arXiv subjects

Luwei Wang

Publications and source records attributed to Luwei Wang.

5 recordsLinked to original sources

arXiv2026

Bayesian Supervised Causal Clustering

Finding patient subgroups with similar characteristics is crucial for personalized decision-making in various disciplines such as healthcare and policy evaluation. While most existing approaches rely on unsupervised clustering methods, there is a growing trend toward using supervised clustering methods that identify operationalizable subgroups in the context of a specific outcome of interest. We propose Bayesian Supervised Causal Clustering (BSCC), with treatment effect as outcome to guide the clustering process. BSCC identifies homogenous subgroups of individuals who are similar in their covariate profiles as well as their treatment effects. We evaluate BSCC on simulated datasets as well as real-world dataset from the third International Stroke Trial to assess the practical usefulness of the framework.

stat.ML↗

arXiv2025

Self-supervised learning for multiplexing super-resolution confocal microscopy

Confocal microscopy has long been a cornerstone technique for visualizing complex interactions and processes within cellular structures. However, achieving super-resolution imaging of multiple organelles and their interactions simultaneously has remained a significant challenge. Here, we present a self-supervised learning approach to transform diffraction-limited, single-colour input images into multi-colour super-resolution outputs. Our approach eliminates the need for paired training data by utilizing a degradation model. By enhancing the resolution of confocal images and improving the identification and separation of cellular targets, this method bypasses the necessity for multi-wavelength excitation or parallel detection systems. Trained on an extensive dataset, the model effectively distinguishes and resolves multiple organelles with high fidelity, overcoming traditional imaging limitations. This technique requires no hardware modifications, making multi-colour super-resolution imaging accessible to any standard confocal microscope. We validated its performance by demonstrating two- and three-colour super-resolution imaging of both fixed and live cells. The technique offers a streamlined and data-efficient solution for multi-channel super-resolution microscopy, while opening new possibilities for investigating dynamic cellular processes with unprecedented clarity.

physics.optics↗

arXiv2025

Three-Dimensional Isotropic STED Nanoscopy using a Single Objective

Accurate three-dimensional (3D) imaging requires an isotropic point spread function (PSF). However, the inherent missing aperture of a single objective lens results in an elongated, cigar-like PSF, which has rendered isotropic resolution in fluorescence microscopy seemingly insurmountable without a 4{\pi} configuration for decades. To address this long-standing challenge, we introduce ISO-STED (Isotropic Single-Objective STED) Nanoscopy, a novel approach that employs a single objective lens and a single depletion beam. By utilizing a hollow depletion focus, ISO-STED achieves an isotropic PSF without relying on a 4{\pi} configuration. This innovative design enables uniform fluorescence suppression in all directions, thereby yielding an isotropic 3D resolution of approximately 70 nm. Our work not only demonstrates the potential of ISO-STED Nanoscopy to provide a compact and versatile solution for isotropic 3D imaging in complex specimens but also paves the way for more accessible and practical applications in various research fields, including biomedical research and neuroscience.

physics.optics↗

arXiv2024

ScrollTimes: Tracing the Provenance of Paintings as a Window into History

The study of cultural artifact provenance, tracing ownership and preservation, holds significant importance in archaeology and art history. Modern technology has advanced this field, yet challenges persist, including recognizing evidence from diverse sources, integrating sociocultural context, and enhancing interactive automation for comprehensive provenance analysis. In collaboration with art historians, we examined the handscroll, a traditional Chinese painting form that provides a rich source of historical data and a unique opportunity to explore history through cultural artifacts. We present a three-tiered methodology encompassing artifact, contextual, and provenance levels, designed to create a "Biography" for handscroll. Our approach incorporates the application of image processing techniques and language models to extract, validate, and augment elements within handscroll using various cultural heritage databases. To facilitate efficient analysis of non-contiguous extracted elements, we have developed a distinctive layout. Additionally, we introduce ScrollTimes, a visual analysis system tailored to support the three-tiered analysis of handscroll, allowing art historians to interactively create biographies tailored to their interests. Validated through case studies and expert interviews, our approach offers a window into history, fostering a holistic understanding of handscroll provenance and historical significance.

cs.HC↗

arXiv2023

Computational Approaches for Traditional Chinese Painting: From the "Six Principles of Painting" Perspective

Traditional Chinese Painting (TCP) is an invaluable cultural heritage resource and a unique visual art style. In recent years, increasing interest has been placed on digitalizing TCPs to preserve and revive the culture. The resulting digital copies have enabled the advancement of computational methods for structured and systematic understanding of TCPs. To explore this topic, we conducted an in-depth analysis of 92 pieces of literature. We examined the current use of computer technologies on TCPs from three perspectives, based on numerous conversations with specialists. First, in light of the "Six Principles of Painting" theory, we categorized the articles according to their research focus on artistic elements. Second, we created a four-stage framework to illustrate the purposes of TCP applications. Third, we summarized the popular computational techniques applied to TCPs. The framework also provides insights into potential applications and future prospects, with professional opinion. The list of surveyed publications and related information is available online at https://ca4tcp.com.

cs.CV↗