arXiv subjects

Marco Ratta

Publications and source records attributed to Marco Ratta.

3 recordsLinked to original sources

arXiv2025

Sample size reassessment in Bayesian hybrid clinical trials

The use of historical controls offers a valuable alternative when traditional randomized controlled trials are not feasible. However, such approaches may introduce bias due to temporal changes in patient populations, diagnostic criteria, and/or treatment standards. Hybrid designs, which combine a concurrent control arm with historical control data, can help mitigate the possible bias. We propose a novel Bayesian two-arm randomized clinical trial design incorporating an interim analysis. At the interim analysis, a new criterion derived from the Hellinger distance is used to quantify the similarity between historical and concurrent control data outcomes. This measure informs both (1) the variance function of the control prior distribution in the final analysis and (2) the sample size reassessment for the second stage of the trial. The proposed approach is designed to accommodate both continuous and binary endpoints and is assessed through extensive simulation studies. Results demonstrate the method flexibility and robustness in adapting to varying degrees of historical-control heterogeneity.

stat.ME↗

arXiv2025

On the interplay between prior weight and variance of the robustification component in Robust Mixture Prior Bayesian Dynamic Borrowing approach

Robust Mixture Prior (RMP) is a popular Bayesian dynamic borrowing method, which combines an informative historical distribution with a less informative component (referred as robustification component) in a mixture prior to enhance the efficiency of hybrid-control randomized trials. Current practice typically focuses solely on the selection of the prior weight that governs the relative influence of these two components, often fixing the variance of the robustification component to that of a single observation. In this study we demonstrate that the performance of RMPs critically depends on the joint selection of both weight and variance of the robustification component. In particular, we show that a wide range of weight-variance pairs can yield practically identical posterior inferences (in particular regions of the parameter space) and that large variance robust components may be employed without incurring in the so called Lindley's paradox. We further show that the use of large variance robustification components leads to improved asymptotic Type I error control and enhanced robustness of the RMP to the specification of the location parameter of the robustification component. Finally, we leverage these theoretical results to propose a novel and practical hyper-parameter elicitation routine.

stat.ME↗

arXiv2023

Streamlining Knowledge Graph Construction with a fa\c{c}ade: The SPARQL Anything project

What should a data integration framework for knowledge engineers look like? Recent research on Knowledge Graph construction proposes the design of a fa\c{c}ade, a notion borrowed from object-oriented software engineering. This idea is applied to SPARQL Anything, a system that allows querying heterogeneous resources as-if they were in RDF, in plain SPARQL 1.1, by overloading the SERVICE clause. SPARQL Anything supports a wide variety of file formats, from popular ones (CSV, JSON, XML, Spreadsheets) to others that are not supported by alternative solutions (Markdown, YAML, DOCx, Bibtex). Features include querying Web APIs with high flexibility, parametrised queries, and chaining multiple transformations into complex pipelines. In this paper, we describe the design rationale and software architecture of the SPARQL Anything system. We provide references to an extensive set of reusable, real-world scenarios from various application domains. We report on the value-to-users of the founding assumptions of its design, compared to alternative solutions through a community survey and a field report from the industry.

cs.DB↗