arXiv subjects

Lu Chen

Publications and source records attributed to Lu Chen.

At least 163 records · Page 9Linked to original sources

arXiv2025

Can artificial intelligence predict clinical trial outcomes?

This study evaluates the performance of large language models (LLMs) and the HINT model in predicting clinical trial outcomes, focusing on metrics including Balanced Accuracy, Matthews Correlation Coefficient (MCC), Recall, and Specificity. Results show that GPT-4o achieves superior overall performance among LLMs but, like its counterparts (GPT-3.5, GPT-4mini, Llama3), struggles with identifying negative outcomes. In contrast, HINT excels in negative sample recognition and demonstrates resilience to external factors (e.g., recruitment challenges) but underperforms in oncology trials, a major component of the dataset. LLMs exhibit strengths in early-phase trials and simpler endpoints like Overall Survival (OS), while HINT shows consistency across trial phases and excels in complex endpoints (e.g., Objective Response Rate). Trial duration analysis reveals improved model performance for medium- to long-term trials, with GPT-4o and HINT displaying stability and enhanced specificity, respectively. We underscore the complementary potential of LLMs (e.g., GPT-4o, Llama3) and HINT, advocating for hybrid approaches to leverage GPT-4o's predictive power and HINT's specificity in clinical trial outcome forecasting.

cs.LG↗

arXiv2025

AIstorian lets AI be a historian: A KG-powered multi-agent system for accurate biography generation

Huawei has always been committed to exploring the AI application in historical research. Biography generation, as a specialized form of abstractive summarization, plays a crucial role in historical research but faces unique challenges that existing large language models (LLMs) struggle to address. These challenges include maintaining stylistic adherence to historical writing conventions, ensuring factual fidelity, and handling fragmented information across multiple documents. We present AIstorian, a novel end-to-end agentic system featured with a knowledge graph (KG)-powered retrieval-augmented generation (RAG) and anti-hallucination multi-agents. Specifically, AIstorian introduces an in-context learning based chunking strategy and a KG-based index for accurate and efficient reference retrieval. Meanwhile, AIstorian orchestrates multi-agents to conduct on-the-fly hallucination detection and error-type-aware correction. Additionally, to teach LLMs a certain language style, we finetune LLMs based on a two-step training approach combining data augmentation-enhanced supervised fine-tuning with stylistic preference optimization. Extensive experiments on a real-life historical Jinshi dataset demonstrate that AIstorian achieves a 3.8x improvement in factual accuracy and a 47.6% reduction in hallucination rate compared to existing baselines. The data and code are available at: https://github.com/ZJU-DAILY/AIstorian.

cs.CL↗

arXiv2025

Phase behaviors and dynamics of active particle systems in double-well potential

In this study, we investigate the behaviors and dynamics of self-propelled particles with active reorientation (AR) in a double-well potential. We explore the competition between AR and external potentials, revealing that self-propelled particles exhibit flocking and clustering behaviors in an asymmetric potential trap. Through molecular dynamics simulations, we obtain a phase diagram that illustrates flocking behavior as a function of active reorientation and potential asymmetry. We compare the responses of inactive and active particles to the potential, finding that active reorientation significantly increases aggregation on one side of the asymmetric potential well. Additionally, by calculating the mean squared displacement and scaling exponent, we identify distinct diffusion regimes. Our findings demonstrate that active particles with active reorientation are more sensitive to variations in double-well potentials.

