arXiv subjects

Manuel Cáceres

Publications and source records attributed to Manuel Cáceres.

15 recordsLinked to original sources

arXiv2026

Maximum Coverage $k$-Antichains and Chains: A Greedy Approach

Given an acyclic digraph $G = (V,E)$ and a positive integer $k$, the problem of Maximum Coverage $k$-Antichains (resp. Chains) denoted as MA-$k$ (resp. MC-$k$) asks to find $k$ sets of pairwise unreachable vertices, known as antichains (resp. $k$ subsequences of paths, known as chains), maximizing the number $α_k$ (resp. $β_k$) of vertices covered by these antichains (resp. chains). While MC-$k$ was solved in almost optimal $|E|^{1+o(1)}$ time~[Kogan and Parter, ICALP'22], the fastest algorithms for MA-$k$ are a $(k|E|)^{1+o(1)}$-time solution and a $|E|^{1+o(1)}$-time $1/2$ approximation~[Kogan and Parter, ESA'24]. We obtain the following for MA-$k$: - An algorithm running in $|E|^{1+o(1)}$ time, and an algorithm running in parameterized near-linear $\tilde{O}(α_k |E|)$ time. Our algorithms are simple solutions exploiting a paths-based proof of the Greene-Kleitman theorems leveraged by the greedy algorithm for set cover as well as recent advances in fast algorithms for flows and shortest paths. - An approximation algorithm running in parameterized linear time $O(α_1^2|V| + (α_1+k)|E|)$ with approximation ratio of $(1-1/e) > 0.63 > 1/2$, beating the state-of-the-art $1/2$ approximation. Our solution uses greedy for antichains and a simple strategy to amortize the cost of computing consecutive maximum antichains. We complement these results with two examples (one for chains and one for antichains) showing that, for every $k \ge 2$, greedy misses the tight $1/e$ portion of the optimal coverage for chains, and a $1/4$ portion for antichains. We also show that greedy is a $Ω(\log{|V|})$ factor away from minimality when required to cover all vertices: previously unknown for sets of chains or antichains.

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arXiv2026

Shifting is Optimal under Gap-ETH: A Lower Bound Framework for Geometric Approximation Schemes

The shifting technique of Hochbaum and Maass [J.ACM'85] produces PTASes with the fastest known running times $n^{O(1/\varepsilon^{d-1})}$ for several $d$-dimensional geometric problems. However, it is only known, due to Marx [FOCS'07], that these algorithms are indeed optimal for dimension $d=2$. We show that these running times are optimal under Gap-ETH for every constant dimension. More precisely, we develop a framework that enables us to prove the conditional optimality of the shifting algorithms for several problems on unit ball graphs, such as maximum independent set, maximum induced forest, and others, as well as for the problem of piercing unit balls. Our framework is built using the cube wiring theorem of De Berg et al. [SICOMP'20] and the reduction steps of Marx and Sidiropoulos [SoCG'14] to create a convenient maximization version of geometric CSP that can be used as a basis for reductions.

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arXiv2026

Identifying bubble-like subgraphs in linear-time via a unified SPQR-tree framework

A fundamental algorithmic problem in computational biology is to find all subgraphs of a given type (superbubbles, snarls, and ultrabubbles) in a directed or bidirected input graph. These correspond to regions of genetic variation and are useful in analyzing collections of genomes. We present the first linear-time algorithms for identifying all snarls and all ultrabubbles, resolving problems open since 2018. The algorithm for snarls relies on a new linear-size representation of all snarls with respect to the number of vertices in the graph. We employ the well-known SPQR-tree decomposition, which encodes all 2-separators of a biconnected graph. After several dynamic-programming-style traversals of this tree, we maintain key properties (such as acyclicity) that allow us to decide whether a given 2-separator defines a subgraph to be reported. A crucial ingredient for linear-time complexity is that acyclicity of linearly many subgraphs can be tested simultaneously via the problem of computing all arcs in a directed graph whose removal renders it acyclic (so-called feedback arcs). As such, we prove a fundamental result for bidirected graphs, that may be of independent interest: all feedback arcs can be computed in linear time for tipless bidirected graphs, while in general this is at least as hard as matrix multiplication, assuming the k-Clique Conjecture. Our results form a unified framework that also yields a completely different linear-time algorithm for finding all superbubbles. Although some of the results are technically involved, the underlying ideas are conceptually simple, and may extend to other bubble-like subgraphs. More broadly, our work contributes to the theoretical foundations of computational biology and advances a growing line of research that uses SPQR-tree decompositions as a general tool for designing efficient algorithms, beyond their traditional role in graph drawing.

