arXiv subjects

Marco D. Santambrogio

Publications and source records attributed to Marco D. Santambrogio.

5 recordsLinked to original sources

arXiv2026

Learning to Optimize Radiotherapy Plans via Fluence Maps Diffusion Model Generation and LSTM-based Optimization

Volumetric Modulated Arc Therapy (VMAT) is a cornerstone of modern radiation therapy, enabling highly conformal tumor irradiation and healthy-tissue sparing. Yet, its planning solves inverse and nested optimization for multi-leaf collimators, monitor units and dose parameters, while enforcing their consistency to ensure mechanical deliverability. Nevertheless, this process often requires repeated re-optimization when treatment configurations change, resulting in substantial planning time per patient. To address these problems, we present a diffusion-driven Learning-to-Optimize (L2O) method for end-to-end VMAT planning. A distribution-matching distilled diffusion model learns a clinically feasible manifold of fluence maps, enabling their one-shot generation. On top of this, an LSTM-based L2O module learns gradient update dynamics to swiftly refine fluence maps toward prescribed dose objectives during inference. Experimental results on clinical and public prostate cancer cohorts demonstrate improved planning efficiency, flexibility, and machine deliverability over currently available end-to-end VMAT planners.

cs.CV↗

arXiv2021

DAG-based Scheduling with Resource Sharing for Multi-task Applications in a Polyglot GPU Runtime

GPUs are readily available in cloud computing and personal devices, but their use for data processing acceleration has been slowed down by their limited integration with common programming languages such as Python or Java. Moreover, using GPUs to their full capabilities requires expert knowledge of asynchronous programming. In this work, we present a novel GPU run time scheduler for multi-task GPU computations that transparently provides asynchronous execution, space-sharing, and transfer-computation overlap without requiring in advance any information about the program dependency structure. We leverage the GrCUDA polyglot API to integrate our scheduler with multiple high-level languages and provide a platform for fast prototyping and easy GPU acceleration. We validate our work on 6 benchmarks created to evaluate task-parallelism and show an average of 44% speedup against synchronous execution, with no execution time slowdown compared to hand-optimized host code written using the C++ CUDA Graphs API.

cs.DC↗

arXiv2020

A reduced-precision streaming SpMV architecture for Personalized PageRank on FPGA

Sparse matrix-vector multiplication is often employed in many data-analytic workloads in which low latency and high throughput are more valuable than exact numerical convergence. FPGAs provide quick execution times while offering precise control over the accuracy of the results thanks to reduced-precision fixed-point arithmetic. In this work, we propose a novel streaming implementation of Coordinate Format (COO) sparse matrix-vector multiplication, and study its effectiveness when applied to the Personalized PageRank algorithm, a common building block of recommender systems in e-commerce websites and social networks. Our implementation achieves speedups up to 6x over a reference floating-point FPGA architecture and a state-of-the-art multi-threaded CPU implementation on 8 different data-sets, while preserving the numerical fidelity of the results and reaching up to 42x higher energy efficiency compared to the CPU implementation.

cs.DC↗

arXiv2020

LOGAN: High-Performance GPU-Based X-Drop Long-Read Alignment

Pairwise sequence alignment is one of the most computationally intensive kernels in genomic data analysis, accounting for more than 90% of the runtime for key bioinformatics applications. This method is particularly expensive for third-generation sequences due to the high computational cost of analyzing sequences of length between 1Kb and 1Mb. Given the quadratic overhead of exact pairwise algorithms for long alignments, the community primarily relies on approximate algorithms that search only for high-quality alignments and stop early when one is not found. In this work, we present the first GPU optimization of the popular X-drop alignment algorithm, that we named LOGAN. Results show that our high-performance multi-GPU implementation achieves up to 181.6 GCUPS and speed-ups up to 6.6x and 30.7x using 1 and 6 NVIDIA Tesla V100, respectively, over the state-of-the-art software running on two IBM Power9 processors using 168 CPU threads, with equivalent accuracy. We also demonstrate a 2.3x LOGAN speed-up versus ksw2, a state-of-art vectorized algorithm for sequence alignment implemented in minimap2, a long-read mapping software. To highlight the impact of our work on a real-world application, we couple LOGAN with a many-to-many long-read alignment software called BELLA, and demonstrate that our implementation improves the overall BELLA runtime by up to 10.6x. Finally, we adapt the Roofline model for LOGAN and demonstrate that our implementation is near-optimal on the NVIDIA Tesla V100s.

q-bio.GN↗

arXiv2019

A Framework For Identifying Group Behavior Of Wild Animals

Activity recognition and, more generally, behavior inference tasks are gaining a lot of interest. Much of it is work in the context of human behavior. New available tracking technologies for wild animals are generating datasets that indirectly may provide information about animal behavior. In this work, we propose a method for classifying these data into behavioral annotation, particularly collective behavior of a social group. Our method is based on sequence analysis with a direct encoding of the interactions of a group of wild animals. We evaluate our approach on a real world dataset, showing significant accuracy improvements over baseline methods.

cs.LG↗