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Lulu Chen

Publications and source records attributed to Lulu Chen.

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Constraint-Aware Hierarchical Search for Regulation-Driven Fine-Grained Classification

Tasks such as customs tariff classification, export control categorization, and standards-based equipment coding require assigning an input instance to a fine-grained class under an explicit regulatory hierarchy. Unlike standard text classification, the correct label in these tasks is not determined by semantic similarity alone, but by rule-defined boundaries, threshold conditions, exclusion clauses, definitions, and local exceptions. As a result, two highly similar inputs may require different labels, while a retrieved passage that appears relevant may still be inapplicable under the governing rules. Existing flat classifiers, hierarchical text classification methods, and retrieval-augmented LLM systems are not designed to jointly enforce hierarchical validity, rule consistency, and fine-grained boundary reasoning. In this paper, we formulate this setting as regulation-driven fine-grained hierarchical classification, where an external instance must be assigned to a fine-grained class through a valid path in a regulatory hierarchy and supported by auditable evidence. We construct four benchmark datasets from representative regulation-intensive scenarios and validate the annotations through an expert-in-the-loop process. We further propose a constraint-aware hierarchical search framework that converts regulatory documents into a searchable tree, retrieves only valid local candidate nodes, and uses structured regulatory fields with evidence snippets to guide each next-hop decision. Experiments show that our method achieves the best mean accuracy on all four datasets and provides interpretable decision paths, with the largest gains on cases involving fine-grained neighboring categories and rule-based boundary conditions.

cs.AI

DreamHome-Pano: Design-Aware and Conflict-Free Panoramic Interior Generation

In modern interior design, the generation of personalized spaces frequently necessitates a delicate balance between rigid architectural structural constraints and specific stylistic preferences. However, existing multi-condition generative frameworks often struggle to harmonize these inputs, leading to "condition conflicts" where stylistic attributes inadvertently compromise the geometric precision of the layout. To address this challenge, we present DreamHome-Pano, a controllable panoramic generation framework designed for high-fidelity interior synthesis. Our approach introduces a Prompt-LLM that serves as a semantic bridge, effectively translating layout constraints and style references into professional descriptive prompts to achieve precise cross-modal alignment. To safeguard architectural integrity during the generative process, we develop a Conflict-Free Control architecture that incorporates structural-aware geometric priors and a multi-condition decoupling strategy, effectively suppressing stylistic interference from eroding the spatial layout. Furthermore, we establish a comprehensive panoramic interior benchmark alongside a multi-stage training pipeline, encompassing progressive Supervised Fine-Tuning (SFT) and Reinforcement Learning (RL). Experimental results demonstrate that DreamHome-Pano achieves a superior balance between aesthetic quality and structural consistency, offering a robust and professional-grade solution for panoramic interior visualization.

cs.CV

A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers

Scientific Large Language Models (Sci-LLMs) are transforming how knowledge is represented, integrated, and applied in scientific research, yet their progress is shaped by the complex nature of scientific data. This survey presents a comprehensive, data-centric synthesis that reframes the development of Sci-LLMs as a co-evolution between models and their underlying data substrate. We formulate a unified taxonomy of scientific data and a hierarchical model of scientific knowledge, emphasizing the multimodal, cross-scale, and domain-specific challenges that differentiate scientific corpora from general natural language processing datasets. We systematically review recent Sci-LLMs, from general-purpose foundations to specialized models across diverse scientific disciplines, alongside an extensive analysis of over 270 pre-/post-training datasets, showing why Sci-LLMs pose distinct demands -- heterogeneous, multi-scale, uncertainty-laden corpora that require representations preserving domain invariance and enabling cross-modal reasoning. On evaluation, we examine over 190 benchmark datasets and trace a shift from static exams toward process- and discovery-oriented assessments with advanced evaluation protocols. These data-centric analyses highlight persistent issues in scientific data development and discuss emerging solutions involving semi-automated annotation pipelines and expert validation. Finally, we outline a paradigm shift toward closed-loop systems where autonomous agents based on Sci-LLMs actively experiment, validate, and contribute to a living, evolving knowledge base. Collectively, this work provides a roadmap for building trustworthy, continually evolving artificial intelligence (AI) systems that function as a true partner in accelerating scientific discovery.

cs.CL

A Comprehensive Review of AI Agents: Transforming Possibilities in Technology and Beyond

