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Lourdes Pena-Castillo

Publications and source records attributed to Lourdes Pena-Castillo.

2 recordsLinked to original sources

VR-NRP: A Virtual Reality Simulation for Training in the Neonatal Resuscitation Program

The use of Virtual Reality (VR) technologies has been extensively researched in surgical and anatomical education. VR provides a lifelike and interactive environment where healthcare providers can practice and refresh their skills in a safe environment. VR has been shown to be as effective as traditional medical education teaching methods, with the potential to provide more cost-effective and convenient means of curriculum delivery, especially in rural and remote areas or in environments with limited access to hands-on training. In this sense, VR offers the potential to be used to support resuscitation training for healthcare providers such as the Neonatal Resuscitation Program (NRP). The NRP program is an evidence-based and standardized approach for training healthcare providers on the resuscitation of the newborn. In this article, we describe a VR simulation environment that was designed and developed to refresh the skills of NRP providers. To validate this platform, we compared the VR-NRP simulation with exposure to 360-degree immersive video. We found that both VR technologies were positively viewed by healthcare professionals and performed very similarly to each other. However, the VR simulation provided a significantly increased feeling of presence. Furthermore, participants found the VR simulation more useful, leading to improved experiential learning outcomes. Also, participants using VR simulation reported higher confidence in certain NRP skills, such as proper mask placement and newborn response evaluation. This research represents a step forward in understanding how VR and related extended reality (XR) technologies can be applied for effective, immersive medical education, with potential benefits for remote and rural healthcare providers.

cs.HC

Assessing the Reproducibility of Machine-learning-based Biomarker Discovery in Parkinson's Disease

Genome-Wide Association Studies (GWAS) help identify genetic variations in people with diseases such as Parkinson's disease (PD), which are less common in those without the disease. Thus, GWAS data can be used to identify genetic variations associated with the disease. Feature selection and machine learning approaches can be used to analyze GWAS data and identify potential disease biomarkers. However, GWAS studies have technical variations that affect the reproducibility of identified biomarkers, such as differences in genotyping platforms and selection criteria for individuals to be genotyped. To address this issue, we collected five GWAS datasets from the database of Genotypes and Phenotypes (dbGaP) and explored several data integration strategies. We evaluated the agreement among different strategies in terms of the Single Nucleotide Polymorphisms (SNPs) that were identified as potential PD biomarkers. Our results showed a low concordance of biomarkers discovered using different datasets or integration strategies. However, we identified fifty SNPs that were identified at least twice, which could potentially serve as novel PD biomarkers. These SNPs are indirectly linked to PD in the literature but have not been directly associated with PD before. These findings open up new potential avenues of investigation.

q-bio.GN