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Manuel Lafond

Publications and source records attributed to Manuel Lafond.

At least 37 records · Page 2Linked to original sources

The Longest Subsequence-Repeated Subsequence Problem

Motivated by computing duplication patterns in sequences, a new fundamental problem called the longest subsequence-repeated subsequence (LSRS) is proposed. Given a sequence $S$ of length $n$, a letter-repeated subsequence is a subsequence of $S$ in the form of $x_1^{d_1}x_2^{d_2}\cdots x_k^{d_k}$ with $x_i$ a subsequence of $S$, $x_j\neq x_{j+1}$ and $d_i\geq 2$ for all $i$ in $[k]$ and $j$ in $[k-1]$. We first present an $O(n^6)$ time algorithm to compute the longest cubic subsequences of all the $O(n^2)$ substrings of $S$, improving the trivial $O(n^7)$ bound. Then, an $O(n^6)$ time algorithm for computing the longest subsequence-repeated subsequence (LSRS) of $S$ is obtained. Finally we focus on two variants of this problem. We first consider the constrained version when $Σ$ is unbounded, each letter appears in $S$ at most $d$ times and all the letters in $Σ$ must appear in the solution. We show that the problem is NP-hard for $d=4$, via a reduction from a special version of SAT (which is obtained from 3-COLORING). We then show that when each letter appears in $S$ at most $d=3$ times, then the problem is solvable in $O(n^5)$ time.

cs.DS↗

Relative Timing Information and Orthology in Evolutionary Scenarios

Evolutionary scenarios describing the evolution of a family of genes within a collection of species comprise the mapping of the vertices of a gene tree $T$ to vertices and edges of a species tree $S$. The relative timing of the last common ancestors of two extant genes (leaves of $T$) and the last common ancestors of the two species (leaves of $S$) in which they reside is indicative of horizontal gene transfers (HGT) and ancient duplications. Orthologous gene pairs, on the other hand, require that their last common ancestors coincides with a corresponding speciation event. The relative timing information of gene and species divergences is captured by three colored graphs that have the extant genes as vertices and the species in which the genes are found as vertex colors: the equal-divergence-time (EDT) graph, the later-divergence-time (LDT) graph and the prior-divergence-time (PDT) graph, which together form an edge partition of the complete graph. Here we give a complete characterization in terms of informative and forbidden triples that can be read off the three graphs and provide a polynomial time algorithm for constructing an evolutionary scenario that explains the graphs, provided such a scenario exists. We show that every EDT graph is perfect. While the information about LDT and PDT graphs is necessary to recognize EDT graphs in polynomial-time for general scenarios, this extra information can be dropped in the HGT-free case. However, recognition of EDT graphs without knowledge of putative LDT and PDT graphs is NP-complete for general scenarios. In contrast, PDT graphs can be recognized in polynomial-time. We finally connect the EDT graph to the alternative definitions of orthology that have been proposed for scenarios with horizontal gene transfer. With one exception, the corresponding graphs are shown to be colored cographs.

q-bio.PE↗

Parameterized Complexity of Domination Problems Using Restricted Modular Partitions

For a graph class $\mathcal{G}$, we define the $\mathcal{G}$-modular cardinality of a graph $G$ as the minimum size of a vertex partition of $G$ into modules that each induces a graph in $\mathcal{G}$. This generalizes other module-based graph parameters such as neighborhood diversity and iterated type partition. Moreover, if $\mathcal{G}$ has bounded modular-width, the W[1]-hardness of a problem in $\mathcal{G}$-modular cardinality implies hardness on modular-width, clique-width, and other related parameters. On the other hand, fixed-parameter tractable (FPT) algorithms in $\mathcal{G}$-modular cardinality may provide new ideas for algorithms using such parameters. Several FPT algorithms based on modular partitions compute a solution table in each module, then combine each table into a global solution. This works well when each table has a succinct representation, but as we argue, when no such representation exists, the problem is typically W[1]-hard. We illustrate these ideas on the generic $(α, β)$-domination problem, which asks for a set of vertices that contains at least a fraction $α$ of the adjacent vertices of each unchosen vertex, plus some (possibly negative) amount $β$. This generalizes known domination problems such as Bounded Degree Deletion, $k$-Domination, and $α$-Domination. We show that for graph classes $\mathcal{G}$ that require arbitrarily large solution tables, these problems are W[1]-hard in the $\mathcal{G}$-modular cardinality, whereas they are fixed-parameter tractable when they admit succinct solution tables. This leads to several new positive and negative results for many domination problems parameterized by known and novel structural graph parameters such as clique-width, modular-width, and $cluster$-modular cardinality.

