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Luis Enrique Nieto-Barajas

Publications and source records attributed to Luis Enrique Nieto-Barajas.

2 recordsLinked to original sources

BNPdensity: Bayesian nonparametric mixture modeling in R

Robust statistical data modelling under potential model mis-specification often requires leaving the parametric world for the nonparametric. In the latter, parameters are infinite dimensional objects such as functions, probability distributions or infinite vectors. In the Bayesian nonparametric approach, prior distributions are designed for these parameters, which provide a handle to manage the complexity of nonparametric models in practice. However, most modern Bayesian nonparametric models seem often out of reach to practitioners, as inference algorithms need careful design to deal with the infinite number of parameters. The aim of this work is to facilitate the journey by providing computational tools for Bayesian nonparametric inference. The article describes a set of functions available in the \R package BNPdensity in order to carry out density estimation with an infinite mixture model, including all types of censored data. The package provides access to a large class of such models based on normalized random measures, which represent a generalization of the popular Dirichlet process mixture. One striking advantage of this generalization is that it offers much more robust priors on the number of clusters than the Dirichlet. Another crucial advantage is the complete flexibility in specifying the prior for the scale and location parameters of the clusters, because conjugacy is not required. Inference is performed using a theoretically grounded approximate sampling methodology known as the Ferguson & Klass algorithm. The package also offers several goodness of fit diagnostics such as QQ-plots, including a cross-validation criterion, the conditional predictive ordinate. The proposed methodology is illustrated on a classical ecological risk assessment method called the Species Sensitivity Distribution (SSD) problem, showcasing the benefits of the Bayesian nonparametric framework.

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Optimal stratification of survival data via Bayesian nonparametric mixtures

The stratified proportional hazards model represents a simple solution to account for heterogeneity within the data while keeping the multiplicative effect on the hazard function. Strata are typically defined a priori by resorting to the values taken by a categorical covariate. A general framework is proposed, which allows for the stratification of a generic accelerated life time model, including as a special case the Weibull proportional hazard model. The stratification is determined a posteriori by taking into account that strata might be characterized by different baseline survivals as well as different effects of the predictors. This is achieved by considering a Bayesian nonparametric mixture model and the posterior distribution it induces on the space of data partitions. The optimal stratification is then identified by means of the variation of information criterion and, in turn, stratum-specific inference is carried out. The performance of the proposed method and its robustness to the presence of right-censored observations are investigated by means of an extensive simulation study. A further illustration is provided by the analysis of a data set extracted from the University of Massachusetts AIDS Research Unit IMPACT Study.

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