arXiv subjects

Lorenzo Mercolli

Publications and source records attributed to Lorenzo Mercolli.

15 recordsLinked to original sources

arXiv2026

Terbium-149 PET/CT: First Quantitative Imaging with a Clinical Long-Axial Field-of-View Scanner

Introduction: Terbium-149 ($^{149}$Tb) is a promising radionuclide for targeted $α$ therapy that has a non-zero branching ratio (BR) for positron decay. However, its relatively low positron branching fraction and multiple prompt $γ$ emissions may challenge quantitative imaging. This study evaluates, for the first time, the imaging performance and quantitative accuracy of $^{149}$Tb using a clinical long axial field-of-view (LAFOV) PET/CT system. Methods: Quantitative accuracy of $^{149}$Tb was assessed with a NEMA IEC body phantom, which was filled with about 45 MBq $^{149}$Tb and a sphere-to-background ration of 10:1. The phantom was scanned for 20 min and shorter scan times and lower activities were simulated. Recovery coefficients, coefficient of variation, and lung residual error were evaluated for different reconstruction settings and compared to the EARL standard 2 for $^{18}$F. Results: High-quality PET images of $^{149}$Tb were obtained, even with a simulated total activity of 4.5 MBq. The 20 min and full activity scan yielded a mean recovery coefficient $RC_\textit{mean}$ of $0.55$, $0.69$, $0.73$, $0.76$, $0.79$, and $0.81$ for the six phantom spheres. Despite the low count statistics, the coefficient of variation stays mostly below $15\,\%$. Relative scatter correction combined with prompt $γ$ modeling provided robust quantification. Conclusion: $^{149}$Tb can be imaged using a commercial LAFOV PET/CT with a quantitative accuracy comparable to the EARL standard 2 for $^{18}$F. These findings demonstrate the feasibility of PET-based treatment verification and dosimetry for targeted $α$ therapy with $^{149}$Tb.

physics.med-ph↗

arXiv2025

Beam Energy Measurement using a Bayesian Approach with the Stacked Foil Method

We present a practical method to measure the energy of proton beams at a medical cyclotron using the stacked foil technique in combination with a Bayesian inference method. By measuring the $^{48}$V activity induced in a stack of irradiated titanium foils, the proton energy can be inferred without relying on direct current or charge measurements, making the method suitable even for low-vacuum environments or air-exposed setups. This technique is further extended to configurations where the beam energy is degraded to levels around 8 MeV. A Bayesian fit of the measured activity profile allows not only for a robust energy estimation but also for a consistent treatment of uncertainties and nuisance parameters. Monte Carlo simulations are employed to validate the underlying assumptions, including the impact of energy dispersion or cross-section uncertainties. Our results demonstrate that this method provides accurate beam energy measurements across several typical experimental setups used at the Bern Medical Cyclotron. Additionally, we evaluate the sensitivity of the method to the choice of nuclear cross-section data and assess how the number of foils in the stack affects the uncertainty in the inferred beam energy.

physics.acc-ph↗

arXiv2025

First Positronium Lifetime Imaging with Scandium-44 on a Long Axial Field-of-view PET/CT

Purpose: 44Sc has been successfully produced, synthesized, labeled and first-in-human studies were conducted some years ago. The decay properties of 44Sc, together with being close to a clinical implementation, make it an ideal candidate for in vivo positronium lifetime measurements. In this study, we investigate the count statistics for ortho-positronium (oPs) measurements with 44Sc. Method: A NEMA image quality phantom was filled with 41.7 MBq of 44Sc dissolved in water and scanned on a commercial long-axial field-of-view PET/CT. Three-photon events were identified using a prototype feature of the scanner and dedicated software. The lifetime of oPs was determined in the phantom spheres and in 4x4x4 mm^3 voxels. Results: All measured oPs lifetimes are compatible, within the uncertainties, with the literature values for water. The oPs lifetime is 2.65+-0.50, 1.39+-0.20 and 1.76+-0.18 ns in the three smallest spheres of the phantom and 1.79+-0.57 ns for a single voxel in the central region of the largest sphere. The relative standard deviation in the background regions of the time difference distributions, i.e., for time differences smaller than -2.7 ns, is above 20% - even for voxels inside the phantom spheres. Conclusions: Despite the favorable physical properties of 44Sc, the count statistics of three-photon events remains a challenge. The high prompt-photon energy causes a significant amount of random three-photon coincidences with the given methodology and, therefore, increases the statistical uncertainties on the measured oPs lifetime.

