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Luca Ridolfi

Publications and source records attributed to Luca Ridolfi.

At least 19 recordsLinked to original sources

Measuring nodes centrality when local and global measures overlap

Centrality metrics aim to identify the most relevant nodes in a network. In literature, a broad set of metrics exists, either measuring local or global centrality characteristics. Nevertheless, when networks exhibit a high spectral gap, the usual global centrality measures typically do not add significant information with respect to the degree, i.e., the simplest local metric. To extract new information from this class of networks, we propose the use of the GENeralized Economic comPlexitY index (GENEPY). Despite its original definition within the economic field, the GENEPY can be easily applied and interpreted on a wide range of networks, characterized by high spectral gap, including monopartite and bipartite networks systems. Tests on synthetic and real-world networks show that the GENEPY can shed new light about the nodes centrality, carrying information generally poorly correlated with the nodes number of direct connections (nodes degree).

physics.soc-ph

Thermodynamics and Legendre Duality in Optimal Networks

Optimality principles in nonequilibrium transport networks are linked to a thermodynamic formalism based on generalized transport potentials endowed with Legendre duality and related contact structure. This allows quantifying the distance from non-equilibrium operating points, analogously to thermodynamic availability as well as to shed light on optimality principles in relation to different imposed constraints. Extremizations of generalized dissipation and entropy production appear as special cases that require power-law resistances and -- for entropy production -- also isothermal conditions. Changes in stability of multiple operating points are interpreted as phase transitions based on non-equilibrium equations of state, while cost-based optimization of transport properties reveals connections to the generalized dissipation in the case of power law costs and linear resistance law, but now with typically unstable operating points which give rise to branched optimal transport.

cond-mat.stat-mech

High resolution wind-tunnel investigation about the effect of street trees on pollutant concentration and street canyon ventilation

Greening cities is a key solution to improve the urban microclimate and mitigate the impact of climate change. However, the effect of tree planting on pollutant dispersion in streets is still a debated topic. To shed light on this issue, we present a wind-tunnel experiment aimed at investigating the effect of trees on street canyon ventilation. An idealized urban district was simulated by an array of blocks, and two rows of model trees were arranged at the sides of a street canyon oriented perpendicularly with respect to the wind direction. Reduced scale trees were chosen to mimic a realistic shape and aerodynamic behaviour. Three different spacings between the trees were considered. A passive scalar was injected from a line source placed at ground level and concentration measurements were performed in the whole canyon. Results show that the presence of trees alters the concentration pattern in the street with a progressive shift from a nearly two-dimensional to a three-dimensional field depending on tree density. Despite the significant change of the concentration field induced by trees, the average level of pollution in the street, and thus the overall ventilation efficiency, does not show a specific trend with the density of trees.

physics.ao-ph

Visibility analysis of boundary layer transition

We study the transition to turbulence in a flat plate boundary layer by means of visibility analysis of velocity time-series extracted across the flow domain. By taking into account the mutual visibility of sampled values, visibility graphs are constructed from each time series. The latter are, thus, transformed into a geometrical object, whose main features can be explored using measures typical of network science that provide a reduced order representation of the underlying flow properties. Using these metrics, we observe the evolution of the flow from laminarity to turbulence and the effects exerted by the free-stream turbulence. Different from other methods requiring an extensive amount of spatiotemporal data (e.g., full velocity field) or a set of parameters and thresholds arbitrarily chosen by the user, the present network-based approach is able to identify the onset markers for transition by means of the streamwise velocity time-series alone.

physics.flu-dyn

Coherent structures at the origin of time irreversibility in wall turbulence

Time irreversibility is a distinctive feature of non-equilibrium phenomena such as turbulent flows, where irreversibility is mainly associated with an energy cascade process. An Eulerian, multiscale analysis of time irreversibility in wall-bounded turbulence is proposed in this study, which differs from previous works relying on a Lagrangian approach and mainly focusing on homogeneous turbulence. Outcomes reveal a strong connection between irreversibility levels and coherent structures in both turbulent channel and boundary layer flows. In the near-wall region, irreversibility is directly related to the inner spectral peak originating from small-scale turbulent structures in the buffer layer. Conversely, stronger irreversibility is found in correspondence of the outer spectral peak originating from larger turbulent flow scales far from the wall. Our results represent a first effort to characterize Eulerian TI in wall-bounded turbulent flows, thus paving the way for new developments in wall-turbulence modeling and control accounting for broken temporal symmetry.

