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Marina Garrote-López

Publications and source records attributed to Marina Garrote-López.

13 recordsLinked to original sources

Algebraic optimization of sequential decision problems

We study the optimization of the expected long-term reward in finite partially observable Markov decision processes over the set of stationary stochastic policies. In the case of deterministic observations, also known as state aggregation, the problem is equivalent to optimizing a linear objective subject to quadratic constraints. We characterize the feasible set of this problem as the intersection of a product of affine varieties of rank one matrices and a polytope. Based on this description, we obtain bounds on the number of critical points of the optimization problem. Finally, we conduct experiments in which we solve the KKT equations or the Lagrange equations over different boundary components of the feasible set, and compare the result to the theoretical bounds and to other constrained optimization methods.

math.OC↗

Posets of trek polynomials for directed trees

When a variety $V_φ$ equals the image of a polynomial map $φ$ whose coordinate functions are combinatorial generating polynomials (i.e.~polynomials enumerating combinatorial objects), the geometry of $V_φ$ reflects identities satisfied by the generating polynomials. The resulting interplay between combinatorics and algebraic geometry can be used to answer questions about $V_φ$. A recent technique proposes to do so using a partially ordered set (poset) $P_φ$ defined via the coefficient vectors of the polynomials defining $φ$. This paper characterizes the poset $P_φ$ when the generating polynomials defining $φ$ enumerate subgraphs of a directed tree known as treks. The characterization is used to compute the linear span of $V_φ$, prove it is toric and deduce a basis for its vanishing ideal. It is also shown that this poset of trek polynomials for a directed tree is a so-called $π$-system if and only if the tree satisfies a property characterized via Stanley's P-partitions. As an additional consequence, it is shown that the varieties for two distinct directed trees intersect in a strictly lower-dimensional variety. This solves an instance of the structural identifiability problem in the graphical models program from statistics.

math.CO↗

On unirational varieties with poset parameterizations

We use partially ordered sets (posets) to provide a canonical parameterization for the Zariski closure of the image of a semialgebraic set under a rational map whose coordinate functions are polynomials with nonnegative integral coefficients. The resulting poset parametrization of such a unirational variety allows us to translate several well-studied problems into combinatorics; e.g. reducing the problems to describing the poset associated to the variety. These problems include, the implicitization problem from algebraic geometry, the toric reparameterization problem, the computation of the linear span of the variety, and the problem of distinguishing two semialgebraic subsets of the same ambient space. The technique applies to instances of these problems in several fields, including algebraic geometry, algebraic combinatorics, statistics and applied algebra. We demonstrate the technique on examples from each field, including degenerate subvarieties of secant varieties, matroid flat varieties -- which generalize toric varieties of edge polytopes, as well as varieties arising in multivariate data analysis and evolutionary biology.

math.CO↗

Algebraic Statistics in OSCAR

We introduce the AlgebraicStatistics section of the OSCAR computer algebra system. We give an overview of its extensible design and highlight its features including serialization of data types for sharing results and creating databases, and state-of-the-art implicitization algorithms.

stat.CO↗

Making mathematical online resources FAIR: at the example of small phylogenetic trees

We report on the process of taking an early 2000's mathematical library, the Small Phylogenetic Trees, and transforming it into a FAIR, modern, and sustainable repository for data from algebraic phylogenetics. This process is based on a three-fold strategy: (1) writing a software package which enables the user to reproduce results of the database; (2) setting up a user-friendly new website with cross links to theoretical publications, code snippets, and serialized output of computations; and (3) all-the-while documenting the steps we take in order to derive lessons learned which may be generalised to other such projects. This paper addresses (3). (1) is found in https://docs.oscar-system.org/dev/Experimental/AlgebraicStatistics/phylogenetics, and (2) is located at https://algebraicphylogenetics.org.

math.HO↗

Methodological considerations for semialgebraic hypothesis testing with incomplete U-statistics

Recently, Sturma, Drton, and Leung proposed a general-purpose stochastic method for hypothesis testing in models defined by polynomial equality and inequality constraints. Notably, the method remains theoretically valid even near irregular points, such as singularities and boundaries, where traditional testing approaches often break down. In this paper, we evaluate its practical performance on a collection of biologically motivated models from phylogenetics. While the method performs remarkably well across different settings, we catalogue a number of issues that should be considered for effective application.

q-bio.PE↗

Causal Discovery for Linear Non-Gaussian Models with Disjoint Cycles

The paradigm of linear structural equation modeling readily allows one to incorporate causal feedback loops in the model specification. These appear as directed cycles in the common graphical representation of the models. However, the presence of cycles entails difficulties such as the fact that models need no longer be characterized by conditional independence relations. As a result, learning cyclic causal structures remains a challenging problem. In this paper, we offer new insights on this problem in the context of linear non-Gaussian models. First, we precisely characterize when two directed graphs determine the same linear non-Gaussian model. Next, we take up a setting of cycle-disjoint graphs, for which we are able to show that simple quadratic and cubic polynomial relations among low-order moments of a non-Gaussian distribution allow one to locate source cycles. Complementing this with a strategy of decorrelating cycles and multivariate regression allows one to infer a block-topological order among the directed cycles, which leads to a {consistent and computationally efficient algorithm} for learning causal structures with disjoint cycles.