cond-mat.soft↗

arXiv2025

Natural Humanoid Robot Locomotion with Generative Motion Prior

Natural and lifelike locomotion remains a fundamental challenge for humanoid robots to interact with human society. However, previous methods either neglect motion naturalness or rely on unstable and ambiguous style rewards. In this paper, we propose a novel Generative Motion Prior (GMP) that provides fine-grained motion-level supervision for the task of natural humanoid robot locomotion. To leverage natural human motions, we first employ whole-body motion retargeting to effectively transfer them to the robot. Subsequently, we train a generative model offline to predict future natural reference motions for the robot based on a conditional variational auto-encoder. During policy training, the generative motion prior serves as a frozen online motion generator, delivering precise and comprehensive supervision at the trajectory level, including joint angles and keypoint positions. The generative motion prior significantly enhances training stability and improves interpretability by offering detailed and dense guidance throughout the learning process. Experimental results in both simulation and real-world environments demonstrate that our method achieves superior motion naturalness compared to existing approaches. Project page can be found at https://sites.google.com/view/humanoid-gmp

cs.RO↗

arXiv2025

Alignment for Efficient Tool Calling of Large Language Models

Recent advancements in tool learning have enabled large language models (LLMs) to integrate external tools, enhancing their task performance by expanding their knowledge boundaries. However, relying on tools often introduces tradeoffs between performance, speed, and cost, with LLMs sometimes exhibiting overreliance and overconfidence in tool usage. This paper addresses the challenge of aligning LLMs with their knowledge boundaries to make more intelligent decisions about tool invocation. We propose a multi objective alignment framework that combines probabilistic knowledge boundary estimation with dynamic decision making, allowing LLMs to better assess when to invoke tools based on their confidence. Our framework includes two methods for knowledge boundary estimation, consistency based and absolute estimation, and two training strategies for integrating these estimates into the model decision making process. Experimental results on various tool invocation scenarios demonstrate the effectiveness of our framework, showing significant improvements in tool efficiency by reducing unnecessary tool usage.

cs.CL↗

arXiv2025

Delusions of Large Language Models

Large Language Models often generate factually incorrect but plausible outputs, known as hallucinations. We identify a more insidious phenomenon, LLM delusion, defined as high belief hallucinations, incorrect outputs with abnormally high confidence, making them harder to detect and mitigate. Unlike ordinary hallucinations, delusions persist with low uncertainty, posing significant challenges to model reliability. Through empirical analysis across different model families and sizes on several Question Answering tasks, we show that delusions are prevalent and distinct from hallucinations. LLMs exhibit lower honesty with delusions, which are harder to override via finetuning or self reflection. We link delusion formation with training dynamics and dataset noise and explore mitigation strategies such as retrieval augmented generation and multi agent debating to mitigate delusions. By systematically investigating the nature, prevalence, and mitigation of LLM delusions, our study provides insights into the underlying causes of this phenomenon and outlines future directions for improving model reliability.

cs.CL↗

arXiv2025

Converging to a Lingua Franca: Evolution of Linguistic Regions and Semantics Alignment in Multilingual Large Language Models

Large language models (LLMs) have demonstrated remarkable performance, particularly in multilingual contexts. While recent studies suggest that LLMs can transfer skills learned in one language to others, the internal mechanisms behind this ability remain unclear. We observed that the neuron activation patterns of LLMs exhibit similarities when processing the same language, revealing the existence and location of key linguistic regions. Additionally, we found that neuron activation patterns are similar when processing sentences with the same semantic meaning in different languages. This indicates that LLMs map semantically identical inputs from different languages into a "Lingua Franca", a common semantic latent space that allows for consistent processing across languages. This semantic alignment becomes more pronounced with training and increased model size, resulting in a more language-agnostic activation pattern. Moreover, we found that key linguistic neurons are concentrated in the first and last layers of LLMs, becoming denser in the first layers as training progresses. Experiments on BLOOM and LLaMA2 support these findings, highlighting the structural evolution of multilingual LLMs during training and scaling up. This paper provides insights into the internal workings of LLMs, offering a foundation for future improvements in their cross-lingual capabilities.