physics.flu-dyn

A review of multiscale 0D-1D computational modeling of coronary circulation with applications to cardiac arrhythmias

Computational hemodynamics is becoming an increasingly important tool in clinical applications and surgical procedures involving the cardiovascular system. Aim of this review is to provide a compact summary of state of the art 0D-1D multiscale models of the arterial coronary system, with particular attention to applications related to cardiac arrhythmias, whose effects on the coronary circulation remain so far poorly understood. The focus on 0D-1D models only is motivated by the competitive computational cost, the reliability of the outcomes for the whole cardiovascular system, and the ability to directly account for cardiac arrhythmias. The analyzed studies show that cardiac arrhythmias by their own are able to promote significant alterations of the coronary hemodynamics, with a worse scenario as the mean heart rate (HR) increases. The present review can stimulate future investigation, both in computational and clinical research, devoted to the hemodynamic effects induced by cardiac arrhythmias on the coronary circulation.

physics.med-ph

Network analysis of Reynolds number scaling in wall-bounded Lagrangian mixing

The dispersion and mixing of passive particles in a turbulent channel flow is investigated by means of a network-based representation of their motion. We employ direct numerical simulations at five different Reynolds numbers, from $\mathrm{Re}_τ$ = 180 up to $\mathrm{Re}_τ$ = 950, and obtain sets of particle trajectories via numerical integration. By dividing the channel domain into wall-normal levels, the motion of particles across these levels is used to build a time-varying complex network, which is able to capture the transient phase of the wall-normal mixing process and its dependence on the Reynolds number, $\mathrm{Re}_τ$. Using network metrics, we observe that the dispersion of clouds of tracers depends highly on both their wall-normal starting position and the time elapsed from their release. We identify two main mechanisms that contribute to the long lasting inhibition of the dispersion of particles released near the walls. We also show how the relative importance of these mechanisms varies with the Reynolds number. In particular, at low $\mathrm{Re}_τ$ the weaker velocity fluctuations appear dominant in inhibiting dispersion, while at higher Reynolds numbers a larger role is played by cyclic patterns of motion. At the higher Reynolds numbers employed in this work, we find that most network properties are Reynolds-independent when scaled with outer flow variables. Instead, at lower $\mathrm{Re}_τ$, the aforementioned scaling is not observed. We explore the meaning of the emergence of this scaling in relation to the features of dispersion and to the network definition.

physics.flu-dyn

Different Impact of Heart Rate Variability in the Deep Cerebral and Central Hemodynamics at Rest: An in silico Investigation

Heart rate variability (HRV), defined as the variability between consecutive heartbeats, is a surrogate measure of cardiac vagal tone. It is widely accepted that a decreased HRV is associated to several risk factors and cardiovascular diseases. However, a possible association between HRV and altered cerebral hemodynamics is still debated, suffering from HRV short-term measures and the paucity of high-resolution deep cerebral data. We propose a computational approach to evaluate the deep cerebral and central hemodynamics subject to physiological alterations of HRV in an ideal young healthy patient at rest. The cardiovascular-cerebral model was validated and recently exploited to understand the hemodynamic mechanisms between cardiac arrythmia and cognitive deficit. Three configurations (baseline, increased HRV, and decreased HRV) are built based on the standard deviation (SDNN) of RR beats. In the cerebral circulation, our results show that HRV has overall a stronger impact on pressure than flow rate mean values but similarly alters pressure and flow rate in terms of extreme events. By comparing reduced and increased HRV, this latter induces a higher probability of altered mean and extreme values, and is therefore more detrimental at distal cerebral level. On the contrary, at central level a decreased HRV induces a higher cardiac effort without improving the mechano-contractile performance, thus overall reducing the heart efficiency. Present results suggest that: (i) the increase of HRV per se does not seem to be sufficient to trigger a better cerebral hemodynamic response; (ii) by accounting for both central and cerebral circulations, the optimal HRV configuration is found at baseline. Given the relation inversely linking HRV and HR, the presence of this optimal condition can contribute to explain why the mean HR of the general population settles around the baseline value (70 bpm).

