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Manu Jayadharan

Publications and source records attributed to Manu Jayadharan.

6 recordsLinked to original sources

Domain decomposition methods for the Stokes-Biot model of fluid-poroelastic structure interaction

We develop a non-overlapping domain decomposition method for the numerical solution of the Stokes-Biot model of fluid-poroelastic structure interaction in a mixed form. The model is based on a velocity-pressure formulation for the free fluid, a three-field stress-displacement-rotation formulation with weakly symmetric stress for the solid deformation, and a Darcy velocity-pressure formulation for the fluid in the poroelastic media. Mass conservation, balance of stress, and the Beavers-Joseph-Saffman slip with friction condition are imposed on the interface. The interface conditions are incorporated through Lagrange multipliers modeling the traces of the displacement and the Darcy pressure. The system is discretized using stable mixed finite element spaces for Stokes flow, elasticity, and Darcy flow. The domain is decomposed into a union of subdomains of either Stokes or Biot type with three types of interfaces: Stokes-Stokes, Biot-Biot, and Stokes-Biot. On the Stokes-Stokes interfaces, a normal stress Lagrange multiplier is introduced to impose weakly velocity continuity, while the Biot-Biot and Stokes-Biot interfaces are equipped with displacement and pressure Lagrange multipliers to impose weakly continuity of normal stress and normal velocity, respectively. The global problem is reduced via Schur complement to an interface problem for the Lagrange multipliers, which is solved by GMRES. Each iteration requires the solution of local Stokes or Biot problems, which can be performed in parallel. We show that the resulting interface operator is positive definite and analyze the convergence of the GMRES iteration through fields-of-value analysis. Numerical experiments are presented to illustrate the performance of the method.

math.NA

Ill-Conditioning in Dictionary-Based Dynamic-Equation Learning: A Systems Biology Case Study

Data-driven discovery of governing equations from time-series data provides a powerful framework for understanding complex biological systems. Library-based approaches that use sparse regression over candidate functions have shown considerable promise, but they face a critical challenge when candidate functions become strongly correlated: numerical ill-conditioning. Poor or restricted sampling, together with particular choices of candidate libraries, can produce strong multicollinearity and numerical instability. In such cases, measurement noise may lead to widely different recovered models, obscuring the true underlying dynamics and hindering accurate system identification. Although sparse regularization promotes parsimonious solutions and can partially mitigate conditioning issues, strong correlations may persist, regularization may bias the recovered models, and the regression problem may remain highly sensitive to small perturbations in the data. We present a systematic analysis of how ill-conditioning affects sparse identification of biological dynamics using benchmark models from systems biology. We show that combinations involving as few as two or three terms can already exhibit strong multicollinearity and extremely large condition numbers. We further show that orthogonal polynomial bases do not consistently resolve ill-conditioning and can perform worse than monomial libraries when the data distribution deviates from the weight function associated with the orthogonal basis. Finally, we demonstrate that when data are sampled from distributions aligned with the appropriate weight functions corresponding to the orthogonal basis, numerical conditioning improves, and orthogonal polynomial bases can yield improved model recovery accuracy across two baseline models.

q-bio.QM

SODAs: Sparse Optimization for the Discovery of Differential and Algebraic Equations

Differential-algebraic equations (DAEs) integrate ordinary differential equations (ODEs) with algebraic constraints, providing a fundamental framework for developing models of dynamical systems characterized by timescale separation, conservation laws, and physical constraints. While sparse optimization has revolutionized model development by allowing data-driven discovery of parsimonious models from a library of possible equations, existing approaches for dynamical systems assume DAEs can be reduced to ODEs by eliminating variables before model discovery. This assumption limits the applicability of such methods for DAE systems with unknown constraints and time scales. We introduce Sparse Optimization for Differential-Algebraic Systems (SODAs), a data-driven method for the identification of DAEs in their explicit form. By discovering the algebraic and dynamic components sequentially without prior identification of the algebraic variables, this approach leads to a sequence of convex optimization problems. It has the advantage of discovering interpretable models that preserve the structure of the underlying physical system. To this end, SODAs improves numerical stability when handling high correlations between library terms, caused by near-perfect algebraic relationships, by iteratively refining the conditioning of the candidate library. We demonstrate the performance of our method on biological, mechanical, and electrical systems, showcasing its robustness to noise in both simulated time series and real-time experimental data.

math.DS

Multiscale mortar mixed finite element methods for the Biot system of poroelasticity

We develop a mixed finite element domain decomposition method on non-matching grids for the Biot system of poroelasticity. A displacement-pressure vector mortar function is introduced on the interfaces and utilized as a Lagrange multiplier to impose weakly continuity of normal stress and normal velocity. The mortar space can be on a coarse scale, resulting in a multiscale approximation. We establish existence, uniqueness, stability, and error estimates for the semidiscrete continuous-in-time formulation under a suitable condition on the richness of the mortar space. We further consider a fully-discrete method based on the backward Euler time discretization and show that the solution of the algebraic system at each time step can be reduced to solving a positive definite interface problem for the composite mortar variable. A multiscale stress-flux basis is constructed, which makes the number of subdomain solves independent of the number of iterations required for the interface problem, as well as the number of time steps. We present numerical experiments verifying the theoretical results and illustrating the multiscale capabilities of the method for a heterogeneous benchmark problem.

math.NA

A space-time multiscale mortar mixed finite element method for parabolic equations

We develop a space-time mortar mixed finite element method for parabolic problems. The domain is decomposed into a union of subdomains discretized with non-matching spatial grids and asynchronous time steps. The method is based on a space-time variational formulation that couples mixed finite elements in space with discontinuous Galerkin in time. Continuity of flux (mass conservation) across space-time interfaces is imposed via a coarse-scale space-time mortar variable that approximates the primary variable. Uniqueness, existence, and stability, as well as a priori error estimates for the spatial and temporal errors are established. A space-time non-overlapping domain decomposition method is developed that reduces the global problem to a space-time coarse-scale mortar interface problem. Each interface iteration involves solving in parallel space-time subdomain problems. The spectral properties of the interface operator and the convergence of the interface iteration are analyzed. Numerical experiments are provided that illustrate the theoretical results and the flexibility of the method for modeling problems with features that are localized in space and time.

math.NA

Domain decomposition and partitioning methods for mixed finite element discretizations of the Biot system of poroelasticity

We develop non-overlapping domain decomposition methods for the Biot system of poroelasticity in a mixed form. The solid deformation is modeled with a mixed three-field formulation with weak stress symmetry. The fluid flow is modeled with a mixed Darcy formulation. We introduce displacement and pressure Lagrange multipliers on the subdomain interfaces to impose weakly continuity of normal stress and normal velocity, respectively. The global problem is reduced to an interface problem for the Lagrange multipliers, which is solved by a Krylov space iterative method. We study both monolithic and split methods. In the monolithic method, a coupled displacement-pressure interface problem is solved, with each iteration requiring the solution of local Biot problems. We show that the resulting interface operator is positive definite and analyze the convergence of the iteration. We further study drained split and fixed stress Biot splittings, in which case we solve separate interface problems requiring elasticity and Darcy solves. We analyze the stability of the split formulations. Numerical experiments are presented to illustrate the convergence of the domain decomposition methods and compare their accuracy and efficiency.

math.NA