cs.CL↗

arXiv2025

Generalization of CNNs on Relational Reasoning with Bar Charts

This paper presents a systematic study of the generalization of convolutional neural networks (CNNs) and humans on relational reasoning tasks with bar charts. We first revisit previous experiments on graphical perception and update the benchmark performance of CNNs. We then test the generalization performance of CNNs on a classic relational reasoning task: estimating bar length ratios in a bar chart, by progressively perturbing the standard visualizations. We further conduct a user study to compare the performance of CNNs and humans. Our results show that CNNs outperform humans only when the training and test data have the same visual encodings. Otherwise, they may perform worse. We also find that CNNs are sensitive to perturbations in various visual encodings, regardless of their relevance to the target bars. Yet, humans are mainly influenced by bar lengths. Our study suggests that robust relational reasoning with visualizations is challenging for CNNs. Improving CNNs' generalization performance may require training them to better recognize task-related visual properties.

cs.CV↗

arXiv2025

Citrus: Leveraging Expert Cognitive Pathways in a Medical Language Model for Advanced Medical Decision Support

Large language models (LLMs), particularly those with reasoning capabilities, have rapidly advanced in recent years, demonstrating significant potential across a wide range of applications. However, their deployment in healthcare, especially in disease reasoning tasks, is hindered by the challenge of acquiring expert-level cognitive data. In this paper, we introduce Citrus, a medical language model that bridges the gap between clinical expertise and AI reasoning by emulating the cognitive processes of medical experts. The model is trained on a large corpus of simulated expert disease reasoning data, synthesized using a novel approach that accurately captures the decision-making pathways of clinicians. This approach enables Citrus to better simulate the complex reasoning processes involved in diagnosing and treating medical conditions. To further address the lack of publicly available datasets for medical reasoning tasks, we release the last-stage training data, including a custom-built medical diagnostic dialogue dataset. This open-source contribution aims to support further research and development in the field. Evaluations using authoritative benchmarks such as MedQA, covering tasks in medical reasoning and language understanding, show that Citrus achieves superior performance compared to other models of similar size. These results highlight Citrus potential to significantly enhance medical decision support systems, providing a more accurate and efficient tool for clinical decision-making.

cs.AI↗

arXiv2025

Dynamic Fault Analysis in Substations Based on Knowledge Graphs

To address the challenge of identifying hidden danger in substations from unstructured text, a novel dynamic analysis method is proposed. We first extract relevant information from the unstructured text, and then leverages a flexible distributed search engine built on Elastic-Search to handle the data. Following this, the hidden Markov model is employed to train the data within the engine. The Viterbi algorithm is integrated to decipher the hidden state sequences, facilitating the segmentation and labeling of entities related to hidden dangers. The final step involves using the Neo4j graph database to dynamically create a knowledge graph that visualizes hidden dangers in the substation. The effectiveness of the proposed method is demonstrated through a case analysis from a specific substation with hidden dangers revealed in the text records.

cs.CL↗

arXiv2025

Snoopy: Effective and Efficient Semantic Join Discovery via Proxy Columns

Semantic join discovery, which aims to find columns in a table repository with high semantic joinabilities to a query column, is crucial for dataset discovery. Existing methods can be divided into two categories: cell-level methods and column-level methods. However, neither of them ensures both effectiveness and efficiency simultaneously. Cell-level methods, which compute the joinability by counting cell matches between columns, enjoy ideal effectiveness but suffer poor efficiency. In contrast, column-level methods, which determine joinability only by computing the similarity of column embeddings, enjoy proper efficiency but suffer poor effectiveness due to the issues occurring in their column embeddings: (i) semantics-joinability-gap, (ii) size limit, and (iii) permutation sensitivity. To address these issues, this paper proposes to compute column embeddings via proxy columns; furthermore, a novel column-level semantic join discovery framework, Snoopy, is presented, leveraging proxy-column-based embeddings to bridge effectiveness and efficiency. Specifically, the proposed column embeddings are derived from the implicit column-to-proxy-column relationships, which are captured by the lightweight approximate-graph-matching-based column projection.To acquire good proxy columns for guiding the column projection, we introduce a rank-aware contrastive learning paradigm. Extensive experiments on four real-world datasets demonstrate that Snoopy outperforms SOTA column-level methods by 16% in Recall@25 and 10% in NDCG@25, and achieves superior efficiency--being at least 5 orders of magnitude faster than cell-level solutions, and 3.5x faster than existing column-level methods.