physics.med-ph↗

arXiv2025

Positronium Lifetime Imaging with the Biograph Vision Quadra using 124I

Purpose: Measuring the ortho-positronium (oPs) lifetime in human tissue bears the potential of adding clinically relevant information about the tissue microenvironment to conventional positron emission tomography (PET). Through phantom measurements, we investigate the voxel-wise measurement of oPs lifetime using a commercial long-axial field-of-view (LAFOV) PET scanner. Methods: We prepared four samples with mixtures of Amberlite XAD4, a porous polymeric adsorbent, and water and added between 1.12 MBq and 1.44 MBq of $^{124}$I. The samples were scanned in two different setups: once with a couple of centimeters between each sample (15 minutes scan time) and once with all samples taped together (40 minutes scan time). For each scan, we determine the oPs lifetime for the full samples and at the voxel level. The voxel sizes under consideration are $10.0^3$ mm$^3$, $7.1^3$ mm$^3$ and $4.0^3$ mm$^3$. Results: Amberlite XAD4 allows the preparation of samples with distinct oPs lifetime. Using a Bayesian fitting procedure, the oPs lifetimes in the whole samples are $2.52 \pm 0.03$ ns, $2.37\pm 0.03$ ns, $2.27\pm0.04$ ns and $1.82\pm 0.02$ ns, respectively. The voxel-wise oPs lifetime fits showed that even with $4.0^3$ mm$^3$ voxels the samples are clearly distinguishable and a central voxels have good count statistics. However, the situation with the samples close together remains challenging with respect to the spatial distinction of regions with different oPs lifetimes. Conclusion: Our study shows that positronium lifetime imaging on a commercial LAFOV PET/CT should be feasible under clinical conditions using $^{124}$I.

physics.med-ph↗

arXiv2024

Phantom study for 90Y post-treatment dosimetry with a long axial field-of-view PET/CT

Purpose: The physical properties of yttrium-90 (90Y) allow for imaging with positron emission tomography/computed tomography (PET/CT). The increased sensitivity of long axial field-of-view (LAFOV) PET/CT scanners possibly allows to overcome the small branching ratio for positron production from 90Y decays and to improve for the post-treatment dosimetry of 90Y of selective internal radiation therapy. Methods: For the challenging case of an image quality body phantom, we compare a full Monte Carlo (MC) dose calculation with the results from the two commercial software packages Simplicit90Y and Hermes. The voxel dosimetry module of Hermes relies on the 90Y images taken with a LAFOV PET/CT, while the MC and Simplicit90Y dose calculations are image independent. Results: The resulting doses from the MC calculation and Simplicit90Y agree well within the error margins. The image-based dose calculation with Hermes, however, consistently underestimates the dose. This is due to the mismatch of the activity distribution in the PET images and the size of the volume of interest. Furthermore, there are likely limitations of Hermes' dose calculation algorithm for 90Y. We found that only for the smallest phantom sphere there is a statistically significant dependence of the Hermes dose on the image reconstruction parameters and scan time. Conclusion: Our study shows that Simplicit90Y's local deposition model can provide a reliable dose estimate. On the other hand, the image based dose calculation requires further benchmarks and verification in order to take full advantage of LAFOV PET/CT systems.

physics.med-ph↗

arXiv2023

Methodology for measuring photonuclear reaction cross sections with an electron accelerator based on Bayesian analysis

Accurate measurements of photonuclear reaction cross sections are crucial for a number of applications, including radiation shielding design, absorbed dose calculations, reactor physics and engineering, nuclear safeguard and inspection, astrophysics, and nuclear medicine. Primarily motivated by the study of the production of selected radionuclides with high-energy photon beams (mainly 225Ac, 47Sc, and 67Cu), we have established a methodology for the measurement of photonuclear reaction cross sections with the microtron accelerator available at the Swiss Federal Institute of Metrology (METAS). The proposed methodology is based on the measurement of the produced activity with a High Purity Germanium (HPGe) spectrometer and on the knowledge of the photon fluence spectrum through Monte Carlo simulations. The data analysis is performed by applying a Bayesian fitting procedure to the experimental data and by assuming a functional trend of the cross section, in our case a Breit-Wigner function. We validated the entire methodology by measuring a well-established photonuclear cross section, namely the 197Au(γ,n)196Au reaction. The results are consistent with those reported in the literature.

