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Luca Maestrini

Publications and source records attributed to Luca Maestrini.

7 recordsLinked to original sources

Restricted maximum likelihood estimation in generalized linear mixed models

Restricted maximum likelihood (REML) estimation is a widely accepted and frequently used method for fitting linear mixed models, with its principal advantage being that it produces less biased estimates of the variance components. However, the concept of REML does not immediately generalize to the setting of non-normally distributed responses, and it is not always clear the extent to which, either asymptotically or in finite samples, such generalizations reduce the bias of variance component estimates compared to standard unrestricted maximum likelihood estimation. In this article, we review various attempts that have been made over the past four decades to extend REML estimation in generalized linear mixed models. We establish four major classes of approaches, namely approximate linearization, integrated likelihood, modified profile likelihoods, and direct bias correction of the score function, and show that while these four classes may have differing motivations and derivations, they often arrive at a similar if not the same REML estimate. We compare the finite sample performance of these four classes, along with methods for REML estimation in hierarchical generalized linear models, through a numerical study involving binary and count data, with results demonstrating that all approaches perform similarly well reducing the finite sample size bias of variance components. Overall, we believe REML estimation should more widely adopted by practitioners using generalized linear mixed models, and that the exact choice of which REML approach to use should, at this point in time, be driven by software availability and ease of implementation.

stat.ME

A variational inference framework for inverse problems

A framework is presented for fitting inverse problem models via variational Bayes approximations. This methodology guarantees flexibility to statistical model specification for a broad range of applications, good accuracy and reduced model fitting times. The message passing and factor graph fragment approach to variational Bayes that is also described facilitates streamlined implementation of approximate inference algorithms and allows for supple inclusion of numerous response distributions and penalizations into the inverse problem model. Models for one- and two-dimensional response variables are examined and an infrastructure is laid down where efficient algorithm updates based on nullifying weak interactions between variables can also be derived for inverse problems in higher dimensions. An image processing application and a simulation exercise motivated by biomedical problems reveal the computational advantage offered by efficient implementation of variational Bayes over Markov chain Monte Carlo.

stat.ME

Variational Bayes for Mixture of Gaussian Structural Equation Models

Structural equation models (SEMs) are commonly used to study the structural relationship between observed variables and latent constructs. Recently, Bayesian fitting procedures for SEMs have received more attention thanks to their potential to facilitate the adoption of more flexible model structures, and variational approximations have been shown to provide fast and accurate inference for Bayesian analysis of SEMs. However, the application of variational approximations is currently limited to very simple, elemental SEMs. We develop mean-field variational Bayes algorithms for two SEM formulations for data that present non-Gaussian features such as skewness and multimodality. The proposed models exploit the use of mixtures of Gaussians, include covariates for the analysis of latent traits and consider missing data. We also examine two variational information criteria for model selection that are straightforward to compute in our variational inference framework. The performance of the MFVB algorithms and information criteria is investigated in a simulated data study and a real data application.

stat.ME

Stochastic Variational Inference for GARCH Models

Stochastic variational inference algorithms are derived for fitting various heteroskedastic time series models. We examine Gaussian, t, and skew-t response GARCH models and fit these using Gaussian variational approximating densities. We implement efficient stochastic gradient ascent procedures based on the use of control variates or the reparameterization trick and demonstrate that the proposed implementations provide a fast and accurate alternative to Markov chain Monte Carlo sampling. Additionally, we present sequential updating versions of our variational algorithms, which are suitable for efficient portfolio construction and dynamic asset allocation.

stat.CO

Second Term Improvement to Generalised Linear Mixed Model Asymptotics

A recent article on generalised linear mixed model asymptotics, Jiang et al. (2022), derived the rates of convergence for the asymptotic variances of maximum likelihood estimators. If $m$ denotes the number of groups and $n$ is the average within-group sample size then the asymptotic variances have orders $m^{-1}$ and $(mn)^{-1}$, depending on the parameter. We extend this theory to provide explicit forms of the $(mn)^{-1}$ second terms of the asymptotically harder-to-estimate parameters. Improved accuracy of studentised confidence intervals is one consequence of our theory.

math.ST

Sparse Linear Mixed Model Selection via Streamlined Variational Bayes

Linear mixed models are a versatile statistical tool to study data by accounting for fixed effects and random effects from multiple sources of variability. In many situations, a large number of candidate fixed effects is available and it is of interest to select a parsimonious subset of those being effectively relevant for predicting the response variable. Variational approximations facilitate fast approximate Bayesian inference for the parameters of a variety of statistical models, including linear mixed models. However, for models having a high number of fixed or random effects, simple application of standard variational inference principles does not lead to fast approximate inference algorithms, due to the size of model design matrices and inefficient treatment of sparse matrix problems arising from the required approximating density parameters updates. We illustrate how recently developed streamlined variational inference procedures can be generalized to make fast and accurate inference for the parameters of linear mixed models with nested random effects and global-local priors for Bayesian fixed effects selection. Our variational inference algorithms achieve convergence to the same optima of their standard implementations, although with significantly lower computational effort, memory usage and time, especially for large numbers of random effects. Using simulated and real data examples, we assess the quality of automated procedures for fixed effects selection that are free from hyperparameters tuning and only rely upon variational posterior approximations. Moreover, we show high accuracy of variational approximations against model fitting via Markov Chain Monte Carlo sampling.

stat.ME

Fitting Structural Equation Models via Variational Approximations

Structural equation models are commonly used to capture the relationship between sets of observed and unobservable variables. Traditionally these models are fitted using frequentist approaches but recently researchers and practitioners have developed increasing interest in Bayesian inference. In Bayesian settings, inference for these models is typically performed via Markov chain Monte Carlo methods, which may be computationally intensive for models with a large number of manifest variables or complex structures. Variational approximations can be a fast alternative; however, they have not been adequately explored for this class of models. We develop a mean field variational Bayes approach for fitting elemental structural equation models and demonstrate how bootstrap can considerably improve the variational approximation quality. We show that this variational approximation method can provide reliable inference while being significantly faster than Markov chain Monte Carlo.

stat.ME