cs.DB↗

arXiv2025

Inference in semiparametric formation models for directed networks

We propose a semiparametric model for dyadic link formations in directed networks. The model contains a set of degree parameters that measure different effects of popularity or outgoingness across nodes, a regression parameter vector that reflects the homophily effect resulting from the nodal attributes or pairwise covariates associated with edges, and a set of latent random noises with unknown distributions. Our interest lies in inferring the unknown degree parameters and homophily parameters. The dimension of the degree parameters increases with the number of nodes. Under the high-dimensional regime, we develop a kernel-based least squares approach to estimate the unknown parameters. The major advantage of our estimator is that it does not encounter the incidental parameter problem for the homophily parameters. We prove consistency of all the resulting estimators of the degree parameters and homophily parameters. We establish high-dimensional central limit theorems for the proposed estimators and provide several applications of our general theory, including testing the existence of degree heterogeneity, testing sparse signals and recovering the support. Simulation studies and a real data application are conducted to illustrate the finite sample performance of the proposed methods.

stat.ME↗

arXiv2025

Hyperdeterminism? Spacetime 'Analyzed'

When modelling spacetime and classical physical fields, one typically assumes smoothness (infinite differentiability). But this assumption and its philosophical implications have not been sufficiently scrutinized. For example, we can appeal to analytic functions instead, which are also often used by physicists. Doing so leads to very different philosophical interpretations of a theory. For instance, our world would be 'hyperdeterministic' with analytic functions, in the sense that every field configuration is uniquely determined by its restriction to an arbitrarily small region. Relatedly, the hole argument of general relativity does not get off the ground. We argue that such an appeal to analytic functions is technically feasible and, conceptually, not obviously objectionable. The moral is to warn against rushing to draw philosophical conclusions from physical theories, given their drastic sensitivity to mathematical formalisms.

physics.hist-ph↗

arXiv2025

Human-Centric Foundation Models: Perception, Generation and Agentic Modeling

Human understanding and generation are critical for modeling digital humans and humanoid embodiments. Recently, Human-centric Foundation Models (HcFMs) inspired by the success of generalist models, such as large language and vision models, have emerged to unify diverse human-centric tasks into a single framework, surpassing traditional task-specific approaches. In this survey, we present a comprehensive overview of HcFMs by proposing a taxonomy that categorizes current approaches into four groups: (1) Human-centric Perception Foundation Models that capture fine-grained features for multi-modal 2D and 3D understanding. (2) Human-centric AIGC Foundation Models that generate high-fidelity, diverse human-related content. (3) Unified Perception and Generation Models that integrate these capabilities to enhance both human understanding and synthesis. (4) Human-centric Agentic Foundation Models that extend beyond perception and generation to learn human-like intelligence and interactive behaviors for humanoid embodied tasks. We review state-of-the-art techniques, discuss emerging challenges and future research directions. This survey aims to serve as a roadmap for researchers and practitioners working towards more robust, versatile, and intelligent digital human and embodiments modeling.

cs.CV↗

arXiv2025

Compliance while resisting: a shear-thickening fluid controller for physical human-robot interaction

Physical human-robot interaction (pHRI) is widely needed in many fields, such as industrial manipulation, home services, and medical rehabilitation, and puts higher demands on the safety of robots. Due to the uncertainty of the working environment, the pHRI may receive unexpected impact interference, which affects the safety and smoothness of the task execution. The commonly used linear admittance control (L-AC) can cope well with high-frequency small-amplitude noise, but for medium-frequency high-intensity impact, the effect is not as good. Inspired by the solid-liquid phase change nature of shear-thickening fluid, we propose a Shear-thickening Fluid Control (SFC) that can achieve both an easy human-robot collaboration and resistance to impact interference. The SFC's stability, passivity, and phase trajectory are analyzed in detail, the frequency and time domain properties are quantified, and parameter constraints in discrete control and coupled stability conditions are provided. We conducted simulations to compare the frequency and time domain characteristics of L-AC, nonlinear admittance controller (N-AC), and SFC, and validated their dynamic properties. In real-world experiments, we compared the performance of L-AC, N-AC, and SFC in both fixed and mobile manipulators. L-AC exhibits weak resistance to impact. N-AC can resist moderate impacts but not high-intensity ones, and may exhibit self-excited oscillations. In contrast, SFC demonstrated superior impact resistance and maintained stable collaboration, enhancing comfort in cooperative water delivery tasks. Additionally, a case study was conducted in a factory setting, further affirming the SFC's capability in facilitating human-robot collaborative manipulation and underscoring its potential in industrial applications.