nucl-ex↗

arXiv2022

Towards Quality Management of Machine Learning Systems for Medical Applications

The use of machine learning systems in clinical routine is still hampered by the necessity of a medical device certification and/or by difficulty to implement these systems in a clinic's quality management system. In this context, the key questions for a user are how to ensure reliable model predictions and how to appraise the quality of a model's results on a regular basis. In this paper we first review why the common out-of-sample performance metrics are not sufficient for assessing the robustness of model predictions. We discuss some conceptual foundation for a clinical implementation of a machine learning system and argue that both vendors and users should take certain responsibilities, as is already common practice for high-risk medical equipment. Along this line the best practices for dealing with robustness (or absence thereof) of machine learning models are revisited. We propose the methodology from AAPM Task Group 100 report no. 283 as a natural framework for developing a quality management program for a clinical process that encompasses a machine learning system. This is illustrated with an explicit albeit generic example. Our analysis shows how the risk evaluation in this framework can accommodate machine learning systems independently of their robustness evaluation. In particular, we highlight how the degree of interpretability of a machine learning system can be accounted for systematically within the risk evaluation and in the development of a quality management system.

physics.med-ph↗

arXiv2016

The Effective Field Theory of Large Scale Structure at Two Loops: the apparent scale dependence of the speed of sound

We study the Effective Field Theory of Large Scale Structure for cosmic density and momentum fields. We show that the finite part of the two-loop calculation and its counterterms introduce an apparent scale dependence for the leading order parameter $c_\text{s}^2$ of the EFT starting at k=0.1 h/Mpc. These terms limit the range over which one can trust the one-loop EFT calculation at the 1 % level to k<0.1 h/Mpc at redshift z=0. We construct a well motivated one parameter ansatz to fix the relative size of the one- and two-loop counterterms using their high-k sensitivity. Although this one parameter model is a very restrictive choice for the counterterms, it explains the apparent scale dependence of $c_\text{s}^2$ seen in simulations. It is also able to capture the scale dependence of the density power spectrum up to k$\approx$ 0.3 h/Mpc at the 1 % level at redshift $z=0$. Considering a simple scheme for the resummation of large scale motions, we find that the two loop calculation reduces the need for this IR-resummation at k<0.2 h/Mpc. Finally, we extend our calculation to momentum statistics and show that the same one parameter model can also describe density-momentum and momentum-momentum statistics.

astro-ph.CO↗

arXiv2015

The Bispectrum in the Effective Field Theory of Large Scale Structure

We study the bispectrum in the Effective Field Theory of Large Scale Structure, consistently accounting for the effects of short-scale dynamics. We begin by proving that, as long as the theory is perturbative, it can be formulated to arbitrary order using only operators that are local in time. We then derive all the new operators required to cancel the UV-divergences and obtain a physically meaningful prediction for the one-loop bispectrum. In addition to new, subleading stochastic noises and the viscosity term needed for the one-loop power spectrum, we find three new effective operators. The three new parameters can be constrained by comparing with N-body simulations. The best fit is precisely what is suggested by the structure of UV-divergences, hence justifying a formula for the EFTofLSS bispectrum whose only fitting parameter is already fixed by the power spectrum. This result predicts the bispectrum of N-body simulations up to $k \approx 0.22\, h\, \text{Mpc}^{-1}$ at $z=0$, an improvement by nearly a factor of two as compared to one-loop standard perturbation theory.

astro-ph.CO↗

arXiv2014

The effective field theory of multi-component fluids

We study the effective Lagrangian, at leading order in derivatives, that describes the propagation of density and metric fluctuations in a fluid composed by an arbitrary number of interacting components. Our results can be applied to any situation in cosmology where different species have non-gravitational interactions. In time-dependent backgrounds, such as FLRW, the quadratic action can only be diagonalized at fixed time slices and flavour mixing is unavoidable as time flows. In spite of this, the fluid can be interpreted at the level of the linear equations of motion as an ensemble of individual interacting species. We show that interactions lead to anisotropic stresses that depend on the mixing terms in the quadratic action for perturbations. In addition to the standard entrainment among different components, we find a new operator in the effective action that behaves as a cosmological constant when it dominates the dynamics.