Artificial Intelligence (AI) agents have rapidly evolved from specialized, rule-based programs to versatile, learning-driven autonomous systems capable of perception, reasoning, and action in complex environments. The explosion of data, advances in deep learning, reinforcement learning, and multi-agent coordination have accelerated this transformation. Yet, designing and deploying unified AI agents that seamlessly integrate cognition, planning, and interaction remains a grand challenge. In this review, we systematically examine the architectural principles, foundational components, and emergent paradigms that define the landscape of contemporary AI agents. We synthesize insights from cognitive science-inspired models, hierarchical reinforcement learning frameworks, and large language model-based reasoning. Moreover, we discuss the pressing ethical, safety, and interpretability concerns associated with deploying these agents in real-world scenarios. By highlighting major breakthroughs, persistent challenges, and promising research directions, this review aims to guide the next generation of AI agent systems toward more robust, adaptable, and trustworthy autonomous intelligence.

cs.MA

From Mind to Machine: The Rise of Manus AI as a Fully Autonomous Digital Agent

Manus AI is a general-purpose AI agent introduced in early 2025, marking a significant advancement in autonomous artificial intelligence. Developed by the Chinese startup Monica.im, Manus is designed to bridge the gap between "mind" and "hand" - combining the reasoning and planning capabilities of large language models with the ability to execute complex, end-to-end tasks that produce tangible outcomes. This paper presents a comprehensive overview of Manus AI, exploring its core technical architecture, diverse applications across sectors such as healthcare, finance, manufacturing, robotics, and gaming, as well as its key strengths, current limitations, and future potential. Positioned as a preview of what lies ahead, Manus AI represents a shift toward intelligent agents that can translate high-level intentions into real-world actions, heralding a new era of human-AI collaboration.

cs.AI

Machine Learning for Synthetic Data Generation: A Review

Machine learning heavily relies on data, but real-world applications often encounter various data-related issues. These include data of poor quality, insufficient data points leading to under-fitting of machine learning models, and difficulties in data access due to concerns surrounding privacy, safety, and regulations. In light of these challenges, the concept of synthetic data generation emerges as a promising alternative that allows for data sharing and utilization in ways that real-world data cannot facilitate. This paper presents a comprehensive systematic review of existing studies that employ machine learning models for the purpose of generating synthetic data. The review encompasses various perspectives, starting with the applications of synthetic data generation, spanning computer vision, speech, natural language processing, healthcare, and business domains. Additionally, it explores different machine learning methods, with particular emphasis on neural network architectures and deep generative models. The paper also addresses the crucial aspects of privacy and fairness concerns related to synthetic data generation. Furthermore, this study identifies the challenges and opportunities prevalent in this emerging field, shedding light on the potential avenues for future research. By delving into the intricacies of synthetic data generation, this paper aims to contribute to the advancement of knowledge and inspire further exploration in synthetic data generation.

cs.LG

Foundation Model in Biomedicine

Foundation models, first introduced in 2021, refer to large-scale pretrained models (e.g., large language models (LLMs) and vision-language models (VLMs)) that learn from extensive unlabeled datasets through unsupervised methods, enabling them to excel in diverse downstream tasks. These models, like GPT, can be adapted to various applications such as question answering and visual understanding, outperforming task-specific AI models and earning their name due to broad applicability across fields. The development of biomedical foundation models marks a significant milestone in the use of artificial intelligence (AI) to understand complex biological phenomena and advance medical research and practice. This survey explores the potential of foundation models in diverse domains within biomedical fields, including computational biology, drug discovery and development, clinical informatics, medical imaging, and public health. The purpose of this survey is to inspire ongoing research in the application of foundation models to health science.

cs.LG

GenoCraft: A Comprehensive, User-Friendly Web-Based Platform for High-Throughput Omics Data Analysis and Visualization

The surge in high-throughput omics data has reshaped the landscape of biological research, underlining the need for powerful, user-friendly data analysis and interpretation tools. This paper presents GenoCraft, a web-based comprehensive software solution designed to handle the entire pipeline of omics data processing. GenoCraft offers a unified platform featuring advanced bioinformatics tools, covering all aspects of omics data analysis. It encompasses a range of functionalities, such as normalization, quality control, differential analysis, network analysis, pathway analysis, and diverse visualization techniques. This software makes state-of-the-art omics data analysis more accessible to a wider range of users. With GenoCraft, researchers and data scientists have access to an array of cutting-edge bioinformatics tools under a user-friendly interface, making it a valuable resource for managing and analyzing large-scale omics data. The API with an interactive web interface is publicly available at https://genocraft.stanford. edu/. We also release all the codes in https://github.com/futianfan/GenoCraft.

