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Manuel Ruiz-Marín

Publications and source records attributed to Manuel Ruiz-Marín.

2 recordsLinked to original sources

Ordinal Patterns Based Testing of Spatial Independence in Irregular Spatial Structures

We propose a nonparametric test of spatial independence for data observed on irregular, non-lattice point clouds $\mathcal{V}_{n}\subset\mathbb{R}^{2}$. For each location $v\in\mathcal{V}_{n}$, we encode the local spatial configuration through the ordinal pattern of the $m$ nearest-neighbour observations, obtaining a symbolic representation that is invariant under strictly monotone transformations and robust to outliers. Under the null hypothesis of spatial independence, the local ordinal patterns are i.i.d.\ and uniformly distributed over the symmetric group $\mathcal{S}_{m}$, regardless of the unknown marginal distribution $F$. We exploit this characterisation to construct a test statistic $L_{n}$ based on the additive log-ratio (ALR) transformation of the empirical ordinal-pattern frequencies. Invoking a central limit theorem for graph-dependent processes under a graph-based $α$-mixing condition, we establish that $L_{n}$ converges in distribution to a $χ^{2}_{m!-1}$ random variable, yielding an asymptotically pivotal procedure with no nuisance parameters. An extensive Monte Carlo study confirms that the $χ^{2}_{m!-1}$ approximation is accurate already at moderate sample sizes, that the test controls size at the nominal level, and that power increases monotonically with the strength of spatial dependence. Notably, the test detects dependence in both linear and nonlinearly transformed spatial autoregressive models, illustrating the robustness that is characteristic of ordinal-pattern methods. Our framework extends the spatial ordinal-pattern testing paradigm from regular lattices to general spatial supports, opening the door to ordinal-pattern inference in the many applied settings where observations are irregularly located.

stat.ME↗

Approaching allelic probabilities and Genome-Wide Association Studies from beta distributions

In this paper we have proposed a model for the distribution of allelic probabilities for generating populations as reliably as possible. Our objective was to develop such a model which would allow simulating allelic probabilities with different observed truncation and de- gree of noise. In addition, we have also introduced here a complete new approach to analyze a genome-wide association study (GWAS) dataset, starting from a new test of association with a statistical distribution and two effect sizes of each genotype. The new methodologi- cal approach was applied to a real data set together with a Monte Carlo experiment which showed the power performance of our new method. Finally, we compared the new method based on beta distribution with the conventional method (based on Chi-Squared distribu- tion) using the agreement Kappa index and a principal component analysis (PCA). Both the analyses show found differences existed between both the approaches while selecting the single nucleotide polymorphisms (SNPs) in association.

q-bio.GN↗