Searcharxiv⌕ Search

arXiv subjects

Luca Pasquini

Publications and source records attributed to Luca Pasquini.

At least 37 records · Page 2Linked to original sources

A new era of fine structure constant measurements at high redshift

New observations of the quasar HE0515$-$4414 have been made using the HARPS spectrograph on the ESO 3.6m telescope, aided by the Laser Frequency Comb (LFC). We present three important advances for $α$ measurements in quasar absorption spectra from these observations. Firstly, the data have been wavelength calibrated using LFC and ThAr methods. The LFC wavelength calibration residuals are six times smaller than when using the standard ThAr calibration. We give a direct comparison between $α$ measurements made using the two methods. Secondly, spectral modelling was performed using Artificial Intelligence (fully automated, all human bias eliminated), including a temperature parameter for each absorption component. Thirdly, in contrast to previous work, additional model parameters were assigned to measure $α$ for each individual absorption component. The increase in statistical uncertainty from the larger number of model parameters is small and the method allows a substantial advantage; outliers that would otherwise contribute a significant systematic, possibly corrupting the entire measurement, are identified and removed, permitting a more robust overall result. The $z_{abs} = 1.15$ absorption system along the HE0515$-$4414 sightline yields 40 new $α$ measurements. We constrain spatial fluctuations in $α$ to be $Δα/α\leq 9 \times 10^{-5}$ on scales $\approx 20\;{\rm km\,s}^{-1}$, corresponding to $\approx25\;$kpc if the $z_{abs} = 1.15$ system arises in a $1\;$Mpc cluster. Collectively, the 40 measurements yield $Δα/α=-0.27\pm2.41\times10^{-6}$, consistent with no variation.

astro-ph.CO↗

Deep learning can differentiate IDH-mutant from IDH-wild type GBM

Background: Distinction of IDH mutant and wildtype GBMs is challenging on MRI, since conventional imaging shows considerable overlap. While few studies employed deep-learning in a mixed low/high grade glioma population, a GBM-specific model is still lacking in the literature. Our objective was to develop a deep-learning model for IDH prediction in GBM by using Convoluted Neural Networks (CNN) on multiparametric MRI. Methods: We included 100 adult patients with pathologically proven GBM and IDH testing. MRI data included: morphologic sequences, rCBV and ADC maps. Tumor area was obtained by a bounding box function on the axial slice with widest tumor extension on T2 images and was projected on every sequence. Data was split into training and test (80:20) sets. A 4 block 2D - CNN architecture was implemented for IDH prediction on every MRI sequence. IDH mutation probability was calculated with softmax activation function from the last dense layer. Highest performance was calculated accounting for model accuracy and categorical cross-entropy loss (CCEL) in the test cohort. Results: Our model achieved the following performance: T1 (accuracy 77%, CCEL 1.4), T2 (accuracy 67%, CCEL 2.41), FLAIR (accuracy 77%, CCEL 1.98), MPRAGE (accuracy 66%, CCEL 2.55), rCBV (accuracy 83%, CCEL 0.64). ADC achieved lower performance. Conclusion: We built a GBM-tailored deep-learning model for IDH mutation prediction, achieving accuracy of 83% with rCBV maps. High predictivity of perfusion images may reflect the known correlation between IDH, hypoxia inducible factor (HIF) and neoangiogenesis. This model may set a path for non-invasive evaluation of IDH mutation in GBM.

q-bio.QM↗

Comparison of Machine Learning Classifiers to Predict Patient Survival and Genetics of GBM: Towards a Standardized Model for Clinical Implementation

