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Lior Rokach

Publications and source records attributed to Lior Rokach.

At least 19 recordsLinked to original sources

The Clinical Trial Pipeline Reveals the Next Wave of Artificial Intelligence in Healthcare: A Multidimensional Analysis of 8,532 Registered Studies

The prospective clinical evaluation of artificial intelligence in medicine has expanded rapidly, but the global AI clinical trial landscape remains incompletely characterized. We systematically identified AI-related trials registered in ClinicalTrials.gov using a broad keyword search followed by an LLM-based classifier. Each trial was classified across seven dimensions: clinical function, data modality, specialty, AI integration and autonomy, workflow position, translational maturity, and epistemic role. We identified 8,532 AI clinical trials across 32 specialties, with 80% registered from 2019 onward and 30.5% using a randomized controlled design. Imaging-based AI was the largest modality, with 2,475 trials (29%), while clinical text and NLP trials increased seven-fold between 2018 and 2025. Prognostic AI (4,324 trials) slightly exceeded diagnostic AI (3,828 trials), suggesting a shift from disease detection toward risk stratification and trajectory prediction. Treatment recommendation remained less developed, with 768 trials (9%). Translational maturity remained limited: 3,259 trials (38%) were retrospective validation studies and 1,802 (21%) were silent prospective evaluations, indicating that much of the pipeline still produces algorithmic rather than clinical evidence. Only 184 trials involved Level 4 semi-autonomous or closed-loop AI, 68% of which focused on glucose management. Multimodal AI accounted for 33.6% of trials, mainly combining imaging, omics, physiological signals, and wearable data. These findings indicate that clinical AI has moved from retrospective development to prospective evaluation, but not yet to adequately powered, geographically representative, long-term outcome trials. Future progress will depend on closing gaps in trial scale, specialty coverage, geographic representation, and translational maturity.

cs.CY

Deepchecks: Evaluating Retrieval-Augmented Generation (RAG)

Large Language Models (LLMs) augmented with Retrieval-Augmented Generation (RAG) techniques are revolutionizing applications across multiple domains, such as healthcare, finance, and customer service. Despite their potential, evaluating RAG systems remains a complex challenge due to the stochastic nature of generated outputs and the intricate interplay between retrieval and generation components. This paper introduces Deepchecks, a comprehensive framework tailored for evaluating RAG applications. Deepchecks' evaluation framework addresses RAG applications evaluation through a multi-faceted approach, root cause analysis and production monitoring. By ensuring alignment with application-specific requirements, Deepchecks framework provides a robust foundation for assessing reliability, relevance, and user satisfaction in RAG systems.

cs.AI

MEMTIER: Tiered Memory Architecture and Retrieval Bottleneck Analysis for Long-Running Autonomous AI Agents

Long-running autonomous AI agents suffer from a well-documented memory coherence problem: tool-execution success rates degrade 14 percentage points over 72-hour operation windows due to four compounding failure modes in existing flat-file memory systems. We present MEMTIER, a tripartite memory architecture for the OpenClaw agent runtime that introduces a structured episodic JSONL store, a five-signal weighted retrieval engine, an attention-attributed cognitive weight update loop, an asynchronous consolidation daemon promoting episodic facts to a semantic tier, and a PPO-based policy framework for adapting retrieval weights (infrastructure validated; performance gains pending camera-ready). On the full 500-question LongMemEval-S benchmark (Wu et al., 2025), MEMTIER achieves Acc=0.382, F1=0.412 with Qwen2.5-7B on a consumer 6GB GPU - a +33 percentage point improvement over the full-context baseline (0.050 -> 0.382, i.e., 5% -> 38%). With DeepSeek-V4-Flash fact pre-population, single-session recall reaches 0.686-0.714, exceeding the paper's RAG BM25 GPT-4o baseline (0.560) on those categories. Temporal reasoning rises to 0.323 and multi-session synthesis to 0.173, demonstrating that structured semantic pre-population qualitatively changes what lightweight retrieval can achieve. All phases run locally on a consumer laptop with a 6GB GPU.

