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M Cristina Marchetti

Publications and source records attributed to M Cristina Marchetti.

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Alignment interactions drive structural transitions in biological tissues

Experimental evidence shows that there is a feedback between cell shape and cell motion. How this feedback impacts the collective behavior of dense cell monolayers remains an open question. We investigate the effect of a feedback that tends to align the cell crawling direction with cell elongation in a biological tissue model. We find that the alignment interaction promotes nematic patterns in the fluid phase that eventually undergo a non-equilibrium phase transition into a quasi-hexagonal solid. Meanwhile, highly asymmetric cells do not undergo the liquid-to-solid transition for any value of the alignment coupling. In this regime, the dynamics of cell centers and shape fluctuation show features typical of glassy systems.

cond-mat.soft

Information and motility exchange in collectives of active particles

We examine the interplay of motility and information exchange in a model of run-and-tumble active particles where the particle's motility is encoded as a bit of information that can be exchanged upon contact according to the rules of AND and OR logic gates in a circuit. Motile AND particles become non-motile upon contact with a non-motile particle. Conversely, motile OR particles remain motile upon collision with their non-motile counterparts. AND particles that have become non-motile additionally "reawaken", i.e., recover their motility, at a fixed rate $μ$, as in the SIS (Susceptible, Infected, Susceptible) model of epidemic spreading, where an infected agent can become healthy again, but keeps no memory of the recent infection, hence it is susceptible to a renewed infection. For $μ=0$, both AND and OR particles relax irreversibly to absorbing states of all non-motile or all motile particles, respectively. The relaxation kinetics is, however, faster for OR particles that remain active throughout the process. At finite $μ$, the AND dynamics is controlled by the interplay between reawakening and collision rates. The system evolves to a state of all motile particles (an absorbing state in the language of absorbing phase transitions) for $μ>μ_c$ and to a mixed state with coexisting motile and non-motile particles (an active state in the language of absorbing phase transitions) for $μ<μ_c$. The final state exhibits a rich structure controlled by motility-induced aggregation. Our work can be relevant to biochemical signaling in motile bacteria, the spreading of epidemics and of social consensus, as well as light-controlled organization of active colloids.

cond-mat.soft

Fractal aggregation of active particles

We study active run-and-tumble particles with an additional two-state internal variable characterizing their motile or non-motile state. Motile particles change irreversibly into non-motile ones upon collision with a non-motile particle. The system evolves towards an absorbing state where all particles are non-motile. We initialize the system with one non-motile particles in a bath of motile ones and study numerically the kinetics of relaxation to absorbing state and its structure as function of the density of the initial bath of motile particles and of their tumbling rate. We find a crossover from fractal aggregates at low density to homogeneous ones at high density. The persistence of single-particle dynamics as quantified by the tumbling rate pushes this crossover to higher density and can be used to tune the porosity of the aggregate. At the lowest density the fractal dimension of the aggregate approaches that obtained in single-particle diffusion limited aggregation. Our results could be exploited for the design of structures of desired porosity. The model is a first step towards the study of the collective dynamics of active particles that can exchange biological information.

cond-mat.soft

Shape and Displacement Fluctuations in Soft Vesicles Filled by Active Particles

We investigate numerically the dynamics of shape and displacement fluctuations of two-dimensional flexible vesicles filled with active particles. At low concentration most of the active particles accumulate at the boundary of the vesicle where positive particle number fluctuations are amplified by trapping, leading to the formation of pinched spots of high density, curvature and pressure. At high concentration the active particles cover the vesicle boundary almost uniformly, resulting in fairly homogeneous pressure and curvature, and nearly circular vesicle shape. The change between polarized and spherical shapes is driven by the number of active particles. The center-of-mass of the vesicle performs a persistent random walk with a long time diffusivity that is strongly enhanced for elongated active particles due to orientational correlations in their direction of propulsive motion. In our model shape-shifting induces directional sensing and the cell spontaneously migrate along the polarization direction.

cond-mat.stat-mech