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Lucas Waldburger

Publications and source records attributed to Lucas Waldburger.

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Hierarchical Generative Agents for Simulating Sequential Human Behavior

Complex cognitive, emotional, and social processes shape human evacuations during natural disasters. Accurate modeling and understanding of human behavior in disasters or emergencies can greatly impact the evacuation process by informing more effective planning and resource allocation. However, collecting human data in these situations is very difficult, and existing computational evacuation models assume rational, homogeneous behavior, leading to unrealistic, overly optimistic predictions. To address this gap, we present a simulation framework of sequential human decision-making during an evacuation scenario, introducing cognitively grounded, persona-driven agents. Our framework models evacuation behavior in a grid-based urban environment that evolves over time, capturing fire and other hazards. Human agents are modeled as personas that make sequential decisions in response to environmental stimuli with cognition structured in three levels: high-level evacuation goals, mid-level route reasoning, and low-level navigation. Decision-making is driven by large language models (LLMs) coupled with a cognitive module and calibrated with empirical human evacuation data. We propose a dynamic, stimulus-driven disaster simulation framework that models human evacuation decision-making using persona-conditioned LLM agents and a cognitive hierarchy.

cs.MA

Perspectives for self-driving labs in synthetic biology

Self-driving labs (SDLs) combine fully automated experiments with artificial intelligence (AI) that decides the next set of experiments. Taken to their ultimate expression, SDLs could usher a new paradigm of scientific research, where the world is probed, interpreted, and explained by machines for human benefit. While there are functioning SDLs in the fields of chemistry and materials science, we contend that synthetic biology provides a unique opportunity since the genome provides a single target for affecting the incredibly wide repertoire of biological cell behavior. However, the level of investment required for the creation of biological SDLs is only warranted if directed towards solving difficult and enabling biological questions. Here, we discuss challenges and opportunities in creating SDLs for synthetic biology.

q-bio.OT