Longmi Gao | Searcharxiv

arXiv2026

Frequency-Aware Dual-Stream Learning for Balanced Realism and Fidelity in Electron Microscopy Imaging

Electron microscopy enables nanoscale cellular visualization but faces a trade-off between imaging resolution and acquisition speed. Existing learning-based methods rely on single-stream architectures that struggle to balance perceptual realism and quantitative fidelity, either over-smoothing details or generating unrealistic hallucinations. This work introduces a frequency-adaptive dual-stream architecture to resolve this conflict. Using discrete wavelet transform, we decompose images into low-frequency structures and high-frequency details, then employ a conditional diffusion model for realistic global synthesis and a transformer network for precise detail recovery. Experiments on the EMDiffuse dataset show the method achieves superior LPIPS and resolution ratio, substantially outperforming existing approaches. The method also shows strong generalization across diverse biological samples, supporting fast and reliable electron microscopy imaging for structural biology and nanotechnology applications. The source code and associated dataset are publicly available to facilitate further research.

eess.IV↗

arXiv2026

VEMamba: Efficient Isotropic Reconstruction of Volume Electron Microscopy with Axial-Lateral Consistent Mamba

Volume Electron Microscopy (VEM) is crucial for 3D tissue imaging but often produces anisotropic data with poor axial resolution, hindering visualization and downstream analysis. Existing methods for isotropic reconstruction often suffer from neglecting abundant axial information and employing simple downsampling to simulate anisotropic data. To address these limitations, we propose VEMamba, an efficient framework for isotropic reconstruction. The core of VEMamba is a novel 3D Dependency Reordering paradigm, implemented via two key components: an Axial-Lateral Chunking Selective Scan Module (ALCSSM), which intelligently re-maps complex 3D spatial dependencies (both axial and lateral) into optimized 1D sequences for efficient Mamba-based modeling, explicitly enforcing axial-lateral consistency; and a Dynamic Weights Aggregation Module (DWAM) to adaptively aggregate these reordered sequence outputs for enhanced representational power. Furthermore, we introduce a realistic degradation simulation and then leverage Momentum Contrast (MoCo) to integrate this degradation-aware knowledge into the network for superior reconstruction. Extensive experiments on both simulated and real-world anisotropic VEM datasets demonstrate that VEMamba achieves highly competitive performance across various metrics while maintaining a lower computational footprint. The source code is available on GitHub: https://github.com/I2-Multimedia-Lab/VEMamba

cs.CV↗