScienceBuddy supports researchers in carrying out scientific tasks while transforming their requests, feedback, and execution evidence into tasks and evaluation rubrics for continual learning. At its core is recursive-in-recursive self-improvement, a paradigm that couples harness evolution with model reinforcement learning: the inner recursion improves the harness with the model fixed, while the outer recursion trains the model under the improved harness. Harness evolution shapes training experience, and model learning creates new opportunities for harness adaptation. We present case studies of researcher interaction, harness refinement, and model learning, with the benchmark cases spanning four scientific task families. By releasing ScienceBuddy as a research product, we make this paradigm available to the scientific community and take a step toward discovery intelligence: scientific AI that advances through sustained collaboration with researchers and evolves alongside the research it supports. Website: http://science-buddy.io

cs.AI↗

arXiv2026

Discovery Foundation Models: Toward Open-Ended Discovery Intelligence

Foundation models have progressed from learning and reasoning over existing knowledge, to increasingly learning through action, tool use, and outcome feedback. We argue that the next frontier is a further transition: from solving and acting within problems specified by humans to participating in the process by which new problems, representations, explanations, and knowledge are created. We refer to this capability as Discovery Intelligence. We formulate Discovery Foundation Models (DFMs) as general-purpose model systems for open-ended discovery. A DFM operates over a revisable research state and supports seven coupled capabilities spanning problem discovery, formulation, representation construction, hypothesis formation, intervention, evidence-grounded revision, and continual discovery improvement. We instantiate this framework with Zetema, which couples explicit research-state dynamics, verification and experimental gating, external grounding, and cross-task Discovery Skill evolution. We further ground the framework with GALILEO, a real therapeutic-discovery system in which Dry-Lab reasoning, robotic and hands-on Wet-Lab experimentation, external biological evidence, and iterative hypothesis and design revision form a closed physical discovery loop. We then formulate a unified approach to capability formation and process-centered evaluation, enabling discovery behavior to be trained, improved, and measured beyond final-answer performance. Together, these components establish discovery as a learnable, executable, and evaluable capability of foundation-model systems. We view this shift as a broader progression in intelligence scaling: from learning over existing knowledge, to learning from action outcomes, and ultimately to participating in the construction, testing, and revision of the structures through which new knowledge is discovered. Code: https://github.com/Gen-Verse/DFM-Plans

cs.CL↗

arXiv2026

An immune world model for multiscale forecasting and therapeutic hypothesis generation

Immune therapies act across cell-intrinsic programs, tissue ecosystems, and patient-specific immune states, yet most predictors address these scales separately. We used a governed evolutionary AI Scientist to construct the Immune World Model, an action-conditioned model that learns how interventions move immune states across cellular, tissue, and individual levels. The Immune World Model--building Scientist searched candidate architectures and workflows, and the resulting world model was frozen before independent confirmation. The frozen model generalized to unseen interventions and biological contexts, recovered intervention-specific cellular programs, integrated cell and tissue information to improve ecosystem and patient-response prediction, and forecast unseen perturbation combinations. Immune World Model--guided analysis then combined measured perturbations with cross-axis inference to nominate IL-36$γ$ plus SIRP$α$ inhibition as a complementary-axis therapeutic hypothesis, whereas a governed self-correction audit rejected every screened cytokine pair. The Immune World Model provides a framework for multiscale immune simulation that connects AI Scientist-driven model construction, intervention forecasting, and the generation of prospectively testable therapeutic hypotheses.

