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Marcus Alley

Publications and source records attributed to Marcus Alley.

3 recordsLinked to original sources

Motion-Robust Deep Reconstruction for Free-Breathing Cardiac Cine MRI

Conventional cardiac cine MRI relies on breath-hold Cartesian acquisitions, which are vulnerable to motion artifacts and can be uncomfortable or infeasible, particularly for pediatric and other noncompliant patients who cannot reliably hold their breath. Free-breathing radial acquisitions can alleviate these limitations, but robust reconstruction at high acceleration remains challenging due to prominent streak artifacts. To address these limitations, we propose Cine-DL, a clinically oriented framework that couples targeted k-space preprocessing with fast, model-based deep reconstruction. In this pipeline, raw free-breathing radial data undergo retrospective cardiac binning and respiratory gating to resolve cardiac phases and discard motion-corrupted spokes. We then introduce Streak Optimized Coil Compression (SOC), which explicitly preserves cardiac signals while suppressing peripheral interference that typically drives the streak artifacts. The resulting 2D+t cine series is reconstructed with an unrolled network that alternates a ResNet proximal operator with physics-based data consistency updates solved via conjugate gradient. We further employ a memory-efficient training strategy that reduces peak memory usage. We evaluate Cine-DL on free-breathing volunteer data against established baselines (k-t SENSE and iGRASP) and demonstrate clinical translation via hospital deployment on newly acquired patient data. Our experiments show that Cine-DL consistently improves quantitative metrics and visual fidelity, supporting a practical route toward routine, time-sensitive clinical adoption of free-breathing cine MRI.

eess.IV

Quantitative Parametric Mapping of Tissues Properties from Standard Magnetic Resonance Imaging Enabled by Deep Learning

Magnetic resonance imaging (MRI) offers superior soft tissue contrast and is widely used in biomedicine. However, conventional MRI is not quantitative, which presents a bottleneck in image analysis and digital healthcare. Typically, additional scans are required to disentangle the effect of multiple parameters of MR and extract quantitative tissue properties. Here we investigate a data-driven strategy Q^2 MRI (Qualitative and Quantitative MRI) to derive quantitative parametric maps from standard MR images without additional data acquisition. By taking advantage of the interdependency between various MRI parametric maps buried in training data, the proposed deep learning strategy enables accurate prediction of tissue relaxation properties as well as other biophysical and biochemical characteristics from a single or a few images with conventional T_1/T_2 weighting. Superior performance has been achieved in quantitative MR imaging of the knee and liver. Q^2 MRI promises to provide a powerful tool for a variety of biomedical applications and facilitate the next generation of digital medicine.

physics.med-ph

Deep Generative Adversarial Networks for Compressed Sensing Automates MRI

Magnetic resonance image (MRI) reconstruction is a severely ill-posed linear inverse task demanding time and resource intensive computations that can substantially trade off {\it accuracy} for {\it speed} in real-time imaging. In addition, state-of-the-art compressed sensing (CS) analytics are not cognizant of the image {\it diagnostic quality}. To cope with these challenges we put forth a novel CS framework that permeates benefits from generative adversarial networks (GAN) to train a (low-dimensional) manifold of diagnostic-quality MR images from historical patients. Leveraging a mixture of least-squares (LS) GANs and pixel-wise $\ell_1$ cost, a deep residual network with skip connections is trained as the generator that learns to remove the {\it aliasing} artifacts by projecting onto the manifold. LSGAN learns the texture details, while $\ell_1$ controls the high-frequency noise. A multilayer convolutional neural network is then jointly trained based on diagnostic quality images to discriminate the projection quality. The test phase performs feed-forward propagation over the generator network that demands a very low computational overhead. Extensive evaluations are performed on a large contrast-enhanced MR dataset of pediatric patients. In particular, images rated based on expert radiologists corroborate that GANCS retrieves high contrast images with detailed texture relative to conventional CS, and pixel-wise schemes. In addition, it offers reconstruction under a few milliseconds, two orders of magnitude faster than state-of-the-art CS-MRI schemes.

cs.CV