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Mario Annunziato

Publications and source records attributed to Mario Annunziato.

4 recordsLinked to original sources

Fokker-Planck analysis of superresolution microscopy images

A method for the analysis of superresolution microscopy images is presented. This method is based on the analysis of stochastic trajectories of particles moving on the membrane of a cell with the assumption that this motion is determined by the properties of this membrane. Thus, the purpose of this method is to recover the structural properties of the membrane by solving an inverse problem governed by the Fokker-Planck equation related to the stochastic trajectories. Results of numerical experiments demonstrate the ability of the proposed method to reconstruct the potential of a cell membrane by using synthetic data similar those captured by superresolution microscopy of luminescent activated proteins.

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Calibration of Lévy Processes using Optimal Control of Kolmogorov Equations with Periodic Boundary Conditions

We present an optimal control approach to the problem of model calibration for Lévy processes based on a non parametric estimation procedure. The calibration problem is of considerable interest in mathematical finance and beyond. Calibration of Lévy processes is particularly challenging as the jump distribution is given by an arbitrary Lévy measure, which form a infinite dimensional space. In this work, we follow an approach which is related to the maximum likelihood theory of sieves. The sampling of the Lévy process is modelled as independent observations of the stochastic process at some terminal time $T$. We use a generic spline discretization of the Lévy jump measure and select an adequate size of the spline basis using the Akaike Information Criterion (AIC). The numerical solution of the Lévy calibration problem requires efficient optimization of the log likelihood functional in high dimensional parameter spaces. We provide this by the optimal control of Kolmogorov's forward equation for the probability density function (Fokker-Planck equation). The first order optimality conditions are derived based on the Lagrange multiplier technique in a functional space. The resulting Partial Integral-Differential Equations (PIDE) are discretized, numerically solved and controlled using scheme a composed of Chang-Cooper, BDF2 and direct quadrature methods. For the numerical solver of the Kolmogorov's forward equation we prove conditions for non-negativity and stability in the $L^1$ norm of the discrete solution. To set boundary conditions, we argue that any Lévy process on the real line can be projected to a torus, where it again is a Lévy process. If the torus is sufficiently large, the loss of information is negligible.

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A finite difference method for Piecewise Deterministic Processes with memory

In this paper the numerical approximation of solutions of Liouville-Master Equations for time-dependent distribution functions of Piecewise Deterministic Processes with memory is considered. These equations are linear hyperbolic PDEs with non-constant coefficients, and boundary conditions that depend on integrals over the interior of the integration domain. We construct a finite difference method of the first order, by a combination of the upwind method, for PDEs, and by a direct quadrature, for the boundary condition. We analyse convergence of the numerical solution for distribution functions evolving towards an equilibrium. Numerical results for two problems, whose analytical solutions are known in closed form, illustrate the theoretical finding.

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A finite difference method for piecewise deterministic Markov processes

An extension of non-deterministic processes driven by the random telegraph signal is introduced in the framework of "piecewise deterministic Markov processes" [Davis], including a broader category of random systems. The corresponding Liouville-Master Equation is established and the upwind method is applied to numerical calculation of the distribution function. The convergence of the numerical solution is proved under an appropriate Courant-Friedrichs-Lewy condition. The same condition preserve the non-decreasing property of the calculated distribution function. Some numerical tests are presented.

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