q-bio.GN

Quantum-inspired Reinforcement Learning for Synthesizable Drug Design

Synthesizable molecular design (also known as synthesizable molecular optimization) is a fundamental problem in drug discovery, and involves designing novel molecular structures to improve their properties according to drug-relevant oracle functions (i.e., objective) while ensuring synthetic feasibility. However, existing methods are mostly based on random search. To address this issue, in this paper, we introduce a novel approach using the reinforcement learning method with quantum-inspired simulated annealing policy neural network to navigate the vast discrete space of chemical structures intelligently. Specifically, we employ a deterministic REINFORCE algorithm using policy neural networks to output transitional probability to guide state transitions and local search using genetic algorithm to refine solutions to a local optimum within each iteration. Our methods are evaluated with the Practical Molecular Optimization (PMO) benchmark framework with a 10K query budget. We further showcase the competitive performance of our method by comparing it against the state-of-the-art genetic algorithms-based method.

cs.LG

RoomDiffusion: A Specialized Diffusion Model in the Interior Design Industry

Recent advancements in text-to-image diffusion models have significantly transformed visual content generation, yet their application in specialized fields such as interior design remains underexplored. In this paper, we present RoomDiffusion, a pioneering diffusion model meticulously tailored for the interior design industry. To begin with, we build from scratch a whole data pipeline to update and evaluate data for iterative model optimization. Subsequently, techniques such as multiaspect training, multi-stage fine-tune and model fusion are applied to enhance both the visual appeal and precision of the generated results. Lastly, leveraging the latent consistency Distillation method, we distill and expedite the model for optimal efficiency. Unlike existing models optimized for general scenarios, RoomDiffusion addresses specific challenges in interior design, such as lack of fashion, high furniture duplication rate, and inaccurate style. Through our holistic human evaluation protocol with more than 20 professional human evaluators, RoomDiffusion demonstrates industry-leading performance in terms of aesthetics, accuracy, and efficiency, surpassing all existing open source models such as stable diffusion and SDXL.

cs.CV

SMILES-Mamba: Chemical Mamba Foundation Models for Drug ADMET Prediction

In drug discovery, predicting the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of small-molecule drugs is critical for ensuring safety and efficacy. However, the process of accurately predicting these properties is often resource-intensive and requires extensive experimental data. To address this challenge, we propose SMILES-Mamba, a two-stage model that leverages both unlabeled and labeled data through a combination of self-supervised pretraining and fine-tuning strategies. The model first pre-trains on a large corpus of unlabeled SMILES strings to capture the underlying chemical structure and relationships, before being fine-tuned on smaller, labeled datasets specific to ADMET tasks. Our results demonstrate that SMILES-Mamba exhibits competitive performance across 22 ADMET datasets, achieving the highest score in 14 tasks, highlighting the potential of self-supervised learning in improving molecular property prediction. This approach not only enhances prediction accuracy but also reduces the dependence on large, labeled datasets, offering a promising direction for future research in drug discovery.

cs.LG

O-PRESS: Boosting OCT axial resolution with Prior guidance, Recurrence, and Equivariant Self-Supervision

Optical coherence tomography (OCT) is a noninvasive technology that enables real-time imaging of tissue microanatomies. The axial resolution of OCT is intrinsically constrained by the spectral bandwidth of the employed light source while maintaining a fixed center wavelength for a specific application. Physically extending this bandwidth faces strong limitations and requires a substantial cost. We present a novel computational approach, called as O-PRESS, for boosting the axial resolution of OCT with Prior Guidance, a Recurrent mechanism, and Equivariant Self-Supervision. Diverging from conventional superresolution methods that rely on physical models or data-driven techniques, our method seamlessly integrates OCT modeling and deep learning, enabling us to achieve real-time axial-resolution enhancement exclusively from measurements without a need for paired images. Our approach solves two primary tasks of resolution enhancement and noise reduction with one treatment. Both tasks are executed in a self-supervised manner, with equivariance imaging and free space priors guiding their respective processes. Experimental evaluations, encompassing both quantitative metrics and visual assessments, consistently verify the efficacy and superiority of our approach, which exhibits performance on par with fully supervised methods. Importantly, the robustness of our model is affirmed, showcasing its dual capability to enhance axial resolution while concurrently improving the signal-to-noise ratio.

