arXiv subjects

Mark Widmaier

Publications and source records attributed to Mark Widmaier.

5 recordsLinked to original sources

arXiv2026

Synthetic Data in MR Spectroscopy: Current Practices, Applications, and Considerations

The use of synthetic data has emerged as an essential tool in Magnetic Resonance Spectroscopy (MRS) research and applications, providing advantages for optimization of acquisition, software validation, deep learning applications, and enhanced reproducibility. Importantly, synthetic data addresses challenges of limited training data availability, particularly for clinical populations, and offers controlled solutions for investigating uncertainties and unexplained variance with in vivo data. This work provides a review and evaluation of current practices in the use and generation of synthetic data within the MRS field. Conducted by the MRS Synthetic Data Working Group under the Code & Data Sharing Committee of the MRS Study Group of the International Society for Magnetic Resonance in Medicine (ISMRM), this manuscript encompasses existing literature, supplemented by collective experience and in-house methodologies.

physics.med-ph↗

arXiv2026

Feasibility of Concurrent 1H MRS & 31P MRSI at 7T: Brain Energy Metabolism Responses to Hyperglycemia

How the human brain adjusts fuel handling and its bioenergetic state during changing glucose levels remains difficult to assess noninvasively. In this study, we established an interleaved multinuclear 7 T MR spectroscopy protocol to track a glucose-related 1H signal alongside 31P measures of high-energy phosphate metabolism during a hyperglycemic clamp. Five healthy adults completed a morning, fasted infusion experiment consisting of baseline, ramp-up, and hyperglycemic stages over approx. 120 min. Short-block, short-TE 1H single-voxel spectroscopy (STEAM, TE = 11 ms; mean block duration 5.71 (SD:0.62 min)) was acquired in frontal cortex and quantified using the composite Glucose+Taurine (Glc+Tau) measure. 31P was acquired with rapid 3D PETALUTE MRSI using an ultrashort echo time (UTE; TE = 65 micros; 381 s per block), and high-energy phosphate ratios were derived from a posterior cortical region of interest. Across participants, 1H Glc+Tau increased with blood glucose and showed significant elevations from baseline into hyperglycemia. In parallel, 31P ratios exhibited smaller but significant glycemia-linked responses: both PCr/Pi and gamma-ATP/Pi increased with blood glucose and differed across glucose clamp stages. These findings show that 1H and 31P MRS(I) can be interleaved at 7 T to measure energy metabolism within a single session

physics.med-ph↗

arXiv2024

Rosette spectroscopic imaging for whole-brain metabolite mapping at 7T: acceleration potential and reproducibility

Whole-brain proton magnetic resonance spectroscopic imaging (1H-MRSI) is a non-invasive technique for assessing neurochemical distribution in the brain, offering valuable insights into brain functions and neural diseases. It greatly benefits from the improved SNR at ultrahigh field strengths ($\geq$7T). However, 1H-MRSI still faces several challenges, such as long acquisition time and severe signal contaminations from water and lipids. In this study, 2D and 3D short TR/TE 1H-FID-MRSI sequences using rosette trajectories were developed with spatial resolutions of 4.48$\times$4.48 mm$^2$ and 4.48$\times$4.48$\times$4.50 mm$^3$, respectively. Water signals were suppressed using an optimized Five-variable-Angle-gaussian-pulses-with-ShorT-total-duration of 76 ms (FAST) water suppression scheme, and lipid signals were removed using the L2 regularization method. Metabolic maps of major 1H metabolites were obtained within 5:40 min with 16 averages and 1 average for the 2D and 3D acquisitions, respectively. Excellent inter-session reproducibility was shown, with the coefficients of variance (CV) being lower than 6% for N-Acetyle-L-aspartic acid (NAA), Glutamate (Glu), Choline Chloride and glycerophosphocholine (tCho), Creatine and Phosphocreatine (tCr), and Glycine and Myo-inositol (Gly+Ins). To explore the potential of further accelerating the acquisition, compressed sensing was applied retrospectively to the 3D datasets. The structural similarity index (SSIM) remained above 0.85 and 0.8 until $R = 2$ and $R = 3$ for the metabolite maps of Glu, NAA, tCr, and tCho, indicating the possibility for further reduction of acquisition time to around 2min.

physics.med-ph↗

arXiv2024

Fast 3D 31P B1+ mapping with a weighted stack of spiral trajectory at 7 Tesla

Purpose: Phosphorus Magnetic Resonance Spectroscopy (31P MRS) enables non-invasive assessment of energy metabolism, yet its application is hindered by sensitivity limitations. To overcome this, often high magnetic fields are used, leading to challenges such as spatial B_1^+ inhomogeneity and therefore the need for accurate flip angle determination in accelerated acquisitions with short repetition times (T_R). In response to these challenges, we propose a novel short T_R and look-up table-based Double-Angle Method for fast 3D 31P B_1^+ mapping (fDAM). Methods: Our method incorporates 3D weighted stack of spiral gradient echo acquisitions and a frequency-selective pulse to enable efficient B_1^+ mapping based on the phosphocreatine signal at 7T. Protocols were optimised using simulations and validated through phantom experiments. The method was validated in phantom experiments and skeletal muscle applications using a birdcage 1H/31P volume coil. Results: The results of fDAM were compared to the classical DAM (cDAM). A good correlation (r=0.94) was obtained between the two B_1^+ maps. A 3D 31P B_1^+ mapping in the human calf muscle was achieved in about 10 min using a birdcage volume coil, with a 20% extended coverage relative to that of the cDAM (24 min). fDAM also enabled the first full brain coverage 31P 3D B_1^+ mapping in approx. 10 min using a 1 Tx/ 32 Rx coil. Conclusion: fDAM is an efficient method for 31P 3D B_1^+ mapping, showing promise for future applications in rapid 31P MRSI.

physics.med-ph↗

arXiv2019

Towards Practical Indoor Positioning Based on Massive MIMO Systems

We showcase the practicability of an indoor positioning system (IPS) solely based on Neural Networks (NNs) and the channel state information (CSI) of a (Massive) multiple-input multiple-output (MIMO) communication system, i.e., only build on the basis of data that is already existent in today's systems. As such our IPS system promises both, a good accuracy without the need of any additional protocol/signaling overhead for the user localization task. In particular, we propose a tailored NN structure with an additional phase branch as feature extractor and (compared to previous results) a significantly reduced amount of trainable parameters, leading to a minimization of the amount of required training data. We provide actual measurements for indoor scenarios with up to 64 antennas covering a large area of 80m2. In the second part, several robustness investigations for real-measurements are conducted, i.e., once trained, we analyze the recall accuracy over a time-period of several days. Further, we analyze the impact of pedestrians walking in-between the measurements and show that finetuning and pre-training of the NN helps to mitigate effects of hardware drifts and alterations in the propagation environment over time. This reduces the amount of required training samples at equal precision and, thereby, decreases the effort of the costly training data acquisition

eess.SP↗