Radiomic models have been shown to outperform clinical data for outcome prediction in glioblastoma (GBM). However, clinical implementation is limited by lack of parameters standardization. We aimed to compare nine machine learning classifiers, with different optimization parameters, to predict overall survival (OS), isocitrate dehydrogenase (IDH) mutation, O-6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation, epidermal growth factor receptor (EGFR) VII amplification and Ki-67 expression in GBM patients, based on radiomic features from conventional and advanced MR. 156 adult patients with pathologic diagnosis of GBM were included. Three tumoral regions were analyzed: contrast-enhancing tumor, necrosis and non-enhancing tumor, selected by manual segmentation. Radiomic features were extracted with a custom version of Pyradiomics, and selected through Boruta algorithm. A Grid Search algorithm was applied when computing 4 times K-fold cross validation (K=10) to get the highest mean and lowest spread of accuracy. Once optimal parameters were identified, model performances were assessed in terms of Area Under The Curve-Receiver Operating Characteristics (AUC-ROC). Metaheuristic and ensemble classifiers showed the best performance across tasks. xGB obtained maximum accuracy for OS (74.5%), AB for IDH mutation (88%), MGMT methylation (71,7%), Ki-67 expression (86,6%), and EGFR amplification (81,6%). Best performing features shed light on possible correlations between MR and tumor histology.

q-bio.QM↗

Inhomogeneity in the early Galactic chemical enrichment exposed by beryllium abundances in extremely metal-poor stars

Abundances of beryllium in metal-poor stars scale linearly with metallicity down to [Fe/H] ~ -3.0. In the stars where Be has been detected at this extremely metal-poor regime, an increased abundance scatter has been previously reported. This scatter could indicate a flattening of the relation between Be and [Fe/H]. Our aim is to perform a new investigation of Be abundances in extremely metal-poor stars and try to clarify whether a Be abundance plateau exists. We revisited the Be abundances in a sample of nine dwarfs with [Fe/H] ~ -3.0. Additionally, we analysed the Be lines in the spectra of stars BPS BS 16968-0061 and CD-33 1173 for the first time. We took advantage of Gaia DR2 parallaxes to refine values of the surface gravity of the stars. Abundances of Be were determined using spectrum synthesis. Some of the stars indeed suggest a flattening. Between [Fe/H] ~ -2.70 and -3.26, the Be abundances stay mostly constant at log(Be/H) ~ -13.2 dex. Nevertheless, for several stars we could only place upper limits that are below that level. Most of the sample stars are consistent with having been formed at the progenitor of the so-called Gaia-Enceladus merger. Two out of the three stars likely formed in-situ are the ones that deviate the most from the linear relation. The mixed origin of these stars offers a clue to understanding the flattening. We suggest that our observations can be understood as a consequence of the inhomogeneous star forming conditions in the early Galaxy. Without efficient mixing, the early ISM would be characterised by a large scatter in Fe abundances at a given moment. Beryllium, on the other hand, because of its origins in cosmic-ray spallation, would have more homogeneous abundances (in a Galaxy-wide sense). We therefore suggest that the observed flattening of the Be-versus-Fe relation reflects a stronger scatter in the Galactic Fe abundances at a given age [abridged].

astro-ph.SR↗

Fundamental physics with Espresso: Towards an accurate wavelength calibration for a precision test of the fine-structure constant

Observations of metal absorption systems in the spectra of distant quasars allow to constrain a possible variation of the fine-structure constant throughout the history of the Universe. Such a test poses utmost demands on the wavelength accuracy and previous studies were limited by systematics in the spectrograph wavelength calibration. A substantial advance in the field is therefore expected from the new ultra-stable high-resolution spectrograph Espresso, recently installed at the VLT. In preparation of the fundamental physics related part of the Espresso GTO program, we present a thorough assessment of the Espresso wavelength accuracy and identify possible systematics at each of the different steps involved in the wavelength calibration process. Most importantly, we compare the default wavelength solution, based on the combination of Thorium-Argon arc lamp spectra and a Fabry-Pérot interferometer, to the fully independent calibration obtained from a laser frequency comb. We find wavelength-dependent discrepancies of up to 24m/s. This substantially exceeds the photon noise and highlights the presence of different sources of systematics, which we characterize in detail as part of this study. Nevertheless, our study demonstrates the outstanding accuracy of Espresso with respect to previously used spectrographs and we show that constraints of a relative change of the fine-structure constant at the $10^{-6}$ level can be obtained with Espresso without being limited by wavelength calibration systematics.

