arXiv subjects

M. Pullia

Publications and source records attributed to M. Pullia.

10 recordsLinked to original sources

arXiv2026

Toward High-Resolution Detection of Target Fragmentation: TEA-Sensitized NIT for Proton Therapy Applications

Nano Imaging Trackers (NIT) are fine-grained nuclear emulsions capable of tracking charged particles with sub-micrometric spatial resolution. The DAMON (Direct Measurement of Target Fragmentation) experiment recently employed NIT to detect target-fragmentation events relevant to proton therapy in direct kinematics. These measurements showed that the small crystal size, while providing high spatial resolution, limits the reconstruction efficiency for primary proton tracks and high-energy secondary protons. This work reports an enhancement of NIT sensitivity achieved through alternative chemical sensitization methods, namely gold-plus-sulfur (Au-S) and triethanolamine (TEA), together with the use of the GR-1 developer. The detector response was evaluated with gamma-ray, carbon-ion and proton exposures, including clinically relevant proton energies.

physics.ins-det↗

arXiv2026

TIARA: a fast gamma-ray detector for range monitoring in Proton Therapy

We developed a novel gamma-ray detection system (TIARA) for range monitoring in Particle Therapy. The system employs Cherenkov-based gamma-ray detection modules arranged around the target or patient, operated in time coincidence with a fast plastic beam monitor (described in a separate paper). This work focuses on the design and comprehensive characterization of the gamma-ray detection module. It consists of a monolithic PbF$_2$ crystal (2 $\times$ 1.5 $\times$ 1.5 cm$^{3}$) coupled to a 2 $\times$ 2 SiPM matrix from Hamamatsu. A series of beam tests at different clinical facilities (MEDICYC and ProteusOne in France, CNAO in Italy) enabled the determination of the detector time resolution under various conditions, with values ranging from 222 to 283 ps FWHM (Full Width Half Maximum). Monte Carlo simulations including the optical response of PbF$_2$ allowed for the determination of the detection efficiency as a function of particle type and energy. For the final TIARA prototype, which will be composed of 30 modules, an overall detection efficiency of 0.45% is expected. Comparison with experimental data confirmed that the modules are effectively insensitive to neutrons, yielding an excellent signal-to-noise ratio (SNR), with an estimated SNR of 17 for a module placed at 25 cm from the 148 MeV proton beam axis. These features translate into high range accuracy: while the performance varies with beam energy and irradiation conditions, a range accuracy of 3.3 mm at 2$\sigma$ significance level was achieved at low intensity with 63 MeV protons at MEDICYC, for a small irradiation spot of $\mathbf{\sim}$10$\mathbf{^{7}}$ protons.

physics.ins-det↗

arXiv2025

First operation of the FAMU experiment at the RIKEN-RAL high intensity muon beam facility

The FAMU experiment, supported and funded by the Italian Institute of Nuclear Physics (INFN) and by the Science and Technology Facilities Council (STFC), aims to perform the first measurement of the ground-state hyperfine splitting (1S-hfs) of muonic hydrogen ($\mu H$). This quantity is highly sensitive to the proton's Zemach radius $R_Z$. An experimental determination of $R_Z$ provides significant constraints on the parametrization of the proton form factors as well as on theoretical models describing the proton's electromagnetic structure. Following years of technological and methodological development, the FAMU experiment began operations in 2023 at Port 1 of the RIKEN-RAL muon beam line at the ISIS Neutron and Muon Source facility (Didcot, UK). In this paper, we first describe the unique detection technique employed by FAMU to determine the 1S-hfs of muonic hydrogen, followed by a detailed presentation of the final experimental layout. Finally, we report the first outcome from the 2023 commissioning run and from the initial physics runs performed in 2023 and 2024.

physics.atom-ph↗

arXiv2025

Calibration of a $\Delta$E-E telescope based on CeBr$_3$ scintillator for secondary charged particles measurements in hadron therapy