cs.CC↗

An FTP Algorithm for Temporal Graph Untangling

Several classical combinatorial problems have been considered and analysed on temporal graphs. Recently, a variant of Vertex Cover on temporal graphs, called MinTimelineCover, has been introduced to summarize timeline activities in social networks. The problem asks to cover every temporal edge while minimizing the total span of the vertices (where the span of a vertex is the length of the timestamp interval it must remain active in, minus one). While the problem has been shown to be NP-hard even in very restricted cases, its parameterized complexity has not been fully understood. The problem is known to be in FPT under the span parameter only for graphs with two timestamps, but the parameterized complexity for the general case is open. We settle this open problem by giving an FPT algorithm that is based on a combination of iterative compression and a reduction to the Digraph Pair Cut problem, a powerful problem that has received significant attention recently.

cs.DS↗

Preprocessing Complexity for Some Graph Problems Parameterized by Structural Parameters

Structural graph parameters play an important role in parameterized complexity, including in kernelization. Notably, vertex cover, neighborhood diversity, twin-cover, and modular-width have been studied extensively in the last few years. However, there are many fundamental problems whose preprocessing complexity is not fully understood under these parameters. Indeed, the existence of polynomial kernels or polynomial Turing kernels for famous problems such as Clique, Chromatic Number, and Steiner Tree has only been established for a subset of structural parameters. In this work, we use several techniques to obtain a complete preprocessing complexity landscape for over a dozen of fundamental algorithmic problems.

cs.CC↗

A lightweight semi-centralized strategy for the massive parallelization of branching algorithms

Several NP-hard problems are solved exactly using exponential-time branching strategies, whether it be branch-and-bound algorithms, or bounded search trees in fixed-parameter algorithms. The number of tractable instances that can be handled by sequential algorithms is usually small, whereas massive parallelization has been shown to significantly increase the space of instances that can be solved exactly. However, previous centralized approaches require too much communication to be efficient, whereas decentralized approaches are more efficient but have difficulty keeping track of the global state of the exploration. In this work, we propose to revisit the centralized paradigm while avoiding previous bottlenecks. In our strategy, the center has lightweight responsibilities, requires only a few bits for every communication, but is still able to keep track of the progress of every worker. In particular, the center never holds any task but is able to guarantee that a process with no work always receives the highest priority task globally. Our strategy was implemented in a generic C++ library called GemPBA, which allows a programmer to convert a sequential branching algorithm into a parallel version by changing only a few lines of code. An experimental case study on the vertex cover problem demonstrates that some of the toughest instances from the DIMACS challenge graphs that would take months to solve sequentially can be handled within two hours with our approach.

cs.DC↗

Finding agreement cherry-reduced subnetworks in level-1 networks

Phylogenetic networks are increasingly being considered as better suited to represent the complexity of the evolutionary relationships between species. One class of phylogenetic networks that has received a lot of attention recently is the class of orchard networks, which is composed of networks that can be reduced to a single leaf using cherry reductions. Cherry reductions, also called cherry-picking operations, remove either a leaf of a simple cherry (sibling leaves sharing a parent) or a reticulate edge of a reticulate cherry (two leaves whose parents are connected by a reticulate edge). In this paper, we present a fixed-parameter tractable algorithm to solve the problem of finding a maximum agreement cherry-reduced subnetwork (MACRS) between two rooted binary level-1 networks. This is first exact algorithm proposed to solve the MACRS problem. As proven in earlier work, there is a direct relationship between finding an MACRS and calculating a distance based on cherry operations. As a result, the proposed algorithm also provides a distance that can be used for the comparison of level-1 networks.

