arXiv subjects

Marco Fedele

Publications and source records attributed to Marco Fedele.

At least 37 records · Page 2Linked to original sources

arXiv2022

Simple and statistically sound recommendations for analysing physical theories

Physical theories that depend on many parameters or are tested against data from many different experiments pose unique challenges to statistical inference. Many models in particle physics, astrophysics and cosmology fall into one or both of these categories. These issues are often sidestepped with statistically unsound ad hoc methods, involving intersection of parameter intervals estimated by multiple experiments, and random or grid sampling of model parameters. Whilst these methods are easy to apply, they exhibit pathologies even in low-dimensional parameter spaces, and quickly become problematic to use and interpret in higher dimensions. In this article we give clear guidance for going beyond these procedures, suggesting where possible simple methods for performing statistically sound inference, and recommendations of readily-available software tools and standards that can assist in doing so. Our aim is to provide any physicists lacking comprehensive statistical training with recommendations for reaching correct scientific conclusions, with only a modest increase in analysis burden. Our examples can be reproduced with the code publicly available at https://doi.org/10.5281/zenodo.4322283.

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arXiv2022

Flavour anomalies and the muon $g-2$ from feebly interacting particles

We perform a phenomenological analysis of simplified models of light, feebly interacting particles~(FIPs)that can provide a combined explanation of the anomalies in $b\to s l^+ l ^-$ transitions at LHCb and the anomalous magnetic moment of the muon. Different scenarios are categorised according to the explicit momentum dependence of the FIP coupling to the $b-s$ and $μ-μ$ vector currents and they are subject to several constraints from flavour and precision physics. We show that viable combined solutions to the muon $g-2$ and flavour anomalies exist with the exchange of a vector FIP with mass larger than $4 \,\textrm{GeV}$. Interestingly, the LHC has the potential to probe this region of the parameter space by increasing the precision of the $Z\to 4μ$ cross-section measurement. Conversely, we find that solutions based on the exchange of a lighter vector, in the $m_V < 1\,\textrm{GeV}$ range, are essentially excluded by a combination of $B\to K +\textrm{invisible}$ and $W$-decay precision bounds.

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arXiv2022

Stellar Evolution confronts Axion Models

Axion production from astrophysical bodies is a topic in continuous development, because of theoretical progress in the estimate of stellar emission rates and, especially, because of improved stellar observations. We carry out a comprehensive analysis of the most informative astrophysics data, revisiting the bounds on axion couplings to photons, nucleons and electrons, and reassessing the significance of various hints of anomalous stellar energy losses. We confront the performance of various theoretical constructions in accounting for these hints, while complying with the observational limits on axion couplings. We identify the most favorable models, and the regions in the mass/couplings parameter space which are preferred by the global fit. Finally, we scrutinize the discovery potential for such models at upcoming helioscopes, namely IAXO and its scaled versions.

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arXiv2021

$B$ anomalies and muon $g-2$ from Dark Matter

Motivated by the result of the Muon g-2 experiment and the long-standing anomalies in semileptonic $B$ meson decays, we systematically build a class of minimal models that can address both experimental results thanks to the contributions of a set of new fields that include a thermal Dark Matter candidate.

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arXiv2021

Electromechanical modeling of human ventricles with ischemic cardiomyopathy: numerical simulations in sinus rhythm and under arrhythmia

We developed a novel patient-specific computational model for the numerical simulation of ventricular electromechanics in patients with ischemic cardiomyopathy (ICM). This model reproduces the activity both in sinus rhythm (SR) and in ventricular tachycardia (VT). The presence of scars, grey zones and non-remodeled regions of the myocardium is accounted for by the introduction of a spatially heterogeneous coefficient in the 3D electromechanics model. This 3D electromechanics model is firstly coupled with a 2-element Windkessel afterload model to fit the pressure-volume (PV) loop of a patient-specific left ventricle (LV) with ICM in SR. Then, we employ the coupling with a 0D closed-loop circulation model to analyze a VT circuit over multiple heartbeats on the same LV. We highlight similarities and differences on the solutions obtained by the electrophysiology model and those of the electromechanics model, while considering different scenarios for the circulatory system. We observe that very different parametrizations of the circulation model induce the same hemodynamical considerations for the patient at hand. Specifically, we classify this VT as unstable. We conclude by stressing the importance of combining electrophysiological, mechanical and hemodynamical models to provide relevant clinical indicators in how arrhythmias evolve and can potentially lead to sudden cardiac death.

