arXiv subjects

Marco Postiglione

Publications and source records attributed to Marco Postiglione.

14 recordsLinked to original sources

arXiv2026

Can "AI" Be a Doctor? A Study of Empathy, Readability, and Alignment in Clinical LLMs

Large Language Models (LLMs) are increasingly deployed in healthcare, yet their communicative alignment with clinical standards remains insufficiently quantified. We conduct a multidimensional evaluation of general-purpose and domain-specialized LLMs across structured medical explanations and real-world physician-patient interactions, analyzing semantic fidelity, readability, and affective resonance. Baseline models amplify affective polarity relative to physicians (Very Negative: 43.14-45.10% vs. 37.25%) and, in larger architectures such as GPT-5 and Claude, produce substantially higher linguistic complexity (FKGL up to 16.91-17.60 vs. 11.47-12.50 in physician-authored responses). Empathy-oriented prompting reduces extreme negativity and lowers grade-level complexity (up to -6.87 FKGL points for GPT-5) but does not significantly increase semantic fidelity. Collaborative rewriting yields the strongest overall alignment. Rephrase configurations achieve the highest semantic similarity to physician answers (up to mean = 0.93) while consistently improving readability and reducing affective extremity. Dual stakeholder evaluation shows that no model surpasses physicians on epistemic criteria, whereas patients consistently prefer rewritten variants for clarity and emotional tone. These findings suggest that LLMs function most effectively as collaborative communication enhancers rather than replacements for clinical expertise.

cs.CL↗

arXiv2026

Human-AI Ensembles Improve Deepfake Detection in Low-to-Medium Quality Videos

Deepfake detection is widely framed as a machine learning problem, yet how humans and AI detectors compare under realistic conditions remains poorly understood. We evaluate 200 human participants and 95 state-of-the-art AI detectors across two datasets: DF40, a standard benchmark, and CharadesDF, a novel dataset of videos of everyday activities. CharadesDF was recorded using mobile phones leading to low/moderate quality videos compared to the more professionally captured DF40. Humans outperform AI detectors on both datasets, with the gap widening in the case of CharadesDF where AI accuracy collapses to near chance (0.537) while humans maintain robust performance (0.784). Human and AI errors are complementary: humans miss high-quality deepfakes while AI detectors flag authentic videos as fake, and hybrid human-AI ensembles reduce high-confidence errors. These findings suggest that effective real-world deepfake detection, especially in non-professionally produced videos, requires human-AI collaboration rather than AI algorithms alone.

cs.CV↗

arXiv2026

Brain3D: Brain Report Automation via Inflated Vision Transformers in 3D

Current medical vision-language models (VLMs) process volumetric brain MRI using 2D slice-based approximations, fragmenting the spatial context required for accurate neuroradiological interpretation. We developed \textbf{Brain3D}, a staged vision-language framework for automated radiology report generation from 3D brain tumor MRI. Our approach inflates a pretrained 2D medical encoder into a native 3D architecture and progressively aligns it with a causal language model through three stages: contrastive grounding, supervised projector warmup, and LoRA-based linguistic specialization. Unlike generalist 3D medical VLMs, \textbf{Brain3D} is tailored to neuroradiology, where hemispheric laterality, tumor infiltration patterns, and anatomical localization are critical. Evaluated on 468 subjects (BraTS pathological cases plus healthy controls), our model achieves a Clinical Pathology F1 of 0.951 versus 0.413 for a strong 2D baseline while maintaining perfect specificity on healthy scans. The staged alignment proves essential: contrastive grounding establishes visual-textual correspondence, projector warmup stabilizes conditioning, and LoRA adaptation shifts output from verbose captions to structured clinical reports\footnote{Our code is publicly available for transparency and reproducibility

cs.CV↗

arXiv2026

SMART: A Social Movement Analysis & Reasoning Tool with Case Studies on #MeToo and #BlackLivesMatter

Social movements supporting the UN's Sustainable Development Goals (SDGs) play a vital role in improving human lives. If journalists were aware of the relationship between social movements and external events, they could provide more precise, time-sensitive reporting about movement issues and SDGs. Our SMART system achieves this goal by collecting data from multiple sources, extracting emotions on various themes, and then using a transformer-based forecasting engine (DEEP) to predict quantity and intensity of emotions in future posts. This paper demonstrates SMART's Retrospective capabilities required by journalists via case studies analyzing social media discussions of the #MeToo and #BlackLivesMatter before and after the 2024 U.S. election. We create a novel 1-year dataset which we will release upon publication. It contains over 2.7M Reddit posts and over 1M news articles. We show that SMART enables early detection of discourse shifts around key political events, providing journalists with actionable insights to inform editorial planning. SMART was developed through multiple interactions with a panel of over 20 journalists from a variety of news organizations over a 2-year period, including an author of this paper.