physics.med-ph

Large-to-small scale frequency modulation analysis in wall-bounded turbulence via visibility networks

Scale interaction is studied in wall-bounded turbulence by focusing on the frequency modulation (FM) mechanism of large scales on small scale velocity fluctuations. Differently from amplitude modulation analysis, frequency modulation has been less investigated also due to the difficulty to develop robust tools for broadband signals. To face this issue, the natural visibility graph approach is proposed in this work to map the full velocity signals into complex networks. We show that the network degree centrality is able to capture the signal structure at local scales directly from the full signal, thereby quantifying FM. Velocity signals from numerically-simulated turbulent channel flows and an experimental turbulent boundary layer are investigated at different Reynolds numbers. A correction of Taylor's hypothesis for time-series is proposed to overcome the overprediction of near-wall frequency modulation obtained when local mean velocity is used as the convective velocity. Results provide network-based evidences of the large-to-small FM features for all the three velocity components in the near-wall region, with a reversal mechanism emerging far from the wall. Additionally, scaling arguments in the view of the quasi-steady quasi-homogeneous hypothesis are discussed, and a delay-time between large and small scales very close to the near-wall cycle characteristic time is detected. Results show that the visibility graph is a parameter-free tool that turns out to be effective and robust to detect FM in different configurations of wall-bounded turbulent flows. Based on present findings, the visibility network-based approach can represent a reliable tool to systematically investigate scale interaction mechanisms in wall-bounded turbulence.

physics.flu-dyn

Testing a patient-specific in-silico model to noninvasively estimate central blood pressure

Purpose: To show some preliminary results about the possibility to exploit a cardiovascular mathematical model - made patient-specific by noninvasive data routinely measured during ordinary clinical examinations - in order to obtain sufficiently accurate central blood pressure (BP) estimates. Methods: A closed-loop multiscale (0D and 1D) model of the cardiovascular system is made patient-specific by using as model inputs the individual mean heart rate and left-ventricular contraction time, weight, height, age, sex and mean/pulse brachial BPs. The resulting framework is used to determine central systolic, diastolic, mean and pulse pressures, which are compared with the beat-averaged invasive pressures of 12 patients aged 72$\pm$6.61 years. Results: Errors in central systolic, diastolic, mean and pulse pressures by the model are 4.26$\pm$2.81 mmHg, 5.86$\pm$4.38 mmHg, 4.98$\pm$3.95 mmHg and 3.51$\pm$2.38 mmHg, respectively. Conclusion: The proposed modeling approach shows a good patient-specific response and appears to be potentially useful in clinical practice. However, this approach needs to be evaluated in a larger cohort of patients and could possibly be improved through more accurate oscillometric BP measurement methods.

physics.med-ph

Blue Holes and Froude Horizons: Circular Shallow Water Profiles for Astrophysical Analogs

Interesting analogies between shallow water dynamics and astrophysical phenomena have offered valuable insight from both the theoretical and experimental point of view. To help organize these efforts, here we analyze systematically the hydrodynamic properties of backwater profiles of the shallow water equations with 2D radial symmetry. In contrast to the more familiar 1D case typical of hydraulics, %already for {even in} isentropic conditions, a solution with minimum-radius horizon for the flow emerges, similar to the black hole and white hole horizons, where the critical conditions of unitary Froude number provide a unidirectional barrier for surface waves. Beyond these time-reversible solutions, a greater variety of cases arises, when allowing for dissipation by turbulent friction and shock waves (i.e., hydraulic jumps) for both convergent and divergent flows. The resulting taxonomy of the base-flow cases may serve as a starting point for a more systematic analysis of higher-order effects linked, e.g., to wave propagation and instabilities, capillarity, variable bed slope, and rotation.

physics.flu-dyn

A review on turbulent and vortical flow analyses via complex networks

Turbulent and vortical flows are ubiquitous and their characterization is crucial for the understanding of several natural and industrial processes. Among different techniques to study spatio-temporal flow fields, complex networks represent a recent and promising tool to deal with the large amount of data on turbulent flows and shed light on their physical mechanisms. The aim of this review is to bring together the main findings achieved so far from the application of network-based techniques to study turbulent and vortical flows. A critical discussion on the potentialities and limitations of the network approach is provided, thus giving an ordered portray of the current diversified literature. The present review can boost future network-based research on turbulent and vortical flows, promoting the establishment of complex networks as a widespread tool for turbulence analysis.