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arXiv2021

What is the scale of new physics behind the muon $g-2$?

We study the constraints imposed by perturbative unitarity on the new physics interpretation of the muon $g-2$ anomaly. Within a Standard Model Effective Field Theory (SMEFT) approach, we find that scattering amplitudes sourced by effective operators saturate perturbative unitarity at about 1 PeV. This corresponds to the highest energy scale that needs to be probed in order to resolve the new physics origin of the muon $g-2$ anomaly. On the other hand, simplified models (e.g.~scalar-fermion Yukawa theories) in which renormalizable couplings are pushed to the boundary of perturbativity still imply new on-shell states below 200 TeV. We finally suggest that the highest new physics scale responsible for the anomalous effect can be reached in non-renormalizable models at the PeV scale.

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arXiv2021

Muon $g-2$ and $B$-anomalies from Dark Matter

In the light of the recent result of the Muon g-2 experiment and the update on the test of lepton flavour universality $R_K$ published by the LHCb collaboration, we systematically build and discuss a set of models with minimal field content that can simultaneously give: (i) a thermal Dark Matter candidate; (ii) large loop contributions to $b\to s\ell\ell$ processes able to address $R_K$ and the other $B$ anomalies; (iii) a natural solution to the muon $g-2$ discrepancy through chirally-enhanced contributions.

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arXiv2021

Generic Loop Effects of New Scalars and Fermions in $b\to s\ell^+\ell^-$, $(g-2)_μ$ and a Vector-like $4^{\rm th}$ Generation

In this article we investigate in detail the possibility of accounting for the $b\to s\ell^+\ell^-$ and $(g-2)_μ$ anomalies via loop contributions involving with new scalars and fermions. For this purpose, we first write down the most general Lagrangian which can generate the desired effects and then calculate the generic expressions for all relevant $b\to s$ Wilson coefficients. Here we extend previous analysis by allowing that the new particles can also couple to right-handed Standard Model (SM) fermions as preferred by recent $b\to s\ell^+\ell^-$ data and the anomalous magnetic moment of the muon. In the second part of this article we illustrate this generic approach for a UV complete model in which we supplement the Standard Model by a $4^{\rm th}$ generation of vector-like fermions and a real scalar field. This model allows one to coherently address the observed anomalies in $b\to s\ell^+\ell^-$ transitions and in $a_μ$ without violating the bounds from other observables (in particular $B_s -\bar B_s$ mixing) or LHC searches. In fact, we find that our global fit to this model, after the recent experimental updates, is very good and prefers couplings to right-handed SM fermions, showing the importance of our generic setup and calculation performed in the first part of the article.

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arXiv2021

Systematic approach to $B$-physics anomalies and $t$-channel dark matter

We study renormalisable models with minimal field content that can provide a viable Dark Matter candidate through the standard freeze-out paradigm and, simultaneously, accommodate the observed anomalies in semileptonic $B$-meson decays at one loop. Following the hypothesis of minimality, this outcome can be achieved by extending the particle spectrum of the Standard Model either with one vector-like fermion and two scalars or two vector-like fermions and one scalar. The Dark Matter annihilations are mediated by $t$-channel exchange of other new particles contributing to the $B$-anomalies, thus resulting in a correlation between flavour observables and Dark Matter abundance. Again based on minimality, we assume the new states to couple only with left-handed muons and second and third generation quarks. Besides an ad hoc symmetry needed to stabilise the Dark Matter, the interactions of the new states are dictated only by gauge invariance. We present here for the first time a systematic classification of the possible models of this kind, according to the quantum numbers of the new fields under the Standard Model gauge group. Within this general setup we identify a group of representative models that we systematically study, applying the most updated constraints from flavour observables, dedicated Dark Matter experiments, and LHC searches of leptons and/or jets and missing energy, and of disappearing charged tracks.

