Lukas Imanuel Scheel-Platz

arXiv2026

Conditioning Deep Anatomical Prior Knowledge for Reconstruction of Multispectral Optoacoustic Tomography Images

Accurately delineating tissues and reconstructing their chromophore compositions from Multispectral Optoacoustic Tomography (MSOT) images is a key challenge in optoacoustic imaging. The difficulty arises because light fluence distributions within tissue intrinsically depend on spectral optical properties, making the inverse problem inherently ill-posed. Currently, there is a lack of studies leveraging a priori probabilistic anatomical knowledge to guide tissue segmentation and infer chromophore composition. Moreover, most current studies address these two tasks sequentially, which can result in errors accumulating. through the process. To address these issues, we present Anatomical Priors for Reconstruction of Optoacoustic Tomography (APRECOT), a method that leverages probabilistic models of anatomical structures and tissue properties, to enable simultaneous segmentation of tissues and reconstruction of their bulk chromophore compositions. In this proof-of-concept using in-silico data, we show that incorporating probabilistic anatomical context strongly improves the accuracy of bulk chromophore concentration estimation compared to reference methods that do not use any anatomical context or use sequential strategies. This work represents an essential step towards an MSOT imaging mode that directly provides clinically relevant information, such as imaging tissue oxygenation dynamics or disease-related changes in tissue composition.

eess.IV↗

arXiv2024

A Method for Accurate Spatial Focusing Simulation via Numerical Integration and its Application in Optoacoustic Tomography

The spatial sensitivity of an ultrasound transducer, which strongly influences its suitability for different applications, depends on the shape of the transducer surface. Accurate simulation of these spatial effects is important for transducer characterization and design, and for system response modelling in imaging applications. In optoacoustic imaging, broadband transducers are used to capitalize on the rich frequency content of the signals, but their usage makes highly accurate simulations with general wave equation solvers prohibitively memory- and time-intensive. Therefore, specialized tools for simulating the isolated spatial focusing properties described by the spatial impulse response (SIR) have been developed. However, the challenging numerics of the SIR and the necessity to convolve the SIR with the wave shape generated by the optoacoustic absorber to simulate the system response lead to numerical inaccuracies of SIR-based methods. In addition, the approximation error of these methods cannot be controlled a priori. To circumvent the problems associated with the explicit calculation of SIR, we propose directly computing the convolution of the required wave shape with the SIR, which we call the spatial pulse response (SPR). We demonstrate that by utilizing an h-adaptive cubature algorithm, SPR can be computed with significantly higher accuracy than an SIR-based reference method, and the approximation error can be controlled with a tolerance parameter. In addition, the integration of accurate SPR simulations into model-based optoacoustic image reconstruction is shown to improve image contrast and reduce noise artifacts. Precise system characterization and simulation leads to improved imaging performance, ultimately increasing the value of optoacoustic imaging systems for clinical applications.

physics.med-ph↗