cs.DS↗

The Two-Squirrel Problem and Its Relatives

In this paper, we start with a variation of the star cover problem called the Two-Squirrel problem. Given a set $P$ of $2n$ points in the plane, and two sites $c_1$ and $c_2$, compute two $n$-stars $S_1$ and $S_2$ centered at $c_1$ and $c_2$ respectively such that the maximum weight of $S_1$ and $S_2$ is minimized. This problem is strongly NP-hard by a reduction from Equal-size Set-Partition with Rationals. Then we consider two variations of the Two-Squirrel problem, namely the Two-MST and Two-TSP problem, which are both NP-hard. The NP-hardness for the latter is obvious while the former needs a non-trivial reduction from Equal-size Set-Partition with Rationals. In terms of approximation algorithms, for Two-MST and Two-TSP we give factor 3.6402 and $4+\varepsilon$ approximations respectively. Finally, we also show some interesting polynomial-time solvable cases for Two-MST.

cs.CG↗

Further results on Hendry's Conjecture

Recently, a conjecture due to Hendry was disproved which stated that every Hamiltonian chordal graph is cycle extendible. Here we further explore the conjecture, showing that it fails to hold even when a number of extra conditions are imposed. In particular, we show that Hendry's Conjecture fails for strongly chordal graphs, graphs with high connectivity, and if we relax the definition of "cycle extendible" considerably. We also consider the original conjecture from a subtree intersection model point of view, showing that a result of Abuieda et al is nearly best possible.

math.CO↗

How brokers can optimally plot against traders

Traders buy and sell financial instruments in hopes of making profit, and brokers are responsible for the transaction. There are several hypotheses and conspiracy theories arguing that in some situations, brokers want their traders to lose money. For instance, a broker may want to protect the positions of a privileged customer. Another example is that some brokers take positions opposite to their traders', in which case they make money whenever their traders lose money. These are reasons for which brokers might manipulate prices in order to maximize the losses of their traders. In this paper, our goal is to perform this shady task optimally -- or at least to check whether this can actually be done algorithmically. Assuming total control over the price of an asset (ignoring the usual aspects of finance such as market conditions, external influence or stochasticity), we show how in quadratic time, given a set of trades specified by a stop-loss and a take-profit price, a broker can find a maximum loss price movement. We also look at an online trade model where broker and trader exchange turns, each trying to make a profit. We show in which condition either side can make a profit, and that the best option for the trader is to never trade.

q-fin.TR↗

Consistency of orthology and paralogy constraints in the presence of gene transfers

Orthology and paralogy relations are often inferred by methods based on gene similarity, which usually yield a graph depicting the relationships between gene pairs. Such relation graphs are known to frequently contain errors, as they cannot be explained via a gene tree that both contains the depicted orthologs/paralogs, and that is consistent with a species tree $S$. This idea of detecting errors through inconsistency with a species tree has mostly been studied in the presence of speciation and duplication events only. In this work, we ask: could the given set of relations be consistent if we allow lateral gene transfers in the evolutionary model? We formalize this question and provide a variety of algorithmic results regarding the underlying problems. Namely, we show that deciding if a relation graph $R$ is consistent with a given species network $N$ is NP-hard, and that it is W[1]-hard under the parameter "minimum number of transfers". However, we present an FPT algorithm based on the degree of the $DS$-tree associated with $R$. We also study analogous problems in the case that the transfer highways on a species tree are unknown.