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arXiv2021

Minimal Froggatt-Nielsen Textures

The flavour problem of the Standard Model can be addressed through the Froggatt-Nielsen (FN) mechanism. In this work, we develop an approach to the study of FN textures building a direct link between FN-charge assignments and the measured masses and mixing angles via unitary transformations in flavour space. We specifically focus on the quark sector to identify the most economic FN models able to provide a dynamical and natural understanding of the flavour puzzle. Remarkably, we find viable FN textures, involving charges under the horizontal symmetry that do not exceed one in absolute value (in units of the flavon charge). Within our approach, we also explore the degree of tuning of FN models in solving the flavour problem via a measure analogous to the Barbieri-Giudice one. We find that most of the solutions do not involve peculiar cancellations in flavour space.

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arXiv2021

Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations

Since myocardial fibers drive the electric signal propagation throughout the myocardium, accurately modeling their arrangement is essential for simulating heart electrophysiology (EP). Rule-Based-Methods (RBMs) represent a commonly used strategy to include cardiac fibers in computational models. A particular class of such methods is known as Laplace-Dirichlet-Rule-Based-Methods (LDRBMs) since they rely on the solution of Laplace problems. In this work we provide a unified framework, based on LDRBMs, for generating full heart muscle fibers. First, we review existing ventricular LDRBMs providing a communal mathematical description and introducing also some modeling improvements with respect to the existing literature. We then carry out a systematic comparison of LDRBMs based on meaningful biomarkers produced by numerical EP simulations. Next we propose, for the first time, a LDRBM to be used for generating atrial fibers. The new method, tested both on idealized and realistic atrial models, can be applied to any arbitrary geometries. Finally, we present numerical results obtained in a realistic whole heart where fibers are included for all the four chambers using the discussed LDRBMs.

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arXiv2020

A cardiac electromechanics model coupled with a lumped parameters model for closed-loop blood circulation. Part I: model derivation

We propose an integrated electromechanical model of the human heart, with focus on the left ventricle, wherein biophysically detailed models describe the different physical phenomena concurring to the cardiac function. We model the subcellular generation of active force by means of an Artificial Neural Network, which is trained by a suitable Machine Learning algorithm from a collection of pre-computed numerical simulations of a biophysically detailed, yet computational demanding, high-fidelity model. To provide physiologically meaningful results, we couple the 3D electromechanical model with a closed-loop 0D (lumped parameters) model describing the blood circulation in the whole cardiovascular network. We prove that the 3D-0D coupling of the two models is compliant with the principle of energy conservation, which is achieved in virtue of energy-consistent boundary conditions that account for the interaction among cardiac chambers within the computational domain, pericardium and surrounding tissue. We thus derive an overall balance of mechanical energy for the 3D-0D model. This provides a quantitative insight into the energy utilization, dissipation and transfer among the different compartments of the cardiovascular network and during different stages of the heartbeat. In virtue of this new model and the energy balance, we propose a new validation tool of heart energy usage against relationships used in the daily clinical practice. Finally, we provide a mathematical formulation of an inverse problem aimed at recovering the reference configuration of one or multiple cardiac chambers, starting from the stressed configuration acquired from medical imaging. This is fundamental to correctly initialize electromechanical simulations. Numerical methods and simulations of the 3D-0D model will be detailed in Part II.

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arXiv2020

A cardiac electromechanics model coupled with a lumped parameters model for closed-loop blood circulation. Part II: numerical approximation

In the framework of accurate and efficient segregated schemes for 3D cardiac electromechanics and 0D cardiovascular models, we propose here a novel numerical approach to address the coupled 3D-0D problem introduced in Part I of this two-part series of papers. We combine implicit-explicit schemes to solve the different cardiac models in a multiphysics setting. We properly separate and manage the different time and space scales related to cardiac electromechanics and blood circulation. We employ a flexible and scalable intergrid transfer operator that enables to interpolate Finite Element functions among different meshes and, possibly, among different Finite Element spaces. We propose a numerical method to couple the 3D electromechanical model and the 0D circulation model in a numerically stable manner within a fully segregated fashion. No adaptations are required through the different phases of the heartbeat. We also propose a robust algorithm to reconstruct the stress-free reference configuration. Due to the computational cost associated with the numerical solution of this inverse problem, the reference configuration recovery algorithm comes along with a novel projection technique to precisely recover the unloaded geometry from a coarser representation of the computational domain. We show the convergence property of our numerical schemes by performing an accuracy study through grid refinement. To prove the biophysical accuracy of our computational model, we also address different scenarios of clinical interest in our numerical simulations by varying preload, afterload and contractility. Indeed, we simulate physiologically relevant behaviors and we reproduce meaningful results in the context of cardiac function.