cs.AI

Beyond Static Sandboxing: Learned Capability Governance for Autonomous AI Agents

Autonomous AI agents built on open-source runtimes such as OpenClaw expose every available tool to every session by default, regardless of the task. A summarization task receives the same shell execution, subagent spawning, and credential access capabilities as a code deployment task, a 15x overprovision ratio that we call the capability overprovisioning problem. Existing defenses, including the NemoClaw container sandbox and the Cisco DefenseClaw skill scanner, address containment and threat detection but do not learn the minimum viable capability set for each task type. We present Aethelgard, a four layer adaptive governance framework that enforces least privilege for AI agents through a learned policy. Layer 1, the Capability Governor, dynamically scopes which tools the agent is aware of in each session. Layer 3, the Safety Router, intercepts tool calls before execution using a hybrid rule based and fine tuned classifier. Layer 2, the RL Learning Policy, trains a PPO policy on the accumulated audit log to learn the minimum viable skill set for each task type.

cs.CR

Dark LLMs: The Growing Threat of Unaligned AI Models

Large Language Models (LLMs) rapidly reshape modern life, advancing fields from healthcare to education and beyond. However, alongside their remarkable capabilities lies a significant threat: the susceptibility of these models to jailbreaking. The fundamental vulnerability of LLMs to jailbreak attacks stems from the very data they learn from. As long as this training data includes unfiltered, problematic, or 'dark' content, the models can inherently learn undesirable patterns or weaknesses that allow users to circumvent their intended safety controls. Our research identifies the growing threat posed by dark LLMs models deliberately designed without ethical guardrails or modified through jailbreak techniques. In our research, we uncovered a universal jailbreak attack that effectively compromises multiple state-of-the-art models, enabling them to answer almost any question and produce harmful outputs upon request. The main idea of our attack was published online over seven months ago. However, many of the tested LLMs were still vulnerable to this attack. Despite our responsible disclosure efforts, responses from major LLM providers were often inadequate, highlighting a concerning gap in industry practices regarding AI safety. As model training becomes more accessible and cheaper, and as open-source LLMs proliferate, the risk of widespread misuse escalates. Without decisive intervention, LLMs may continue democratizing access to dangerous knowledge, posing greater risks than anticipated.

cs.CL

X-Cross: Dynamic Integration of Language Models for Cross-Domain Sequential Recommendation

As new products are emerging daily, recommendation systems are required to quickly adapt to possible new domains without needing extensive retraining. This work presents ``X-Cross'' -- a novel cross-domain sequential-recommendation model that recommends products in new domains by integrating several domain-specific language models; each model is fine-tuned with low-rank adapters (LoRA). Given a recommendation prompt, operating layer by layer, X-Cross dynamically refines the representation of each source language model by integrating knowledge from all other models. These refined representations are propagated from one layer to the next, leveraging the activations from each domain adapter to ensure domain-specific nuances are preserved while enabling adaptability across domains. Using Amazon datasets for sequential recommendation, X-Cross achieves performance comparable to a model that is fine-tuned with LoRA, while using only 25% of the additional parameters. In cross-domain tasks, such as adapting from Toys domain to Tools, Electronics or Sports, X-Cross demonstrates robust performance, while requiring about 50%-75% less fine-tuning data than LoRA to make fine-tuning effective. Furthermore, X-Cross achieves significant improvement in accuracy over alternative cross-domain baselines. Overall, X-Cross enables scalable and adaptive cross-domain recommendations, reducing computational overhead and providing an efficient solution for data-constrained environments.

