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Marco Coisson

Publications and source records attributed to Marco Coisson.

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Lagrange: Operating Italy's First Publicly-Accessible Quantum Computer for Research and Education

We describe the design, implementation, and nine-month operational experience of the software management stack for Lagrange, an IQM Spark five-qubit superconducting quantum computer jointly acquired by LINKS Foundation, Politecnico di Torino and the Italian National Institute of Metrological Research (INRiM), and managed by LINKS. Lagrange is, to our knowledge, the first quantum computer in Italy that is fully operational and accessible to students and researchers from multiple institutions under formal service agreements, and to the general public under commercial agreements. When installed in mid-2025, the IQM Spark hardware was delivered by the vendor with authentication only: no billing, project management or fair usage enforcement were provided. We developed a modular middleware layer that filled that gap without modifying any vendor client software, by intercepting API calls through a proxy that enforces project-based budgets, reservation-aware authorisation, and per-user fairness policies. The middleware adopts a plugin architecture that cleanly separates vendor-specific logic from site-specific policies, enabling reuse across different quantum hardware backends and deployment contexts. Since entering production in September 2025, the system has processed over 240,000 quantum jobs totalling more than 1 week of QPU execution time, with greater than 98% uptime. Notably, students at Politecnico di Torino regularly use the machine during both lectures and formal examinations -- a practice we believe to be unique in Europe. We report on the system architecture, the operational lessons learned, and the infrastructure choices that made this deployment possible.

quant-ph

Enhanced Mesenchymal Stem Cell Response with Preserved Biocompatibility via (MnZn)Ferrite--Polyacrylonitrile Composite Nanofiber Membranes

This study focuses on the synthesis and characterization of advanced polymeric composite electrospun nanofibers (NFs) containing magnetic oxide nanoparticles (NPs). By leveraging the method of electrospinning, the research aims to investigate polymer composites with enhanced interfacial properties, improved double-layer capacitance, and adequate biocompatibility. Electrospun polyacrylonitrile (PAN) NFs embedded with Fe2O3 and MnZn ferrite NPs were comprehensively characterized using advanced techniques, i.e., Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), high-resolution scanning electron microscopy (HR-SEM), X-ray diffraction (XRD), and alternating gradient field magnetometry (AGFM). The incorporation of metal oxide NPs led to significant changes in the thermal, spectroscopic, and morphological properties of the NFs. XPS analysis confirmed increased oxidation, graphitic carbon content, and the formation of new nitrogen functionalities after heat treatment. Furthermore, interactions between nitrile groups and metal ions were observed, indicating the influence of nanoparticles on surface chemistry. Magnetic characterization demonstrated the potential of these composite NFs to generate magnetic fields for biomedical manipulation. Cytocompatibility studies revealed no significant impact on the viability or morphology of human mesenchymal stromal cells, highlighting their biocompatibility. These findings suggest the promising use of PAN-magnetic NFs in applications including targeted drug administration, magnetic resonance imaging (MRI), and magnetic hyperthermia for cancer treatment.

q-bio.QM

European research on magnetic nanoparticles for biomedical applications: standardisation aspects

Magnetic nanoparticles have many applications in biomedicine and other technical areas. Despite their huge economic impact, there are no standardised procedures available to measure their basic magnetic properties. The International Organization for Standardization is working on a series of documents on the definition of characteristics of magnetic nanomaterials. We review previous and ongoing European research projects on characteristics of magnetic nanoparticles and present results of an online survey among European researchers.

physics.med-ph