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arXiv2020

Lessons from the $B^{0,+}\to K^{*0,+}μ^+μ^-$ angular analyses

We perform an analysis within the Standard Model of $B^{0,+} \to K^{*0,+} μ^+ μ^-$ decays in light of the recent measurements from the LHCb experiment, showing that new data strengthen the need for sizable hadronic contributions and correlations among them. We then extend our analysis to New Physics via the Standard Model Effective Theory, and carry out a state-of-the-art fit of available $b \to s \ell^+ \ell^-$ data, including possible hadronic contributions. We find the case of a fully left-handed operator standing out as the simplest scenario with a significance of almost $6σ$.

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arXiv2020

Solar axions cannot explain the XENON1T excess

We argue that the interpretation in terms of solar axions of the recent XENON1T excess is not tenable when confronted with astrophysical observations of stellar evolution. We discuss the reasons why the emission of a flux of solar axions sufficiently intense to explain the anomalous data would radically alter the distribution of certain type of stars in the color-magnitude diagram in first place, and would also clash with a certain number of other astrophysical observables. Quantitatively, the significance of the discrepancy ranges from $3.3σ$ for the rate of period change of pulsating White Dwarfs, and exceedes $19σ$ for the $R$-parameter and for $M_{I,{\rm TRGB}}$.

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arXiv2020

Flavour anomalies from a split dark sector

We investigate solutions to the flavour anomalies in $B$ decays based on loop diagrams of a "split" dark sector characterised by the simultaneous presence of heavy particles at the TeV scale and light particles around and below the $B$-meson mass scale. We show that viable parameter space exists for solutions based on penguin diagrams with a vector mediator, while minimal constructions relying on box diagrams are in strong tension with the constraints from the LHC, LEP, and the anomalous magnetic moment of the muon. In particular, we highlight a regime where the mediator lies close to the $B$-meson mass, naturally realising a resonance structure and a $q^2$-dependent effective coupling. We perform a full fit to the relevant flavour observables and analyse the constraints from intensity frontier experiments. Besides new measurements of the anomalous magnetic moment of the muon, we find that decays of the $B$ meson, $B_s$-mixing, missing energy searches at Belle-II, and LHC searches for top/bottom partners can robustly test these scenarios in the near future.

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arXiv2019

New Physics in $b \to s \ell^+ \ell^-$ confronts new data on Lepton Universality

In light of the very recent updates on the $R_K$ and $R_{K^*}$ measurements from the LHCb and Belle collaborations, we systematically explore here imprints of New Physics in $b \to s \ell^+ \ell^- $ transitions using the language of effective field theories. We focus on effects that violate Lepton Flavour Universality both in the Weak Effective Theory and in the Standard Model Effective Field Theory. In the Weak Effective Theory we find a preference for scenarios with the simultaneous presence of two operators, a left-handed quark current with vector muon coupling and a right-handed quark current with axial muon coupling, irrespective of the treatment of hadronic uncertainties. In the Standard Model Effective Field Theory we select different scenarios according to the treatment of hadronic effects: while an aggressive estimate of hadronic uncertainties points to the simultaneous presence of two operators, one with left-handed quark and muon couplings and one with left-handed quark and right-handed muon couplings, a more conservative treatment of hadronic matrix elements leaves room for a broader set of scenarios, including the one involving only the purely left-handed operator with muon coupling.

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arXiv2019

Lepton Flavor Universality tests through angular observables of $\overline{B}\to D^{(\ast)}\ell\overlineν$ decay modes

We discuss the possibility of using the observables deduced from the angular distribution of the $B\to D^{(\ast)} \ell\barν$ decays to test the effects of lepton flavor universality violation (LFUV). We show that the measurement of even a subset of these observables could be very helpful in distinguishing the Lorentz structure of the New Physics contributions to these decays. To do so we use the low energy effective theory in which besides the Standard Model contribution we add all possible Lorentz structures with the couplings (Wilson coefficients) that are determined by matching theory with the measured ratios $R{(D^{(\ast)})}^\mathrm{exp}$. We argue that even in the situation in which the measured $R{(D^{(\ast)})}^\mathrm{exp}$ becomes fully compatible with the Standard Model, one can still have significant New Physics contributions the size of which could be probed by measuring the observables discussed in this paper and comparing them with their Standard Model predictions.

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