cs.LG↗

arXiv2026

Recursive Experiential-Working Memory Evolution for Long-Horizon Agent Harnesses

Recursive self-improvement (RSI) remains hard in long-horizon tasks, where growing histories obscure the task state and misalign skill invocation. We introduce Recuris, a recursive Experiential-Working Memory architecture for long-horizon agent harnesses, in which Working Memory tracks task progress and guides skill selection from Experiential Memory, grounding skill use in current needs rather than the full history. This coupling also turns execution into structured evidence that localizes failures to specific memory components. Across tasks, a fixed Meta-Agent turns that evidence into localized, validation-gated updates to Skill Memory that reshape execution and yield new evidence, forming a bounded recursive memory-evolution loop. Across four long-horizon benchmarks and ten models, Recuris improves task success in 35 of the 37 completed model-benchmark pairs, carrying frontier models to SOTA-level task success: on tau-bench it adds +17.8 points to GPT-5.6 Sol and +15.6 to Claude Opus 5, taking Opus 5 to 87.9%, and +16.6/+13.5 points on Qwen3.6-27B/35B on SkillFlow. The advantage widens as the interaction horizon grows, to +32.2 points on the longest tasks, and common long-horizon failures fall by up to 80%. These results position recursively evolving memory as a scalable foundation for RSI, enabling agents to continuously transform accumulated experience into increasingly effective long-horizon behavior. Code: https://github.com/Gen-Verse/Recuris

cs.AI↗

arXiv2026

Toward Skill-Native LLMs: Skill Entropy for Benchmarking and Training Long-Horizon Reasoning

Long-horizon reasoning in recent LLMs demands that the model switch between distinct skills inside a reasoning chain, such as first doing a math derivation, then using the result to plan a schedule. We call such problems cross-skill long-horizon tasks: multi-step tasks whose steps require different reasoning skills and depend on earlier outputs. Existing benchmarks often evaluate individual skills, lacking a principled way to measure how well a model switches between skills. We address this gap from both the evaluation and training sides. We introduce Skill Entropy, a measure of the difficulty of switching from one skill to another. We then propose Skill^2-Bench, a benchmark of cross-skill long-horizon tasks built over 558 skills across 9 verifiable and open-ended domains. Each task is assigned a task-level skill-entropy score and grouped into three difficulty levels. Evaluating 8 frontier and 4 open-source models on Skill^2-Bench reveals a skill-switching gap: accuracy decreases on higher-entropy tasks. We then turn skill entropy from a benchmark scale into a training signal. We propose Skill-Entropy RL, an RL framework where the model predicts not only the answer at each step but also the skill used to produce it. The reward combines step-level correctness with a skill-entropy reward that measures the alignment between the model-predicted skill sequence and the gold skill sequence. On Qwen3-4B-Instruct and Qwen3-1.7B, Skill-Entropy RL improves the Skill^2-Bench score from 34.4% to 68.4% and from 14.6% to 40.1%, respectively, outperforming competitive baselines. The same pipeline can be applied to off-the-shelf training data such as OpenR1-Math, indicating that skill entropy is a reusable training signal. Code available at: https://github.com/Gen-Verse/Skill-Entropy-RL

cs.CL↗

arXiv2026

PAST-Bench: Benchmarking the Foundations of Recursive Self-Improvement in Personal Agents

Recursive self-improvement requires agents to turn accumulated experience into better future behavior. Personal AI agents offer a concrete setting for studying this capability because they retain preferences, task histories, tool routines, and learned skills across sessions. Yet whether retained experience actually improves them over time has not been systematically tested. We introduce PAST-Bench, a benchmark designed to isolate this question. Each agent runs through ordered sequences of fresh-session tasks under matched conditions that turn retained experience on and off. It spans 26 scenarios and 204 episodes across memory, procedural reuse, information gathering, and update. We report both later-task gains and whether those gains follow the intended save, retrieve, and update pathway. Across seven base models and four agent frameworks, improvement is real but uneven across capabilities. Agents with the same headline gain can differ markedly in whether that gain is supported by evidence of the intended pathway. Guided by these findings, we develop Hermes+, which extends Hermes with five targeted interventions across stages of the agent loop. Hermes+ raises the average gain from retained experience and provides clearer pathway evidence, with its strongest improvement on tasks requiring outdated state to be replaced, although the effect remains capability- and model-dependent. Together, PAST-Bench and Hermes+ provide an evaluation and diagnostic foundation for studying how persistent agents can progress from retaining experience to systematically improving through it. Code: https://github.com/Gen-Verse/PAST-Bench