astro-ph.IM↗

Monolingual and bilingual language networks in healthy subjects using functional MRI and graph theory

Pre-surgical language mapping with functional magnetic resonance imaging (fMRI) is routinely conducted to assist the neurosurgeon in preventing damage to brain regions responsible for language. Functional differences exist between the monolingual versus the bilingual brain, whereas clinical fMRI tasks are typically conducted in a single language. The presence of secondary language processing mechanisms is a potential source of error in the inferred language map. From fMRI data of healthy bilingual and monolingual subjects we obtain language maps as functional networks. Our results show a sub-network "core" architecture consisting of the Broca's, pre-supplementary motor, and premotor areas present across all subjects. Wernicke's Area was found to connect to the "core" to a different extent across groups. The $k$ core centrality measure shows "core" areas belong to the maximum core while WA and other fROIs vary across groups. The results may provide a benchmark to preserve equal treatment outcomes for bilingual patients.

q-bio.NC↗

Materials for hydrogen-based energy storage: Past, recent progress and future outlook

Magnesium hydride owns the largest share of publications on solid materials for hydrogen storage. The Magnesium group of international experts contributing to IEA Task 32 Hydrogen Based Energy Storage recently published two review papers presenting the activities of the group focused on magnesium hydride based materials and on Mg based compounds for hydrogen and energy storage. This review article not only overviews the latest activities on both fundamental aspects of Mg-based hydrides and their applications, but also presents a historic overview on the topic and outlines projected future developments. Particular attention is paid to the theoretical and experimental studies of Mg-H system at extreme pressures, kinetics and thermodynamics of the systems based on MgH2,nanostructuring, new Mg-based compounds and novel composites, and catalysis in the Mg based H storage systems. Finally, thermal energy storage and upscaled H storage systems accommodating MgH2 are presented.

cond-mat.mtrl-sci↗

Four direct measurements of the fine-structure constant 13 billion years ago

Observations of the redshift z=7.085 quasar J1120+0641 have been used to search for variations of the fine structure constant, alpha, over the redshift range 5.5 to 7.1. Observations at z=7.1 probe the physics of the universe when it was only 0.8 billion years old. These are the most distant direct measurements of alpha to date and the first measurements made with a near-IR spectrograph. A new AI analysis method has been employed. Four measurements from the X-SHOOTER spectrograph on the European Southern Observatory's Very Large Telescope (VLT) directly constrain any changes in alpha relative to the value measured on Earth (alpha_0). The weighted mean strength of the electromagnetic force over this redshift range in this location in the universe is da/a = (alpha_z - alpha_0)/alpha_0 = (-2.18 +/- 7.27) X 10^{-5}, i.e. we find no evidence for a temporal change from the 4 new very high redshift measurements. When the 4 new measurements are combined with a large existing sample of lower redshift measurements, a new limit on possible spatial variation of da/a is marginally preferred over a no-variation model at the 3.7 sigma level.

astro-ph.CO↗

Nightside condensation of iron in an ultra-hot giant exoplanet

Ultra-hot giant exoplanets receive thousands of times Earth's insolation. Their high-temperature atmospheres (>2,000 K) are ideal laboratories for studying extreme planetary climates and chemistry. Daysides are predicted to be cloud-free, dominated by atomic species and substantially hotter than nightsides. Atoms are expected to recombine into molecules over the nightside, resulting in different day-night chemistry. While metallic elements and a large temperature contrast have been observed, no chemical gradient has been measured across the surface of such an exoplanet. Different atmospheric chemistry between the day-to-night ("evening") and night-to-day ("morning") terminators could, however, be revealed as an asymmetric absorption signature during transit. Here, we report the detection of an asymmetric atmospheric signature in the ultra-hot exoplanet WASP-76b. We spectrally and temporally resolve this signature thanks to the combination of high-dispersion spectroscopy with a large photon-collecting area. The absorption signal, attributed to neutral iron, is blueshifted by -11+/-0.7 km s-1 on the trailing limb, which can be explained by a combination of planetary rotation and wind blowing from the hot dayside. In contrast, no signal arises from the nightside close to the morning terminator, showing that atomic iron is not absorbing starlight there. Iron must thus condense during its journey across the nightside.

