arXiv subjects

Mansu Kim

Publications and source records attributed to Mansu Kim.

5 recordsLinked to original sources

arXiv2026

ARNAI: Artifact Removal Network based on Autoencoding and Inpainting for Robust Spinal Image Segmentation and Measurement

Purpose: This study aims to develop an AI framework applicable for postoperative imaging for automated measurement of spinopelvic parameters on radiographs with robustness to the presence of spinal implants. Materials and Methods: We retrospectively reviewed lateral lumbar spine radiographs from two institutions (Internal: January 2017--December 2024; External: October 2021--September 2025). We developed the Restore, Segment, and Measure (RSM) framework, incorporating a novel Artifact Removal Network based on Autoencoding and Inpainting (ARNAI) to mitigate implant-related artifacts in postoperative radiographs. Segmentation and spinopelvic parameter (PT, LL, SS, SCA) measurement performance were assessed using Wilcoxon signed-rank tests and intraclass correlation coefficients. Results: When ARNAI was added to a recent Transformer-based segmentation model, FCBFormer, the mean DSC increased to 0.870 from 0.814, with marked gains at L3--L5 and smaller improvements at L1--L2. On 91 radiographs with implants, the mean L4--L5 segmental Cobb angle error decreased to 4.7 {\deg} from 15.6--16.2 {\deg}, an average error reduction of 70%. The ICC for L4--L5 segmental Cobb angle improved to 0.54 (Rater 1) and 0.59 (Rater 2) from 0.18, and ICCs for pelvic tilt, lumbar lordosis, and sacral slope all exceeded 0.70. The improvement in L4--L5 segmental Cobb angle error was statistically significant in the internal implant-containing cohort after correction for multiple comparisons. Conclusion: The proposed RSM framework improved automated spinopelvic parameter measurement in implant-containing postoperative radiographs. By mitigating implant-related artifacts, ARNAI improved segmentation and downstream measurement accuracy, with the greatest benefit observed for L4--L5 segmental Cobb angle estimation, where the mean error was reduced by approximately 70%.

cs.CV↗

arXiv2026

MolDA: Molecular Understanding and Generation via Large Language Diffusion Model

Large Language Models (LLMs) have significantly advanced molecular discovery, but existing multimodal molecular architectures fundamentally rely on autoregressive (AR) backbones. This strict left-to-right inductive bias is sub-optimal for generating chemically valid molecules, as it struggles to account for non-local global constraints (e.g., ring closures) and often accumulates structural errors during sequential generation. To address these limitations, we propose MolDA (Molecular language model with masked Diffusion with mAsking), a novel multimodal framework that replaces the conventional AR backbone with a discrete Large Language Diffusion Model. MolDA extracts comprehensive structural representations using a hybrid graph encoder, which captures both local and global topologies, and aligns them into the language token space via a Q-Former. Furthermore, we mathematically reformulate Molecular Structure Preference Optimization specifically for the masked diffusion. Through bidirectional iterative denoising, MolDA ensures global structural coherence, chemical validity, and robust reasoning across molecule generation, captioning, and property prediction.

cs.AI↗

arXiv2024

Brain-Aware Readout Layers in GNNs: Advancing Alzheimer's early Detection and Neuroimaging

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory and cognitive decline, affecting millions worldwide. Diagnosing AD is challenging due to its heterogeneous nature and variable progression. This study introduces a novel brain-aware readout layer (BA readout layer) for Graph Neural Networks (GNNs), designed to improve interpretability and predictive accuracy in neuroimaging for early AD diagnosis. By clustering brain regions based on functional connectivity and node embedding, this layer improves the GNN's capability to capture complex brain network characteristics. We analyzed neuroimaging data from 383 participants, including both cognitively normal and preclinical AD individuals, using T1-weighted MRI, resting-state fMRI, and FBB-PET to construct brain graphs. Our results show that GNNs with the BA readout layer significantly outperform traditional models in predicting the Preclinical Alzheimer's Cognitive Composite (PACC) score, demonstrating higher robustness and stability. The adaptive BA readout layer also offers enhanced interpretability by highlighting task-specific brain regions critical to cognitive functions impacted by AD. These findings suggest that our approach provides a valuable tool for the early diagnosis and analysis of Alzheimer's disease.

q-bio.NC↗

arXiv2024

Domain Aware Multi-Task Pretraining of 3D Swin Transformer for T1-weighted Brain MRI

The scarcity of annotated medical images is a major bottleneck in developing learning models for medical image analysis. Hence, recent studies have focused on pretrained models with fewer annotation requirements that can be fine-tuned for various downstream tasks. However, existing approaches are mainly 3D adaptions of 2D approaches ill-suited for 3D medical imaging data. Motivated by this gap, we propose novel domain-aware multi-task learning tasks to pretrain a 3D Swin Transformer for brain magnetic resonance imaging (MRI). Our method considers the domain knowledge in brain MRI by incorporating brain anatomy and morphology as well as standard pretext tasks adapted for 3D imaging in a contrastive learning setting. We pretrain our model using large-scale brain MRI data of 13,687 samples spanning several large-scale databases. Our method outperforms existing supervised and self-supervised methods in three downstream tasks of Alzheimer's disease classification, Parkinson's disease classification, and age prediction tasks. The ablation study of the proposed pretext tasks shows the effectiveness of our pretext tasks.

eess.IV↗

arXiv2024

CXR-LLAVA: a multimodal large language model for interpreting chest X-ray images

Purpose: This study aimed to develop an open-source multimodal large language model (CXR-LLAVA) for interpreting chest X-ray images (CXRs), leveraging recent advances in large language models (LLMs) to potentially replicate the image interpretation skills of human radiologists Materials and Methods: For training, we collected 592,580 publicly available CXRs, of which 374,881 had labels for certain radiographic abnormalities (Dataset 1) and 217,699 provided free-text radiology reports (Dataset 2). After pre-training a vision transformer with Dataset 1, we integrated it with an LLM influenced by the LLAVA network. Then, the model was fine-tuned, primarily using Dataset 2. The model's diagnostic performance for major pathological findings was evaluated, along with the acceptability of radiologic reports by human radiologists, to gauge its potential for autonomous reporting. Results: The model demonstrated impressive performance in test sets, achieving an average F1 score of 0.81 for six major pathological findings in the MIMIC internal test set and 0.62 for seven major pathological findings in the external test set. The model's F1 scores surpassed those of GPT-4-vision and Gemini-Pro-Vision in both test sets. In human radiologist evaluations of the external test set, the model achieved a 72.7% success rate in autonomous reporting, slightly below the 84.0% rate of ground truth reports. Conclusion: This study highlights the significant potential of multimodal LLMs for CXR interpretation, while also acknowledging the performance limitations. Despite these challenges, we believe that making our model open-source will catalyze further research, expanding its effectiveness and applicability in various clinical contexts. CXR-LLAVA is available at https://github.com/ECOFRI/CXR_LLAVA.

cs.CL↗