cs.CL↗

arXiv2026

Latent Collaboration in Multi-Agent Systems

Multi-agent systems (MAS) extend large language models (LLMs) from independent single-model reasoning to coordinative system-level intelligence. While existing LLM agents depend on text-based mediation for reasoning and communication, we take a step forward by enabling models to collaborate directly within the continuous latent space. We introduce LatentMAS, an end-to-end training-free framework that enables pure latent collaboration among LLM agents. In LatentMAS, each agent first performs auto-regressive latent thoughts generation through last-layer hidden embeddings instead of text. Then, a shared latent working memory preserves and transfers each agent's internal representations and latent thoughts, ensuring lossless information exchange without re-encoding. We provide detailed theoretical analyses showing that LatentMAS achieves higher expressiveness and lossless information preservation with lower overall complexity than standard text-based MAS. In addition, empirical evaluations across 9 comprehensive benchmarks spanning math and science reasoning, commonsense understanding, and code generation show that LatentMAS outperforms advanced single agents and text-based MAS baselines, achieving up to 14.6% higher accuracy, reducing output token usage by 70.8%-83.7%, and providing 4$\times$-4.3$\times$ faster end-to-end inference. Code and data are fully open-sourced at https://github.com/Gen-Verse/LatentMAS.

cs.CL↗

arXiv2026

CoWeaver: A Bi-directional, Learnable and Explainable Matching Engine for Mixed Human-Agent Science Collaboration

LLM-based agents excel at writing articles, coding and information retrieval. However, they fail to form strong collaborations within the scientific community due to the bidirectional, dynamic nature of the problem and a high demand of decision interpretability. We proposed COWEAVER, a bidirectional, learnable and explainable algorithm to match scientists and form strong collaborations within a human-agent network. COWEAVER matches candidates and requesters through filling capability gaps and filters candidates through a two-stage ranking step. Finally, the model explores newcomers by maintaining uncertainty-aware capability estimates and updating them through requester's feedback. We show that the selection mechanism of combining both exploration (UCB) and greedy of COWEAVER exceeds the greedy-only mechanism - the analytical best solution - on 6 out of the 20 tasks and performed on par with the greedy-only mechanism in terms of selecting the best candidate. We compared COWEAVER baselines in terms of matching quality and efficiency. COWEAVER outperforms baselines on all metrics.

cs.MA↗

arXiv2026

PerceptionDLM: Parallel Region Perception with Multimodal Diffusion Language Models

Multimodal large language models (MLLMs) have achieved remarkable progress in visual understanding tasks. However, most existing MLLMs rely on autoregressive generation, which limits their efficiency for perception tasks that require captioning multiple regions. In this work, we propose PerceptionDLM, a multimodal diffusion language model optimized for efficient parallel region perception. Built upon PerceptionDLM-Base, a strong foundational baseline that achieves state-of-the-art performance among open-source diffusion MLLMs, our architecture fully leverages the parallel decoding nature of DLMs. Specifically, we introduce efficient prompting and structured attention masking to enable simultaneous perception of multiple masked regions, allowing the model to generate region descriptions in parallel at both the sequence and token levels. This design significantly improves inference efficiency compared with existing approaches that process regions sequentially. To systematically evaluate the parallelism property of visual perception capability for DLMs, we construct a new Parallel Detailed Localized Captioning Benchmark (ParaDLC-Bench) by scaling the DLC-Bench to include multiple region masks per image, enabling joint evaluation of both caption quality and inference efficiency. Experiments demonstrate that PerceptionDLM maintains competitive performance in region captioning while achieving substantial speed improvements for multi-region perception tasks. Our results highlight the potential of multimodal diffusion language models for efficient, parallel visual perception. To the best of our knowledge, we are the first to achieve parallel region caption and perception by leveraging the advantages of diffusion language models. Code, models, and datasets are released.

cs.CV↗