astro-ph.EP↗

A crucial test for astronomical spectrograph calibration with frequency combs

Laser frequency combs (LFCs) are well on their way to becoming the next-generation calibration sources for precision astronomical spectroscopy. This development is considered key in the hunt for low-mass rocky exoplanets around solar-type stars whose discovery with the radial-velocity method requires cm/s Doppler precision. In order to prove such precise calibration with an LFC, it must be compared to another calibrator of at least the same precision. Being the best available spectrograph calibrator, this means comparing it to a second - fully independent - LFC. This test had long been pending, but our installation of two LFCs at the ultra-stable spectrograph HARPS presented the so far unique opportunity for simultaneous calibrations with two separate LFCs. Although limited in time, the test results confirm the 1 cm/s stability that has long been anticipated by the astronomical community.

astro-ph.IM↗

Precision and consistency of astrocombs

Astrocombs are ideal spectrograph calibrators whose limiting precision can be derived using a second, independent, astrocomb system. We therefore analyse data from two astrocombs (one 18 GHz and one 25 GHz) used simultaneously on the HARPS spectrograph at the European Southern Observatory. The first aim of this paper is to quantify the wavelength repeatability achieved by a particular astrocomb. The second aim is to measure wavelength calibration consistency between independent astrocombs, that is to place limits or measure any possible zero-point offsets. We present three main findings, each with important implications for exoplanet detection, varying fundamental constant and redshift drift measurements. Firstly, wavelength calibration procedures are important: using multiple segmented polynomials within one echelle order results in significantly better wavelength calibration compared to using a single higher-order polynomial. Segmented polynomials should be used in all applications aimed at precise spectral line position measurements. Secondly, we found that changing astrocombs causes significant zero-point offsets ($\approx 60{\rm cms}^{-1}$ in our raw data) which were removed. Thirdly, astrocombs achieve a precision of $\lesssim 4{\rm cms}^{-1}$ in a single exposure ($\approx 10\% $ above the measured photon-limited precision) and $1 {\rm cms}^{-1}$ when time-averaged over a few hours, confirming previous results. Astrocombs therefore provide the technological requirements necessary for detecting Earth-Sun analogues, measuring variations of fundamental constants and the redshift drift.

astro-ph.IM↗

Bioinspired Nanocomposites: 2D Materials Within a 3D Lattice

Advanced composites are used in a variety of industrial applications and therefore attract much scientific interest. Here we describe the formation of novel carbon-based nanocomposites via incorporation of graphene oxide into the crystal lattice of single crystals of calcite. Incorporation of a 2D organic material into single-crystal lattices has never before been reported. To characterize the resulting nanocomposites we employed high-resolution synchrotron powder X-ray diffraction, electron microscopy, transmission electron microscopy, fluorescence microscopy, and nanoindentation tests. Detailed analysis revealed a layered distribution of graphene oxide sheets incorporated within the calcite host. Moreover, the optical and mechanical properties of the calcite host were altered when a carbon-based nanomaterial was introduced into its lattice. Compared to pure calcite, the composite GO-calcite crystals exhibited lower elastic modulus and higher hardness. The results of this study show that the incorporation of a 2D material within a 3D crystal lattice is not only feasible but also can lead to the formation of hybrid crystals exhibiting new properties.