cs.IR

Forget What You Know about LLMs Evaluations -- LLMs are Like a Chameleon

Large language models (LLMs) often appear to excel on public benchmarks, but these high scores may mask an overreliance on dataset-specific surface cues rather than true language understanding. We introduce the Chameleon Benchmark Overfit Detector (C-BOD), a meta-evaluation framework that systematically distorts benchmark prompts via a parametric transformation and detects overfitting of LLMs. By rephrasing inputs while preserving their semantic content and labels, C-BOD exposes whether a model's performance is driven by memorized patterns. Evaluated on the MMLU benchmark using 26 leading LLMs, our method reveals an average performance degradation of 2.15% under modest perturbations, with 20 out of 26 models exhibiting statistically significant differences. Notably, models with higher baseline accuracy exhibit larger performance differences under perturbation, and larger LLMs tend to be more sensitive to rephrasings, indicating that both cases may overrely on fixed prompt patterns. In contrast, the Llama family and models with lower baseline accuracy show insignificant degradation, suggesting reduced dependency on superficial cues. Moreover, C-BOD's dataset- and model-agnostic design allows easy integration into training pipelines to promote more robust language understanding. Our findings challenge the community to look beyond leaderboard scores and prioritize resilience and generalization in LLM evaluation.

cs.CL

DFPE: A Diverse Fingerprint Ensemble for Enhancing LLM Performance

Large Language Models (LLMs) have shown remarkable capabilities across various natural language processing tasks but often struggle to excel uniformly in diverse or complex domains. We propose a novel ensemble method - Diverse Fingerprint Ensemble (DFPE), which leverages the complementary strengths of multiple LLMs to achieve more robust performance. Our approach involves: (1) clustering models based on response "fingerprints" patterns, (2) applying a quantile-based filtering mechanism to remove underperforming models at a per-subject level, and (3) assigning adaptive weights to remaining models based on their subject-wise validation accuracy. In experiments on the Massive Multitask Language Understanding (MMLU) benchmark, DFPE outperforms the best single model by 3% overall accuracy and 5% in discipline-level accuracy. This method increases the robustness and generalization of LLMs and underscores how model selection, diversity preservation, and performance-driven weighting can effectively address challenging, multi-faceted language understanding tasks.

cs.LG

FairTTTS: A Tree Test Time Simulation Method for Fairness-Aware Classification

Algorithmic decision-making has become deeply ingrained in many domains, yet biases in machine learning models can still produce discriminatory outcomes, often harming unprivileged groups. Achieving fair classification is inherently challenging, requiring a careful balance between predictive performance and ethical considerations. We present FairTTTS, a novel post-processing bias mitigation method inspired by the Tree Test Time Simulation (TTTS) method. Originally developed to enhance accuracy and robustness against adversarial inputs through probabilistic decision-path adjustments, TTTS serves as the foundation for FairTTTS. By building on this accuracy-enhancing technique, FairTTTS mitigates bias and improves predictive performance. FairTTTS uses a distance-based heuristic to adjust decisions at protected attribute nodes, ensuring fairness for unprivileged samples. This fairness-oriented adjustment occurs as a post-processing step, allowing FairTTTS to be applied to pre-trained models, diverse datasets, and various fairness metrics without retraining. Extensive evaluation on seven benchmark datasets shows that FairTTTS outperforms traditional methods in fairness improvement, achieving a 20.96% average increase over the baseline compared to 18.78% for related work, and further enhances accuracy by 0.55%. In contrast, competing methods typically reduce accuracy by 0.42%. These results confirm that FairTTTS effectively promotes more equitable decision-making while simultaneously improving predictive performance.

