Mario de Lucio | Searcharxiv

arXiv2026

Effect of Electric Charge on Biotherapeutic Transport, Binding and Absorption: A Computational Study

This study explores the effects of electric charge on the dynamics of drug transport and absorption in subcutaneous injections of monoclonal antibodies (mAbs). We develop a novel mathematical and computational model, based on the Nernst-Planck equations and porous media flow theory, to investigate the complex interactions between mAbs and charged species in subcutaneous tissue. The model enables us to study short-term transport dynamics and long-term binding and absorption for two mAbs with different electric properties. We examine the influence of buffer pH, body mass index, injection depth, and formulation concentration on drug distribution and compare our numerical results with experimental data from the literature.

cs.CE↗

arXiv2025

AneuPy: An open source Python tool for creating simulation-ready geometries of abdominal aortic aneurysms

Abdominal aortic aneurysms (AAAs) are localized dilatations of the abdominal aorta that can lead to life-threatening rupture if left untreated. AAAs primarily affect older individuals, with high mortality rates following rupture, so early diagnosis and risk assessment are critical. The geometrical characteristics of an AAA, such as its maximum diameter, asymmetry, and wall thickness, are extremely significant in biomechanical models for the assessment of rupture risk. Despite the growing use of computational modeling for AAA investigation, there is a notable gap in accessible, open-source software capable of generating simulation-ready geometries for biomechanical and hemodynamic simulations. To address this gap, we introduce \textbf{AneuPy}, an open-source Python-based tool designed to create both idealized and patient-specific AAA geometric models. \textbf{AneuPy} is a fast and automated approach for generating aneurysm geometries from minimal input data, allowing for extensive parameter customization. By automating the creation of simulation-ready geometries for finite element analysis (FEA), computational fluid dynamics (CFD), or fluid-structure interaction (FSI) models, \textbf{AneuPy} can facilitate research in AAA and improve patient-specific risk prediction.

physics.med-ph↗