cs.DS↗

Recognizing k-leaf powers in polynomial time, for constant k

A graph $G$ is a $k$-leaf power if there exists a tree $T$ whose leaf set is $V(G)$, and such that $uv \in E(G)$ if and only if the distance between $u$ and $v$ in $T$ is at most $k$. The graph classes of $k$-leaf powers have several applications in computational biology, but recognizing them has remained a challenging algorithmic problem for the past two decades. The best known result is that $6$-leaf powers can be recognized in polynomial time. In this paper, we present an algorithm that decides whether a graph $G$ is a $k$-leaf power in time $O(n^{f(k)})$ for some function $f$ that depends only on $k$ (but has the growth rate of a power tower function). Our techniques are based on the fact that either a $k$-leaf power has a corresponding tree of low maximum degree, in which case finding it is easy, or every corresponding tree has large maximum degree. In the latter case, large degree vertices in the tree imply that $G$ has redundant substructures which can be pruned from the graph. In addition to solving a longstanding open problem, we hope that the structural results presented in this work can lead to further results on $k$-leaf powers.

cs.DS↗

Indirect Identification of Horizontal Gene Transfer

Several implicit methods to infer Horizontal Gene Transfer (HGT) focus on pairs of genes that have diverged only after the divergence of the two species in which the genes reside. This situation defines the edge set of a graph, the later-divergence-time (LDT) graph, whose vertices correspond to genes colored by their species. We investigate these graphs in the setting of relaxed scenarios, i.e., evolutionary scenarios that encompass all commonly used variants of duplication-transfer-loss scenarios in the literature. We characterize LDT graphs as a subclass of properly vertex-colored cographs, and provide a polynomial-time recognition algorithm as well as an algorithm to construct a relaxed scenario that explains a given LDT. An edge in an LDT graph implies that the two corresponding genes are separated by at least one HGT event. The converse is not true, however. We show that the complete xenology relation is described by an rs-Fitch graph, i.e., a complete multipartite graph satisfying constraints on the vertex coloring. This class of vertex-colored graphs is also recognizable in polynomial time. We finally address the question "how much information about all HGT events is contained in LDT graphs" with the help of simulations of evolutionary scenarios with a wide range of duplication, loss, and HGT events. In particular, we show that a simple greedy graph editing scheme can be used to efficiently detect HGT events that are implicitly contained in LDT graphs.

q-bio.PE↗

Comparing copy-number profiles under multi-copy amplifications and deletions

During cancer progression, malignant cells accumulate somatic mutations that can lead to genetic aberrations. In particular, evolutionary events akin to segmental duplications or deletions can alter the copy-number profile (CNP) of a set of genes in a genome. Our aim is to compute the evolutionary distance between two cells for which only CNPs are known. This asks for the minimum number of segmental amplifications and deletions to turn one CNP into another. This was recently formalized into a model where each event is assumed to alter a copy-number by $1$ or $-1$, even though these events can affect large portions of a chromosome. We propose a general cost framework where an event can modify the copy-number of a gene by larger amounts. We show that any cost scheme that allows segmental deletions of arbitrary length makes computing the distance strongly NP-hard. We then devise a factor $2$ approximation algorithm for the problem when copy-numbers are non-zero and provide an implementation called \textsf{cnp2cnp}. We evaluate our approach experimentally by reconstructing simulated cancer phylogenies from the pairwise distances inferred by \textsf{cnp2cnp} and compare it against two other alternatives, namely the \textsf{MEDICC} distance and the Euclidean distance. The experimental results show that our distance yields more accurate phylogenies on average than these alternatives if the given CNPs are error-free, but that the \textsf{MEDICC} distance is slightly more robust against error in the data. In all cases, our experiments show that either our approach or the \textsf{MEDICC} approach should preferred over the Euclidean distance.