physics.flu-dyn

Wall-induced anisotropy effects on turbulent mixing in channel flow: A network-based analysis

Turbulent mixing is studied in the Lagrangian framework with an approach based on the complex network formalism. We consider the motion of passive, noninertial particles inside a turbulent channel simulated at $Re_τ = 950$. The time-dependent network is built to evaluate the transfer of tracers between thin wall-parallel layers which partition the channel in the wall-normal direction. By doing so, we are able to assess the spatial and temporal complexities arising from turbulence dynamics and their influence on the mixing process. This approach highlights the effects of small-scale features of turbulent flow structures and also the larger scale effects determined by wall-induced anisotropy. Complex networks, coupled to the Lagrangian description of turbulence, are effective in providing novel insights into inhomogeneous turbulence and mixing.

physics.flu-dyn

Cardiovascular deconditioning during long-term spaceflight through multiscale modeling

Human spaceflight has been fascinating man for centuries, representing the intangible need to explore the unknown, challenge new frontiers, advance technology and push scientific boundaries further. A key area of importance is cardiovascular deconditioning, that is, the collection of hemodynamic changes - from blood volume shift and reduction to altered cardiac function - induced by sustained presence in microgravity. A thorough grasp of the 0G adjustment point per se is important from a physiological viewpoint and fundamental for astronauts' safety and physical capability on long spaceflights. However, hemodynamic details of cardiovascular deconditioning are incomplete, inconsistent and poorly measured to date; thus a computational approach can be quite valuable. We present a validated 1D-0D multiscale model to study the cardiovascular response to long-term 0G spaceflight in comparison to the 1G supine reference condition. Cardiac work, oxygen consumption and contractility indexes, as well as central mean and pulse pressures were reduced, augmenting the cardiac deconditioning scenario. Exercise tolerance of a spaceflight traveler was found to be comparable to an untrained person with a sedentary lifestyle. At the capillary-venous level significant waveform alterations were observed which can modify the regular perfusion and average nutrient supply at the cellular level. The present study suggests special attention should be paid to future long spaceflights which demand prompt physical capacity at the time of restoration of partial gravity (e.g., Moon/Mars landing). Since spaceflight deconditioning has features similar to accelerated aging understanding deconditioning mechanisms in microgravity are also relevant to the understanding of aging physiology on Earth.

physics.med-ph

Embedding the intrinsic relevance of vertices in network analysis: the case of centrality metrics

Complex network theory (CNT) is gaining a lot of attention in the scientific community, due to its capability to model and interpret an impressive number of natural and anthropic phenomena. One of the most active CNT field concerns the evaluation of the centrality of vertices and edges in the network. Several metrics have been proposed, but all of them share a topological point of view, namely centrality descends from the local or global connectivity structure of the network. However, vertices can exhibit their own intrinsic relevance independent from topology; e.g., vertices representing strategic locations (e.g., hospitals, water and energy sources, etc.) or institutional roles (e.g., presidents, agencies, etc.). In these cases, the connectivity network structure and vertex intrinsic relevance mutually concur to define the centrality of vertices and edges. The purpose of this work is to embed the information about the intrinsic relevance of vertices into CNT tools to enhance the network analysis. We focus on the degree, closeness and betweenness metrics, being among the most used. Two examples, concerning a social (the historical Florence family marriage network) and an infrastructure (a water supply system) network, demonstrate the effectiveness of the proposed relevance-embedding extension of the centrality metrics.

cs.SI

Experimental investigation of vertical turbulent transport of a passive scalar in a boundary layer: statistics and visibility graph analysis