cs.SI↗

arXiv2026

Context and Transcripts Improve Detection of Deepfake Audios of Public Figures

Humans use context to assess the veracity of information. However, current audio deepfake detectors only analyze the audio file without considering either context or transcripts. We create and analyze a Journalist-provided Deepfake Dataset (JDD) of 255 public deepfakes which were primarily contributed by over 70 journalists since early 2024. We also generate a synthetic audio dataset (SYN) of dead public figures and propose a novel Context-based Audio Deepfake Detector (CADD) architecture. In addition, we evaluate performance on two large-scale datasets: ITW and P$^2$V. We show that sufficient context and/or the transcript can significantly improve the efficacy of audio deepfake detectors. Performance (measured via F1 score, AUC, and EER) of multiple baseline audio deepfake detectors and traditional classifiers can be improved by 5%-37.58% in F1-score, 3.77%-42.79% in AUC, and 6.17%-47.83% in EER. We additionally show that CADD, via its use of context and/or transcripts, is more robust to 5 adversarial evasion strategies, limiting performance degradation to an average of just -0.71% across all experiments. Code, models, and datasets are available at our project page: https://sites.northwestern.edu/nsail/cadd-context-based-audio-deepfake-detection (access restricted during review).

cs.AI↗

arXiv2025

SOLVE-Med: Specialized Orchestration for Leading Vertical Experts across Medical Specialties

Medical question answering systems face deployment challenges including hallucinations, bias, computational demands, privacy concerns, and the need for specialized expertise across diverse domains. Here, we present SOLVE-Med, a multi-agent architecture combining domain-specialized small language models for complex medical queries. The system employs a Router Agent for dynamic specialist selection, ten specialized models (1B parameters each) fine-tuned on specific medical domains, and an Orchestrator Agent that synthesizes responses. Evaluated on Italian medical forum data across ten specialties, SOLVE-Med achieves superior performance with ROUGE-1 of 0.301 and BERTScore F1 of 0.697, outperforming standalone models up to 14B parameters while enabling local deployment. Our code is publicly available on GitHub: https://github.com/PRAISELab-PicusLab/SOLVE-Med.

cs.CL↗

arXiv2025

DEEP: A Discourse Evolution Engine for Predictions about Social Movements

Numerous social movements (SMs) around the world help support the UN's Sustainable Development Goals (SDGs). Understanding how key events shape SMs is key to the achievement of the SDGs. We have developed SMART (Social Media Analysis & Reasoning Tool) to track social movements related to the SDGs. SMART was designed by a multidisciplinary team of AI researchers, journalists, communications scholars and legal experts. This paper describes SMART's transformer-based multivariate time series Discourse Evolution Engine for Predictions about Social Movements (DEEP) to predict the volume of future articles/posts and the emotions expressed. DEEP outputs probabilistic forecasts with uncertainty estimates, providing critical support for editorial planning and strategic decision-making. We evaluate DEEP with a case study of the #MeToo movement by creating a novel longitudinal dataset (433K Reddit posts and 121K news articles) from September 2024 to June 2025 that will be publicly released for research purposes upon publication of this paper.

cs.SI↗

arXiv2025

IMB: An Italian Medical Benchmark for Question Answering

Online medical forums have long served as vital platforms where patients seek professional healthcare advice, generating vast amounts of valuable knowledge. However, the informal nature and linguistic complexity of forum interactions pose significant challenges for automated question answering systems, especially when dealing with non-English languages. We present two comprehensive Italian medical benchmarks: \textbf{IMB-QA}, containing 782,644 patient-doctor conversations from 77 medical categories, and \textbf{IMB-MCQA}, comprising 25,862 multiple-choice questions from medical specialty examinations. We demonstrate how Large Language Models (LLMs) can be leveraged to improve the clarity and consistency of medical forum data while retaining their original meaning and conversational style, and compare a variety of LLM architectures on both open and multiple-choice question answering tasks. Our experiments with Retrieval Augmented Generation (RAG) and domain-specific fine-tuning reveal that specialized adaptation strategies can outperform larger, general-purpose models in medical question answering tasks. These findings suggest that effective medical AI systems may benefit more from domain expertise and efficient information retrieval than from increased model scale. We release both datasets and evaluation frameworks in our GitHub repository to support further research on multilingual medical question answering: https://github.com/PRAISELab-PicusLab/IMB.

cs.CL↗

arXiv2025

DART: A Structured Dataset of Regulatory Drug Documents in Italian for Clinical NLP

The extraction of pharmacological knowledge from regulatory documents has become a key focus in biomedical natural language processing, with applications ranging from adverse event monitoring to AI-assisted clinical decision support. However, research in this field has predominantly relied on English-language corpora such as DrugBank, leaving a significant gap in resources tailored to other healthcare systems. To address this limitation, we introduce DART (Drug Annotation from Regulatory Texts), the first structured corpus of Italian Summaries of Product Characteristics derived from the official repository of the Italian Medicines Agency (AIFA). The dataset was built through a reproducible pipeline encompassing web-scale document retrieval, semantic segmentation of regulatory sections, and clinical summarization using a few-shot-tuned large language model with low-temperature decoding. DART provides structured information on key pharmacological domains such as indications, adverse drug reactions, and drug-drug interactions. To validate its utility, we implemented an LLM-based drug interaction checker that leverages the dataset to infer clinically meaningful interactions. Experimental results show that instruction-tuned LLMs can accurately infer potential interactions and their clinical implications when grounded in the structured textual fields of DART. We publicly release our code on GitHub: https://github.com/PRAISELab-PicusLab/DART.