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arXiv2025

Identifying all snarls and superbubbles in linear-time, via a unified SPQR-tree framework

Snarls and superbubbles are fundamental pangenome decompositions capturing variant sites. These bubble-like structures underpin key tasks in computational pangenomics, including structural-variant genotyping, distance indexing, haplotype sampling, and variant annotation. Snarls can be quadratically-many in the size of the graph, and since their introduction in 2018 with the vg toolkit, there has been no work on identifying all snarls in linear time. Moreover, while it is known how to find superbubbles in linear time, this result is a highly specialized solution only achieved after a long series of papers. We present the first algorithm identifying all snarls in linear time. This is based on a new representation of all snarls, of size linear in the input graph size, and which can be computed in linear time. Our algorithm is based on a unified framework that also provides a new linear-time algorithm for finding superbubbles. An observation behind our results is that all such structures are separated from the rest of the graph by two vertices (except for cases which are trivially computable), i.e. their endpoints are a 2-separator of the underlying undirected graph. Based on this, we employ the well-known SPQR tree decomposition, which encodes all 2-separators, to guide a traversal that finds the bubble-like structures efficiently. We implemented our algorithms in C++ (available at https://github.com/algbio/BubbleFinder) and evaluated them on various pangenomic datasets. Our algorithms outcompete or they are on the same level of existing methods. For snarls, we are up to two times faster than vg, while identifying all snarls. When computing superbubbles, we are up to 50 times faster than BubbleGun. Our SPQR tree framework provides a unifying perspective on bubble-like structures in pangenomics, together with a template for finding other bubble-like structures efficiently.

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arXiv2025

Practical colinear chaining on sequences revisited

Colinear chaining is a classical heuristic for sequence alignment and is widely used in modern practical aligners. Jain et al. (J. Comput. Biol. 2022) proposed an $O(n \log^3 n)$ time algorithm to chain a set of $n$ anchors so that the chaining cost matches the edit distance of the input sequences, when anchors are all the maximal exact matches. Moreover, assuming a uniform and sparse distribution of anchors, they provided a practical solution ($\mathtt{ChainX}$) working in $O(n \cdot \mathrm{SOL} + n \log n)$ average-case time, where $\mathrm{SOL}$ is the cost of the output chain. This practical solution is not guaranteed to be optimal: we study the failing cases, introduce the anchor diagonal distance, and find and implement an optimal algorithm working in $O(n \cdot \mathrm{OPT} + n \log n)$ average-case time, where $\mathrm{OPT}$ $\le \mathrm{SOL}$ is the optimal chaining cost. We validate the results by Jain et al., show that $\mathtt{ChainX}$ can be suboptimal with a realistic long read dataset, and show minimal computational slowdown for our solution.

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arXiv2023

Sorting Finite Automata via Partition Refinement

Wheeler nondeterministic finite automata (WNFAs) were introduced as a generalization of prefix sorting from strings to labeled graphs. WNFAs admit optimal solutions to classic hard problems on labeled graphs and languages. The problem of deciding whether a given NFA is Wheeler is known to be NP-complete. Recently, however, Alanko et al. showed how to side-step this complexity by switching to preorders: letting $Q$ be the set of states, $E$ the set of transitions, $|Q|=n$, and $|E|=m$, they provided a $O(mn^2)$-time algorithm computing a totally-ordered partition of the WNFA's states such that (1) equivalent states recognize the same regular language, and (2) the order of non-equivalent states is consistent with any Wheeler order, when one exists. Then, the output is a preorder of the states as useful for pattern matching as standard Wheeler orders. Further research generalized these concepts to arbitrary NFAs by introducing co-lex partial preorders: any NFA admits a partial preorder of its states reflecting the co-lex order of their accepted strings; the smaller the width of such preorder is, the faster regular expression matching queries can be performed. To date, the fastest algorithm for computing the smallest-width partial preorder on NFAs runs in $O(m^2+n^{5/2})$ time, while on DFAs the same can be done in $O(\min(n^2\log n,mn))$ time. In this paper, we provide much more efficient solutions to the problem above. Our results are achieved by extending a classic algorithm for the relational coarsest partition refinement problem to work with ordered partitions. Specifically, we provide a $O(m\log n)$-time algorithm computing a co-lex total preorder when the input is a WNFA, and an algorithm with the same time complexity computing the smallest-width co-lex partial order of any DFA. Also, we present implementations of our algorithms and show that they are very efficient in practice.

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arXiv2023

Minimum Path Cover: The Power of Parameterization

Computing a minimum path cover (MPC) of a directed acyclic graph (DAG) is a fundamental problem with a myriad of applications, including reachability. Although it is known how to solve the problem by a simple reduction to minimum flow, recent theoretical advances exploit this idea to obtain algorithms parameterized by the number of paths of an MPC, known as the width. These results obtain fast [Mäkinen et al., TALG] and even linear time [Cáceres et al., SODA 2022] algorithms in the small-width regime. In this paper, we present the first publicly available high-performance implementation of state-of-the-art MPC algorithms, including the parameterized approaches. Our experiments on random DAGs show that parameterized algorithms are orders-of-magnitude faster on dense graphs. Additionally, we present new pre-processing heuristics based on transitive edge sparsification. We show that our heuristics improve MPC-solvers by orders-of-magnitude.