Hadrontherapy is an established cancer treatment method that enables a more localized dose deposition compared to conventional radiotherapy, potentially reducing the dose to surrounding healthy tissues in certain clinical cases. However, a key limitation in current treatment planning lies in the limited experimental data available for the characterization of secondary particles generated by nuclear interactions of the primary beam with tissues, which directly impacts the accuracy of Monte Carlo tools and analytical models used in dose calculations. Indeed, this leads to the adoption of larger safety margins and can limit the use of hadrontherapy for treating certain complex or sensitive tumor locations. This work is part of the context of the characterization of secondary charged particles generated by ion beams in the energy range relevant for particle therapy applications, using a $\Delta E-E$ telescope comprising a CeBr$_3$ crystal scintillator and a plastic scintillator. The calibration and response of this telescope to ions commonly used in clinical settings is presented in this work, highlighting adherence to Birks' law for accurate energy measurements. This study is the first to optimize a $\Delta E-E$ telescope combining CeBr$_3$ and plastic scintillators specifically for secondary particle detection in hadrontherapy. It represents an essential step toward the experimental acquisition of nuclear data, enabling accurate measurement and identification of secondary charged particles generated by therapeutic beams in tissue-equivalent materials. The system is designed for use in controlled experimental setups that reproduce clinical conditions, with the goal of improving the predictive accuracy of treatment planning software through enhanced Monte Carlo simulation inputs.

physics.ins-det↗

arXiv2025

Cross Section Measurements of Large Angle Fragments Production in the Interaction of Carbon Ion Beams with Thin Targets

The fragmentation cross sections of carbon ion beams with kinetic energies of $115 - 353~\text{MeV/u}$ impinging on thin targets of graphite (C), polyvinyl-toluene (C$_9$H$_{10}$) and PMMA (C$_2$O$_5$H$_8$) have been measured at 90$^{\text{o}}$ and 60$^{\text{o}}$ at the CNAO particle therapy center (Pavia, Italy). The presented measurements are a complete reanalysis by the FOOT collaboration of already published elemental cross section on composite targets, in order to refine the analysis, improve the systematic uncertainties and show the comparison with the FLUKA Monte Carlo code calculations. In this work, the kinetic energy at production of measured fragments has been completely redefined, together with the efficiencies computation. The new analysis strategy has been successfully validated against the Monte Carlo cross sections. Two detection arms were positioned at two different angles to perform the measurement at 90$^{\text{o}}$ and 60$^{\text{o}}$. The fragment species have been identified in charge (Z$_{id}$ = H) and mass (M$_{id}$ = $^1$H, $^2$H, $^3$H) combining the information of the deposited energy in thin plastic scintillators, of the deposited energy in a thick LYSO crystal and of the fragments Time of Flight (ToF) measurement. The ToF was also used to compute the fragments measured kinetic energy. The cross sections are presented as a function of the fragments kinetic energy at production thanks to an unfolding technique applied to the data.

nucl-ex↗

arXiv2024

Angular differential and elemental fragmentation cross sections of a $400\,\text{MeV/nucleon}$ $^{16}\text{O}$ beam on a graphite target with the FOOT experiment

This paper presents the measurements of the angular differential cross sections for the forward production of He, Li, Be, B, C and N nuclei in the fragmentation process of a 400$\text{MeV/nucleon}$ $^{16}\text{O}$ beam interacting with a graphite target. Due to the limited data available in this energy regime, these measurements of nuclear fragmentation cross sections are relevant to improve nuclear interaction models for Particle Therapy and space radioprotection applications. The data analyzed in this paper were collected during a measurement campaign carried out at the GSI Helmholtz Center for Heavy Ion Research facility in Darmstadt (Germany) by the FOOT collaboration. The results are compared with similar results found in the literature and with a previous FOOT measurement of the same process, using the same setup, from a previous pilot run performed at GSI. The pilot run data, however, had limited statistics and only allowed for the measurement of elemental fragmentation cross sections integrated in the setup acceptance. This data set, with statistics more than 100 times larger compared to the data collected in the previous run, enabled the measurement of angular differential cross sections, fully exploiting the granularity of the FOOT $\Delta \text{E}$-TOF system. Furthermore, a better comprehension of the FOOT apparatus allowed to improve the analysis techniques, leading to a reduction in the final systematic uncertainties.