hep-th↗

arXiv2014

On the Velocity in the Effective Field Theory of Large Scale Structures

We compute the renormalized two-point functions of density, divergence and vorticity of the velocity in the Effective Field Theory of Large Scale Structures. Because of momentum and mass conservation, the corrections from short scales to the large-scale power spectra of density, divergence and vorticity must start at order $k^{4}$. For the vorticity this constitutes one of the two leading terms. Exact (approximated) self-similarity of an Einstein-de Sitter ($Λ$CDM) background fixes the time dependence so that the vorticity power spectrum at leading order is determined by the symmetries of the problem and the power spectrum around the non-linear scale. We show that to cancel all divergences in the velocity correlators one needs new counterterms. These fix the definition of velocity and do not represent new properties of the system. For an Einstein-de Sitter universe, we show that all three renormalized cross- and auto-correlation functions have the same structure but different numerical coefficients, which we compute. We elucidate the differences between using momentum and velocity.

astro-ph.CO↗

arXiv2013

Towards a determination of the tau lepton dipole moments

The tau anomalous magnetic moment (a_tau) and electric dipole moment (d_tau) have not yet been observed. The present bounds on their values are of order 10^-2 and 10^-17 e*cm, respectively. We propose to measure a_tau with a precision of O(10^-3) or better and improve the existing limits on d_tau using precise tau- -> l- nu_tau \bar{nu}_l gamma (l=e or mu) data from high-luminosity B factories. A detailed feasibility study of this method is underway.

hep-ph↗

arXiv2011

B -> X_d gamma and constraints on new physics

We combine recent progress in measuring the branching ratio of the decay B->X_d gamma$ with the discovery that hadronic uncertainties in the CP-averaged branching ratio drop out to a large extent. Implications of these improvements on the size of possible new physics effects are investigated. We find the updated SM prediction for the CP-averaged branching ratio to be Br[B->X_d gamma]^SM_E_gamma>1.6 GeV = 1.54^+0.26-0.31*10^-5, which should be compared with the experimental value of Br[B->X_d gamma]^exp_E_gamma>1.6GeV = (1.41+-0.57) 10^-5. After performing a model independent analysis, we consider different new physics models: the MSSM with generic sources of flavor violation, the two Higgs doublet model of type III and a model with right-handed charged currents. It is found that the constraints on the SUSY parameters delta^d_13 have improved and that the absolute value of the right-handed quark mixing matrix element |V^R_td| must be smaller than 1.5*10^-4.

hep-ph↗

arXiv2009

Revisiting CP-violation in Minimal Flavour Violation

After a brief review of the minimal flavour violation hypothesis and its implementation in the MSSM, the most general parametrisation of the soft supersymmetry-breaking terms by means of the charged lepton and neutrino spurions is constructed. Thereby a type I seesaw mechanism is assumed to generate neutrino masses. This expansion introduces several new CP-violating phases, whose effects on the leptonic electric dipole moments are investigated.

hep-ph↗

arXiv2009

EDM constraints on flavored CP-violating phases

The CP-violating phenomenology of the MSSM with Minimal Flavor Violation (MFV) in the lepton sector is revisited. To this end, the most general parametrizations of the slepton soft-breaking terms are constructed assuming a seesaw mechanism of type I. After a critical reassessment of how the CP-symmetry is broken within the MFV framework, all possible CP-violating phases are introduced. From the strong hierarchy of their contributions to the Electric Dipole Moments (EDMs), these phases are split into three classes: flavor-blind, flavor-diagonal and flavor off-diagonal. In particular, the phases from the neutrino sector belong to the last class; they start to contribute only at the second order in the mass-insertion approximation and have thus a negligible effect. It is then shown that to each class of phases corresponds a unique largely dominant term in the MFV expansion. Numerically, for a realistic range of MSSM and neutrino parameters, such that B(mu --> e gamma) does not exceed its experimental bound, the three types of phases are found to be allowed by the current bound on the electron EDM, though the next generation of experiments should constrain tightly the flavor-blind phase. Finally, we relax the MFV hypothesis and show how in the general MSSM, the MFV operator basis can be used to judge of the naturality of the slepton soft-breaking terms.

hep-ph↗