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Luca Ratti

Publications and source records attributed to Luca Ratti.

21 records · Page 2Linked to original sources

A phase-field approach for the interface reconstruction in a nonlinear elliptic problem arising from cardiac electrophysiology

In this work we tackle the reconstruction of discontinuous coefficients in a semilinear elliptic equation from the knowledge of the solution on the boundary of the domain, an inverse problem motivated by biological application in cardiac electrophysiology. We formulate a constraint minimization problem involving a quadratic mismatch functional enhanced with a regularization term which penalizes the perimeter of the inclusion to be identified. We introduce a phase-field relaxation of the problem, replacing the perimeter term with a Ginzburg-Landau-type energy. We prove the $Γ$-convergence of the relaxed functional to the original one (which implies the convergence of the minimizers), we compute the optimality conditions of the phase-field problem and define a reconstruction algorithm based on the use of the Frèchet derivative of the functional. After introducing a discrete version of the problem we implement an iterative algorithm and prove convergence properties. Several numerical results are reported, assessing the effectiveness and the robustness of the algorihtm in identifying arbitrarily-shaped inclusions. Finally, we compare our approach to a shape derivative based technique, both from a theoretical point of view (computing the sharp interface limit of the optimality conditions) and from a numerical one.

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On the inverse problem of detecting cardiac ischemias: theoretical analysis and numerical reconstruction

In this paper we develop theoretical analysis and numerical reconstruction techniques for the solution of an inverse boundary value problem dealing with the nonlinear, time-dependent monodomain equation, which models the evolution of the electric potential in the myocardial tissue. The goal is the detection of a small inhomogeneity $ω_\varepsilon$ (where the coefficients of the equation are altered) located inside a domain $Ω$ starting from observations of the potential on the boundary $\partial Ω$. Such a problem is related to the detection of myocardial ischemic regions, characterized by severely reduced blood perfusion and consequent lack of electric conductivity. In the first part of the paper we provide an asymptotic formula for electric potential perturbations caused by internal conductivity inhomogeneities of low volume fraction, extending the results published in [7] to the case of three-dimensional, parabolic problems. In the second part we implement a reconstruction procedure based on the topological gradient of a suitable cost functional. Numerical results obtained on an idealized three-dimensional left ventricle geometry for different measurement settings assess the feasibility and robustness of the algorithm.

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A reconstruction algorithm based on topological gradient for an inverse problem related to a semilinear elliptic boundary value problem

In this paper we develop a reconstruction algorithm for the solution of an inverse boundary value problem dealing with a semilinear elliptic partial differential equation of interest in cardiac electrophysiology. The goal is the detection of small inhomogeneities located inside a domain $Ω$, where the coefficients of the equation are altered, starting from observations of the solution of the equation on the boundary $\partial Ω$. Exploiting theoretical results recently achieved in [11], we implement a reconstruction procedure based on the computation of the topological gradient of a suitable cost functional. Numerical results obtained for several test cases finally assess the feasibility and the accuracy of the proposed technique.

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