physics.app-ph↗

SpecTel: A 10-12 meter class Spectroscopic Survey Telescope

We recommend a conceptual design study for a spectroscopic facility in the southern hemisphere comprising a large diameter telescope, fiber system, and spectrographs collectively optimized for massively-multiplexed spectroscopy. As a baseline, we propose an 11.4-meter aperture, optical spectroscopic survey telescope with a five square degree field of view. Using current technologies, the facility could be equipped with 15,000 robotically-controlled fibers feeding spectrographs over 360<lambda<1330 nm with options for fiber-fed spectrographs at high resolution and a panoramic IFU at a separate focus. This would enable transformational progress via its ability to access a larger fraction of objects from Gaia, LSST, Euclid, and WFIRST than any currently funded or planned spectroscopic facility. An ESO-sponsored study (arXiv:1701.01976) discussed the scientific potential in ambitious new spectroscopic surveys in Galactic astronomy, extragalactic astronomy, and cosmology. The US community should establish links with European and other international communities to plan for such a powerful facility and maximize the potential of large aperture multi-object spectroscopy given the considerable investment in deep imaging surveys.

astro-ph.IM↗

Core language brain network for fMRI-language task used in clinical applications

Functional magnetic resonance imaging (fMRI) is widely used in clinical applications to highlight brain areas involved in specific cognitive processes. Brain impairments, such as tumors, suppress the fMRI activation of the anatomical areas they invade and, thus, brain-damaged functional networks present missing links/areas of activation. The identification of the missing circuitry components is of crucial importance to estimate the damage extent. The study of functional networks associated to clinical tasks but performed by healthy individuals becomes, therefore, of paramount concern. These `healthy' networks can, indeed, be used as control networks for clinical studies. In this work we investigate the functional architecture of 20 healthy individuals performing a language task designed for clinical purposes. We unveil a common architecture persistent across all subjects under study, which involves Broca's area, Wernicke's area, the Premotor area, and the pre-Supplementary motor area. We study the connectivity weight of this circuitry by using the k-core centrality measure and we find that three of these areas belong to the most robust structure of the functional language network for the specific task under study. Our results provide useful insight for clinical applications on primarily important functional connections which, thus, should be preserved through brain surgery.

q-bio.NC↗

Accurate effective temperature from H$α$ profiles

The determination of stellar effective temperature ($T_{\mathrm{eff}}$) in F, G, and K stars using H$α$ profile fitting is a quite remarkable and powerful tool, because it practically does not depend on other atmospheric parameters and reddening. Nevertheless, this technique is not frequently used because of the complex procedure to recover the profile of broad lines in echelle spectra. As a consequence, tests performed on different models have sometimes provided ambiguous results. We have developed a normalization method for recovering undistorted H$α$ profiles and we have first applied it to spectra acquired with the single order instrument at do Pico dos Dias Observatory to avoid the problem of blaze correction. The continuum location is optimized using an iterative procedure, where the identification of minute telluric features is performed. A set of spectra was acquired with the MUSICOS echelle spectrograph ($R = 40~000$) to independently validate the normalization method. The accuracy of the method and of the 1D + LTE model is determined using coudé/HARPS/MUSICOS spectra of the Sun and a sample of 10 Gaia Benchmark Stars with effective temperature determined from interferometric measurements. We find that the most used solar atlases cannot be used as templates for H$α$ temperature diagnostics without renormalization. The comparison with the Sun shows that $T_{\mathrm{eff}}$ derived with H$α$ profiles from 1D + LTE models underestimate the solar effective temperature by 28 K. Interferometry and Infrared Flux Method show a dependency on metallicity according to the relation $T_{\mathrm{eff}} = T_{\mathrm{eff}}^{Hα}$ $-159$[Fe/H] + 28 K within the metallicity range $-0.7$ to $+0.45$ dex. We find 3D models largely improve the agreement with the interferometric and Infrared Flux Method measurements.