cs.LG

BiasGuard: Guardrailing Fairness in Machine Learning Production Systems

As machine learning (ML) systems increasingly impact critical sectors such as hiring, financial risk assessments, and criminal justice, the imperative to ensure fairness has intensified due to potential negative implications. While much ML fairness research has focused on enhancing training data and processes, addressing the outputs of already deployed systems has received less attention. This paper introduces 'BiasGuard', a novel approach designed to act as a fairness guardrail in production ML systems. BiasGuard leverages Test-Time Augmentation (TTA) powered by Conditional Generative Adversarial Network (CTGAN), a cutting-edge generative AI model, to synthesize data samples conditioned on inverted protected attribute values, thereby promoting equitable outcomes across diverse groups. This method aims to provide equal opportunities for both privileged and unprivileged groups while significantly enhancing the fairness metrics of deployed systems without the need for retraining. Our comprehensive experimental analysis across diverse datasets reveals that BiasGuard enhances fairness by 31% while only reducing accuracy by 0.09% compared to non-mitigated benchmarks. Additionally, BiasGuard outperforms existing post-processing methods in improving fairness, positioning it as an effective tool to safeguard against biases when retraining the model is impractical.

cs.LG

A Novel Method for News Article Event-Based Embedding

Embedding news articles is a crucial tool for multiple fields, such as media bias detection, identifying fake news, and making news recommendations. However, existing news embedding methods are not optimized to capture the latent context of news events. Most embedding methods rely on full-text information and neglect time-relevant embedding generation. In this paper, we propose a novel lightweight method that optimizes news embedding generation by focusing on entities and themes mentioned in articles and their historical connections to specific events. We suggest a method composed of three stages. First, we process and extract events, entities, and themes from the given news articles. Second, we generate periodic time embeddings for themes and entities by training time-separated GloVe models on current and historical data. Lastly, we concatenate the news embeddings generated by two distinct approaches: Smooth Inverse Frequency (SIF) for article-level vectors and Siamese Neural Networks for embeddings with nuanced event-related information. We leveraged over 850,000 news articles and 1,000,000 events from the GDELT project to test and evaluate our method. We conducted a comparative analysis of different news embedding generation methods for validation. Our experiments demonstrate that our approach can both improve and outperform state-of-the-art methods on shared event detection tasks.

cs.CL

The Branch Not Taken: Predicting Branching in Online Conversations

Multi-participant discussions tend to unfold in a tree structure rather than a chain structure. Branching may occur for multiple reasons -- from the asynchronous nature of online platforms to a conscious decision by an interlocutor to disengage with part of the conversation. Predicting branching and understanding the reasons for creating new branches is important for many downstream tasks such as summarization and thread disentanglement and may help develop online spaces that encourage users to engage in online discussions in more meaningful ways. In this work, we define the novel task of branch prediction and propose GLOBS (Global Branching Score) -- a deep neural network model for predicting branching. GLOBS is evaluated on three large discussion forums from Reddit, achieving significant improvements over an array of competitive baselines and demonstrating better transferability. We affirm that structural, temporal, and linguistic features contribute to GLOBS success and find that branching is associated with a greater number of conversation participants and tends to occur in earlier levels of the conversation tree. We publicly release GLOBS and our implementation of all baseline models to allow reproducibility and promote further research on this important task.

cs.CL

BagStacking: An Integrated Ensemble Learning Approach for Freezing of Gait Detection in Parkinson's Disease

This paper introduces BagStacking, a novel ensemble learning method designed to enhance the detection of Freezing of Gait (FOG) in Parkinson's Disease (PD) by using a lower-back sensor to track acceleration. Building on the principles of bagging and stacking, BagStacking aims to achieve the variance reduction benefit of bagging's bootstrap sampling while also learning sophisticated blending through stacking. The method involves training a set of base models on bootstrap samples from the training data, followed by a meta-learner trained on the base model outputs and true labels to find an optimal aggregation scheme. The experimental evaluation demonstrates significant improvements over other state-of-the-art machine learning methods on the validation set. Specifically, BagStacking achieved a MAP score of 0.306, outperforming LightGBM (0.234) and classic Stacking (0.286). Additionally, the run-time of BagStacking was measured at 3828 seconds, illustrating an efficient approach compared to Regular Stacking's 8350 seconds. BagStacking presents a promising direction for handling the inherent variability in FOG detection data, offering a robust and scalable solution to improve patient care in PD.