nucl-ex↗

arXiv2024

The muon beam monitor for the FAMU experiment: design, simulation, test and operation

FAMU is an INFN-led muonic atom physics experiment based at the RIKEN-RAL muon facility at the ISIS Neutron and Muon Source (United Kingdom). The aim of FAMU is to measure the hyperfine splitting in muonic hydrogen to determine the value of the proton Zemach radius with accuracy better than 1%.The experiment has a scintillating-fibre hodoscope for beam monitoring and data normalisation. In order to carry out muon flux estimation, low-rate measurements were performed to extract the single-muon average deposited charge. Then, detector simulation in Geant4 and FLUKA allowed a thorough understanding of the single-muon response function, crucial for determining the muon flux. This work presents the design features of the FAMU beam monitor, along with the simulation and absolute calibration measurements in order to enable flux determination and enable data normalisation.

physics.ins-det↗

arXiv2023

Status of the detector setup for the FAMU experiment at RIKEN-RAL for a precision measurement of the Zemach radius of the proton in muonic hydrogen

The FAMU experiment at RIKEN-RAL is a muonic atom experiment with the aim to determine the Zemach radius of the proton by measuring the 1s hyperfine splitting in muonic hydrogen. The activity of the FAMU Collaboration in the years 2015-2023 enabled the final optimisation of the detector-target setup as well as the gas working condition in terms of temperature, pressure and gas mixture composition. The experiment has started its data taking in July 2023. The status of the detector setup for the 2023 experimental runs, for the beam characterisation and muonic X-ray detection in the 100-200 keV energy range, is presented and discussed.

physics.atom-ph↗

arXiv2020

Beam test characterisation of a Plastic Scintillator Prototype for the space-based cosmic ray experiment HERD

The High Energy cosmic-Radiation Detector (HERD) facility is planned to go onboard China's Space Station, planned to be operational starting in around 2025 for about 10 years. The main scientific objectives of HERD are the search for signals of dark matter annihilation products, precise cosmic electron/positron spectrum and measurements of anisotropy up to 10 TeV, precise cosmic ray spectrum and composition measurements up to the knee energy (1 PeV), and high energy $\gamma$-ray monitoring and survey. HERD consists of a 3D cubic crystals calorimeter (CALO) surrounded by microstrip silicon trackers (STKs) and scintillating fiber trackers (FIT) and by a Plastic Scintillator Detector (PSD) for $\gamma$-ray veto and ion charge measurement. A PSD prototype consisting of a scintillator tile readout by two arrays of SiPMs on opposite sides has been tested with proton and C ion beam at the CNAO (Centro Nazionale Adroterapia Oncologica) in Pavia, (Italy). Preliminary results on charge resolution are presented.

physics.ins-det↗

arXiv2014

First tests for an online treatment monitoring system with in-beam PET for proton therapy

PET imaging is a non-invasive technique for particle range verification in proton therapy. It is based on measuring the beta+ annihilations caused by nuclear interactions of the protons in the patient. In this work we present measurements for proton range verification in phantoms, performed at the CNAO particle therapy treatment center in Pavia, Italy, with our 10 x 10 cm^2 planar PET prototype DoPET. PMMA phantoms were irradiated with mono-energetic proton beams and clinical treatment plans, and PET data were acquired during and shortly after proton irradiation. We created 1-D profiles of the beta+ activity along the proton beam-axis, and evaluated the difference between the proximal rise and the distal fall-off position of the activity distribution. A good agreement with FLUKA Monte Carlo predictions was obtained. We also assessed the system response when the PMMA phantom contained an air cavity. The system was able to detect these cavities quickly after irradiation.

physics.med-ph↗