astro-ph.SR↗

Multiple Star Systems in the Orion Nebula

This work presents an interferometric study of the massive-binary fraction in the Orion Trapezium Cluster with the recently comissioned GRAVITY instrument. We observe a total of 16 stars of mainly OB spectral type. We find three previously unknown companions for $θ^1$ Ori B, $θ^2$ Ori B, and $θ^2$ Ori C. We determine a separation for the previously suspected companion of NU Ori. We confirm four companions for $θ^1$ Ori A, $θ^1$ Ori C, $θ^1$ Ori D, and $θ^2$ Ori A, all with substantially improved astrometry and photometric mass estimates. We refine the orbit of the eccentric high-mass binary $θ^1$ Ori C and we are able to derive a new orbit for $θ^1$ Ori D. We find a system mass of 21.7 $M_{\odot}$ and a period of $53$ days. Together with other previously detected companions seen in spectroscopy or direct imaging, eleven of the 16 high-mass stars are multiple systems. We obtain a total number of 22 companions with separations up to 600 AU. The companion fraction of the early B and O stars in our sample is about 2, significantly higher than in earlier studies of mostly OB associations. The separation distribution hints towards a bimodality. Such a bimodality has been previously found in A stars, but rarely in OB binaries, which up to this point have been assumed to be mostly compact with a tail of wider companions. We also do not find a substantial population of equal-mass binaries. The observed distribution of mass ratios declines steeply with mass, and like the direct star counts, indicates that our companions follow a standard power law initial mass function. Again, this is in contrast to earlier findings of flat mass ratio distributions in OB associations. We exclude collision as a dominant formation mechanism but find no clear preference for core accretion or competitive accretion.

astro-ph.SR↗

The ESO Spectroscopic facility

We present the concept of a novel facility dedicated to massively-multiplexed spectroscopy. The telescope has a very wide field Cassegrain focus optimised for fibre feeding. With a Field of View (FoV) of 2.5 degrees diameter and a 11.4m pupil, it will be the largest etendue telescope. The large focal plane can easily host up to 16.000 fibres. In addition, a gravity invariant focus for the central 10 arc-minutes is available to host a giant integral field unit (IFU). The 3 lenses corrector includes an ADC, and has good performance in the 360-1300 nm wavelength range. The top level science requirements were developed by a dedicated ESO working group, and one of the primary cases is high resolution spectroscopy of GAIA stars and, in general, how our Galaxy formed and evolves. The facility will therefore be equipped with both, high and low resolution spectrographs. We stress the importance of developing the telescope and instrument designs simultaneously. The most relevant R\&D aspect is also briefly discussed.

astro-ph.IM↗

A complete census of $Hα$ emitters in NGC 6397

We used a dataset of archival Hubble Space Telescope images obtained through the F555W, F814W and F656N filters, to perform a complete search for objects showing $Hα$ emission in the globular cluster NGC 6397. As photometric diagnostic, we used the $(V-Hα)_0$ color excess in the $(V-Hα)_0$-$(V-I)_0$ color-color diagram. In the analysed field of view, we identified 53 $Hα$ emitters. In particular, we confirmed the optical counterpart to 20 X-ray sources (7 cataclysmic variables, 2 millisecond pulsars and 11 active binaries) and identified 33 previously unknown sources, thus significantly enlarging the population of known active binaries in this cluster. We report the main characteristics for each class of objects. Photometric estimates of the equivalent width of the $Hα$ emission line, were derived from the $(V-Hα)_0$-excess and, for the first time, compared to the spectroscopic measurements obtained from the analysis of MUSE spectra. The very good agreement between the spectroscopic and photometric measures fully confirmed the reliability of the proposed approach to measure the $Hα$ emission. The search demonstrated the efficiency of this novel approach to pinpoint and measure $Hα$-emitters, thus offering a powerful tool to conduct complete census of objects whose formation and evolution can be strongly affected by dynamical interactions in star clusters.

astro-ph.SR↗