SearcharxivSearch

arXiv subjects

Luca Allegri

Publications and source records attributed to Luca Allegri.

2 recordsLinked to original sources

Scaling laws in complex component systems as consequences of heterogeneous sampling

Complex component systems are collections of discrete units such as species, words, genes, whose observed realizations are naturally summarized by component counts. Many empirical laws have been observed in those systems, such as Taylor's law, Zipf's law, and Heaps' law, and domain-specific mechanisms are often employed to explain their emergence but, despite their ubiquity, a unifying framework remains elusive. In this work, we propose a null model showing that, under heterogeneous latent rates and finite sampling, several commonly observed scaling relations can arise without invoking domain-specific mechanisms. Taylor's law, for instance, reflects a crossover between sampling noise and genuine system heterogeneity and it is largely insensitive to the detailed latent distribution, while Zipf's and Heaps' laws arise from the convergence of order statistics and distinct component counts under heavy-tailed but otherwise generic priors. Our work thus suggests that these ubiquitous patterns are better interpreted as a transient sign of statistical convergence instead of fundamental principles that require tailored generative explanations.

physics.soc-ph

Challenges and opportunities for digital twins in precision medicine: a complex systems perspective

The adoption of digital twins (DTs) in precision medicine is increasingly viable, propelled by extensive data collection and advancements in artificial intelligence (AI), alongside traditional biomedical methodologies. However, the reliance on black-box predictive models, which utilize large datasets, presents limitations that could impede the broader application of DTs in clinical settings. We argue that hypothesis-driven generative models, particularly multiscale modeling, are essential for boosting the clinical accuracy and relevance of DTs, thereby making a significant impact on healthcare innovation. This paper explores the transformative potential of DTs in healthcare, emphasizing their capability to simulate complex, interdependent biological processes across multiple scales. By integrating generative models with extensive datasets, we propose a scenario-based modeling approach that enables the exploration of diverse therapeutic strategies, thus supporting dynamic clinical decision-making. This method not only leverages advancements in data science and big data for improving disease treatment and prevention but also incorporates insights from complex systems and network science, quantitative biology, and digital medicine, promising substantial advancements in patient care.

physics.bio-ph