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arXiv2023

Chaining of Maximal Exact Matches in Graphs

We show how to chain maximal exact matches (MEMs) between a query string $Q$ and a labeled directed acyclic graph (DAG) $G=(V,E)$ to solve the longest common subsequence (LCS) problem between $Q$ and $G$. We obtain our result via a new symmetric formulation of chaining in DAGs that we solve in $O(m+n+k^2|V| + |E| + kN\log N)$ time, where $m=|Q|$, $n$ is the total length of node labels, $k$ is the minimum number of paths covering the nodes of $G$ and $N$ is the number of MEMs between $Q$ and node labels, which we show encode full MEMs.

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arXiv2023

Finding Maximal Exact Matches in Graphs

We study the problem of finding maximal exact matches (MEMs) between a query string $Q$ and a labeled graph $G$. MEMs are an important class of seeds, often used in seed-chain-extend type of practical alignment methods because of their strong connections to classical metrics. A principled way to speed up chaining is to limit the number of MEMs by considering only MEMs of length at least $κ$ ($κ$-MEMs). However, on arbitrary input graphs, the problem of finding MEMs cannot be solved in truly sub-quadratic time under SETH (Equi et al., ICALP 2019) even on acyclic graphs. In this paper we show an $O(n\cdot L \cdot d^{L-1} + m + M_{κ,L})$-time algorithm finding all $κ$-MEMs between $Q$ and $G$ spanning exactly $L$ nodes in $G$, where $n$ is the total length of node labels, $d$ is the maximum degree of a node in $G$, $m = |Q|$, and $M_{κ,L}$ is the number of output MEMs. We use this algorithm to develop a $κ$-MEM finding solution on indexable Elastic Founder Graphs (Equi et al., Algorithmica 2022) running in time $O(nH^2 + m + M_κ)$, where $H$ is the maximum number of nodes in a block, and $M_κ$ is the total number of $κ$-MEMs. Our results generalize to the analysis of multiple query strings (MEMs between $G$ and any of the strings). Additionally, we provide some preliminary experimental results showing that the number of graph MEMs is an order of magnitude smaller than the number of string MEMs of the corresponding concatenated collection.

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arXiv2023

Width Helps and Hinders Splitting Flows

Minimum flow decomposition (MFD) is the NP-hard problem of finding a smallest decomposition of a network flow/circulation $X$ on a directed graph $G$ into weighted source-to-sink paths whose superposition equals $X$. We show that, for acyclic graphs, considering the \emph{width} of the graph (the minimum number of paths needed to cover all of its edges) yields advances in our understanding of its approximability. For the version of the problem that uses only non-negative weights, we identify and characterise a new class of \emph{width-stable} graphs, for which a popular heuristic is a \gwsimple-approximation ($|X|$ being the total flow of $X$), and strengthen its worst-case approximation ratio from $Ω(\sqrt{m})$ to $Ω(m / \log m)$ for sparse graphs, where $m$ is the number of edges in the graph. We also study a new problem on graphs with cycles, Minimum Cost Circulation Decomposition (MCCD), and show that it generalises MFD through a simple reduction. For the version allowing also negative weights, we give a $(\lceil \log \Vert X \Vert \rceil +1)$-approximation ($\Vert X \Vert$ being the maximum absolute value of $X$ on any edge) using a power-of-two approach, combined with parity fixing arguments and a decomposition of unitary circulations ($\Vert X \Vert \leq 1$), using a generalised notion of width for this problem. Finally, we disprove a conjecture about the linear independence of minimum (non-negative) flow decompositions posed by Kloster et al. [ALENEX 2018], but show that its useful implication (polynomial-time assignments of weights to a given set of paths to decompose a flow) holds for the negative version.

