arXiv subjects

M. Jech

Publications and source records attributed to M. Jech.

2 recordsLinked to original sources

arXiv2026

Controlled kHz laser-driven electron irradiations for pre-clinical applications

We report the first in-air irradiations of biological samples with kHz laser-driven electrons with beam energy 20 MeV, high-energy tail extending to 40 MeV, and average dose rate up to 30 Gy/min. An in-house procedure has been developed to characterize and deliver on-demand (i.e. pre-agreed date and time) the target electron beam energy, dose and dose uniformity. We present a tolerance analysis on the laser electron parameters, highlighting the importance of beam stability for precise irradiations of in vivo zebrafish embryos and in vitro U251 glioblastoma cell line. The observed improvement in the survival rate of the zebrafish embryos, combined with unchanged cytotoxicity in the cell cultures, indicates promising results for normal tissue sparing while maintaining anticancer efficacy. The pre-clinical results of this work represent an important milestone towards the clinical translation of laser-plasma accelerators.

physics.med-ph↗

arXiv2025

Optimized matching conditions for self-guided laser wakefield accelerators

We revisit the matching conditions for self-guided laser pulse propagation in plasma and refine their formulation to maximize the energy of electrons produced via laser wakefield acceleration. Bayesian optimization, combined with particle-in-cell simulations carried out in a quasi-three-dimensional geometry and a Lorentz-boosted frame, is employed. The optimization identifies the maximum electron energy that a self-guided laser wakefield accelerator, driven by a laser of a given energy, can produce, together with the corresponding acceleration distance. Our results further demonstrate that electrons with energies close to the maximum value can be obtained across a relatively wide range of input parameters and without the need for their precise tuning. This provides substantial flexibility for experimental implementation and significantly relaxes the operational constraints associated with self-guided laser wakefield accelerators.

physics.plasm-ph↗