q-bio.GN↗

Genomic Problems Involving Copy Number Profiles: Complexity and Algorithms

Recently, due to the genomic sequence analysis in several types of cancer, the genomic data based on {\em copy number profiles} ({\em CNP} for short) are getting more and more popular. A CNP is a vector where each component is a non-negative integer representing the number of copies of a specific gene or segment of interest. In this paper, we present two streams of results. The first is the negative results on two open problems regarding the computational complexity of the Minimum Copy Number Generation (MCNG) problem posed by Qingge et al. in 2018. It was shown by Qingge et al. that the problem is NP-hard if the duplications are tandem and they left the open question of whether the problem remains NP-hard if arbitrary duplications are used. We answer this question affirmatively in this paper; in fact, we prove that it is NP-hard to even obtain a constant factor approximation. We also prove that the parameterized version is W[1]-hard, answering another open question by Qingge et al. The other result is positive and is based on a new (and more general) problem regarding CNP's. The \emph{Copy Number Profile Conforming (CNPC)} problem is formally defined as follows: given two CNP's $C_1$ and $C_2$, compute two strings $S_1$ and $S_2$ with $cnp(S_1)=C_1$ and $cnp(S_2)=C_2$ such that the distance between $S_1$ and $S_2$, $d(S_1,S_2)$, is minimized. Here, $d(S_1,S_2)$ is a very general term, which means it could be any genome rearrangement distance (like reversal, transposition, and tandem duplication, etc). We make the first step by showing that if $d(S_1,S_2)$ is measured by the breakpoint distance then the problem is polynomially solvable.

cs.DS↗

Reconstruction of time-consistent species trees

The history of gene families -- which are equivalent to event-labeled gene trees -- can to some extent be reconstructed from empirically estimated evolutionary event-relations containing pairs of orthologous, paralogous or xenologous genes. The question then arises as whether inferred event-labeled gene trees are "biologically feasible" which is the case if one can find a species tree with which the gene tree can be reconciled in a time-consistent way. In this contribution, we consider event-labeled gene trees that contain speciation, duplication as well as horizontal gene transfer and we assume that the species tree is unknown. We provide a cubic-time algorithm to decide whether a "time-consistent" binary species for a given event-labeled gene tree exists and, in the affirmative case, to construct the species tree within the same time-complexity.

cs.DM↗

Constructing a Consensus Phylogeny from a Leaf-Removal Distance

Understanding the evolution of a set of genes or species is a fundamental problem in evolutionary biology. The problem we study here takes as input a set of trees describing {possibly discordant} evolutionary scenarios for a given set of genes or species, and aims at finding a single tree that minimizes the leaf-removal distance to the input trees. This problem is a specific instance of the general consensus/supertree problem, widely used to combine or summarize discordant evolutionary trees. The problem we introduce is specifically tailored to address the case of discrepancies between the input trees due to the misplacement of individual taxa. Most supertree or consensus tree problems are computationally intractable, and we show that the problem we introduce is also NP-hard. We provide tractability results in form of a 2-approximation algorithm. We also introduce a variant that minimizes the maximum number $d$ of leaves that are removed from any input tree, and provide a parameterized algorithm for this problem with parameter $d$.

cs.DS↗

The Tandem Duplication Distance is NP-hard

In computational biology, tandem duplication is an important biological phenomenon which can occur either at the genome or at the DNA level. A tandem duplication takes a copy of a genome segment and inserts it right after the segment - this can be represented as the string operation $AXB \Rightarrow AXXB$. For example, Tandem exon duplications have been found in many species such as human, fly or worm, and have been largely studied in computational biology. The Tandem Duplication (TD) distance problem we investigate in this paper is defined as follows: given two strings $S$ and $T$ over the same alphabet, compute the smallest sequence of tandem duplications required to convert $S$ to $T$. The natural question of whether the TD distance can be computed in polynomial time was posed in 2004 by Leupold et al. and had remained open, despite the fact that tandem duplications have received much attention ever since. In this paper, we prove that this problem is NP-hard. We further show that this hardness holds even if all characters of $S$ are distinct. This is known as the exemplar TD distance, which is of special relevance in bioinformatics. One of the tools we develop for the reduction is a new problem called the Cost-Effective Subgraph, for which we obtain W[1]-hardness results that might be of independent interest. We finally show that computing the exemplar TD distance between $S$ and $T$ is fixed-parameter tractable. Our results open the door to many other questions, and we conclude with several open problems.

cs.DS↗