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Lingli He

Publications and source records attributed to Lingli He.

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HVR-Met: A Hypothesis-Verification-Replanning Agentic System for Extreme Weather Diagnosis

While deep learning-based weather forecasting paradigms have made significant strides, addressing extreme weather diagnostics remains a formidable challenge. This gap exists primarily because the diagnostic process demands sophisticated multi-step logical reasoning, dynamic tool invocation, and expert-level prior judgment. Although agents possess inherent advantages in task decomposition and autonomous execution, current architectures are still hampered by critical bottlenecks: inadequate expert knowledge integration, a lack of professional-grade iterative reasoning loops, and the absence of fine-grained validation and evaluation systems for complex workflows under extreme conditions. To this end, we propose HVR-Met, a multi-agent meteorological diagnostic system characterized by the deep integration of expert knowledge. Its central innovation is the ``Hypothesis-Verification-Replanning'' closed-loop mechanism, which facilitates sophisticated iterative reasoning for anomalous meteorological signals during extreme weather events. To bridge gaps within existing evaluation frameworks, we further introduce a novel benchmark focused on atomic-level subtasks. Experimental evidence demonstrates that the system excels in complex diagnostic scenarios.

cs.AI

Kainate receptor modulation by NETO2

Glutamate-gated kainate receptors (KARs) are ubiquitous in the central nervous system of vertebrates, mediate synaptic transmission on post-synapse, and modulate transmitter release on pre-synapse. In the brain, the trafficking, gating kinetics, and pharmacology of KARs are tightly regulated by Neuropilin and tolloid-like proteins (Netos). Here we report cryo-EM structures of homo-tetrameric GluK2 in complex with Neto2 at inhibited and desensitized states, illustrating variable stoichiometry of GluK2-Neto2 complexes, with one or two Neto2 subunits associate with the GluK2. We find that Neto2 accesses only two broad faces of KARs, intermolecularly crosslinking the lower-lobe of ATDA/C, upper-lobe of LBDB/D, and lower-lobe of LBDA/C, illustrating how Neto2 regulates receptor-gating kinetics. The transmembrane helix of Neto2 is positioned proximal to the selectivity filter and competes with the amphiphilic H1-helix after M4 for interacting with an ICD formed by the M1-M2 linkers of the receptor, revealing how rectification is regulated by Neto2.

q-bio.BM