The dynamics of a passive scalar plume in a turbulent boundary layer is experimentally investigated via vertical turbulent transport time-series. Data are acquired in a rough-wall turbulent boundary layer that develops in a recirculating wind tunnel set-up. Two source sizes in an elevated position are considered in order to investigate the influence of the emission conditions on the plume dynamics. The analysis is focused on the effects of the meandering motion and the relative dispersion. First, classical statistics are investigated. We found that (in accordance with previous studies) the meandering motion is the main responsible for differences in the variance and intermittency, as well as the kurtosis and power spectral density, between the two source sizes. On the contrary, the mean and the skewness are slightly affected by the emission conditions. To characterize the temporal structure of the turbulent transport series, the visibility algorithm is exploited to carry out a complex network-based analysis. Two network metrics -- the average peak occurrence and the assortativity coefficient -- are analysed, as they can capture the temporal occurrence of extreme events and their relative intensity in the series. The effects of the meandering motion and the relative dispersion of the plume are discussed in the view of the network metrics, revealing that a stronger meandering motion is associated with higher values of both the average peak occurrence and the assortativity coefficient. The network-based analysis advances the level of information of classical statistics, by characterizing the impact of the emission conditions on the temporal structure of the signals in terms of extreme events and their relative intensity. In this way, complex networks provide -- through the evaluation of network metrics -- an effective tool for time-series analysis of experimental data.

physics.flu-dyn

Impaired coronary blood flow at higher heart rates during atrial fibrillation: investigation via multiscale modelling

Background. Different mechanisms have been proposed to relate atrial fibrillation (AF) and coronary flow impairment, even in absence of relevant coronary artery disease (CAD). However, the underlying hemodynamics remains unclear. Aim of the present work is to computationally explore whether and to what extent ventricular rate during AF affects the coronary perfusion. Methods. AF is simulated at different ventricular rates (50, 70, 90, 110, 130 bpm) through a 0D-1D multiscale validated model, which combines the left heart-arterial tree together with the coronary circulation. Artificially-built RR stochastic extraction mimics the \emph{in vivo} beating features. All the hemodynamic parameters computed are based on the left anterior descending (LAD) artery and account for the waveform, amplitude and perfusion of the coronary blood flow. Results. Alterations of the coronary hemodynamics are found to be associated either to the heart rate increase, which strongly modifies waveform and amplitude of the LAD flow rate, and to the beat-to-beat variability. The latter is overall amplified in the coronary circulation as HR grows, even though the input RR variability is kept constant at all HRs. Conclusions. Higher ventricular rate during AF exerts an overall coronary blood flow impairment and imbalance of the myocardial oxygen supply-demand ratio. The combined increase of heart rate and higher AF-induced hemodynamic variability lead to a coronary perfusion impairment exceeding 90-110 bpm in AF. Moreover, it is found that coronary perfusion pressure (CPP) is no longer a good measure of the myocardial perfusion for HR higher than 90 bpm.

physics.med-ph

Higher ventricular rate during atrial fibrillation relates to increased cerebral hypoperfusions and hypertensive events

Atrial fibrillation (AF) is associated with cognitive impairment/dementia, independently of clinical cerebrovascular events (stroke/TIA). One of the plausible mechanisms is the occurrence of AF-induced transient critical hemodynamic events; however, it is presently unknown, if ventricular response rate during AF may impact on cerebral hemodynamics. AF was simulated at different ventricular rates (50, 70, 90, 110, 130 bpm) by two coupled lumped parameter validated models (systemic and cerebral circulation), and compared to corresponding control normal sinus rhythm simulations (NSR). Hemodynamic outcomes and occurrence of critical events (hypoperfusions and hypertensive events) were assessed along the internal carotid artery-middle cerebral artery pathway up to the capillary-venous bed. At the distal cerebral circle level (downstream middle cerebral artery), increasing ventricular rates lead to a reduced heart rate-related dampening of hemodynamic signals compared to NSR (p=0.003 and 0.002 for flow rate and pressure, respectively). This response causes a significant progressive increase in critical events in the distal cerebral circle (p<0.001) as ventricular rate increases during AF. On the other side, at the lowest ventricular response rates (HR 50 bpm), at the systemic-proximal cerebral circle level (up to middle cerebral artery) hypoperfusions (p<0.001) occur more commonly, compared to faster AF simulations. This computational study suggests that higher ventricular rates relate to a progressive increase in critical cerebral hemodynamic events (hypoperfusions and hypertensive events) at the distal cerebral circle. Thus, a rate control strategy aiming to around 60 bpm could be beneficial in terms on cognitive outcomes in patients with permanent AF.

physics.med-ph