eess.SP

Silent Killer: A Stealthy, Clean-Label, Black-Box Backdoor Attack

Backdoor poisoning attacks pose a well-known risk to neural networks. However, most studies have focused on lenient threat models. We introduce Silent Killer, a novel attack that operates in clean-label, black-box settings, uses a stealthy poison and trigger and outperforms existing methods. We investigate the use of universal adversarial perturbations as triggers in clean-label attacks, following the success of such approaches under poison-label settings. We analyze the success of a naive adaptation and find that gradient alignment for crafting the poison is required to ensure high success rates. We conduct thorough experiments on MNIST, CIFAR10, and a reduced version of ImageNet and achieve state-of-the-art results.

cs.CR

AMFPMC -- An improved method of detecting multiple types of drug-drug interactions using only known drug-drug interactions

Adverse drug interactions are largely preventable causes of medical accidents, which frequently result in physician and emergency room encounters. The detection of drug interactions in a lab, prior to a drug's use in medical practice, is essential, however it is costly and time-consuming. Machine learning techniques can provide an efficient and accurate means of predicting possible drug-drug interactions and combat the growing problem of adverse drug interactions. Most existing models for predicting interactions rely on the chemical properties of drugs. While such models can be accurate, the required properties are not always available.

cs.LG

Cross Version Defect Prediction with Class Dependency Embeddings

Software Defect Prediction aims at predicting which software modules are the most probable to contain defects. The idea behind this approach is to save time during the development process by helping find bugs early. Defect Prediction models are based on historical data. Specifically, one can use data collected from past software distributions, or Versions, of the same target application under analysis. Defect Prediction based on past versions is called Cross Version Defect Prediction (CVDP). Traditionally, Static Code Metrics are used to predict defects. In this work, we use the Class Dependency Network (CDN) as another predictor for defects, combined with static code metrics. CDN data contains structural information about the target application being analyzed. Usually, CDN data is analyzed using different handcrafted network measures, like Social Network metrics. Our approach uses network embedding techniques to leverage CDN information without having to build the metrics manually. In order to use the embeddings between versions, we incorporate different embedding alignment techniques. To evaluate our approach, we performed experiments on 24 software release pairs and compared it against several benchmark methods. In these experiments, we analyzed the performance of two different graph embedding techniques, three anchor selection approaches, and two alignment techniques. We also built a meta-model based on two different embeddings and achieved a statistically significant improvement in AUC of 4.7% (p < 0.002) over the baseline method.

cs.SE

Transfer learning for time series classification using synthetic data generation

In this paper, we propose an innovative Transfer learning for Time series classification method. Instead of using an existing dataset from the UCR archive as the source dataset, we generated a 15,000,000 synthetic univariate time series dataset that was created using our unique synthetic time series generator algorithm which can generate data with diverse patterns and angles and different sequence lengths. Furthermore, instead of using classification tasks provided by the UCR archive as the source task as previous studies did,we used our own 55 regression tasks as the source tasks, which produced better results than selecting classification tasks from the UCR archive

cs.LG

A Universal Adversarial Policy for Text Classifiers

Discovering the existence of universal adversarial perturbations had large theoretical and practical impacts on the field of adversarial learning. In the text domain, most universal studies focused on adversarial prefixes which are added to all texts. However, unlike the vision domain, adding the same perturbation to different inputs results in noticeably unnatural inputs. Therefore, we introduce a new universal adversarial setup - a universal adversarial policy, which has many advantages of other universal attacks but also results in valid texts - thus making it relevant in practice. We achieve this by learning a single search policy over a predefined set of semantics preserving text alterations, on many texts. This formulation is universal in that the policy is successful in finding adversarial examples on new texts efficiently. Our approach uses text perturbations which were extensively shown to produce natural attacks in the non-universal setup (specific synonym replacements). We suggest a strong baseline approach for this formulation which uses reinforcement learning. It's ability to generalise (from as few as 500 training texts) shows that universal adversarial patterns exist in the text domain as well.

cs.LG