cs.RO↗

arXiv2025

Effective and efficient modeling of the hydrodynamics for bacterial flagella

The hydrodynamic interactions among bacterial cell bodies, flagella, and surrounding boundaries are essential for understanding bacterial motility in complex environments. In this study, we demonstrate that each slender flagellum can be modeled as a series of spheres, and that the interactions between these spheres can be accurately characterized using a resistance matrix. This approach allows us to effectively and efficiently evaluate the propulsive effects of the flagella. Notably, our investigation into bacterial motility near a colloidal sphere reveals significant discrepancies between results derived from the twin multipole moment and those obtained through resistive force theory. Consequently, neglecting the hydrodynamic interactions among cell bodies, flagella, and colloidal spheres may lead to substantial inaccuracies. Our model simplifies bacteria into a series of spheres, making it well-suited for examining bacterial motility near spherical boundaries, as well as the nonlinear deformation dynamics of elastic flagella.

cond-mat.soft↗

arXiv2025

ChemDFM-X: Towards Large Multimodal Model for Chemistry

Rapid developments of AI tools are expected to offer unprecedented assistance to the research of natural science including chemistry. However, neither existing unimodal task-specific specialist models nor emerging general large multimodal models (LMM) can cover the wide range of chemical data modality and task categories. To address the real demands of chemists, a cross-modal Chemical General Intelligence (CGI) system, which serves as a truly practical and useful research assistant utilizing the great potential of LMMs, is in great need. In this work, we introduce the first Cross-modal Dialogue Foundation Model for Chemistry (ChemDFM-X). Diverse multimodal data are generated from an initial modality by approximate calculations and task-specific model predictions. This strategy creates sufficient chemical training corpora, while significantly reducing excessive expense, resulting in an instruction-tuning dataset containing 7.6M data. After instruction finetuning, ChemDFM-X is evaluated on extensive experiments of different chemical tasks with various data modalities. The results demonstrate the capacity of ChemDFM-X for multimodal and inter-modal knowledge comprehension. ChemDFM-X marks a significant milestone toward aligning all modalities in chemistry, a step closer to CGI.

cs.LG↗

arXiv2024

From Generalist to Specialist: A Survey of Large Language Models for Chemistry

Large Language Models (LLMs) have significantly transformed our daily life and established a new paradigm in natural language processing (NLP). However, the predominant pretraining of LLMs on extensive web-based texts remains insufficient for advanced scientific discovery, particularly in chemistry. The scarcity of specialized chemistry data, coupled with the complexity of multi-modal data such as 2D graph, 3D structure and spectrum, present distinct challenges. Although several studies have reviewed Pretrained Language Models (PLMs) in chemistry, there is a conspicuous absence of a systematic survey specifically focused on chemistry-oriented LLMs. In this paper, we outline methodologies for incorporating domain-specific chemistry knowledge and multi-modal information into LLMs, we also conceptualize chemistry LLMs as agents using chemistry tools and investigate their potential to accelerate scientific research. Additionally, we conclude the existing benchmarks to evaluate chemistry ability of LLMs. Finally, we critically examine the current challenges and identify promising directions for future research. Through this comprehensive survey, we aim to assist researchers in staying at the forefront of developments in chemistry LLMs and to inspire innovative applications in the field.

physics.chem-ph↗