arXiv subjects

M. Nevrkla

Publications and source records attributed to M. Nevrkla.

4 recordsLinked to original sources

arXiv2026

Controlled kHz laser-driven electron irradiations for pre-clinical applications

We report the first in-air irradiations of biological samples with kHz laser-driven electrons with beam energy 20 MeV, high-energy tail extending to 40 MeV, and average dose rate up to 30 Gy/min. An in-house procedure has been developed to characterize and deliver on-demand (i.e. pre-agreed date and time) the target electron beam energy, dose and dose uniformity. We present a tolerance analysis on the laser electron parameters, highlighting the importance of beam stability for precise irradiations of in vivo zebrafish embryos and in vitro U251 glioblastoma cell line. The observed improvement in the survival rate of the zebrafish embryos, combined with unchanged cytotoxicity in the cell cultures, indicates promising results for normal tissue sparing while maintaining anticancer efficacy. The pre-clinical results of this work represent an important milestone towards the clinical translation of laser-plasma accelerators.

physics.med-ph↗

arXiv2024

Demonstration of The Brightest Nano-size Gamma Source

Gamma rays selectively interact with nuclei, induce and mediate nuclear reactions and elementary particle interactions, and exceed x-rays in penetrating power and thus are indispensable for analysis and modification of dense objects. Yet, the available gamma sources lack sufficient power and brightness. The predicted and highly desirable laser-driven gamma flash, from here on termed "Gamma Flash", based on inverse Compton scattering from solid targets at extreme irradiances (>$10^{23}W/cm^2$), would be the highest-power and the brightest terrestrial gamma source with a 30-40% laser-to-gamma energy conversion. However, Gamma Flash remains inaccessible experimentally due to the Bremsstrahlung background. Here we experimentally demonstrate a new interaction regime at the highest effective irradiance where Gamma Flash scaled quickly with the laser power and produced several times the number of Bremsstrahlung photons. Simulations revealed an attosecond, Terawatt Gamma Flash with a nanometre source size achieving a record brightness exceeding $~10^{23}photons/mm^2mrad^2s$ per 0.1% bandwidth at tens of MeV photon energies, surpassing astrophysical Gamma Ray Bursts. These findings could revolutionize inertial fusion energy by enabling unprecedented sub-micrometre/femtosecond resolution radiography of fuel mixing instabilities in extremely-compressed targets. The new gamma source could facilitate significant advances in time-resolved nuclear physics, homeland security, nuclear waste management and non-proliferation, while opening possibilities for spatially-coherent gamma rays.

physics.plasm-ph↗

arXiv2024

Ultrarelativistic electron beams accelerated by terawatt scalable kHz laser

We show the laser-driven acceleration of unprecedented, collimated ($ 2 \ \mathrm{mrad} $ divergence), and quasi-monoenergetic ($ 25 \ \% $ energy spread) electron beams with energy up to $ 50 \ \mathrm{MeV} $ at $ 1 \ \mathrm{kHz} $ repetition rate. The laser driver is a multi-cycle ($ 15 \ \mathrm{fs} $) $ 1 \ \mathrm{kHz} $ optical parametric chirped pulse amplification (OPCPA) system, operating at $ 26 \ \mathrm{mJ} $ ($ 1.7 \ \mathrm{TW} $). The scalability of the driver laser technology and the electron beams reported in this work pave the way towards developing high-brilliance x-ray sources for medical imaging, innovative devices for brain cancer treatment, and represent a step towards the realization of a kHz GeV electron beamline.

physics.plasm-ph↗

arXiv2022

Phase-matched high-order harmonic generation in pre-ionized noble gases

One of the main difficulties to efficiently generating high-order harmonics in long neutral-gas targets is to reach the phase-matching conditions. One issue is that the medium cannot be sufficiently ionized by the driving laser due to plasma defocusing. We propose a method to improve the phase-matching by pre-ionizing the gas using a weak capillary discharge. We have demonstrated this mechanism, for the first time, in absorption-limited XUV generation by an 800 nm femtosecond laser in argon and krypton. The phase-mismatch control ability of our method is confirmed by an analytical model and numerical simulation of the complete generation process. Our method allows increasing the efficiency of the harmonic generation significantly, paving the way towards photon-hungry applications of these short-wavelength compact sources.

physics.optics↗