eess.IV

Smoothing spline analysis of variance models: A new tool for the analysis of accelerometer data

Accelerometer data is commonplace in physical activity research, exercise science, and public health studies, where the goal is to understand and compare physical activity differences between groups and/or subject populations, and to identify patterns and trends in physical activity behavior to inform interventions for improving public health. We propose using mixed-effects smoothing spline analysis of variance (SSANOVA) as a new tool for analyzing accelerometer data. By representing data as functions or curves, smoothing spline allows for accurate modeling of the underlying physical activity patterns throughout the day, especially when the accelerometer data is continuous and sampled at high frequency. The SSANOVA framework makes it possible to decompose the estimated function into the portion that is common across groups (i.e., the average activity) and the portion that differs across groups. By decomposing the function of physical activity measurements in such a manner, we can estimate group differences and identify the regions of difference. In this study, we demonstrate the advantages of utilizing SSANOVA models to analyze accelerometer-based physical activity data collected from community-dwelling older adults across various fall risk categories. Using Bayesian confidence intervals, the SSANOVA results can be used to reliably quantify physical activity differences between fall risk groups and identify the time regions that differ throughout the day.

stat.AP

From RDMA to RDCA: Toward High-Speed Last Mile of Data Center Networks Using Remote Direct Cache Access

In this paper, we conduct systematic measurement studies to show that the high memory bandwidth consumption of modern distributed applications can lead to a significant drop of network throughput and a large increase of tail latency in high-speed RDMA networks.We identify its root cause as the high contention of memory bandwidth between application processes and network processes. This contention leads to frequent packet drops at the NIC of receiving hosts, which triggers the congestion control mechanism of the network and eventually results in network performance degradation. To tackle this problem, we make a key observation that given the distributed storage service, the vast majority of data it receives from the network will be eventually written to high-speed storage media (e.g., SSD) by CPU. As such, we propose to bypass host memory when processing received data to completely circumvent this performance bottleneck. In particular, we design Lamda, a novel receiver cache processing system that consumes a small amount of CPU cache to process received data from the network at line rate. We implement a prototype of Lamda and evaluate its performance extensively in a Clos-based testbed. Results show that for distributed storage applications, Lamda improves network throughput by 4.7% with zero memory bandwidth consumption on storage nodes, and improves network throughput by up 17% and 45% for large block size and small size under the memory bandwidth pressure, respectively. Lamda can also be applied to latency-sensitive HPC applications, which reduces their communication latency by 35.1%.

cs.NI

A Comprehensive Study on Optimizing Systems with Data Processing Units

New hardware, such as SmartNICs, has been released to offload network applications in data centers. Off-path SmartNICs, a type of multi-core SoC SmartNICs, have attracted the attention of many researchers. Unfortunatelly, they lack the fully exploration of off-path SmartNICs. In this paper, we use a BlueField SmartNIC as an example to conduct a systematical study on the advantages and disadvantages of off-path SmartNICs. We make a detailed performance characterization on an off-path SmartNIC including computing power and network communication overhead, and propose the following advices: 1) Directly utilize the specific accelerators on the SmartNIC to offload applications; 2) Offload latency-insensitive background processing to the SmartNIC to reduce the load on the host; 3) Regard the SmartNIC as a new endpoint in the network to expand the computing power and storage resources of the server host; 4) Avoid directly employing the design method for systems based on on-path SmartNICs. We apply these advices to several use cases and show the performance improvements.

cs.NI

Voltage-induced high-speed DW motion in a synthetic antiferromagnet

Voltage-induced motion of a magnetic domain wall (DW) has potential in developing novel devices with ultralow dissipation. However, the speed for the voltage-induced DW motion (VIDWM) in a single ferromagnetic layer is usually very low. In this work, we proposed VIDWM with high speed in a synthetic antiferromaget (SAF). The velocity for the coupled DWs in the SAF is significantly higher than its counterpart in a single ferromagnetic layer. Strong interlayer antiferromagnetic exchange coupling plays a critical role for the high DW velocity since it inhibits the tilting of DW plane with strong Dzyaloshinskii-Moriya interaction. On the other hand, the Walker breakdown of DW motion is also inhibited due to the stabilization of moment orientation under a strong interlayer antiferromagnetic coupling. In theory, the voltage-induced gradient of magnetic anisotropy is proved to be equal to an effective magnetic field that drives DW.

physics.app-ph