math.ST↗

Cumulant Tensors in Partitioned Independent Component Analysis

In this work, we explore Partitioned Independent Component Analysis (PICA), an extension of the well-established Independent Component Analysis (ICA) framework. Traditionally, ICA focuses on extracting a vector of independent source signals from a linear combination of them defined by a mixing matrix. We aim to provide a comprehensive understanding of the identifiability of this mixing matrix in ICA. Significant to our investigation, recent developments by Mesters and Zwiernik relax these strict independence requirements, studying the identifiability of the mixing matrix from zero restrictions on cumulant tensors. In this paper, we assume alternative independence conditions, in particular, the PICA case, where only partitions of the sources are mutually independent. We study this case from an algebraic perspective, and our primary result generalizes previous results on the identifiability of the mixing matrix.

math.ST↗

Computing algebraic degrees of phylogenetic varieties

A phylogenetic variety is an algebraic variety parameterized by a statistical model of the evolution of biological sequences along a tree. Understanding this variety is an important problem in the area of algebraic statistics with applications in phylogeny reconstruction. In the broader area of algebra statistics, there have been important theoretical advances in computing certain invariants associated to algebraic varieties arising in applications. Beyond the dimension and degree of a variety, one is interested in computing other algebraic degrees, such as the maximum likelihood degree and the Euclidean distance degree. Despite these efforts, the current literature lacks explicit computations of these invariants for the particular case of phylogenetic varieties. In our work, we fill this gap by computing these invariants for phylogenetic varieties arising from the simplest group-based models of nucleotide substitution Cavender-Farris-Neyman model, Jukes-Cantor model, Kimura 2-parameter model, and the Kimura 3-parameter model on small phylogenetic trees with at most 5 leaves.

q-bio.PE↗

Designing weights for quartet-based methods when data is heterogeneous across lineages

Homogeneity across lineages is a common assumption in phylogenetics according to which nucleotide substitution rates remain constant in time and do not depend on lineages. This is a simplifying hypothesis which is often adopted to make the process of sequence evolution more tractable. However, its validity has been explored and put into question in several papers. On the other hand, dealing successfully with the general case (heterogeneity across lineages) is one of the key features of phylogenetic reconstruction methods based on algebraic tools. The goal of this paper is twofold. First, we present a new weighting system for quartets (ASAQ) based on algebraic and semi-algebraic tools, thus specially indicated to deal with data evolving under heterogeneus rates. This method combines the weights two previous methods by means of a test based on the positivity of the branch length estimated with the paralinear distance. ASAQ is statistically consistent when applied to GM data, considers rate and base composition heterogeneity among lineages and does not assume stationarity nor time-reversibility. Second, we test and compare the performance of several quartet-based methods for phylogenetic tree reconstruction (namely, Quartet Puzzling, Weight Optimization and Wilson's method) in combination with ASAQ weights and other weights based on algebraic and semi-algebraic methods or on the paralinear distance. These tests are applied to both simulated and real data and support Weight Optimization with ASAQ weights as a reliable and successful reconstruction method.

q-bio.PE↗

Robust estimation of tree structured models

Consider the problem of learning undirected graphical models on trees from corrupted data. Recently Katiyar et al. showed that it is possible to recover trees from noisy binary data up to a small equivalence class of possible trees. Their other paper on the Gaussian case follows a similar pattern. By framing this as a special phylogenetic recovery problem we largely generalize these two settings. Using the framework of linear latent tree models we discuss tree identifiability for binary data under a continuous corruption model. For the Ising and the Gaussian tree model we also provide a characterisation of when the Chow-Liu algorithm consistently learns the underlying tree from the noisy data.

stat.ML↗

SAQ: semi-algebraic quartet reconstruction method

We present the phylogenetic quartet reconstruction method SAQ (Semi-algebraic quartet reconstruction). SAQ is consistent with the most general Markov model of nucleotide substitution and, in particular, it allows for rate heterogeneity across lineages. Based on the algebraic and semi-algebraic description of distributions that arise from the general Markov model on a quartet, the method outputs normalized weights for the three trivalent quartets (which can be used as input of quartet-base methods). We show that SAQ is a highly competitive method that outperforms most of the well known reconstruction methods on data simulated under the general Markov model on 4-taxon trees. Moreover, it also achieves a high performance on data that violates the underlying assumptions.

q-bio.PE↗

Distance to the stochastic part of phylogenetic varieties

Modelling the substitution of nucleotides along a phylogenetic tree is usually done by a hidden Markov process. This allows to define a distribution of characters at the leaves of the trees and one might be able to obtain polynomial relationships among the probabilities of different characters. The study of these polynomials and the geometry of the algebraic varieties defined by them can be used to reconstruct phylogenetic trees. However, not all points in these algebraic varieties have biological sense. In this paper, we explore the extent to which adding semi-algebraic conditions arising from the restriction to parameters with statistical meaning can improve existing methods of phylogenetic reconstruction. To this end, our aim is to compute the distance of data points to algebraic varieties and to the stochastic part of these varieties. Computing these distances involves optimization by nonlinear programming algorithms. We use analytical methods to find some of these distances for quartet trees evolving under the Kimura 3-parameter or the Jukes-Cantor models. Numerical algebraic geometry and computational algebra play also a fundamental role in this paper.

q-bio.PE↗