cs.CL↗

arXiv2025

Combining Evidence and Reasoning for Biomedical Fact-Checking

Misinformation in healthcare, from vaccine hesitancy to unproven treatments, poses risks to public health and trust in medical systems. While machine learning and natural language processing have advanced automated fact-checking, validating biomedical claims remains uniquely challenging due to complex terminology, the need for domain expertise, and the critical importance of grounding in scientific evidence. We introduce CER (Combining Evidence and Reasoning), a novel framework for biomedical fact-checking that integrates scientific evidence retrieval, reasoning via large language models, and supervised veracity prediction. By integrating the text-generation capabilities of large language models with advanced retrieval techniques for high-quality biomedical scientific evidence, CER effectively mitigates the risk of hallucinations, ensuring that generated outputs are grounded in verifiable, evidence-based sources. Evaluations on expert-annotated datasets (HealthFC, BioASQ-7b, SciFact) demonstrate state-of-the-art performance and promising cross-dataset generalization. Code and data are released for transparency and reproducibility: https: //github.com/PRAISELab-PicusLab/CER.

cs.CL↗

arXiv2025

Combating Biomedical Misinformation through Multi-modal Claim Detection and Evidence-based Verification

cs.CL↗

arXiv2025

Perturbed Public Voices (P$^{2}$V): A Dataset for Robust Audio Deepfake Detection

Current audio deepfake detectors cannot be trusted. While they excel on controlled benchmarks, they fail when tested in the real world. We introduce Perturbed Public Voices (P$^{2}$V), an IRB-approved dataset capturing three critical aspects of malicious deepfakes: (1) identity-consistent transcripts via LLMs, (2) environmental and adversarial noise, and (3) state-of-the-art voice cloning (2020-2025). Experiments reveal alarming vulnerabilities of 22 recent audio deepfake detectors: models trained on current datasets lose 43% performance when tested on P$^{2}$V, with performance measured as the mean of F1 score on deepfake audio, AUC, and 1-EER. Simple adversarial perturbations induce up to 16% performance degradation, while advanced cloning techniques reduce detectability by 20-30%. In contrast, P$^{2}$V-trained models maintain robustness against these attacks while generalizing to existing datasets, establishing a new benchmark for robust audio deepfake detection. P$^{2}$V will be publicly released upon acceptance by a conference/journal.

cs.SD↗

arXiv2024

Agent-Based Modelling Meets Generative AI in Social Network Simulations

Agent-Based Modelling (ABM) has emerged as an essential tool for simulating social networks, encompassing diverse phenomena such as information dissemination, influence dynamics, and community formation. However, manually configuring varied agent interactions and information flow dynamics poses challenges, often resulting in oversimplified models that lack real-world generalizability. Integrating modern Large Language Models (LLMs) with ABM presents a promising avenue to address these challenges and enhance simulation fidelity, leveraging LLMs' human-like capabilities in sensing, reasoning, and behavior. In this paper, we propose a novel framework utilizing LLM-empowered agents to simulate social network users based on their interests and personality traits. The framework allows for customizable agent interactions resembling various social network platforms, including mechanisms for content resharing and personalized recommendations. We validate our framework using a comprehensive Twitter dataset from the 2020 US election, demonstrating that LLM-agents accurately replicate real users' behaviors, including linguistic patterns and political inclinations. These agents form homogeneous ideological clusters and retain the main themes of their community. Notably, preference-based recommendations significantly influence agent behavior, promoting increased engagement, network homophily and the formation of echo chambers. Overall, our findings underscore the potential of LLM-agents in advancing social media simulations and unraveling intricate online dynamics.

cs.SI↗

arXiv2021

Few-shot Named Entity Recognition with Cloze Questions

Despite the huge and continuous advances in computational linguistics, the lack of annotated data for Named Entity Recognition (NER) is still a challenging issue, especially in low-resource languages and when domain knowledge is required for high-quality annotations. Recent findings in NLP show the effectiveness of cloze-style questions in enabling language models to leverage the knowledge they acquired during the pre-training phase. In our work, we propose a simple and intuitive adaptation of Pattern-Exploiting Training (PET), a recent approach which combines the cloze-questions mechanism and fine-tuning for few-shot learning: the key idea is to rephrase the NER task with patterns. Our approach achieves considerably better performance than standard fine-tuning and comparable or improved results with respect to other few-shot baselines without relying on manually annotated data or distant supervision on three benchmark datasets: NCBI-disease, BC2GM and a private Italian biomedical corpus.

cs.CL↗