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arXiv2022

Safety and Completeness in Flow Decompositions for RNA Assembly

Decomposing a network flow into weighted paths has numerous applications. Some applications require any decomposition that is optimal w.r.t. some property such as number of paths, robustness, or length. Many bioinformatic applications require a specific decomposition where the paths correspond to some underlying data that generated the flow. For real inputs, no optimization criteria guarantees to uniquely identify the correct decomposition. Therefore, we propose to report safe paths, i.e., subpaths of at least one path in every flow decomposition. Ma, Zheng, and Kingsford [WABI 2020] addressed the existence of multiple optimal solutions in a probabilistic framework, i.e., non-identifiability. Later [RECOMB 2021], they gave a quadratic-time algorithm based on a global criterion for solving a problem called AND-Quant, which generalizes the problem of reporting whether a given path is safe. We give the first local characterization of safe paths for flow decompositions in directed acyclic graphs (DAGs), leading to a practical algorithm for finding the complete set of safe paths. We evaluated our algorithms against the trivial safe algorithms (unitigs, extended unitigs) and the popularly used heuristic (greedy-width) for flow decomposition on RNA transcripts datasets. Despite maintaining perfect precision our algorithm reports significantly higher coverage ($\approx 50\%$ more) than trivial safe algorithms. The greedy-width algorithm though reporting a better coverage, has significantly lower precision on complex graphs. Overall, our algorithm outperforms (by $\approx 20\%$) greedy-width on a unified metric (F-Score) when the dataset has significant number of complex graphs. Moreover, it has superior time ($3-5\times$) and space efficiency ($1.2-2.2\times$), resulting in a better and more practical approach for bioinformatics applications of flow decomposition.

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arXiv2021

Sparsifying, Shrinking and Splicing for Minimum Path Cover in Parameterized Linear Time

A minimum path cover (MPC) of a directed acyclic graph (DAG) $G = (V,E)$ is a minimum-size set of paths that together cover all the vertices of the DAG. Computing an MPC is a basic polynomial problem, dating back to Dilworth's and Fulkerson's results in the 1950s. Since the size $k$ of an MPC (also known as the width) can be small in practical applications, research has also studied algorithms whose complexity is parameterized on $k$. We obtain two new MPC parameterized algorithms for DAGs running in time $O(k^2|V|\log{|V|} + |E|)$ and $O(k^3|V| + |E|)$. We also obtain a parallel algorithm running in $O(k^2|V| + |E|)$ parallel steps and using $O(\log{|V|})$ processors (in the PRAM model). Our latter two algorithms are the first solving the problem in parameterized linear time. Finally, we present an algorithm running in time $O(k^2|V|)$ for transforming any MPC to another MPC using less than $2|V|$ distinct edges, which we prove to be asymptotically tight. As such, we also obtain edge sparsification algorithms preserving the width of the DAG with the same running time as our MPC algorithms. At the core of all our algorithms we interleave the usage of three techniques: transitive sparsification, shrinking of a path cover, and the splicing of a set of paths along a given path.

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arXiv2021

A linear-time parameterized algorithm for computing the width of a DAG

The width $k$ of a directed acyclic graph (DAG) $G = (V, E)$ equals the largest number of pairwise non-reachable vertices. Computing the width dates back to Dilworth's and Fulkerson's results in the 1950s, and is doable in quadratic time in the worst case. Since $k$ can be small in practical applications, research has also studied algorithms whose complexity is parameterized on $k$. Despite these efforts, it is still open whether there exists a linear-time $O(f(k)(|V| + |E|))$ parameterized algorithm computing the width. We answer this question affirmatively by presenting an $O(k^24^k|V| + k2^k|E|)$ time algorithm, based on a new notion of frontier antichains. As we process the vertices in a topological order, all frontier antichains can be maintained with the help of several combinatorial properties, paying only $f(k)$ along the way. The fact that the width can be computed by a single $f(k)$-sweep of the DAG is a new surprising insight into this classical problem. Our algorithm also allows deciding whether the DAG has width at most $w$ in time $O(f(\min(w,k))(|V|+|E|))$.

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arXiv2020

Fast Indexes for Gapped Pattern Matching

We describe indexes for searching large data sets for variable-length-gapped (VLG) patterns. VLG patterns are composed of two or more subpatterns, between each adjacent pair of which is a gap-constraint specifying upper and lower bounds on the distance allowed between subpatterns. VLG patterns have numerous applications in computational biology (motif search), information retrieval (e.g., for language models, snippet generation, machine translation) and capture a useful subclass of the regular expressions commonly used in practice for searching source code. Our best approach provides search speeds several times faster than prior art across a broad range of patterns and texts.

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arXiv2019

Faster Repetition-Aware Compressed Suffix Trees based on Block Trees

Suffix trees are a fundamental data structure in stringology, but their space usage, though linear, is an important problem for its applications. We design and implement a new compressed suffix tree targeted to highly repetitive texts, such as large genomic collections of the same species. Our suffix tree tree builds on Block Trees, a recent Lempel-Ziv-bounded data structure that captures the repetitiveness of its input. We use Block Trees to compress the topology of the suffix tree, and augment the Block Tree nodes with data that speeds up suffix tree navigation. Our compressed suffix tree is slightly larger than previous repetition-aware suffix trees based on grammars, but outperforms them in time, often by orders of magnitude. The component that represents the tree topology achieves a speed comparable to that of general-purpose compressed trees, while using 2.3--10 times less space, and might be of interest in other scenarios.

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