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Marc Harary

Publications and source records attributed to Marc Harary.

7 recordsLinked to original sources

A Courcelle-Type Metatheorem for Rank-Bounded Unconstrained Binary Optimization

We present the first uniform XP exact algorithm for unconstrained binary optimization of quadratic, polynomial, fractional, and other objectives under a single parameter, the differentially affine (DA) rank $r$. An objective $f: \{0,1\}^n \to \mathbb{R}$ has DA rank $r$ if there is a feature map $\psi: \{0,1\}^n \to \mathbb{R}^r$ such that each coordinate flip has finite gain $\Delta_{\pm e_i}f(x)=\langle v_{\pm e_i},\psi(x)\rangle+\beta_{\pm e_i}$. Our algorithm enumerates the $O((2n)^r)$ chambers of the induced hyperplane arrangement and applies a two-sided local-optimality test: a solution exists on a chamber and is unique iff $\operatorname{sign}\Delta_{+e_i}=-\operatorname{sign}\Delta_{-e_i}$ for all $i$, in which case $x_i^\star=1$ iff $\Delta_{+e_i}>0$. This yields $n^{O(r)}$ time with $O(n)$ decoding per chamber. The framework uniformly covers a wide range of nonlinear functions, including all rank-$r$ quadratics, low-Waring-rank pseudo-Boolean polynomials, finite products/ratios on positive domains, finite-basis separable sums via explicit lifts, Taylor-series approximations of analytic functions, and compositions of all the foregoing. Applications include Ising spin models, optimal experimental design, portfolio optimization, and robust statistics. Prior to our work, only specialized subcases involving sparsity, convexity, submodularity, etc. were known to be tractable. Analogous in spirit to Courcelle's theorem (MSO on bounded treewidth graphs) and Grohe's meta-theorems for constraint satisfaction, our result replaces logical width with analytic rank for nonlinear pseudo-Boolean optimization.

cs.CC

AdvDINO: Domain-Adversarial Self-Supervised Representation Learning for Spatial Proteomics

Self-supervised learning (SSL) has emerged as a powerful approach for learning visual representations without manual annotations. However, the robustness of standard SSL methods to domain shift -- systematic differences across data sources -- remains uncertain, posing an especially critical challenge in biomedical imaging where batch effects can obscure true biological signals. We present AdvDINO, a domain-adversarial SSL framework that integrates a gradient reversal layer into the DINOv2 architecture to promote domain-invariant feature learning. Applied to a real-world cohort of six-channel multiplex immunofluorescence (mIF) whole slide images from lung cancer patients, AdvDINO mitigates slide-specific biases to learn more robust and biologically meaningful representations than non-adversarial baselines. Across more than 5.46 million mIF image tiles, the model uncovers phenotype clusters with differing proteomic profiles and prognostic significance, and enables strong survival prediction performance via attention-based multiple instance learning. The improved robustness also extends to a breast cancer cohort. While demonstrated on mIF data, AdvDINO is broadly applicable to other medical imaging domains, where domain shift is a common challenge.

cs.CV

Fluoroformer: Scaling multiple instance learning to multiplexed images via attention-based channel fusion

Though multiple instance learning (MIL) has been a foundational strategy in computational pathology for processing whole slide images (WSIs), current approaches are designed for traditional hematoxylin and eosin (H&E) slides rather than emerging multiplexed technologies. Here, we present an MIL strategy, the Fluoroformer module, that is specifically tailored to multiplexed WSIs by leveraging scaled dot-product attention (SDPA) to interpretably fuse information across disparate channels. On a cohort of 434 non-small cell lung cancer (NSCLC) samples, we show that the Fluoroformer both obtains strong prognostic performance and recapitulates immuno-oncological hallmarks of NSCLC. Our technique thereby provides a path for adapting state-of-the-art AI techniques to emerging spatial biology assays.

eess.IV

Combinatorial optimization of the coefficient of determination

Robust correlation analysis is among the most critical challenges in statistics. Herein, we develop an efficient algorithm for selecting the $k$- subset of $n$ points in the plane with the highest coefficient of determination $\left( R^2 \right)$. Drawing from combinatorial geometry, we propose a method called the \textit{quadratic sweep} that consists of two steps: (i) projectively lifting the data points into $\mathbb R^5$ and then (ii) iterating over each linearly separable $k$-subset. Its basis is that the optimal set of outliers is separable from its complement in $\mathbb R^2$ by a conic section, which, in $\mathbb R^5$, can be found by a topological sweep in $\Theta \left( n^5 \log n \right)$ time. Although key proofs of quadratic separability remain underway, we develop strong mathematical intuitions for our conjectures, then experimentally demonstrate our method's optimality over several million trials up to $n=30$ without error. Implementations in Julia and fully seeded, reproducible experiments are available at https://github.com/marc-harary/QuadraticSweep.

stat.ML

Kirigami: large convolutional kernels improve deep learning-based RNA secondary structure prediction

We introduce a novel fully convolutional neural network (FCN) architecture for predicting the secondary structure of ribonucleic acid (RNA) molecules. Interpreting RNA structures as weighted graphs, we employ deep learning to estimate the probability of base pairing between nucleotide residues. Unique to our model are its massive 11-pixel kernels, which we argue provide a distinct advantage for FCNs on the specialized domain of RNA secondary structures. On a widely adopted, standardized test set comprised of 1,305 molecules, the accuracy of our method exceeds that of current state-of-the-art (SOTA) secondary structure prediction software, achieving a Matthews Correlation Coefficient (MCC) over 11-40% higher than that of other leading methods on overall structures and 58-400% higher on pseudoknots specifically.

q-bio.BM

Efficient algorithms for the sensitivities of the Pearson correlation coefficient and its statistical significance to online data

Reliably measuring the collinearity of bivariate data is crucial in statistics, particularly for time-series analysis or ongoing studies in which incoming observations can significantly impact current collinearity estimates. Leveraging identities from Welford's online algorithm for sample variance, we develop a rigorous theoretical framework for analyzing the maximal change to the Pearson correlation coefficient and its p-value that can be induced by additional data. Further, we show that the resulting optimization problems yield elegant closed-form solutions that can be accurately computed by linear- and constant-time algorithms. Our work not only creates new theoretical avenues for robust correlation measures, but also has broad practical implications for disciplines that span econometrics, operations research, clinical trials, climatology, differential privacy, and bioinformatics. Software implementations of our algorithms in Cython-wrapped C are made available at https://github.com/marc-harary/sensitivity for reproducibility, practical deployment, and future theoretical development.

stat.ME

SHIELD: Secure Haplotype Imputation Employing Local Differential Privacy

We introduce Secure Haplotype Imputation Employing Local Differential privacy (SHIELD), a program for accurately estimating the genotype of target samples at markers that are not directly assayed by array-based genotyping platforms while preserving the privacy of donors to public reference panels. At the core of SHIELD is the Li-Stephens model of genetic recombination, according to which genomic information is comprised of mosaics of ancestral haplotype fragments that coalesce via a Markov random field. We use the standard forward-backward algorithm for inferring the ancestral haplotypes of target genomes, and hence the most likely genotype at unobserved sites, using a reference panel of template haplotypes whose privacy is guaranteed by the randomized response technique from differential privacy.

q-bio.QM